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Selected AbstractsBotulinum Toxin Type B (MYOBLOC) Versus Botulinum Toxin Type A (BOTOX) Frontalis Study: Rate of Onset and Radius of DiffusionDERMATOLOGIC SURGERY, Issue 5 2003Timothy Corcoran Flynn MD Background. Botulinum toxin types A and B can improve the appearance of facial wrinkles. Differences in the time until onset and the degree of diffusion have been observed anecdotally, but no direct comparative studies have been done. Objective. To compare the rate of onset and the radius of diffusion of botulinum toxin types A and B in the rhytides of the forehead. Methods. Adults with symmetrical moderate to severe forehead wrinkles at full contracture received botulinum toxin type A (BOTOX; 5 U) on one side of the forehead and type B (MYOBLOC; 500 U) on the other side. Photographs taken at rest and full frontalis contracture were analyzed by computer, and a time-lapse motion picture was created. Radius of diffusion and time until full effect were measured. Results. Botulinum toxin type B had a slightly faster onset of action than type A. All patients responded to type B quickly, whereas some had a delayed response to type A. A greater radius of diffusion was consistently observed with botulinum toxin type B, as measured by the greater area of wrinkle reduction at the doses used. Conclusions. In this comparative study of patients with symmetrical forehead wrinkles, botulinum toxin type B produced a greater area of diffusion and a more rapid onset of action than type A. [source] Public Pension Reform in the United Kingdom: What Effect on the Financial Well-Being of Current and Future Pensioners?,FISCAL STUDIES, Issue 1 2005Richard Disney Abstract Unlike many tax and benefit changes, reforms to public pension programmes take many years to have their full effect. This paper examines the effect of reforms to the public pension programme in the United Kingdom on the state retirement incomes of current generations of pensioners and on the prospective state incomes of future generations of pensioners. We show that, for an individual with lifetime earnings close to male average earnings, the UK pension system is at its most generous to those reaching the state pension age around the year 2000, but that the introduction of the state second pension and the pension credit postpones this peak for individuals on lower incomes and for those with substantial periods out of paid employment spent with caring responsibilities. We also consider how the ,mix' of benefits, particularly between the contributory and income-tested sectors, could change over time, and the impact that this would have on incentives to save for retirement. [source] Assessing Women, Gender, and Empire in Britain's Nineteenth-Century Protestant Missionary MovementHISTORY COMPASS (ELECTRONIC), Issue 3 2009Elizabeth Prevost Although women constituted the majority of British missionary labor by the turn of the twentieth century, they were largely discounted from the official record of mission work , a silence that until recently has been preserved by women's history, mission history, and imperial history. Over the past two decades, new historical and interpretive frameworks have brought into clearer focus the role of women missionaries and the gendered fabric of the ,civilizing mission' in evangelistic, colonial, and feminist projects. Yet the privileging of race as an analytic category has produced a lopsided historiography, in which Christianity has been marginalized in studies of gender and empire, and in which gender has not been used to full effect in explicating the uneven contours of religion and colonialism. This essay explores how studies of women, gender, and the Protestant missionary movement over the ,long nineteenth century' have responded to and manifested some of the larger tensions of women's and gender history, feminist history, postcolonial studies, the new imperial history, and area studies, and suggests some avenues for addressing lingering questions of recovery and representation, center and periphery. [source] Co-operative interactions control conjugative transfer of broad host-range plasmid RK2: full effect of minor changes in TrbA operator depends on KorBMOLECULAR MICROBIOLOGY, Issue 4 2003Lewis E.H. Bingle Summary A network of circuits, with KorB and TrbA as key regulators, controls genes for conjugative transfer of broad host range plasmid RK2. To assess the importance of the TrbA regulon, mutational analysis was applied to the TrbA operator at the trbB promoter and then to other TrbA-regulated promoters in the tra region. All identified TrbA operators are submaximal; in the case of trbBp, a G to A transition that made the operator core a perfect palindrome increased repression by about 50% compared to the wild type. When this change was introduced into the RK2 genome, decreases in transfer frequency of up to three orders of magnitude were observed, with bigger effects when Escherichia coli was the donor compared to Pseudomonas putida. Western blotting showed a significant decrease in Trb protein levels. These effects were much greater than the effect of the mutation on repression by TrbA alone. When KorB was introduced into the reporter system, the effects were closer to those observed in the whole RK2 context. These results indicate that co-operativity, previously observed between TrbA and KorB, allows big changes in transfer gene expression to result from small changes in individual regulator activities. [source] The effect of a binary source companion on the astrometric microlensing behaviourMONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, Issue 2 2001Cheongho Han If gravitational microlensing occurs in a binary source system, both source components are magnified, and the resulting light curve deviates from the standard one of a single source event. However, in most cases only one source component is highly magnified and the other component (the companion) can be treated as a simple blending source: this is a blending approximation. In this paper we show that, unlike the light curves, the astrometric curves, representing the trajectories of the source image centroid, of an important fraction of binary source events will not be sufficiently well-modelled by the blending effect alone. This is because the centroid shift induced by the source companion endures to considerable distances from the lens. Therefore, in determining the lens parameters from astrometric curves to be measured by future high-precision astrometric instruments, it will be important to take the full effect of the source companion into consideration. [source] UV Exposure, Genetic Targets in Melanocytic Tumors and Transgenic Mouse Models,PHOTOCHEMISTRY & PHOTOBIOLOGY, Issue 1 2005Frank R. de Gruijl ABSTRACT The genetic changes and corruption of kinase activity in melanomas appear to revolve around a central axis: mitogenic signaling along the RAS pathway down to transcription regulation by pRB. Epidemiological studies point to the importance of ultraviolet (UV) radiation in the etiology of melanoma, but where and how UV radiation is targeted to contribute to the oncogenic signaling remains obscure. Animal models of melanoma genesis could serve to clarify this issue, but many of these models are not responsive to UV exposure. Most interesting advances have been made by using transgenic mice that carry genetic defects that are known to be relevant to human melanoma: specifically, dysfunction in the tumor suppressive action of p161NK4a or a receptor tyrosine kinase/RAS pathway, that is constitutively activated in melanocytes. The latter types of mice appear to be most responsive to (neonatal) UV exposure. Whether this is due to a general increase in target cells by melanocytosis and a paucity or complete lack of pigment, or a possible UV-induced response of the promoter,enhancer of the transgene or a genuinely independent and additional genetic alteration caused by UV exposure needs to be established. Importantly, the full effect of UV radiation needs to be ascertained in mice with different pigmentation by varying the wavelengths, UV-B versus UV-A1, and the exposure schedules, i.e. neonatal versus adult and chronic versus intermittent overexposure. Intermittent UV-B overexposure deserves special attention because it most strongly evokes proliferative responses in melanocytes. [source] The Enjoyment of Rights and Freedoms: A New Conception of the ,Ambit' under Article 14 ECHRTHE MODERN LAW REVIEW, Issue 5 2006Aaron Baker, Article first published online: 16 AUG 200 Article 14 of the European Convention on Human Rights, as applied by the UK judiciary under the Human Rights Act 1998, is in danger of becoming as ,parasitic' as it is often described. Judges have inappropriately narrowed the scope of the ,ambit' of other Convention articles, and thus limited the number of claims to which Article 14 can apply, by defining it according to considerations more properly weighed in a justification analysis incorporating proportionality. The emerging approach departs from Strasbourg jurisprudence, and fails to give full effect to the language and intent of Article 14. This trend need not continue. This article begins the process of fashioning a new conception of the ambit of Convention articles: one that could change the fortunes of Article 14 cases in the UK, but that flows naturally from the precedents of the European Court of Human Rights, and gives effect to the spirit of the HRA. [source] Muon Implantation of Metallocenes: FerroceneCHEMISTRY - A EUROPEAN JOURNAL, Issue 8 2007Upali Abstract Muon Spin Relaxation and Avoided Level Crossing (ALC) measurements of ferrocene are reported. The main features observed are five high field resonances in the ALC spectrum at about 3.26, 2.44, 2.04, 1.19 and 1.17,T, for the low-temperature phase at 18,K. The high-temperature phase at 295,K shows that only the last feature shifted down to about 0.49,T and a muon spin relaxation peak at about 0.106,T which approaches zero field when reaching the phase transition temperature of 164,K. A model involving three muoniated radicals, two with muonium addition to the cyclopentadienyl ring and the other to the metal atom, is postulated to rationalise these observations. A theoretical treatment involving spin-orbit coupling is found to be required to understand the Fe,Mu adduct, where an interesting interplay between the ferrocene ring dynamics and the spin-orbit coupling of the unpaired electron is shown to be important. The limiting temperature above which the full effect of spin-orbit interaction is observable in the ,SR spectra of ferrocene was estimated to be 584,K. Correlation time for the ring rotation dynamics of the Fe,Mu radical at this temperature is 3.2,ps. Estimated electron g values and the changes in zero-field splittings for this temperature range are also reported. [source] | ||||||||||