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Fundamental Properties (fundamental + property)
Selected Abstracts"Nanoions": Fundamental Properties and Analytical Applications of Charged NanoparticlesCHEMPHYSCHEM, Issue 15 2007Kyle J. M. Bishop Abstract Mixtures of oppositely charged nanoparticles (NPs) precipitate sharply only at the point of NP electroneutrality. This behavior,reminiscent of the threshold precipitation of inorganic ions,is specific to the nanoscale and can be attributed to the formation of like-charged NP clusters stabilized in solution by mutual electrostatic repulsions. NP titrations based on this phenomenon provide a uniquely accurate tool for measuring charges tethered onto nanoscopic objects and for studying the thermodynamics of surface reactions at the nanoscale. [source] Hydride-based silica stationary phases for HPLC: Fundamental properties and applicationsJOURNAL OF SEPARATION SCIENCE, JSS, Issue 15 2005Joseph J. Pesek Abstract Silica hydride is a recent development in chromatographic support materials for HPLC where hydride groups replace 95% of the silanols on the surface. This conversion changes many of the fundamental properties of the material as well as the bonded stationary phases that are the result of further chemical modification of the hydride surface. The general approach for fabricating the silica hydride and subsequent bonded phases is reviewed. Properties of the silica hydride surface are compared to those of the standard material obtained in the preparation of most commercial HPLC stationary phases. Some unique chromatographic properties of hydride-based phases are described as well as some general application areas where these bonded materials may be used in preference to or have advantages not available from typical stationary phases. [source] Molecular dynamics and multiscale homogenization analysis of seepage/diffusion problem in bentonite clayINTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING, Issue 12 2002Y. Ichikawa Abstract A scheme combining a molecular behaviour and macro-continuum phenomenon is presented for bentonite clay, which is a key component of a barrier system for disposal and containment of hazardous wastes. On designing a disposal facility we use a macro-phenomenological model. However the existing model is not sufficiently effective. Bentonite is a microinhomogeneous material. Properties of the saturated bentonite are characterized by montmorillonite and water, called montmorillonite hydrate. Since the crystalline structure of montmorillonite determines the fundamental properties of the montmorillonite hydrate, we analyse its molecular behaviour by applying a molecular dynamics simulation to enquire into the physicochemical properties of the montmorillonite hydrate such as diffusivity of chemical species. For extending the microscopic characteristics of constituent materials to a macroscopic diffusion behaviour of the microinhomogeneous material we apply a multiscale homogenization analysis, especially in order to treat micro-level of adsorption behaviour. Copyright © 2002 John Wiley & Sons, Ltd. [source] Linking physiological mechanisms of coherent cellular behaviour with more general physical approaches towards the coherence of lifeIUBMB LIFE, Issue 11 2006Laurent Jaeken Abstract Schrödinger pointed out that one of the most fundamental properties of life is its coherent behaviour. This property has been approached from a physiological point of view by Ling in his 'association-induction hypothesis' and extended by Pollack (gel-sol theory), by Chaplin and by Kaivarainen (detailed studies of cellular water). The question of coherence has also been attacked from general physics in three independent approaches: from non-linear thermodynamics (Fröhlich), from quantum field theory (Del Giudice and his group) and from quantum mechanics (Davydov). In this paper all these approaches are unified. The emerging picture constitutes a new paradigm of life. iubmb Life, 58: 642 - 646, 2006 [source] Minimizing errors in identifying Lévy flight behaviour of organismsJOURNAL OF ANIMAL ECOLOGY, Issue 2 2007DAVID W. SIMS Summary 1Lévy flights are specialized random walks with fundamental properties such as superdiffusivity and scale invariance that have recently been applied in optimal foraging theory. Lévy flights have movement lengths chosen from a probability distribution with a power-law tail, which theoretically increases the chances of a forager encountering new prey patches and may represent an optimal solution for foraging across complex, natural habitats. 2An increasing number of studies are detecting Lévy behaviour in diverse organisms such as microbes, insects, birds, and mammals including humans. A principal method for detecting Lévy flight is whether the exponent (µ) of the power-law distribution of movement lengths falls within the range 1 < µ , 3. The exponent can be determined from the histogram of frequency vs. movement (step) lengths, but different plotting methods have been used to derive the Lévy exponent across different studies. 3Here we investigate using simulations how different plotting methods influence the µ-value and show that the power-law plotting method based on 2k (logarithmic) binning with normalization prior to log transformation of both axes yields low error (1·4%) in identifying Lévy flights. Furthermore, increasing sample size reduced variation about the recovered values of µ, for example by 83% as sample number increased from n = 50 up to 5000. 4Simple log transformation of the axes of the histogram of frequency vs. step length underestimated µ by c.40%, whereas two other methods, 2k (logarithmic) binning without normalization and calculation of a cumulative distribution function for the data, both estimate the regression slope as 1 , µ. Correction of the slope therefore yields an accurate Lévy exponent with estimation errors of 1·4 and 4·5%, respectively. 5Empirical reanalysis of data in published studies indicates that simple log transformation results in significant errors in estimating µ, which in turn affects reliability of the biological interpretation. The potential for detecting Lévy flight motion when it is not present is minimized by the approach described. We also show that using a large number of steps in movement analysis such as this will also increase the accuracy with which optimal Lévy flight behaviour can be detected. [source] In situ high-temperature powder diffraction study of reversible phase transitions in decagonal Al71.2Co12.8Ni16JOURNAL OF APPLIED CRYSTALLOGRAPHY, Issue 4 2003Christian Soltmann This experimental work is aimed at confirming and broadening findings of former investigations into the type I,S1 phase transition in Al,Co,Ni quasicrystals. In situ high-temperature synchrotron radiation measurements were carried out on Al71.2Co12.8Ni16 powder samples. The cell parameters were precisely determined at various temperatures in the range 290,1110,K. The data provided a new extended insight into the thermal expansion of Al71.2Co12.8Ni16 and into fundamental properties of the phase transition. [source] Mobile discourse: political bumper stickers as a communication event in IsraelJOURNAL OF COMMUNICATION, Issue 2 2000L-R Bloch The use of political bumper stickers in Israel began as a spontaneous protest medium, evolving into a routinized form of public discourse, taking place throughout the year, independently of national elections. The rules of interaction of this nontraditional means of political communication are identified and the complex relationships between the messages within their social situation are investigated using an ethnographic model. This analysis reveals that the medium does indeed constitute a structured means of expression with identifiable forms, rules, and usages, affording the person in the street a way of participating in the national discourse, bypassing traditional avenues of influence. The detailed examination of a single political bumper sticker reveals a structure parallel to the overall code, further demonstrating the intricacy of the messages. The analysis shows how this political discourse reflects social norms peculiar to Israel and how its use has become an affirmation of cultural identity. Because the fundamental properties of political bumper stickers have now been exposed, it is possible to examine how the actual use of this medium changes the structure of political agency in society through the presumption that ordinary individuals have the right of access to the public debate of national political issues, a right heretofore exclusively the prerogative of institutional power holders. [source] Comparative Structural, Emulsifying, and Biological Properties of 2 Major Canola Proteins, Cruciferin and NapinJOURNAL OF FOOD SCIENCE, Issue 3 2008J. Wu ABSTRACT:, Canola is an economically important farm-gate crop in Canada. To further explore the potential of canola protein as value-added food and nutraceutical ingredients, a better understanding of fundamental properties of 2 major canola proteins is necessary. Two major protein components, cruciferin and napin, were isolated from defatted canola meal by Sephacryl S-300 gel filtration chromatography. SDS-PAGE showed that cruciferin consists of more than 10 polypeptides, and noncovalent links are more important than disulphide bonds in stabilizing the structural conformation. Napin consists of 2 polypeptides and is stabilized primarily by disulphide bonds. Purified cruciferin showed 1 major endothermic peak at 91 °C compared with that of 110 °C for napin. Emulsion prepared by cruciferin showed significant higher specific surface area and lower particle size than that of napin. The study indicated that the presence of napin could detrimentally affect the emulsion stability of canola protein isolates. Hydrolysates from cruciferin and napin showed potent angiotensin I-converting enzyme inhibitory activity (IC50: 0.035 and 0.029 mg/mL, respectively), but weaker than that of canola protein isolate hydrolysate (IC50: 0.015 mg/mL). [source] Role of thermodynamic, molecular, and kinetic factors in crystallization from the amorphous stateJOURNAL OF PHARMACEUTICAL SCIENCES, Issue 4 2008Chandan Bhugra Abstract Though there is an advantage in using the higher solubility amorphous state in cases where low solubility limits absorption, physical instability poses a significant barrier limiting its use in solid oral dosage forms. Unlike chemical instability, where useful accelerated stability testing protocols are common, no methodology has been established to predict physical instability. Therefore, an understanding of the factors affecting crystallization from the amorphous state is not only important from a scientific perspective but also has practical applications. Crystallization from the amorphous matrix has been linked to the molecular mobility in the amorphous matrix and recent research has focused on developing the link between these two fundamental properties of glass forming materials. Although researchers have been actively working in this area for some time, there is no current review describing the present state of understanding of crystallization from the amorphous state. The purpose of this review therefore is to examine the roles of different factors such as molecular mobility, thermodynamic factors, and the implication of different processing condition, in crystallization from the amorphous state. We believe an increased understanding of the relative contributions of molecular mobility and processing conditions are vital to increased usage of the amorphous state in solid oral dosage forms. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 97:1329,1349, 2008 [source] Hydride-based silica stationary phases for HPLC: Fundamental properties and applicationsJOURNAL OF SEPARATION SCIENCE, JSS, Issue 15 2005Joseph J. Pesek Abstract Silica hydride is a recent development in chromatographic support materials for HPLC where hydride groups replace 95% of the silanols on the surface. This conversion changes many of the fundamental properties of the material as well as the bonded stationary phases that are the result of further chemical modification of the hydride surface. The general approach for fabricating the silica hydride and subsequent bonded phases is reviewed. Properties of the silica hydride surface are compared to those of the standard material obtained in the preparation of most commercial HPLC stationary phases. Some unique chromatographic properties of hydride-based phases are described as well as some general application areas where these bonded materials may be used in preference to or have advantages not available from typical stationary phases. [source] Multi-periodic eigensolutions to the Dirac operator and applications to the generalized Helmholtz equation on flat cylinders and on the n -torusMATHEMATICAL METHODS IN THE APPLIED SCIENCES, Issue 16 2009Denis Constales Abstract In this paper, we study the solutions to the generalized Helmholtz equation with complex parameter on some conformally flat cylinders and on the n -torus. Using the Clifford algebra calculus, the solutions can be expressed as multi-periodic eigensolutions to the Dirac operator associated with a complex parameter ,,,. Physically, these can be interpreted as the solutions to the time-harmonic Maxwell equations on these manifolds. We study their fundamental properties and give an explicit representation theorem of all these solutions and develop some integral representation formulas. In particular, we set up Green-type formulas for the cylindrical and toroidal Helmholtz operator. As a concrete application, we explicitly solve the Dirichlet problem for the cylindrical Helmholtz operator on the half cylinder. Finally, we introduce hypercomplex integral operators on these manifolds, which allow us to represent the solutions to the inhomogeneous Helmholtz equation with given boundary data on cylinders and on the n -torus. Copyright © 2009 John Wiley & Sons, Ltd. [source] Observations at terrestrial impact structures: Their utility in constraining crater formationMETEORITICS & PLANETARY SCIENCE, Issue 2 2004Richard A. F. Grieve Local geology of the target area tends to be of secondary importance, and the net result is that impacts of similar size on a given planetary body produce similar results. This is the essence of the utility of observations at impact craters, particularly terrestrial craters, in constraining impact processes. Unfortunately, there are few well-documented results from systematic contemporaneous campaigns to characterize specific terrestrial impact structures with the full spectrum of geoscientific tools available at the time. Nevertheless, observations of the terrestrial impact record have contributed substantially to fundamental properties of impact. There is a beginning of convergence and mutual testing of observations at terrestrial impact structures and the results of modeling, in particular from recent hydrocode models. The terrestrial impact record provides few constraints on models of ejecta processes beyond a confirmation of the involvement of the local substrate in ejecta lithologies and shows that Z-models are, at best, first order approximations. Observational evidence to date suggests that the formation of interior rings is an extension of the structural uplift process that occurs at smaller complex impact structures. There are, however, major observational gaps and cases, e.g., Vredefort, where current observations and hydrocode models are apparently inconsistent. It is, perhaps, time that the impact community as a whole considers documenting the existing observational and modeling knowledge gaps that are required to be filled to make the intellectual breakthroughs equivalent to those of the 1970s and 1980s, which were fueled by observations at terrestrial impact structures. Filling these knowledge gaps would likely be centered on the later stages of formation of complex and ring structures and on ejecta. [source] The properties of Ly, emitting galaxies in hierarchical galaxy formation modelsMONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, Issue 3 2006M. Le Delliou ABSTRACT We present detailed predictions for the properties of Ly,-emitting galaxies in the framework of the , cold dark matter cosmology, calculated using the semi-analytical galaxy formation model galform. We explore a model that assumes a top-heavy initial mass function in starbursts and that has previously been shown to explain the sub-millimetre number counts and the luminosity function of Lyman-break galaxies at high redshift. We show that this model, with the simple assumption that a fixed fraction of Ly, photons escape from each galaxy, is remarkably successful at explaining the observed luminosity function of Ly, emitters (LAEs) over the redshift range 3 < z < 6.6. We also examine the distribution of Ly, equivalent widths and the broad-band continuum magnitudes of emitters, which are in good agreement with the available observations. We look more deeply into the nature of LAEs, presenting predictions for fundamental properties such as the stellar mass and radius of the emitting galaxy and the mass of the host dark matter halo. The model predicts that the clustering of LAEs at high redshifts should be strongly biased relative to the dark matter, in agreement with observational estimates. We also present predictions for the luminosity function of LAEs at z > 7, a redshift range that is starting to be be probed by near-infrared surveys and using new instruments such as the Dark Ages Z Lyman Explorer (DAzLE). [source] The constant-density region of the dark haloes of spiral galaxiesMONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, Issue 1 2001Paolo Salucci We determine a crucial feature of the dark halo density distribution from the fact that the luminous matter dominates the gravitational potential at about one disc scalelength Rd, but at the optical edge the dark matter has already become the main component of the galaxy density. From the kinematics of 137 spirals we find that the dark matter halo density profiles are self-similar at least out to Ropt and show core radii much larger than the corresponding disc scalelengths. The luminous regions of spirals consist of stellar discs embedded in dark haloes with roughly constant density. This invariant dark matter profile is very difficult to reconcile with the fundamental properties of the density distribution of cold dark matter haloes. With respect to previous work, the present evidence is obtained by means of a robust method and for a large and complete sample of normal spirals. [source] Time-Resolved and Steady-State Fluorescence Spectroscopy of Eumelanin and Indolic PolymersPHOTOCHEMISTRY & PHOTOBIOLOGY, Issue 6 2007Stephen P. Nighswander-Rempel Eumelanin plays a variety of important physiological roles in human skin. However, its structure and fundamental properties still remain poorly understood. Although the absorbance of eumelanin is broad and reveals little about its structure, a variety of techniques have revealed the presence of a disordered array of chromophores within the melanin compound. In order to examine the fluorescence decay dynamics of these chromophores, time-resolved spectroscopy was applied to solutions of synthetic eumelanin and a melanin-like polymer of N-methyl,5-hydroxy,6-methoxyindole (N-Me-5H6MI). Solutions were excited with 80 fs laser pulses at 355, 370, 390 and 400 nm, and decay time courses were acquired at 20 nm intervals between 400 and 600 nm for each excitation wavelength. Decay profiles for both eumelanin and the polymer exhibited a characteristic multiexponential behavior with decay times between 0.5 and 15 ns, although steady-state spectra for the polymer exhibited only two peaks. The long-decay component in the polymer showed a significant decrease in both amplitude (30,5%) and decay time (14,6 ns) with increasing emission wavelength. In contrast, the amplitude and decay time in melanin increased slightly (10,15% and 7,10 ns, respectively) from 400 to 520 nm emission, at which point they leveled off. These trends were consistent for all excitation wavelengths. These results suggest that the multiexponential behavior of melanin fluorescence is characteristic of each oligomer within the eumelanin compound, and is consistent with the assertion that the diversity of constituents within eumelanin provides it with a robustness in spectral properties. [source] Full-color nanostructured thin-film electroluminescent device utilizing ZnS nanocrystals doped with activator-ionsPHYSICA STATUS SOLIDI (A) APPLICATIONS AND MATERIALS SCIENCE, Issue 1 2008T. Toyama Abstract We have studied nanostructured (NS-) thin-film electroluminescent (TFEL) devices utilizing the ZnS nanocrystals (NCs) with the mean crystal sizes of ca. 2,4 nm doped with activator-ions. As compared to the conventional TFEL device, we have achieved a remarkable reduction in the operation voltages by >100 V0,p. Moreover, toward full-color emissions, EL emissions of three primary colors, i.e., red, green, and blue have been derived from Mn2+, Tb3+, and Tm3+ ions, respectively. In this article, we review the studies on the fundamental properties of ZnS NCs as well as the device performance of the NS-TFEL devices. We also discuss the excitation mechanisms of the activator-ions in the ZnS NCs. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Proceedings of the 10th International Conference on Shallow-Level Centers in Semiconductors (SLCS-10)PHYSICA STATUS SOLIDI (C) - CURRENT TOPICS IN SOLID STATE PHYSICS, Issue 2 2003Marek Godlewski The 10th SLCS conference covered a broad range of the topics concerned with the fundamental properties of shallow levels in semiconductors and with impurity related issues of importance to semiconductor technology. [source] Submarket Dynamics of Time to SaleREAL ESTATE ECONOMICS, Issue 3 2006Gwilym Pryce We argue that the rush to apply multiple regression estimation to time on the market (TOM) durations may have led to important details and idiosyncrasies in local housing market dynamics being overlooked. What is needed is a more careful examination of the fundamental properties of time to sale data. The approach promoted and presented here, therefore, is to provide an examination of housing sale dynamics using a step-by-step approach. We present three hypotheses about TOM: (i) there is nonmonotonic duration dependence in the hazard of sale, (ii) the hazard curve will vary both over time and across intra-urban areas providing evidence of the existence of submarkets and (iii) institutional idiosyncrasies can have a profound effect on the shape and position of the hazard curve. We apply life tables, kernel-smoothed hazard functions and likelihood ratio tests for homogeneity to a large Scottish data set to investigate these hypotheses. Our findings have important implications for TOM analysis. [source] THE REGRESS OF PURE POWERS?THE PHILOSOPHICAL QUARTERLY, Issue 229 2007Alexander Bird Dispositional monism is the view that natural properties and relations are ,pure powers'. It is often objected that dispositional monism involves some kind of vicious or otherwise unpalatable regress or circularity. I examine ways of making this objection precise. The most pressing interpretation is that the theory fails to make the identities of powers determinate. I demonstrate that this objection is in error. It does, however, put certain constraints on what the structure of fundamental properties is like. I show what a satisfactory structure would be. [source] HUMEAN SUPERVENIENCE AND PERSONAL IDENTITYTHE PHILOSOPHICAL QUARTERLY, Issue 221 2005Ryan Wasserman Humeans hold that the nomological features of our world, including causal facts, are determined by the global distribution of fundamental properties. Since persistence presupposes causation, it follows that facts about personal identity are also globally determined. I argue that this is unacceptable for a number of reasons, and that the doctrine of Humean supervenience should therefore be rejected. [source] Systems biology and its application to the understanding of neurological diseases,ANNALS OF NEUROLOGY, Issue 2 2009Pablo Villoslada MD Recent advances in molecular biology, neurobiology, genetics, and imaging have demonstrated important insights about the nature of neurological diseases. However, a comprehensive understanding of their pathogenesis is still lacking. Although reductionism has been successful in enumerating and characterizing the components of most living organisms, it has failed to generate knowledge on how these components interact in complex arrangements to allow and sustain two of the most fundamental properties of the organism as a whole: its fitness, also termed its robustness, and its capacity to evolve. Systems biology complements the classic reductionist approaches in the biomedical sciences by enabling integration of available molecular, physiological, and clinical information in the context of a quantitative framework typically used by engineers. Systems biology employs tools developed in physics and mathematics such as nonlinear dynamics, control theory, and modeling of dynamic systems. The main goal of a systems approach to biology is to solve questions related to the complexity of living systems such as the brain, which cannot be reconciled solely with the currently available tools of molecular biology and genomics. As an example of the utility of this systems biological approach, network-based analyses of genes involved in hereditary ataxias have demonstrated a set of pathways related to RNA splicing, a novel pathogenic mechanism for these diseases. Network-based analysis is also challenging the current nosology of neurological diseases. This new knowledge will contribute to the development of patient-specific therapeutic approaches, bringing the paradigm of personalized medicine one step closer to reality. Ann Neurol 2009;65:124,139 [source] Modelling growth and body composition in fish nutrition: where have we been and where are we going?AQUACULTURE RESEARCH, Issue 2 2010André Dumas Abstract Mathematical models in fish nutrition have proven indispensable in estimating growth and feed requirements. Nowadays, reducing the environmental footprint and improving product quality of fish culture operations are of increasing interest. This review starts by examining simple models applied to describe/predict fish growth profiles and progresses towards more comprehensive concepts based on bioenergetics and nutrient metabolism. Simple growth models often lack biological interpretation and overlook fundamental properties of fish (e.g. ectothermy, indeterminate growth). In addition, these models disregard possible variations in growth trajectory across life stages. Bioenergetic models have served to predict not only fish growth but also feed requirements and waste outputs from fish culture operations. However, bioenergetics is a concept based on energy-yielding equivalence of chemicals and has significant limitations. Nutrient-based models have been introduced into the fish nutrition literature over the last two decades and stand as a more biologically sound alternative to bioenergetic models. More mechanistic models are required to expand current understanding about growth targets and nutrient utilization for biomass gain. Finally, existing models need to be adapted further to address effectively concerns regarding sustainability, product quality and body traits. [source] Characterization of electrochemically active bacteria utilizing a high-throughput voltage-based screening assayBIOTECHNOLOGY & BIOENGINEERING, Issue 2 2009Justin Biffinger Abstract Metal reduction assays are traditionally used to select and characterize electrochemically active bacteria (EAB) for use in microbial fuel cells (MFCs). However, correlating the ability of a microbe to generate current from an MFC to the reduction of metal oxides has not been definitively established in the literature. As these metal reduction assays may not be generally reliable, here we describe a four- to nine-well prototype high throughput voltage-based screening assay (VBSA) designed using MFC engineering principles and a universal cathode. Bacterial growth curves for Shewanella oneidensis strains DSP10 and MR-1 were generated directly from changes in open circuit voltage and current with five percent deviation calculated between each well. These growth curves exhibited a strong correlation with literature doubling times for Shewanella indicating that the VBSA can be used to monitor distinct fundamental properties of EAB life cycles. In addition, eight different organic electron donors (acetate, lactate, citrate, fructose, glucose, sucrose, soluble starch, and agar) were tested with S. oneidensis MR-1 in anode chambers exposed to air. Under oxygen exposure, we found that current was generated in direct response to additions of acetate, lactate, and glucose. Biotechnol. Bioeng. 2009;102: 436,444. © 2008 Wiley Periodicals, Inc. [source] The gastrointestinal stem cellCELL PROLIFERATION, Issue 1 2004M. Brittan Due to the rapid rate of cell turnover in the gastrointestinal tract, the stem cells of this tissue are amongst the most assiduous in the body, although they remain unidentified to this day due to their immature, undifferentiated phenotype. However, our knowledge of the mechanisms regulating gastrointestinal stem cell function is evolving, with the identification of putative cellular markers and the elucidation of signalling pathways which regulate cell behaviour in the normal and neoplastic gastrointestinal tract. This review describes the fundamental properties of the gastrointestinal stem cell including: (i) their number, location and origins, (ii) their primary function of deriving gastrointestinal cell lineages and maintaining tissue homeostasis, (iii) the acquisition of gastrointestinal cell lineages from adult stem cells of extraneous tissues and the consequences of this in a therapeutic context, and (iv) the genetic and morphological phenomena surrounding neoplastic transformation in the gastrointestinal tract. [source] Direct Assignment of Enantiofacial Discrimination on Single Heterocyclic Substrates by Self-induced CDCHEMISTRY - A EUROPEAN JOURNAL, Issue 6 2005Carsten Siering Abstract The first direct assignment of highly dynamic enantiofacial discrimination acting on a single heterocyclic substrate has been achieved by a combination of experimental and theoretical CD spectroscopy. The interaction of chirally modified hosts based on triphenylene ketals with appropriate prochiral guests can lead to the preferential formation of one diastereomeric host,guest complex. This reversible stereoselective binding transmits the chiral information from remote chiral groups in the host to the strongly absorbing triphenylene chromophore, which gives rise to self-induced CD. This effect was exploited for the determination of the enantiofacial recognition in various host,guest systems. Inversion of the steric demand either of the chiral substituents at the host or of the prochiral guest leads to almost complete inversion of the resulting CD spectra. For the assignment of the absolute stereochemistry of the complexes, a combined molecular dynamics/quantum-chemical approach was successfully employed. Despite the size and the highly dynamic character of the supramolecular systems, fundamental properties of the systems and details of the spectra were simulated accurately, providing access to fast and reliable assignment of the enantiofacial preference. The results are highly consistent with available X-ray data. [source] Hemicrania Continua Responsive to Intravenous Methyl PrednisoloneHEADACHE, Issue 4 2009Sanjay Prakash DM Hemicrania continua (HC) is a strictly unilateral, continuous primary headache disorder with periodic exacerbations, usually accompanied by cranial autonomic disturbances. Exquisite and persistent effect of indomethacin is a fundamental property of HC. We report 2 patients of HC in which attacks were successfully eliminated by repeated infusion of methyl prednisolone. [source] Evolution of cranial development and the role of neural crest: insights from amphibiansJOURNAL OF ANATOMY, Issue 5 2005James Hanken Abstract Contemporary studies of vertebrate cranial development document the essential role played by the embryonic neural crest as both a source of adult tissues and a locus of cranial form and patterning. Yet corresponding and basic features of cranial evolution, such as the extent of conservation vs. variation among species in the contribution of the neural crest to specific structures, remain to be adequately resolved. Investigation of these features requires comparable data from species that are both phylogenetically appropriate and taxonomically diverse. One key group are amphibians, which are uniquely able to inform our understanding of the ancestral patterns of ontogeny in fishes and tetrapods as well as the evolution of presumably derived patterns reported for amniotes. Recent data support the hypothesis that a prominent contribution of the neural crest to cranial skeletal and muscular connective tissues is a fundamental property that evolved early in vertebrate history and is retained in living forms. The contribution of the neural crest to skull bones appears to be more evolutionarily labile than that of cartilages, although significance of the limited comparative data is difficult to establish at present. Results underline the importance of accurate and reliable homology assessments for evaluating the contrasting patterns of derivation reported for the three principal tetrapod models: mouse, chicken and frog. [source] The Frequency of Financial Analysts' Forecast Revisions: Theory and Evidence about Determinants of Demand for Predisclosure InformationJOURNAL OF BUSINESS FINANCE & ACCOUNTING, Issue 7-8 2008Craig W. Holden Abstract:, A fundamental property of a financial market is its degree of price informativeness. A major determinant of price informativeness is predisclosure information collected by financial analysts and then privately disseminated to clients, who make the recommended trades. We develop a dynamic model of the analyst's optimal strategy of forecast revision frequency with endogenous analysts and endogenous traders. We then empirically test the model's predictions. We find that forecast revision frequency is positively associated with earnings variability, trading volume, and earnings response coefficients, and negatively associated with skewness of trading volume. Thus, we find strong empirical support for our dynamic model. [source] HIF-1 and p53: communication of transcription factors under hypoxiaJOURNAL OF CELLULAR AND MOLECULAR MEDICINE, Issue 4 2004Tobias Schmid Abstract Oxygen sensing and reactivity to changes in the concentration of oxygen is a fundamental property of cell physiology. The lack of O2 (hypoxia) is transmitted into many adaptive responses, a process that is largely controlled by a transcription factor known as hypoxia inducible factor-1 (HIF-1). More recent reports suggest that besides its traditional regulation via proteasomal degradation other signaling pathways contribute to stability regulation of the HIF-1, subunit and/or HIF-1 transactivation. These regulatory circuits allow for the integration of HIF-1 into scenarios of cell-survival vs. cell-death with the rule of the thumb that short-term mild hypoxia maintains cell viability while prolonged and severe hypoxia provokes cell demise. Cell death pathways are associated with stabilization of the tumor suppressor p53, a response also seen under hypoxic conditions. Here we summarize recent information on accumulation of HIF-1, and p53 under hypoxia and provide a model to explain the communication between HIF-1 and p53 under (patho)physiological conditions. [source] The continuity of microevolution and macroevolutionJOURNAL OF EVOLUTIONARY BIOLOGY, Issue 5 2002Andrew M. Simons Abstract A persistent debate in evolutionary biology is one over the continuity of microevolution and macroevolution , whether macroevolutionary trends are governed by the principles of microevolution. The opposition of evolutionary trends over different time scales is taken as evidence that selection is uncoupled over these scales. I argue that the paradox inferred by trend opposition is eliminated by a hierarchical application of the ,geometric-mean fitness' principle, a principle that has been invoked only within the limited context of microevolution in response to environmental variance. This principle implies the elimination of well adapted genotypes , even those with the highest arithmetic mean fitness over a shorter time scale. Contingent on premises concerning the temporal structure of environmental variance, selectivity of extinction, and clade-level heritability, the evolutionary outcome of major environmental change may be viewed as identical in principle to the outcome of minor environmental fluctuations over the short-term. Trend reversals are thus recognized as a fundamental property of selection operating at any phylogenetic level that occur in response to event severities of any magnitude over all time scales. This ,bet-hedging' perspective differs from others in that a specified, single hierarchical selective process is proposed to explain observed hierarchical patterns of extinction. [source] | ||||||||||||||||||||||||||||