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Fundamental Concepts (fundamental + concept)
Selected AbstractsConfucianism and Ethics in the Western Philosophical Tradition II: A Comparative Analysis of PersonhoodPHILOSOPHY COMPASS (ELECTRONIC), Issue 4 2010Mary I. Bockover This Philosophy Compass article continues the comparison between Confucian and mainstream Western views of personhood and their connection with ethics begun in Confucianism and Ethics in the Western Philosophical Tradition: Fundamental Concepts (CEWI), by focusing on the Western self conceived as an independent agent with moral and political rights. More specifically, the present article briefly accounts for how the more strictly and explicitly individualistic notion of self dominating Western philosophy has developed, leading up to a recent debate in modern Western rights theory between Herbert Fingarette and Henry Rosemont, Jr., two contemporary Western philosophers who are both steeped in Confucian thought as well as moral and political philosophy. This compares and contrasts Confucian principles with some basic to modern Western rights theory and the more individualistic view of self they entail. In the end, a new view of personhood and "free will" is offered that synthesizes insights from the Confucian treatment of persons as being essentially interdependent with the Western treatment of persons as being essentially independent. [Correction added after online publication 31 May 2010: Sentence changed.] [source] Stem cells in pathobiology and regenerative medicine,THE JOURNAL OF PATHOLOGY, Issue 2 2009MR Alison Abstract This issue of the Journal of Pathology contains 16 articles largely dealing with the role of tissue-specific adult stem cells in the pathogenesis of disease, notably cancer. These authoritative reviews begin by describing the current knowledge regarding the identity and molecular regulation of normal tissue-specific stem cells, before itemizing their role in the aetiology and progression of disease. Fundamental concepts regarding the stem cell niche have been gleaned from studies of germ line stem cells in Drosophila and Caenorhabditis elegans, and these are described in detail in this issue. Somatic cell reprogramming, a process underlying not only therapeutic cloning but also the production of induced pluripotent stem (iPS) cells, is further discussed. Much attention is given to embryonic stem (ES) and iPS cells within the scientific community; this issue of the Journal of Pathology redresses this imbalance by illustrating the pivotal role of adult stem cells in much of human disease. Copyright © 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. [source] Reformer and membrane modules plant to optimize natural gas conversion to hydrogenASIA-PACIFIC JOURNAL OF CHEMICAL ENGINEERING, Issue 3 2009M. De Falco Abstract Membrane technology may play a crucial role in the efficient production of hydrogen from natural gas and heavy hydrocarbons. The present work assesses the performance of a hydrogen production plant utilizing by reformer and membrane modules (RMM), by which the hydrogen produced in reaction units is separated by Pd-based membranes. A major advantage of RMM architecture is the shift of chemical equilibria favoring hydrogen production due to the removal of hydrogen through membranes at each reaction step, thus improving hydrogen yield while simultaneously allowing methane conversion at temperatures below 650 °C. Lower operating temperatures allow location of the modules downstream of a gas turbine, achieving an efficient hybrid system producing electric power and hydrogen with a significant reduction in energy consumption of approximately 10% relative to conventional systems. Fundamental concepts are analyzed and integrated into a process scheme. Effects of variables including reactor temperature outlet, steam-to-carbon ratio and recycle ratio throughout pinch and sensitivity analysis are described. Copyright © 2009 Curtin University of Technology and John Wiley & Sons, Ltd. [source] Rationality in Strategic Information Technology Decisions: The Impact of Shared Domain Knowledge and IT Unit Structure,DECISION SCIENCES, Issue 1 2002C. Ranganathan ABSTRACT Rationality is a fundamental concept to several models of IT planning and implementation. Though the importance of following rational processes in making strategic IT decisions is well acknowledged, there is not much understanding on why discrepancies occur in the IT decision-making process and what factors affect rationality. Drawing upon structural and resource-based perspectives of strategy, this study examines the influence of shared domain knowledge and IT unit structure on rationality in strategic IT decisions. Data were gathered from 223 senior IT executives using a survey to examine the relationships among the research constructs. The results suggest a positive impact of shared domain knowledge and formalization of IT unit structure on rationality in strategic IT decisions. Further, a highly centralized IT unit structure was found to negatively influence shared domain knowledge. On the other hand, formalization of IT structure positively influenced shared domain knowledge. The implications of the findings for research and practice are presented. [source] EXPERIMENTAL EVIDENCE FOR MULTIVARIATE STABILIZING SEXUAL SELECTIONEVOLUTION, Issue 4 2005Robert Brooks Abstract Stabilizing selection is a fundamental concept in evolutionary biology. In the presence of a single intermediate optimum phenotype (fitness peak) on the fitness surface, stabilizing selection should cause the population to evolve toward such a peak. This prediction has seldom been tested, particularly for suites of correlated traits. The lack of tests for an evolutionary match between population means and adaptive peaks may be due, at least in part, to problems associated with empirically detecting multivariate stabilizing selection and with testing whether population means are at the peak of multivariate fitness surfaces. Here we show how canonical analysis of the fitness surface, combined with the estimation of confidence regions for stationary points on quadratic response surfaces, may be used to define multivariate stabilizing selection on a suite of traits and to establish whether natural populations reside on the multivariate peak. We manufactured artificial advertisement calls of the male cricket Teleogryllus commodus and played them back to females in laboratory phonotaxis trials to estimate the linear and nonlinear sexual selection that female phonotactic choice imposes on male call structure. Significant nonlinear selection on the major axes of the fitness surface was convex in nature and displayed an intermediate optimum, indicating multivariate stabilizing selection. The mean phenotypes of four independent samples of males, from the same population as the females used in phonotaxis trials, were within the 95% confidence region for the fitness peak. These experiments indicate that stabilizing sexual selection may play an important role in the evolution of male call properties in natural populations of T. commodus. [source] Probabilistic safety analysis of structures under hybrid uncertaintyINTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING, Issue 4 2007Subrata Chakraborty Abstract The probabilistic and the possibilistic methods of safety evaluation of structure under uncertain parameters have been developed independently. When the structural system is defined with some of the input parameters as possibilistic and others are sufficient enough to model as probabilistic, available literatures normally start with either probabilistic or possibilistic description of all the variables. This may pose restriction on necessary flexibility to the designer at early stage of modelling of the structural system. The primary objective of the present work is to critically examine various emerging methods of transformation of the possibilistic variables to equivalent probabilistic variables so that probabilistic safety evaluation approach becomes compatible with the nature and quality of the input data. Relying on the fundamental concept of equivalent transformations, i.e. the entropy based transformation and the scaling of fuzzy membership function, the reliability analysis is proposed in the framework of second moment format. In doing so, the bounds on the reliability indices based on the evidence theory are also obtained encompassing the first-order reliability analysis for consistent comparison among alternative transformations. Finally, the reliability computation under hybrid uncertainty is elucidated numerically with examples for comparative study on the suitability of the transformation alternatives. Copyright © 2006 John Wiley & Sons, Ltd. [source] Sperm function tests and fertilityINTERNATIONAL JOURNAL OF ANDROLOGY, Issue 1 2006R. J. Aitken Summary Traditionally, the diagnosis of male infertility has depended upon a descriptive evaluation of human semen with emphasis on the number of spermatozoa that are present in the ejaculate, their motility and their morphology. The fundamental tenet underlying this approach is that male fertility can be defined by reference to a threshold concentration of motile, morphologically normal spermatozoa that must be exceeded in order to achieve conception. Many independent studies have demonstrated that this fundamental concept is flawed and, in reality, it is not so much the absolute number of spermatozoa that determines fertility, but their functional competence. In the light of this conclusion, a range of in vitro tests have been developed to monitor various aspects of sperm function including their potential for movement, cervical mucus penetration, capacitation, zona recognition, the acrosome reaction and sperm,oocyte fusion. Such functional assays have been found to predict the fertilizing capacity of human spermatozoa in vitro and in vivo with some accuracy. Recent developments in this field include the introduction of tests to assess the degree to which human spermatozoa have suffered oxidative stress as well as the integrity of their nuclear and mitochondrial DNA. Such assessments not only yield information on the fertilizing capacity of human spermatozoa but also their ability to support normal embryonic development. [source] Describing migration spatial structure,PAPERS IN REGIONAL SCIENCE, Issue 1 2002Andrei Rogers Migration; spatial structure; log-linear models Abstract The age structure of a population is a fundamental concept in demography and is generally depicted in the form of an age pyramid. The spatial structure of an interregional system of origin-destination-specific migration streams is, however, a notion lacking a widely accepted definition. We offer a definition in this article, one that draws on the log-linear specification of the geographer's spatial interaction model. We illustrate our definition with observed migration data, we discuss extensions and special cases, and proceed to contrast our definition and associated empirical findings against another measure having an alternative definition. [source] An evidence-based approach to human dermatomesCLINICAL ANATOMY, Issue 5 2008M.W.L. Lee Abstract The dermatome is a fundamental concept in human anatomy and of major importance in clinical practice. There are significant variations in current dermatome maps in standard anatomy texts. The aim of this study was to undertake a systematic literature review of the available evidence for the distribution of human dermatomes. Particular emphasis was placed on the technique of ascertainment, the location and extent of each dermatome, the number of subjects studied, and methodologic limitations. Our findings demonstrate that current dermatome maps are inaccurate and based on flawed studies. After selecting the best available evidence, a novel evidence-based dermatome map was constructed. This represents the most consistent tactile dermatomal areas for each spinal dorsal nerve root found in most individuals. In addition to highlighting the orderly arrangement, areas of consistency and clinical usefulness of dermatomes, their overlap and variability deserve greater emphasis. This review demonstrates the validity of an evidence-based approach to an anatomical concept. Clin. Anat. 21:363,373, 2008. © 2008 Wiley-Liss, Inc. [source] A Windows-based interface for teaching image processingCOMPUTER APPLICATIONS IN ENGINEERING EDUCATION, Issue 2 2010Melvin Ayala Abstract The use of image processing in research represents a challenge to the scientific community interested in its various applications but is not familiar with this area of expertise. In academia as well as in industry, fundamental concepts such as image transformations, filtering, noise removal, morphology, convolution/deconvolution among others require extra efforts to be understood. Additionally, algorithms for image reading and visualization in computers are not always easy to develop by inexperienced researchers. This type of environment has lead to an adverse situation where most students and researchers develop their own image processing code for operations which are already standards in image processing, a redundant process which only exacerbates the situation. The research proposed in this article, with the aim to resolve this dilemma, is to propose a user-friendly computer interface that has a dual objective which is to free students and researchers from the learning time needed for understanding/applying diverse imaging techniques but to also provide them with the option to enhance or reprogram such algorithms with direct access to the software code. The interface was thus developed with the intention to assist in understanding and performing common image processing operations through simple commands that can be performed mostly by mouse clicks. The visualization of pseudo code after each command execution makes the interface attractive, while saving time and facilitating to users the learning of such practical concepts. © 2009 Wiley Periodicals, Inc. Comput Appl Eng Educ 18: 213,224, 2010; Published online in Wiley InterScience (www.interscience.wiley.com); DOI 10.1002/cae.20171 [source] Investigative Visual Analysis of Global TerrorismCOMPUTER GRAPHICS FORUM, Issue 3 2008Xiaoyu Wang Abstract Recent increases in terrorist activity around the world have made analyzing and understanding such activities more critical than ever. With the help of organizations such as the National Center for the Study of Terrorism and Responses to Terrorism (START), we now have detailed historical information on each terrorist event around the world since 1970. However, due to the size and complexity of the data, identifying terrorists' patterns and trends has been difficult. To better enable investigators in understanding terrorist activities, we propose a visual analytical system that focuses on depicting one of the most fundamental concepts in investigative analysis, the five W's (who, what, where, when, and why). Views in our system are highly correlated, and each represents one of the W's. With this approach, an investigator can interactively explore terrorist activities efficiently and discover reasons of attacks (why) by identifying patterns temporally (when), geo-spatially (where), between multiple terrorist groups (who), and across different methods or modes of attacks (what). By coupling a global perspective with the details gleaned from asking these five questions, the system allows analysts to think both tactically and strategically. [source] NMR and the uncertainty principle: How to and how not to interpret homogeneous line broadening and pulse nonselectivity.CONCEPTS IN MAGNETIC RESONANCE, Issue 4 2008Abstract Following the treatments presented in Parts I and II, I herein discuss in more detail the popular notion that the frequency of a monochromatic RF pulse as well as that of a monochromatic FID is "in effect" uncertain due to the (Heisenberg) Uncertainty Principle, which also manifests itself in the fact that the FT-spectrum of these temporal entities is spread over a nonzero frequency band. In Part III, I continue my preliminary review of some further fundamental concepts, such as the Heisenberg and Fourier Uncertainty Principles, that are needed to understand whether or not the NMR linewidth and the RF excitation bandwidth have anything to do with "uncertainty". The article then culminates in re-addressing our Two NMR Problems in a more conscientious frame of mind by using a more refined formalism. The correct interpretation of these problems will be discussed in Part IV. © 2008 Wiley Periodicals, Inc. Concepts Magn Reson Part A 32A: 302,325, 2008. [source] Stellate Purse-String ClosureDERMATOLOGIC SURGERY, Issue 5 2000Minh Dang MD Background. There are fundamental concepts we use in managing surgical defects. Whether planning a primary closure or a local flap, we frequently modify the basic design to maximize aesthetic outcomes, taking into consideration a number of factors including the location of the defect and tissue availability. Objective. We describe the stellate modified purse-string closure, a novel flap modification. Method. Report of an illustrated case. Result. A patient with vertex scalp defect was reconstructed using the stellate purse-string flap. Conclusion. Certain modifications of commonly used reconstructive techniques can be utilized in specific situations to enhance cosmesis. Advantages of this modification are discussed. [source] Modified Burow's Wedge Flap for Upper Lateral Lip DefectsDERMATOLOGIC SURGERY, Issue 5 2000Minh Dang MD Background. There are fundamental concepts we use in managing surgical defects. Whether planning a primary closure or a local flap, we frequently modify the basic design to maximize aesthetic outcomes, taking into consideration a number of factors including the location of the defect and tissue availability. Objective. We describe a modified Burow's wedge flap for upper lateral lip defects. Method. Report of an illustrated case. Result. A patient with an upper lip defect was successfully reconstructed using the modified Burow's wedge flap, where the Burrow's wedge is placed on the mucocutaneous lip. Conclusion. Certain modifications of commonly used reconstructive techniques can be utilized in specific situations to enhance cosmesis. For the Burow's wedge flap, the dermatologic surgeon has several options in placing the Burow's triangle. This is an example of how alternatives in a closure can be used depending on the laxity of the skin and the size of the defect. Advantages and disadvantages of this alternative placement of the Burow's triangle are discussed. [source] Cover Picture: Electrophoresis 7'09ELECTROPHORESIS, Issue 10 2009Article first published online: 13 MAY 200 Issue no. 10 is a special issue on CE-MS edited by Phillipe Schmitt-Kopplin. It has three review articles describing recent advances in fundamental concepts, instrumentation, food safety, food quality, trace analysis of environmental pollutants and food contaminants, as well as many other applications. In addition, the special issue consists of 22 research articles on various topics of CE-MS, including technical and method developments, residue analysis in food and environmental applications and applications in diagnostic and life sciences. [source] Sampling and variance estimation on continuous domainsENVIRONMETRICS, Issue 6 2006Cynthia Cooper Abstract This paper explores fundamental concepts of design- and model-based approaches to sampling and estimation for a response defined on a continuous domain. The paper discusses the concepts in design-based methods as applied in a continuous domain, the meaning of model-based sampling, and the interpretation of the design-based variance of a model-based estimate. A model-assisted variance estimator is examined for circumstances for which a direct design-based estimator may be inadequate or not available. The alternative model-assisted variance estimator is demonstrated in simulations on a realization of a response generated by a process with exponential covariance structure. The empirical results demonstrate that the model-assisted variance estimator is less biased and more efficient than Horvitz,Thompson and Yates,Grundy variance estimators applied to a continuous-domain response. Copyright © 2006 John Wiley & Sons, Ltd. [source] Space, Place and Sexual Sociality: Towards an ,Atmospheric Analysis'GENDER, WORK & ORGANISATION, Issue 1 2010Adam Isaiah Green In this article we seek to contribute to the spatial turn in sociology by highlighting the socializing, cultivating and pedagogical properties of space in relation to sexual sociality and sexual practice. Towards this end, we develop two fundamental concepts , space and place , and anchor these to an existing corpus of empirical research on sexuality and space. This article explores public restrooms, bathhouses and sadomasochistic dungeons as organized sexual spaces, and in particular analyses how these places and spaces are organized and become organized around sexual activity. We argue that analysing the role of space in sexual sociality requires attention to both space and place, and their interrelationships , in short, an atmospheric analysis. [source] A critical assessment of the ecological risk assessment process: A review of misapplied conceptsINTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT, Issue 1 2005Lawrence V. Tannenbaum Abstract A frank assessment of present-day ecological risk assessments (ERA) for managed contaminated sites reveals that fundamental concepts regarding the receptors that are considered and the chemical exposures they experience are commonly misapplied. As a consequence, environmental managers are not being supplied with the information needed for proper decision making. The stepwise review of ecological risk issues provided here suggests that the ERA process needs to be severely revamped. Further, what is likely hindering the development of a refined ecological assessment process that is better suited to environmental problem solving and land management is the unwillingness of stakeholders to agree that much of the current ERA practice and convention is flawed. [source] A review of the GOLD guidelines for the diagnosis and treatment of patients with COPDINTERNATIONAL JOURNAL OF CLINICAL PRACTICE, Issue 8 2008L. Fromer Summary Chronic obstructive pulmonary disease (COPD) is a leading cause of death in the USA, and represents a major health, social and economic burden. COPD is underdiagnosed and often misdiagnosed, which likely contributes to the continuing increases in the prevalence, morbidity and mortality associated with this disease. This is unfortunate because whereas COPD cannot be cured, it can be treated effectively, particularly during the earlier stages of the disease. Evidence-based guidelines, developed to assist in the prevention, diagnosis and management of COPD, are available to healthcare professionals interested in learning more about COPD. These guidelines are updated and revised on a regular basis to reflect recent advances in our understanding of the pathophysiology of and treatments available for COPD. Nevertheless, primary-care physicians have reported a lack of awareness of the fundamental concepts underpinning the optimal treatment and management of COPD presented in the guidelines. Thus, the objective of this article is to summarise key physiologic, diagnostic and management concepts provided in the most recent update of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines, which were published in November 2006. [source] Unipolarity, Globalization, and the War on Terror: Why Security Studies Should Refocus on Comparative Defense,INTERNATIONAL STUDIES REVIEW, Issue 3 2007Damon Coletta Changes in the international environment such as the shift toward unipolarity, the rise of globalization, and the expansion of terrorist networks have redefined the sorts of problems confronted by policymakers and military practitioners in the arena of national security. With most of its fundamental concepts and frameworks rooted in the study of international relations (IR), the field of security studies has failed to keep up. Highly educated soldiers and diplomats sent to help rebuild failed or fragmented states are still poorly equipped to identify major obstacles or formulate solutions for accomplishing their missions. The safety of states and societies today depends less exclusively on blocking the military, economic, and ideological initiatives of a foreign power and more on supporting the integrity of members that can participate in an international system regulated by generally agreed-upon rules and conventions. The need to help various types of states under a variety of cultural and economic conditions build legitimate, durable political institutions and functioning societies should push security studies toward a broader examination of comparative politics. Beyond the balance of power and modalities of interstate competition, the new security studies should embrace fundamentals found outside of IR to make more robust intellectual contributions to the examination of comparative defense. [source] Data analysis in plant physiology: are we missing the reality?PLANT CELL & ENVIRONMENT, Issue 9 2001G. N. Amzallag Abstract In plant physiology, data analysis is based on the comparison of mean values. In this perspective, variability around the mean value has no significance per se, but only for estimating statistical significance of the difference between two mean values. Another approach to variability is proposed here, derived from the difference between redundant and deterministic patterns of regulation in their capacity to buffer noise. From this point of view, analysis of variability enables the investigation of the level of redundancy of a regulation pattern, and even allows us to study its modifications. As an example, this method is used to investigate the effect of brassinosteroids (BSs) during vegetative growth in Sorghum bicolor. It is shown that, at physiological concentrations, BSs modulate the network of regulation without affecting the mean value. Thus, it is concluded that the physiological effect of BSs cannot be revealed by comparison of mean values. This example illustrates how a part of the reality (in this case, the most relevant one) is hidden by the classical methods of comparison between mean values. The proposed tools of analysis open new perspectives in understanding plant development and the non-linear processes involved in its regulation. They also ask for a redefinition of fundamental concepts in physiology, such as growth regulator, optimality, stress and adaptation. [source] Differential geometry: a natural tool for describing symmetry operationsACTA CRYSTALLOGRAPHICA SECTION A, Issue 5 2009Philippe Kocian Differential geometry provides a useful mathematical framework for describing the fundamental concepts in crystallography. The notions of point and associated vector spaces correspond to those of manifold and tangent space at a given point. A space-group operation is a one-to-one map acting on the manifold, whereas a point-group operation is a linear map acting between two tangent spaces of the manifold. Manifold theory proves particularly powerful as a unified formalism describing symmetry operations of conventional as well as modulated crystals without requiring a higher-dimensional space. We show, in particular, that a modulated structure recovers a three-dimensional periodicity in any tangent space and that its point group consists of linear applications. [source] Sphericity Governs Both Stereochemistry in a Molecule and Stereoisomerism Among MoleculesTHE CHEMICAL RECORD, Issue 3 2002Shinsaku Fujita Abstract The concept of sphericity and relevant fundamental concepts that we have proposed have produced a systematized format for comprehending stereochemical phenomena. Permutability of ligands in conventional approaches is discussed from a stereochemical point of view. After the introduction of orbits governed by coset representations, the concepts of subduction and sphericity are proposed to characterize desymmetrization processes, with a tetrahedral skeleton as an example. The stereochemistry and stereoisomerism of the resulting promolecules (molecules formulated abstractly) are discussed in terms of the concept of sphericity as a common mathematical and logical framework. Thus, these promolecules are characterized by point group and permutation group symmetry. Prochirality, stereogenicity, prostereogenicity, and relevant topics are described in terms of the concept of sphericity. © 2002 The Japan Chemical Journal Forum and Wiley Periodicals, Inc., Chem Rec 2: 164,176; 2002: Published online in Wiley InterScience (www.interscience.wiley.com) DOI 10.1002/tcr.10018 [source] Tutorials in Clinical Research: Part VII.THE LARYNGOSCOPE, Issue 9 2003Part A: General Concepts of Statistical Significance, Understanding Comparative Statistics (Contrast) Abstract Objectives/Hypothesis The present tutorial is the seventh in a series of Tutorials in Clinical Research. The specific purpose of the tutorial (Part A) and its sequel (Part B) is to introduce and explain three commonly used statistical tools for assessing contrast in the comparison between two groups. Study Design Tutorial. Methods The authors met weekly for 10 months discussing clinical research studies and the applied statistics. The difficulty was not in the material but in the effort to make the report easy to read and as short as possible. Results The tutorial is organized into two parts. Part A, which is the present report, focuses on the fundamental concepts of the null hypothesis and comparative statistical significance. The sequel, Part B, discusses the application of three common statistical indexes of contrast, the ,2, Mann-Whitney U, and Student t tests. Conclusions Assessing the validity of medical studies requires a working knowledge of research design and statistics; obtaining this knowledge need not be beyond the ability of the busy surgeon. The authors have tried to construct an accurate, easy-to-read, easy-to-apply, basic introduction to comparing two groups. The long-term goal of the present tutorial and others in the series is to facilitate basic understanding of clinical research, thereby stimulating reading of some of the numerous well-written research design and statistical texts. This knowledge may then be applied to the continuing educational review of the literature and the systematic prospective analysis of individual practices. [source] Social network analysis: A methodological introductionASIAN JOURNAL OF SOCIAL PSYCHOLOGY, Issue 1 2008Carter T. Butts Social network analysis is a large and growing body of research on the measurement and analysis of relational structure. Here, we review the fundamental concepts of network analysis, as well as a range of methods currently used in the field. Issues pertaining to data collection, analysis of single networks, network comparison, and analysis of individual-level covariates are discussed, and a number of suggestions are made for avoiding common pitfalls in the application of network methods to substantive questions. [source] | |||||||||||||||||||||||||