Home About us Contact
|
Home About us Contact | ||
|
|
||
Functional Integration (functional + integration)
Selected AbstractsTransportation and the Geographical and Functional Integration of Global Production NetworksGROWTH AND CHANGE, Issue 4 2006JEAN-PAUL RODRIGUE ABSTRACT The growing interest in the relationships between transportation and globalization has spurred many inquires in the nature of production, consumption and distribution, especially within transport geography. It is widely acknowledged that improvements in transport and distribution have contributed to significant changes in the geographies of production (and vice versa). In a context of intense global competition and diminishing profit margins, logistics and the formation of global production networks offer additional opportunities to improve the efficiency of production through distribution strategies. The spatial and functional fragmentation of manufacturing and attempts at reducing inventories have led to smaller, more frequent and synchronized shipments, transforming the logistics industry, but placing intense pressures on transport systems to support these flows. The benefits derived from global production networks thus cannot be achieved without improvements in logistics and supply chain management. This article seeks to assess the conditions driving the global forms of production, distribution, and transport mainly by looking at the levels of geographical and functional integration of global production networks in view of the high level of fragmentation observed within them. However, there are still many uncertainties and delays in distribution, which can only be compensated by a better organization of freight distribution systems supporting global production networks. [source] Functional Integration of Health ServicesAUSTRALIAN JOURNAL OF RURAL HEALTH, Issue 2 2004Stuart Schneider No abstract is available for this article. [source] Nucleotides and epidermal growth factor induce parallel cytoskeletal rearrangements and migration in cultured adult murine neural stem cellsACTA PHYSIOLOGICA, Issue 2 2010I. Grimm Abstract Aim:, The adult subventricular zone (SVZ) contains neural stem cells that generate neuroblasts migrating to the olfactory bulb (OB) and differentiating into interneurones. The molecular cues controlling essential functions within the neurogenesis pathway such as proliferation, short and long distance migration, functional integration and cell survival are poorly understood. We have previously shown that cultured adult neural stem cells express a considerable variety of nucleotide receptors and that nucleotides and epidermal growth factor (EGF) induce converging intracellular signalling pathways that carry potential for synergism in the control of neural stem cell proliferation and cell survival. Here we investigate the role of EGF and the nucleotides ATP, ADP,S and UTP in neural stem cell migration. Methods:, Neural stem cells were prepared from adult mice and subjected to adherent culture. Labelling of F-actin was performed with tetramethylrhodamine isothiocyanate-phalloidin. Images were processed for quantitative evaluation of fluorescence labelling. Agonist-induced phosphorylation of AKT and focal adhesion kinase was analysed by quantitative Western blotting. Agonist-dependent cell migration was assayed using 48-well microchemotaxis chambers. Results:, Nucleotides and EGF induce the formation of stress fibres, an increase in the cortical actin cytoskeleton and in cell spreading. This is associated with increased phosphorylation of AKT and focal adhesion kinase. Using microchemotaxis chambers we demonstrate a parallel increase in cell migration. Conclusion:, Our results suggest that nucleotides and EGF acting as paracrine or autocrine signalling substances can be of relevance for structuring and maintaining the cytoarchitecture of the SVZ and the stream of neuroblasts migrating to the OB. [source] Behavioural activity levels and expression of stress proteins under predation risk in two damselfly speciesECOLOGICAL ENTOMOLOGY, Issue 3 2009STEFANIE SLOS Abstract 1.,It has become apparent that predators may strongly decrease prey fitness without direct contact with the prey, as they induce the development of defence systems that limit the availability of energy for growth and reproduction. Recent studies suggest that stress proteins may help prey organisms deal with this stress. The pattern is not general, however, and little is known about species differences in physiological traits in coping with predator stress, and covariation of physiological with other antipredator traits. 2.,To explore these issues, we quantified levels of constitutive and fish-induced stress proteins (Hsp60 and Hsp70) and anti-predator behaviours in larvae of two damselfly species that differ in lifestyle. Both stress proteins were fixed at higher levels in Erythromma najas, which has a slow lifestyle, than in Lestes sponsa, which has a fast lifestyle. Similarly, anti-predator behaviours were fixed at safer levels in E. najas than in L. sponsa. 3.,These results suggest that stress proteins may be part of anti-predator syndromes of damselfly larvae, and there may be trait co-specialisation between stress proteins and behavioural anti-predator traits. Studies formally testing these hypotheses in more species may prove rewarding in advancing our understanding of the functional integration of physiological anti-predator traits in relation to the prey's lifestyle. [source] INTRA-REGIONAL EMPLOYMENT GROWTH IN LUXEMBOURG (1994,2005)GEOGRAFISKA ANNALER SERIES B: HUMAN GEOGRAPHY, Issue 1 2010Olivier Walther ABSTRACT. The specialization of city-centres towards more advanced service activities has mostly been studied in the largest city-regions, the case of smaller urban centres being less well documented. In that context, the objective of this article is to analyse the role of sectoral and regional factors in employment growth in Luxembourg between 1994 and 2005. Using statistical data from the Luxembourg General Inspection of Social Security, this contribution distinguishes 12 categories of manufacturing industries and services according to an OECD-Eurostat knowledge-based classification. Five intra-regional areas are distinguished based on morphological and functional criteria in the Luxembourg Metropolitan Area. Using several indexes, this article first analyses the sectoral specialization and geographical concentration of employment. A model of intra-regional employment growth, initially developed by Marimon and Zilibotti and applied at the European level, is then shown to account for 40 per cent of employment growth. An estimation of the contributions of sectoral and geographical factors highlights the primacy of the latter over the former. Finally, the construction of virtual economies confirms the City's overall lower performance as compared to its close periphery. Results underscore a process of functional integration in the Luxembourg metropolitan area: as the core of the city undergoes a specialization process, the urban area benefits from a relocation of activities less sensitive to distance and transaction costs, while the periphery becomes increasingly diversified, notably in the South where traditional industrial activities are being replaced by service activities. These results suggest that the evolution pattern of employment growth in Luxembourg is very similar to that of some larger metropolitan centres, owing to its exceptional financial service activities. [source] Transportation and the Geographical and Functional Integration of Global Production NetworksGROWTH AND CHANGE, Issue 4 2006JEAN-PAUL RODRIGUE ABSTRACT The growing interest in the relationships between transportation and globalization has spurred many inquires in the nature of production, consumption and distribution, especially within transport geography. It is widely acknowledged that improvements in transport and distribution have contributed to significant changes in the geographies of production (and vice versa). In a context of intense global competition and diminishing profit margins, logistics and the formation of global production networks offer additional opportunities to improve the efficiency of production through distribution strategies. The spatial and functional fragmentation of manufacturing and attempts at reducing inventories have led to smaller, more frequent and synchronized shipments, transforming the logistics industry, but placing intense pressures on transport systems to support these flows. The benefits derived from global production networks thus cannot be achieved without improvements in logistics and supply chain management. This article seeks to assess the conditions driving the global forms of production, distribution, and transport mainly by looking at the levels of geographical and functional integration of global production networks in view of the high level of fragmentation observed within them. However, there are still many uncertainties and delays in distribution, which can only be compensated by a better organization of freight distribution systems supporting global production networks. [source] Changes in the interaction of resting-state neural networks from adolescence to adulthoodHUMAN BRAIN MAPPING, Issue 8 2009Michael C. Stevens Abstract This study examined how the mutual interactions of functionally integrated neural networks during resting-state fMRI differed between adolescence and adulthood. Independent component analysis (ICA) was used to identify functionally connected neural networks in 100 healthy participants aged 12,30 years. Hemodynamic timecourses that represented integrated neural network activity were analyzed with tools that quantified system "causal density" estimates, which indexed the proportion of significant Granger causality relationships among system nodes. Mutual influences among networks decreased with age, likely reflecting stronger within-network connectivity and more efficient between-network influences with greater development. Supplemental tests showed that this normative age-related reduction in causal density was accompanied by fewer significant connections to and from each network, regional increases in the strength of functional integration within networks, and age-related reductions in the strength of numerous specific system interactions. The latter included paths between lateral prefrontal-parietal circuits and "default mode" networks. These results contribute to an emerging understanding that activity in widely distributed networks thought to underlie complex cognition influences activity in other networks. Hum Brain Mapp 2009. © 2009 Wiley-Liss, Inc. [source] Mitochondria and Ca2+ signalingJOURNAL OF CELLULAR AND MOLECULAR MEDICINE, Issue 3 2000Emil C. Toescu Abstract Mitochondria play a central role in cell homeostasis. Amongst others, one of the important functions of mitochondria is to integrate its metabolic response with one of the major signaling pathways - the Ca2+ signaling. Mitochondria are capable to sense the levels of cytosolic Ca2+ and generate mitochondrial Ca2+ responses. Specific mechanisms for both Ca2+ uptake and Ca2+ release exist in the mitochondrial membranes. In turn, the mitochondrial Ca2+ signals are able to produce changes in the mitochondrial function and metabolism, which provide the required level of functional integration. This essay reviews briefly the current available information regarding the mitochondrial Ca2+ transport systems and some of the functional consequences of mitochondrial Ca2+ uptake [source] A cell-biological model of p75NTR signalingJOURNAL OF NEUROCHEMISTRY, Issue 2 2007A. Blöchl Abstract Neurotrophin stimulation of tropomyosin-related kinase (Trk) and p75 receptors influences cellular processes such as proliferation, growth, differentiation, and other cell-specific functions, as well as regeneration. In contrast to Trk receptors, which have a well-defined trophic role, p75 has activities ranging from trophism to apoptosis. Continued neurotrophin stimulation of differentiating neurons transforms the initially trophic character of p75 signaling into negative growth control and overstimulation leads to apoptosis. This function shift reflects the signaling effects of ceramide that is generated upon stimulation of p75. The use of ceramide signaling by p75 may provide a key to understanding the cell-biological role of p75. The review presents arguments that the control of cell shape formation and cell selection can serve as an organizing principle of p75 signaling. Concurrent stimulation by neurotrophins of p75 and Trk receptors constitutes a dual growth control with antagonistic and synergistic elements aimed at optimal morphological and functional integration of cells and cell populations into their context. [source] GEOGRAPHIC SCALE AND FUNCTIONAL SCOPE IN METROPOLITAN GOVERNANCE REFORM: THEORY AND EVIDENCE FROM GERMANYJOURNAL OF URBAN AFFAIRS, Issue 2 2006Joachim K. Blatter New dichotomies emerge, for example, "jumping of scale" versus "relativation of scales"; "deterritorializiaton" versus "reterritorialization"; "spaces of place" versus "space of flows." These dichotomies can be interpreted as different proposals and/or diagnoses in respect to the geographic scale and functional scope of emerging institutions of metropolitan governance. The paper aims to trace the empirical question of which direction we are heading by analyzing recent metropolitan governance reforms in six West German metropolitan areas. The findings show that there is a general trend to create soft institutions of governance on a larger scale as a reaction to global competition and continental integration. Beyond this commonality, we discover quite different institutional trajectories. The regions which are strongly embedded in the global economy tend toward a "deterritorialized" form of metropolitan governance with rather weak institutions characterized by large geographic scales and functional specialization. In contrast, the regions which are not as much embedded in the global economy have been able to create strong governance institutions on a regional level characterized by a rather small geographic scope and based on a territorial logic of functional integration and geographic congruence. [source] Human neural stem cell grafts in the spinal cord of SOD1 transgenic rats: Differentiation and structural integration into the segmental motor circuitryTHE JOURNAL OF COMPARATIVE NEUROLOGY, Issue 4 2009Leyan Xu Abstract Cell replacement strategies for degenerative and traumatic diseases of the nervous system depend on the functional integration of grafted cells into host neural circuitry, a condition necessary for the propagation of physiological signals and, perhaps, targeting of trophic support to injured neurons. We have recently shown that human neural stem cell (NSC) grafts ameliorate motor neuron disease in SOD1 transgenic rodents. Here we study structural aspects of integration of neuronally differentiated human NSCs in the motor circuitry of SOD1 G93A rats. Human NSCs were grafted into the lumbar protuberance of 8-week-old SOD1 G93A rats; the results were compared to those on control Sprague-Dawley rats. Using pre-embedding immuno-electron microscopy, we found human synaptophysin (+) terminals contacting the perikarya and proximal dendrites of host , motor neurons. Synaptophysin (+) terminals had well-formed synaptic vesicles and were associated with membrane specializations primarily in the form of symmetrical synapses. To analyze the anatomy of motor circuits engaging differentiated NSCs, we injected the retrograde transneuronal tracer Bartha-pseudorabies virus (PRV) or the retrograde marker cholera toxin B (CTB) into the gastrocnemius muscle/sciatic nerve of SOD1 rats before disease onset and also into control rats. With this tracing, NSC-derived neurons were labeled with PRV but not CTB, a pattern suggesting that PRV entered NSC-derived neurons via transneuronal transfer from host motor neurons but not via direct transport from the host musculature. Our results indicate an advanced degree of structural integration, via functional synapses, of differentiated human NSCs into the segmental motor circuitry of SOD1-G93A rats. J. Comp. Neurol. 514:297,309, 2009. © 2009 Wiley-Liss, Inc. [source] Microdamage and altered vascularity at the enthesis,bone interface provides an anatomic explanation for bone involvement in the HLA,B27,associated spondylarthritides and allied disordersARTHRITIS & RHEUMATISM, Issue 1 2007M. Benjamin Objective To describe the basis for entheseal-associated bone disease in the spondylarthritides, by analyzing microanatomic and histopathologic relationships between soft tissue, bone cortex, and adjacent trabeculae. Methods Serial sections from 52 entheses were examined; these entheses encompassed small and large insertions in the upper limb (n = 21), lower limb (n = 27), and spine (n = 4) from 60 cadavers. Enthesis microdamage (fissuring) as well as vascular and reparative changes were evaluated. Contact radiographs were used to ascertain the relationship between entheses and the trabecular network. Results At virtually all fibrocartilaginous entheses, the deep cortical boundary was extremely thin (typically 50,600 ,m) or indistinguishable, and 96% of entheses had small holes in the cortical shell (typically 100,400 ,m wide). Such regions were frequent sites of bone formation and renewal (96%) and microdamage (31%); these changes were more common in the lower limb. The presence of blood vessels near holes in the cortical shell was common; in 85% of attachments, blood vessels were present on the soft tissue side of the enthesis. Highly orientated trabeculae were more obvious in the lower limb than the upper limb (59% versus 29%). Conclusion The trabecular network supporting the cortical shell is an integral part of the enthesis, transferring load to an extensive skeletal region. In many cases, tendons/ligaments are anchored directly to such networks. This functional integration is associated with microdamage and repair at the hard tissue,soft tissue interface. These findings have implications for understanding bone involvement in SpA and for the SpA concept in general, especially the hypothesis that enthesis,bone architecture may be important in disease initiation. [source] Individual versus social complexity, with particular reference to ant coloniesBIOLOGICAL REVIEWS, Issue 2 2001CARL ANDERSON ABSTRACT Insect societies , colonies of ants, bees, wasps and termites , vary enormously in their social complexity. Social complexity is a broadly used term that encompasses many individual and colony-level traits and characteristics such as colony size, polymorphism and foraging strategy. A number of earlier studies have considered the relationships among various correlates of social complexity in insect societies; in this review, we build upon those studies by proposing additional correlates and show how all correlates can be integrated in a common explanatory framework. The various correlates are divided among four broad categories (sections). Under ,polyphenism' we consider the differences among individuals, in particular focusing upon ,caste' and specialization of individuals. This is followed by a section on ,totipotency' in which we consider the autonomy and subjugation of individuals. Under this heading we consider various aspects such as intracolony conflict, worker reproductive potential and physiological or morphological restrictions which limit individuals' capacities to perform a range of tasks or functions. A section entitled ,organization of work' considers a variety of aspects, e.g. the ability to tackle group, team or partitioned tasks, foraging strategies and colony reliability and efficiency. A final section,,communication and functional integration', considers how individual activity is coordinated to produce an integrated and adaptive colony. Within each section we use illustrative examples drawn from the social insect literature (mostly from ants, for which there is the best data) to illustrate concepts or trends and make a number of predictions concerning how a particular trait is expected to correlate with other aspects of social complexity. Within each section we also expand the scope of the arguments to consider these relationships in a much broader sense of'sociality' by drawing parallels with other ,social' entities such as multicellular individuals, which can be understood as ,societies' of cells. The aim is to draw out any parallels and common causal relationships among the correlates. Two themes run through the study. The first is the role of colony size as an important factor affecting social complexity. The second is the complexity of individual workers in relation to the complexity of the colony. Consequently, this is an ideal opportunity to test a previously proposed hypothesis that ,individuals of highly social ant species are less complex than individuals from simple ant species' in light of numerous social correlates. Our findings support this hypothesis. In summary, we conclude that, in general, complex societies are characterized by large colony size, worker polymorphism, strong behavioural specialization and loss of totipotency in its workers, low individual complexity, decentralized colony control and high system redundancy, low individual competence, a high degree of worker cooperation when tackling tasks, group foraging strategies, high tempo, multi-chambered tailor-made nests, high functional integration, relatively greater use of cues and modulatory signals to coordinate individuals and heterogeneous patterns of worker-worker interaction. Key words: Ants, insect societies, individual complexity, social complexity, polyphenism, totitpotency, work organization, functional integration, sociality. [source] Biological Motion Displays Elicit Social Behavior in 12-Month-OldsCHILD DEVELOPMENT, Issue 4 2009Jennifer M. D. Yoon To test the hypothesis that biological motion perception is developmentally integrated with important social cognitive abilities, 12-month-olds (N = 36) were shown a display of a human point-light figure turning to observe a target. Infants spontaneously and reliably followed the figure's "gaze" despite the absence of familiar and socially informative features such as a face or eyes. This suggests that biological motion displays are sufficient to convey rich psychological information such as attentional orientation and is the first evidence to show that biological motion perception and social cognitive abilities are functionally integrated early in the course of typical development. The question of whether common neural substrates for biological motion perception and analysis of gaze direction underlies the functional integration seen behaviorally is discussed. [source] Embryonic striatal grafts restore bi-directional synaptic plasticity in a rodent model of Huntington's diseaseEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 11 2009David Mazzocchi-Jones Abstract Embryonic striatal grafts integrate with the host striatal circuitry, forming anatomically appropriate connections capable of influencing host behaviour. In addition, striatal grafts can influence host behaviour via a variety of non-specific, trophic and pharmacological mechanisms; however, direct evidence that recovery is dependent on circuit reconstruction is lacking. Recent studies suggest that striatal grafts alleviate simple motor deficits, and also that learning of complex motor skills and habits can also be restored. However, although the data suggest that such ,re-learning' requires integration of the graft into the host striatal circuitry, little evidence exists to demonstrate that such integration includes functional synaptic connections. Here we demonstrate that embryonic striatal grafts form functional connections with the host striatal circuitry, capable of restoring stable synaptic transmission, within an excitotoxic lesion model of Huntington's disease. Furthermore, such ,functional integration' of the striatal graft enables the expression of host,graft bi-directional synaptic plasticity, similar to the normal cortico-striatal circuit. These results indicate that striatal grafts express synaptic correlates of learning, and thereby provide direct evidence of functional neuronal circuit repair, an essential component of ,functional integration'. [source] Individual versus social complexity, with particular reference to ant coloniesBIOLOGICAL REVIEWS, Issue 2 2001CARL ANDERSON ABSTRACT Insect societies , colonies of ants, bees, wasps and termites , vary enormously in their social complexity. Social complexity is a broadly used term that encompasses many individual and colony-level traits and characteristics such as colony size, polymorphism and foraging strategy. A number of earlier studies have considered the relationships among various correlates of social complexity in insect societies; in this review, we build upon those studies by proposing additional correlates and show how all correlates can be integrated in a common explanatory framework. The various correlates are divided among four broad categories (sections). Under ,polyphenism' we consider the differences among individuals, in particular focusing upon ,caste' and specialization of individuals. This is followed by a section on ,totipotency' in which we consider the autonomy and subjugation of individuals. Under this heading we consider various aspects such as intracolony conflict, worker reproductive potential and physiological or morphological restrictions which limit individuals' capacities to perform a range of tasks or functions. A section entitled ,organization of work' considers a variety of aspects, e.g. the ability to tackle group, team or partitioned tasks, foraging strategies and colony reliability and efficiency. A final section,,communication and functional integration', considers how individual activity is coordinated to produce an integrated and adaptive colony. Within each section we use illustrative examples drawn from the social insect literature (mostly from ants, for which there is the best data) to illustrate concepts or trends and make a number of predictions concerning how a particular trait is expected to correlate with other aspects of social complexity. Within each section we also expand the scope of the arguments to consider these relationships in a much broader sense of'sociality' by drawing parallels with other ,social' entities such as multicellular individuals, which can be understood as ,societies' of cells. The aim is to draw out any parallels and common causal relationships among the correlates. Two themes run through the study. The first is the role of colony size as an important factor affecting social complexity. The second is the complexity of individual workers in relation to the complexity of the colony. Consequently, this is an ideal opportunity to test a previously proposed hypothesis that ,individuals of highly social ant species are less complex than individuals from simple ant species' in light of numerous social correlates. Our findings support this hypothesis. In summary, we conclude that, in general, complex societies are characterized by large colony size, worker polymorphism, strong behavioural specialization and loss of totipotency in its workers, low individual complexity, decentralized colony control and high system redundancy, low individual competence, a high degree of worker cooperation when tackling tasks, group foraging strategies, high tempo, multi-chambered tailor-made nests, high functional integration, relatively greater use of cues and modulatory signals to coordinate individuals and heterogeneous patterns of worker-worker interaction. Key words: Ants, insect societies, individual complexity, social complexity, polyphenism, totitpotency, work organization, functional integration, sociality. [source] | ||||||||||||||||