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Full Series (full + series)
Selected AbstractsPreparation and Properties of the Full Series of Cuboidal Clusters [MoxW4-xSe4(H2O)12] n+ (n = 4,6) and Their Derivatives.CHEMINFORM, Issue 20 2005M. Sokolov Abstract For Abstract see ChemInform Abstract in Full Text. [source] Mixed-Ligand Oxidovanadium(V) Complexes with N, -Salicylidenehydrazides: Synthesis, Structure, and 51V Solid-State MAS NMR Investigation,EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, Issue 14 2008Simona Nica Abstract The synthesis and spectroscopic characterization of a series of three oxidovanadium(V) complexes with 8-hydroxyquinoline and Schiff-base ligands derived from salicylaldehyde and ,-hydroxy-functionalized carbohydrazides with different chain lengths are reported. The complex with the hydrazone ligand containing the shortest chain length was crystallographically characterized. This complex crystallizes in the triclinic space group P with two structurally similar but crystallographically independent oxidovanadium(V) complexes. Each vanadium atom is six-coordinate in a distorted-octahedral geometry. The two molecules are assembled through hydrogen-bonding interactions between the hydroxyl groups of the side-chain substituted Schiff-base ligand and the oxido group of one of the two complexes. Electrochemical measurements performed in acetonitrile solution reveal two reversible one-electron reduction steps. The observed pre-wave feature of the second reduction step indicates the presence of dissociation equilibria related to the 8-hydroxyquinoline coligand. Magic-angle spinning solid-state 51V NMR spectroscopy allowed to characterize the full series of complexes with alkyl and hydroxy alkyl-substituted hydrazone ligands that were used. The quadrupolar coupling constants are small with a value of about 4 MHz and show little variation within the series. The asymmetry of the chemical shift tensor indicates a rather axial symmetric environment around the vanadium(V) center. The isotropic chemical shifts observed in the solid state occur at about 30 ppm, which is in the same order of magnitude as the solvent induced variations, about 10 ppm, found for different solvents.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008) [source] Association of CASP8 D302H polymorphism with reduced risk of aggressive prostate carcinomaTHE PROSTATE, Issue 6 2010Jessica Lubahn Abstract BACKGROUND Because of the dramatically different clinical course of aggressive and indolent prostate carcinoma (PCa), markers that distinguish between these phenotypes are of critical importance. Apoptosis is an important protective mechanism for unrestrained cellular growth and metastasis. Therefore, dysfunction in this pathway is a key step in cancer progression. As such, genetic variants in apoptosis genes are potential markers of aggressive PCa. Recent work in breast carcinoma has implicated the histidine variant of CASP8 D302H (rs1045485) as a protective risk allele. METHODS We tested the hypothesis that the H variant was protective for aggressive PCa in a pooled analysis of 796 aggressive cases and 2,060 controls. RESULTS The H allele was associated with a reduced risk of aggressive PCa (ORper allele,= 0.67, 95% CI: 0.54,0.83, Ptrend,=,0.0003). The results were similar for European-Americans (ORper allele,=,0.68; 95% CI: 0.54,0.86) and African-Americans (ORper allele,=,0.61; 95% CI: 0.34,1.10). We further determined from the full series of 1,160 cases and 1,166 controls in the Prostate, Lung, Colorectal, Ovarian (PLCO) population that the protective effect of the H allele tended to be limited to high-grade and advanced PCa (all cases ORper allele,=,0.94; 95% CI: 0.79,1.11; localized, low-grade disease ORper allele,=,0.98; 95% CI: 0.79,1.23; and aggressive disease ORper allele,=,0.73; 95% CI: 0.50,1.07). CONCLUSION These results suggest that histidine variant of CASP8 D302H is a protective allele for aggressive PCa with potential utility for identification of patients at differential risk for this clinically significant phenotype. Prostate 70: 646,653, 2010. © 2009 Wiley-Liss, Inc. [source] Synchrotron X-ray analysis of the electron density in CoF2 and ZnF2ACTA CRYSTALLOGRAPHICA SECTION B, Issue 2 2001Nicholas J. O'Toole Accurate structure factors for small crystals of the rutile-type structures CoF2, cobalt difluoride, and ZnF2, zinc difluoride, have been measured with focused , = 0.8400,(2),Å synchrotron X-radiation at room temperature. Phenomenological structural trends across the full series of rutile-type transition metal difluorides are analysed, showing the importance of the metal atom in the degree of distortion of the metal,F6 octahedra in these structures. Multipole models reveal strong asphericities in the electron density surrounding the transition metals, which are consistent with expectations from crystal field theory and the structural trends in these compounds. Transition metal 3d -orbital populations were computed from the multipole refinement parameters, showing significant repopulation of orbitals compared with the free atom, particularly for CoF2. [source] | ||||||||||