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Selected AbstractsEffect of RBP4 gene variants on circulating RBP4 concentration and Type 2 diabetes in a Chinese populationDIABETIC MEDICINE, Issue 1 2008C. Hu Abstract Aims Retinol binding protein 4 (RBP4) is a newly discovered adipokine, which plays a role in insulin resistance and obesity. The aim of this study was to determine the relationship between genetic variants of the RBP4 gene, circulating RBP4 concentrations and phenotypes related to glucose and lipid metabolism in the Chinese population. Methods We sequenced exons and the putative promoter region to identify single nucleotide polymorphisms (SNPs) in the RBP4 gene in 32 Chinese subjects. Additional SNPs were selected from a public database to increase marker density. Taking account of the pairwise linkage disequilibrium and minor allele frequencies, a subset of SNPs was further genotyped in 255 Type 2 diabetic patients and 372 normal control subjects. Circulating RBP4 concentrations and phenotypes related to glucose and lipid metabolism were measured. Results Ten SNPs were identified and five were further genotyped in the full sample. No individual SNP was significantly associated with Type 2 diabetes, but a rare haplotype CAA formed by +5388 C>T, +8201 T>A and +8204 T>A was more frequent in diabetic patients (P = 0.0343, empirical P = 0.0659 on 10 000 permutations). In both groups, non-coding SNPs were associated with circulating RBP4 concentrations (P < 0.05). In the normal control subjects, the SNP +5388 C>T was associated with serum C-peptide levels both fasting and 2 h after an oral glucose tolerance test (P = 0.0162 and P = 0.0075, respectively). Conclusion Our findings suggest that genetic variants in the RBP4 gene may be associated with circulating RBP4 concentration and phenotypes related to glucose metabolism. [source] Downstream variation in bed sediment size along the East Carpathian rivers: evidence of the role of sediment sourcesEARTH SURFACE PROCESSES AND LANDFORMS, Issue 5 2008Maria R, doane Abstract Taking as an example six main rivers that drain the western flank of the Eastern Carpathians, a conceptual model has been developed, according to which fluvial bed sediment bimodality can be explained by the overlapping of two grain size distribution curves of different origins. Thus, for Carpathian tributaries of the Siret, coarse gravel joins an unimodal distribution presenting a right skewness with enhanced downstream fining. The source of the coarse material distributions is autohtonous (by abrasion and hydraulic sorting mechanisms). A second distribution with a sandy mode is, in general, skewed to the left. The source of the second distribution is allohtonous (the quantity of sand that reaches the river-bed through the erosion of the hillslope basin terrains). The intersection of the two distributions occurs in the area of the 0·5,8 mm fractions, where, in fact, the right skewness (for gravel) and left skewness (for sand) histogram tails meet. This also explains the lack of particles in the 0·5,8 mm interval. For rivers where fine sediment sources are low, the 0·5,8 mm fractions have a higher proportion than the fractions under 1 mm. For the Siret River itself, bed sediment bimodality is greatly enhanced due to the fact that the second mode is more than 25% of the full sample. As opposed to its tributaries, the source of the first mode, of gravel, is allohtonous to the Siret river, generated by the massive input of coarse sediment through the Carpathian tributaries, while the second mode, of the sands, is local. In this case we can also observe that the two distributions of particles of different origins overlap in the 0·5,8 mm fraction domain, creating the illusion of ,particle lack' in the fluvial bed sediments. Copyright © 2007 John Wiley & Sons, Ltd. [source] Divergence of US and Local Returns in the After-market for Equity Issuing ADRsEUROPEAN FINANCIAL MANAGEMENT, Issue 3 2004Padma Kadiyala F30; G12; G14 Abstract We study one-year post-listing prices and returns to equity issuing ADRs that listed in the US between January 1991 and October 2000. ADRs from countries that impose restrictions on capital flows are priced at a premium to their home market ordinaries. While the mean premium for the full sample is statistically indistinguishable from zero, after an adjustment for asynchronous trading, the magnitude of the premium to ADRs from restricted markets is 11.33% at the 300-day post listing interval, which is statistically significant. In the short run (30 days) following listing, the magnitude of the premium is larger for ADRs with larger excess demand from US investors. At the longer 300-day horizon, Nasdaq listed ADRs earn a larger premium than their NYSE/AMEX listed counterparts. Time-series regressions and two-stage cross-sectional regressions establish that the premium to foreign equity issuers is greater if the US listing attracts liquidity and if US returns have a lower correlation with the local country index. [source] THE COMBINED EFFECT OF DONATION PRICE AND ADMINISTRATIVE INEFFICIENCY ON DONATIONS TO US NONPROFIT ORGANIZATIONSFINANCIAL ACCOUNTABILITY & MANAGEMENT, Issue 1 2009Fred A. Jacobs We examine the effects that two accounting measures of nonprofit organization (NPO) inefficiency, administrative inefficiency and donation price, have on donations to US NPOs using a better-specified model and industry-specific samples. Although numerous studies examine the effect that donation price has on donations (e.g., Marudas and Jacobs, 2006; Marudas, 2004; Khanna and Sandler, 2000; and Tinkelman, 1999), only three studies examine the effect of administrative inefficiency on donations (Tinkelman and Mankaney, 2007; Frumkin and Kim, 2001; and Greenlee and Brown, 1999). However, none of these studies tests donation price and administrative inefficiency in one model and only two test industry-specific samples of NPOs. We find that misspecifying the model by including only one of these two inefficiency measures creates substantial bias and the effect of administrative inefficiency on donations varies substantially across industries. Administrative inefficiency has a significantly negative effect on donations to NPOs in the full sample and the philanthropy sample, but no significant effect on donations to NPOs in the arts, education, health, or human services samples. Furthermore, donation price has a significantly negative effect on donations to NPOs in the full sample and the education, health and human services samples, but not in the arts or philanthropy samples. Results are also reported for the other variables in the model , government support, program service revenue, fundraising and organizational age, wealth and size. [source] Selection of the most informative individuals from families with multiple siblings for association studiesGENETIC EPIDEMIOLOGY, Issue 4 2009Chunyu Liu Abstract Association analyses may follow an initial linkage analysis for mapping and identifying genes underlying complex quantitative traits and may be conducted on unrelated subsets of individuals where only one member of a family is included. We evaluate two methods to select one sibling per sibship when multiple siblings are available: (1) one sibling with the most extreme trait value; and (2) one sibling using a combination score statistic based on extreme trait values and identity-by-descent sharing information. We compare the type I error and power. Furthermore, we compare these selection strategies with a strategy that randomly selects one sibling per sibship and with an approach that includes all siblings, using both simulation study and an application to fasting blood glucose in the Framingham Heart Study. When genetic effect is homogeneous, we find that using the combination score can increase power by 30,40% compared to a random selection strategy, and loses only 8,13% of power compared to the full sibship analysis, across all additive models considered, but offers at least 50% genotyping cost saving. In the presence of genetic heterogeneity, the score offers a 50% increase in power over a random selection strategy, but there is substantial loss compared to the full sibship analysis. In application to fasting blood sample, two SNPs are found in common for the selection strategies and the full sample among the 10 highest ranked single nucleotide polymorphisms. The EV strategy tends to agree with the IBD-EV strategy and the analysis of the full sample. Genet. Epidemiol. 2009. © 2008 Wiley-Liss, Inc. [source] Assessing Treatment Effects of Inhaled Corticosteroids on Medical Expenses and Exacerbations among COPD Patients: Longitudinal Analysis of Managed Care ClaimsHEALTH SERVICES RESEARCH, Issue 6 2008Manabu Akazawa Objective. To assess costs, effectiveness, and cost-effectiveness of inhaled corticosteroids (ICS) augmenting bronchodilator treatment for chronic obstructive pulmonary disease (COPD). Data Sources. Claims between 1997 and 2005 from a large managed care database. Study Design. Individual-level, fixed-effects regression models estimated the effects of initiating ICS on medical expenses and likelihood of severe exacerbation. Bootstrapping provided estimates of the incremental cost per severe exacerbation avoided. Data Extraction Methods. COPD patients aged 40 or older with ,15 months of continuous eligibility were identified. Monthly observations for 1 year before and up to 2 years following initiation of bronchodilators were constructed. Principal Findings. ICS treatment reduced monthly risk of severe exacerbation by 25 percent. Total costs with ICS increased for 16 months, but declined thereafter. ICS use was cost saving 46 percent of the time, with an incremental cost-effectiveness ratio of $2,973 per exacerbation avoided; for patients ,50 years old, ICS was cost saving 57 percent of time. Conclusions. ICS treatment reduces exacerbations, with an increase in total costs initially for the full sample. Compared with younger patients with COPD, patients aged 50 or older have reduced costs and improved outcomes. The estimated cost per severe exacerbation avoided, however, may be high for either group because of uncertainty as reflected by the large standard errors of the parameter estimates. [source] Black and white and read all over: Race differences in reactions to recruitment Web sitesHUMAN RESOURCE MANAGEMENT, Issue 2 2008Caren B. Goldberg Based on signaling theory, this study examines the impact of Web-site design and content characteristics on applicants' intentions to pursue employment, the mediating effects of engagement with the Web site and attitude toward the organization, and the moderating effects of applicant race on these relationships. The design characteristics of ease of use and usefulness impact attraction indirectly through Web-site engagement and attitude toward the organization. Further, Web sites' parasocial interaction (allowance for two-way communication) predicts intentions to pursue both directly and indirectly through engagement and attitude toward the organization. Unexpectedly, diversity statements did not impact attraction in the full sample. Multigroup analyses revealed that many of the paths between the predictors of parasocial interaction and (to a lesser extent) diversity statements and the outcomes differed by race, with stronger effects observed for blacks than whites. Theoretical and practical implications are discussed. © 2008 Wiley Periodicals, Inc. [source] Initial evidence on whether use of professional fundraising services increases fundraising effectivenessINTERNATIONAL JOURNAL OF NONPROFIT & VOLUNTARY SECTOR MARKETING, Issue 1 2010Nicholas P. Marudas We provide initial evidence on whether use of professional fundraising services by US nonprofit organizations (NPOs) increases the effectiveness of NPOs' fundraising efforts. To a well-tested model of organization-level donations, we add an interaction term that captures the impact that professional fundraising fees an NPO incurs has on the effectiveness of an NPOs' spending on fundraising in raising donations. We find that professional fundraising fees has a significant positive impact on the effectiveness of fundraising efforts in raising donations for NPOs in the full, education, and health samples, but no impact for NPOs in the arts and human services samples. For NPOs in the full sample and NPOs in the education sample, one quarter of the effect of fundraising on donations stems from the positive impact of professional fundraising services on the effectiveness of fundraising in raising donations. For NPOs in the health sample, one half of the effect of fundraising on donations stems from the positive impact of professional fundraising services on the effectiveness of fundraising in raising donations. These results suggest that professional fundraising services significantly enhance the effectiveness of fundraising for these types of NPOs. While the results of this study seem to confirm the decisions of managers of education and health NPOs to utilize professional fundraising services, the results also suggest that managers of arts and human services NPOs may want to reconsider using professional fundraising services, at least the types of services they currently purchase and the way they currently utilize such services. Copyright © 2009 John Wiley & Sons, Ltd. [source] Cost Analysis of the Geriatric Resources for Assessment and Care of Elders Care Management InterventionJOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 8 2009Steven R. Counsell MD OBJECTIVES: To provide, from the healthcare delivery system perspective, a cost analysis of the Geriatric Resources for Assessment and Care of Elders (GRACE) intervention, which is effective in improving quality of care and outcomes. DESIGN: Randomized controlled trial with physicians as the unit of randomization. SETTING: Community-based primary care health centers. PARTICIPANTS: Nine hundred fifty-one low-income seniors aged 65 and older; 474 participated in the intervention and 477 in usual care. INTERVENTION: Home-based care management for 2 years by a nurse practitioner and social worker who collaborated with the primary care physician and a geriatrics interdisciplinary team and were guided by 12 care protocols for common geriatric conditions. MEASUREMENTS: Chronic and preventive care costs, acute care costs, and total costs in the full sample (n=951) and predefined high-risk (n=226) and low-risk (n=725) groups. RESULTS: Mean 2-year total costs for intervention patients were not significantly different from those for usual care patients in the full sample ($14,348 vs $11,834; P=.20) and high-risk group ($17,713 vs $18,776; P=.38). In the high-risk group, increases in chronic and preventive care costs were offset by reductions in acute care costs, and the intervention was cost saving during the postintervention, or third, year ($5,088 vs $6,575; P<.001). Mean 2-year total costs were higher in the low-risk group ($13,307 vs $9,654; P=.01). CONCLUSION: In patients at high risk of hospitalization, the GRACE intervention is cost neutral from the healthcare delivery system perspective. A cost-effectiveness analysis is needed to guide decisions about implementation in low-risk patients. [source] Multimorbidity and Survival in Older Persons with Colorectal CancerJOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 12 2006Cary P. Gross MD OBJECTIVES: To ascertain the effect of common chronic conditions on mortality in older persons with colorectal cancer. DESIGN: Retrospective cohort study. SETTING: Population-based cancer registry. PARTICIPANTS: Patients in the Surveillance Epidemiology and End Results,Medicare linked database who were aged 67 and older and had a primary diagnosis of Stage 1 to 3 colorectal cancer during 1993 through 1999. MEASUREMENTS: Chronic conditions were identified using claims data, and vital status was determined from the Medicare enrollment files. After estimating the adjusted hazard ratios for mortality associated with each condition using a Cox model, the population attributable risk (PAR) was calculated for the full sample and by age subgroup. RESULTS: The study sample consisted of 29,733 patients, 88% of whom were white and 55% were female. Approximately 9% of deaths were attributable to congestive heart failure (CHF; PAR =9.4%, 95% confidence interval (CI) =8.4,10.5%), more than 5% were attributable to chronic obstructive pulmonary disease (COPD; PAR =5.3%, 95% CI=4.7,6.6%), and nearly 4% were attributable to diabetes mellitus (PAR =3.9%, 95% CI=3.1,4.8%). The PAR associated with CHF increased with age, from 6.3% (95% CI=4.4,8.8%) in patients aged 67 to 70 to 14.5% (95% CI=12.0,17.5%) in patients aged 81 to 85. Multiple conditions were common. More than half of the patients who had CHF also had diabetes mellitus or COPD. The PAR associated with CHF alone (4.29%, 95% CI=3.68,4.94%) was similar to the PAR for CHF in combination with diabetes mellitus (3.08, 95% CI=2.60,3.61%) or COPD (3.93, 95% CI=3.41,4.54%). CONCLUSION: A substantial proportion of deaths in older persons with colorectal cancer can be attributed to CHF, diabetes mellitus, and COPD. Multimorbidity is common and exerts a substantial effect on colorectal cancer survival. [source] On the Market Reaction to Revenue and Earnings SurprisesJOURNAL OF BUSINESS FINANCE & ACCOUNTING, Issue 1-2 2009Itay Kama Abstract:, This study extends Ertimur et al. (2003) and Jegadeesh and Livnat (2006a) by providing a contextual framework for the information content of revenue and earnings surprises. I find that the influence of earnings surprises (revenue surprises) on stock returns is lower (higher) in R&D intensive companies. Also, market reaction to earnings surprises is lower in the fourth quarter, and to revenue surprises it is higher in industries with oligopolistic competition. A comprehensive analysis indicates that, in contrast to previous studies for the full sample, in several contexts market reaction to earnings surprises is not higher than to revenue surprises. [source] The Overlap in Predicting Alcohol Outcome for Two Measures of the Level of Response to AlcoholALCOHOLISM, Issue 3 2009Marc A. Schuckit Background:, Two different measures have been used to establish a person's level of response (LR) to alcohol as a risk factor for alcohol use disorders. LR values established by the alcohol challenge protocol and the Self-Report of the Effects of Ethanol (SRE) questionnaire usually correlate at 0.3 to 0.4, up to 0.6. However, it is not clear how this correlation relates to the ability of each measure to predict alcohol outcomes. This paper evaluates that overlap. Methods:, Sixty-six Caucasian males (mean age = 22 years) from 2 protocols participated in alcohol challenges with 0.75 ml/kg of ethanol, filled out the SRE, and were followed with a structured interview ,5 years later. The relationship between the subjective feelings of intoxication at the time of peak breath alcohol levels from the alcohol challenge and the SRE score for a time early in the drinking career were evaluated regarding predicting the drinks per occasion in the 6 months prior to follow-up. Results:, Cross-sectional correlations between alcohol challenge and SRE LR's ranged from ,0.25 (p < 0.05) to ,0.32 (p = 0.02) for the full sample, and the 2 LR measures correlated with drinking at follow-up (,0.26 and 0.41, respectively). The SRE measure was more robust than the challenge in a regression analysis predicting the outcome in the context of other baseline predictors (e.g., drinking at baseline). As much as 60% of the ability of the more well established (gold standard) alcohol challenge LR to predict outcome was shared with the SRE. The alcohol challenge accounted for as much as 44% of the ability of the SRE to predict outcome. Conclusions:, The SRE-generated LR overlapped considerably with the alcohol challenge LR in the ability to predict future heavier drinking. [source] Do Parental Transfers Reduce Youths' Incentives to Work?LABOUR, Issue 4 2009Tao Gong The results from a fixed-effects two-stage least squares estimator suggest that: (i) parental pocket money reduces youths' incentives to work; (ii) parental allowances have a non-linear effect on hours worked; (iii) the subsample of siblings shows similar patterns that parental transfers have a negative impact on hours worked, although the magnitudes are slightly weaker than the full sample; and (iv) the response to parental transfers varies by age. [source] The Stability of General Foreign Language Classroom Anxiety across English and FrenchMODERN LANGUAGE JOURNAL, Issue 3 2003M´ximo Rodríguez The present study examined the stability of the general foreign language classroom anxiety construct across English and French. Preservice teachers from two western universities in Venezuela, who were majoring simultaneously in these two foreign languages, participated in the study. The students represented a variety of levels within each language. They completed two Spanish versions (one for each language) of the Foreign Language Classroom Anxiety Scale (FLCAS; Horwitz, Horwitz, & Cope, 1986). Separate analyses were performed on the full sample and on a restricted sample that included only those students who were at the same level in both languages. The results supported the indirect findings reported by Saito, Horwitz, and Garza (1999) while providing direct evidence suggesting the stability of the construct across English and French. Evidence obtained for overall, within-institution, and within-level comparisons. Furthermore, analysis of psychometric technical aspects of the FLCAS indicated that the scale exhibited high reliability but moderate construct validity. [source] Deep radio imaging of the SCUBA 8-mJy survey fields: submillimetre source identifications and redshift distributionMONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, Issue 1 2002R. J. Ivison Abstract The SCUBA 8-mJy survey is the largest submillimetre (submm) extragalactic mapping survey undertaken to date, covering 260 arcmin2 to a 4 , detection limit of ,8 mJy at 850 ,m, centred on the Lockman Hole and ELAIS N2 regions. Here, we present the results of new 1.4-GHz imaging of these fields, of the depth and resolution necessary to reliably identify radio counterparts for 18 of 30 submm sources, with possible detections of a further 25 per cent. Armed with this greatly improved positional information, we present and analyse new optical, near-infrared (near-IR) and XMM,Newton X-ray imaging to identify optical/IR host galaxies to half of the submm-selected sources in those fields. As many as 15 per cent of the submm sources detected at 1.4 GHz are resolved by the 1.4-arcsec beam and a further 25 per cent have more than one radio counterpart, suggesting that radio and submm emission arise from extended starbursts and that interactions are common. We note that less than a quarter of the submm-selected sample would have been recovered by targeting optically faint radio sources, underlining the selective nature of such surveys. At least 60 per cent of the radio-confirmed optical/IR host galaxies appear to be morphologically distorted; many are composite systems , red galaxies with relatively blue companions; just over one half are found to be very red (I , K > 3.3) or extremely red (I , K > 4); contrary to popular belief, most are sufficiently bright to be tackled with spectrographs on 8-m telescopes. We find one submm source which is associated with the steep-spectrum lobe of a radio galaxy, at least two more with flatter radio spectra typical of radio-loud active galactic nuclei (AGN), one of them variable. The latter is amongst four sources (,15 per cent of the full sample) with X-ray emission consistent with obscured AGN, though the AGN would need to be Compton thick to power the observed far-IR luminosity. We exploit our well-matched radio and submm data to estimate the median redshift of the S850,m , 8 mJy submm galaxy population. If the radio/far-IR correlation holds at high redshift, and our sample is unbiased, we derive a conservative limit of ,z, ,2.0, or ,2.4 using spectral templates more representative of known submm galaxies. [source] The relationship between European genetic admixture and body composition among Hispanics and Native AmericansAMERICAN JOURNAL OF HUMAN BIOLOGY, Issue 3 2009Y.C. Klimentidis Previous studies have shown a relationship between health-related phenotypes and the degree of African, European, or Native American genetic admixture, indicating that there may be a genetic component to these phenotypes. However, these relationships may be driven to a large extent by the environmental differences that co-vary with admixture differences between and within groups. In this study, we examine the relationship between genetic admixture and two phenotypic measurements that are potentially related to health: body mass index (BMI) and percent body fat (PBF). In addition to admixture proportions, we attempt to assess the influence of some environmental covariates by examining how the phenotypes vary with self-reported household income, education of parents, and physical activity level. Genetic, anthropometric, and environmental data were collected from 170 self-reported Hispanic and Native American university students in Albuquerque, NM. We examine the relationships between genetic admixture, phenotype, and environment in both the full sample, as well as in Hispanics and Native Americans separately. Among Hispanics, we find no significant relationship between genetic admixture and body composition. Among Native Americans, despite a small sample size, we find a statistically significant, negative relationship between European genetic admixture and PBF and BMI, after adjusting for other predictor variables. We compare our findings to previous research, and discuss their implications for understanding health disparities within and between ethnic groups. Am. J. Hum. Biol. 2009. © 2009 Wiley-Liss, Inc. [source] The Implicit Motives of Terrorist Groups: How the Needs for Affiliation and Power Translate into Death and DestructionPOLITICAL PSYCHOLOGY, Issue 1 2008Allison G. Smith This study explored the dynamics of terrorism through a quantitative content analysis of documents issued by terrorist groups and nonterrorist comparison groups. Thirteen terrorist groups were matched with comparison groups that shared the same ideologies, and their documents were coded for ingroup affiliation, outgroup affiliation, and power motive imagery. As hypothesized, compared with nonterrorist groups, terrorist groups were significantly higher in ingroup affiliation motive imagery and significantly lower in outgroup affiliation motive imagery in the full sample of documents and in an indicator sample that included only terrorist groups' preterrorism documents. Terrorist groups were significantly higher than comparison groups in power motive imagery in the full sample and marginally significantly higher in power motive imagery in the indicator sample. These results highlight the important role that group dynamics play in terrorist groups. [source] Exercise and quality of life during and after treatment for breast cancer: results of two randomized controlled trialsPSYCHO-ONCOLOGY, Issue 4 2009Lisa A. Cadmus Abstract Objective: To determine the effect of exercise on quality of life in (a) a randomized controlled trial of exercise among recently diagnosed breast cancer survivors undergoing adjuvant therapy and (b) a similar trial among post-treatment survivors. Methods: Fifty newly diagnosed breast cancer survivors were recruited through a hospital-based tumor registry and randomized to a 6-month, home-based exercise program (n=25) or a usual care group (n=25). In a separate trial, 75 post-treatment survivors were randomized to a 6-month, supervised exercise intervention (n=37) or to usual care (n=38). Participants in both studies completed measures of happiness, depressive symptoms, anxiety, stress, self-esteem, and quality of life at baseline and 6 months. Results: Forty-five participants completed the trial for newly diagnosed survivors and 67 completed the trial for post-treatment survivors. Good adherence was observed in both studies. Baseline quality of life was similar for both studies on most measures. Exercise was not associated with quality of life benefits in the full sample of either study; however exercise was associated with improved social functioning among post-treatment survivors who reported low social functioning at baseline (p<0.05). Conclusions: Exercise did not affect quality of life in either recently diagnosed or post-treatment breast cancer survivors; however this may be due in part to relatively high baseline functioning among participants in both studies. Strategies for future research include limiting enrollment to survivors who report reduced quality of life on screening questionnaires and targeting survivor subgroups known to be at particular risk for quality of life impairment. Copyright © 2009 John Wiley & Sons, Ltd. [source] Political Cycles in the Australian Stock Market since FederationTHE AUSTRALIAN ECONOMIC REVIEW, Issue 4 2009Andrew C. Worthington This article examines the political cycles in Australian stock returns from 1901,2005. The article defines the political cycle in terms of the party in power, ministerial tenure and election information effects. The market variables are returns, excess returns over inflation and excess returns over interest rates. Descriptive analysis suggests differences in the variance of returns under Labor and non-Labor ministries, but no significant differences in mean returns. Using a generalised autoregressive conditional heteroskedastistic-M model, returns are found to be higher only for non-Labor ministries before 1949 and there is no difference in excess returns over inflation or interest throughout the full sample. [source] DOES ELECTRICITY RESTRUCTURING WORK?THE JOURNAL OF INDUSTRIAL ECONOMICS, Issue 3 2007EVIDENCE FROM THE U.S. NUCLEAR ENERGY INDUSTRY This paper examines whether electricity restructuring improves the efficiency of U.S. nuclear power generation. Using a panel dataset consisting of the full sample of 73 investor-owned nuclear plants in the United States from 1992 to 1998, I estimate the plant-level cross-sectional and longitudinal efficiency changes associated with restructuring. Special attention is given to the potential policy endogeneity bias and different modeling strategies are presented to cope with the issue. Overall, I find a striking positive relationship between restructuring and cost reduction, and increased plant utilization. [source] Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke,ANNALS OF NEUROLOGY, Issue 5 2009Andreas Gschwendtner MD Objective Recent studies have identified a major locus for risk for coronary artery disease and myocardial infarction on chromosome 9p21.3. Stroke, in particular, ischemic stroke caused by atherosclerotic disease, shares common mechanisms with myocardial infarction. We investigated whether the 9p21 region contributes to ischemic stroke risk. Methods In an initial screen, 15 single nucleotide polymorphisms (SNPs) covering the critical genetic interval on 9p21 were genotyped in samples from Southern Germany (1,090 cases, 1,244 control subjects) and the United Kingdom (758 cases, 872 control subjects, 3 SNPs). SNPs significantly associated with ischemic stroke or individual stroke subtypes in either of the screening samples were subsequently genotyped in 2,528 additional cases and 2,189 additional control subjects from Europe and North America. Results Genotyping of the screening samples demonstrated associations between seven SNPs and atherosclerotic stroke (all p < 0.05). Analysis of the full sample confirmed associations between six SNPs and atherosclerotic stroke in multivariate analyses controlling for demographic variables, coronary artery disease, myocardial infarction, and vascular risk factors (all p < 0.05). The odds ratios for the lead SNP (rs1537378-C) were similar in the various subsamples with a pooled odds ratio of 1.21 (95% confidence interval, 1.07,1.37) under both fixed- and random-effects models (p = 0.002). The point estimate for the population attributable risk is 20.1% for atherosclerotic stroke. Interpretation The chromosome 9p21.3 region represents a major risk locus for atherosclerotic stroke. The effect of this locus on stroke appears to be independent of its relation to coronary artery disease and other stroke risk factors. Our findings support a broad role of the 9p21 region in arterial disease. Ann Neurol 2009;65:531,539 [source] Polarimetric observations of a sample of Compact Steep-Spectrum sourcesASTRONOMISCHE NACHRICHTEN, Issue 2-3 2009F. Mantovani Abstract Measurements of the polarised emission from Compact Steep-Spectrum (CSS) sources can give important information about the physical conditions inside and around the region of radio emission, essentially on the Narrow Line Region. We have observed the sample of CSS sources constructed by Fanti et al. (1990) with the Effelsberg 100-m radio telescope at four frequencies between 2.7 GHz and 10.4 GHz in order to measure the polarisation parameters. Results from the NRAO VLA Sky Survey (Condon et al. 1998) at 1.4 GHz were combined with our measurements for the full sample. The sample is considered statistically complete and allows comprehensive statistical analysis. Some of our conclusions are in disagreement with previous results obtained by polarimetric observations of other samples, for example the B3-VLA sample (© 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Acceptance of Functional Foods: A Comparison of French, American, and French Canadian ConsumersCANADIAN JOURNAL OF AGRICULTURAL ECONOMICS, Issue 4 2006JoAnne Labrecque Food products have diversified with industry globalization. To market functional foods efficiently, food managers must gauge cross-cultural variance of functional food acceptance. Expanding on previous research, we investigate young consumers' acceptance of functional foods. Data collected in French Canada, United States, and France in 2004 reveal that business students are slightly in favor of functional foods, and associate health benefits with these foods but very few product-related benefits. Students do not have strong opinions on the trustworthiness of information and expressed a slight interest in purchasing this type of product. Analyses of cultural differences revealed significant, albeit small, divergence in these variables. Statistical analysis performed on the full sample assessed the impact of food attitudes and other cognitive and attitudinal factors on the general attitude toward functional foods. Health and product-related benefits and belief about the credibility of information are the main positive determinants of the acceptance of functional foods, followed by high knowledge. Apart from the negative impact of Neophobia, none of the other food attitudes influences attitudes toward functional foods. Linear regressions performed on each subgroup indicated similar positive cross-cultural results for health and product-related benefits. However, cross-cultural differences are detected for knowledge, credibility of information, and food attitudes that influence acceptance of functional foods. Les produits alimentaires se sont diversifiés avec l'avènement de la mondialisation. Pour commercialiser efficacement les aliments fonctionnels, les gestionnaires du secteur alimentaire doivent évaluer l'acceptation des aliments fonctionnels par les diverses cultures. À partir de travaux de recherche antérieurs, nous avons examiné l'acceptation des aliments fonctionnels par les jeunes consommateurs. Des données recueillies en 2004 au Canada français, aux États-Unis et en France ont révélé que les étudiants en commerce étaient légèrement en faveur des aliments fonctionnels, leur associaient des avantages pour la santé, mais très peu d'avantages liés aux produits. Les étudiants n'avaient pas une très bonne opinion concernant la crédibilité de l'information et ont manifesté un faible intérêt pour l'achat de ces produits. Des analyses des différences culturelles ont révélé des divergences, petites mais significatives. Les analyses statistiques effectuées sur l'échantillon total ont évalué l'impact des attitudes envers les aliments ainsi que d'autres facteurs cognitifs et attitudinaux sur l'attitude générale envers les aliments fonctionnels. Les avantages pour la santé, les avantages liés aux produits et les croyances concernant la crédibilité de l'information sont les principaux facteurs favorables à l'acceptation des aliments fonctionnels, suivis d'un degré de connaissances élevé. Outre l'impact négatif de la néophobie, aucune autre des attitudes envers les aliments n'influe sur les attitudes envers les aliments fonctionnels. Les régressions linéaires effectuées pour chaque sous-groupe ont indiqué des résultats positifs similaires. Toutefois, nous avons noté des différences interculturelles quant à la connaissance, à la crédibilité de l'information et aux attitudes envers les aliments qui influencent l'acceptation des aliments fonctionnels. [source] Accounting Conservatism and the Temporal Trends in Current Earnings' Ability to Predict Future Cash Flows versus Future Earnings: Evidence on the Trade-off between Relevance and ReliabilityCONTEMPORARY ACCOUNTING RESEARCH, Issue 2 2010SATI P. BANDYOPADHYAY M41; C23; D21; G38 This research reports that an increasing level of accounting conservatism over the 1973,2005 period is associated with: (1) an increase in the ability of current earnings to predict future cash flows and (2) a decrease in the ability of current earnings to predict future earnings. We also find that usefulness of earnings for explaining stock prices over book values is positively related to reliability but not to relevance. Our results hold for the constant and full samples in both in-sample and out-of-sample analyses and are robust to the use of alternative measures for relevance, reliability, earnings usefulness, and conservatism. Our findings about the relations among conservatism, relevance, reliability, and usefulness suggest a trade-off between relevance and reliability and seem to indicate that the adoption of an increasing number of conservative accounting standards has a possible adverse impact on earnings usefulness through a negative effect on reliability. [source] Linkage Analysis of Alcohol Dependence Symptoms in the CommunityALCOHOLISM, Issue 1 2010Narelle K. Hansell Background:, We have previously identified suggestive linkage for alcohol consumption in a community-based sample of Australian adults. In this companion paper, we explore the strength of genetic linkage signals for alcohol dependence symptoms. Methods:, An alcohol dependence symptom score, based on DSM-IIIR and DSM-IV criteria, was examined. Twins and their nontwin siblings (1,654 males, 2,518 females), aged 21 to 81 years, were interviewed, with 803 individuals interviewed on 2 occasions, approximately 10 years apart. Linkage analyses were conducted on datasets compiled to maximize data collected at either the younger or the older age. In addition, linkage was compared between full samples and truncated samples that excluded the lightest drinkers (approximately 10% of the sample). Results:, Suggestive peaks on chromosome 5p (LODs >2.2) were found in a region previously identified in alcohol linkage studies using clinical populations. Linkage signal strength was found to vary between full and truncated samples and when samples differed only on the collection age for a sample subset. Conclusions:, The results support the finding that large community samples can be informative in the study of alcohol-related traits. [source] Can We Identify Genes For Alcohol Consumption In Samples Ascertained For Heterogeneous Purposes?ALCOHOLISM, Issue 4 2009Narelle K. Hansell Background:, Previous studies have identified evidence of genetic influence on alcohol use in samples selected to be informative for alcoholism research. However, there are a growing number of genome-wide association studies (GWAS) using samples unselected for alcohol consumption (i.e., selected on other traits and forms of psychopathology), which nevertheless assess consumption as a risk factor. Is it reasonable to expect that genes contributing to variation in alcohol consumption can be identified in such samples? Methods:, An exploratory approach was taken to determine whether linkage analyses for heaviness of alcohol consumption, using a sample collected for heterogeneous purposes, could replicate previous findings. Quantity and frequency measures of consumption were collected in telephone interviews from community samples. These measures, and genotyping, were available for 5,441 individuals (5,067 quasi-independent sibling pairs). For 1,533 of these individuals, data were collected on 2 occasions, about 8.2 years apart, providing 2 datasets that maximize data collected at either a younger or an older age. Analyses were conducted to address the question of whether age and heavier levels of alcohol consumption effects outcome. Linkage results were compared in the younger and older full samples, and with samples in which approximately 10, 20, and 40 of drinkers from the lower end of the distribution of alcohol consumption were dropped. Results:, Linkage peaks varied for the age differentiated samples and for percentage of light drinkers retained. Larger peaks (LOD scores >2.0) were typically found in regions previously identified in linkage studies and/or containing proposed candidate genes for alcoholism including AGT, CARTPT, OPRD1, PIK3R1, and PDYN. Conclusions:, The results suggest that GWAS assessing alcohol consumption as a covariate for other conditions will have some success in identifying genes contributing to consumption-related variation. However, sample characteristics, such as participant age, and trait distribution, may have substantial effects on the strength of the genetic signal. These results can inform forthcoming GWAS where the same restrictions apply. [source] | ||||||||||||||||||||||