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Selected AbstractsStipanowich resigns, and heads to Pepperdine's Straus InstituteALTERNATIVES TO THE HIGH COST OF LITIGATION, Issue 4 2006Russ Bleemer CPR President Thomas J. Stipanowich will depart to become academic director at Pepperdine University School of Law's Straus Institute. Full details on the move are provided, along with information on CPR's Annual ADR Award winners; a new commission on facilities for mass claims' resolution, and more. [source] Molecular Reproduction & Development: Volume 77, Issue 3MOLECULAR REPRODUCTION & DEVELOPMENT, Issue 3 2010Article first published online: 15 JAN 2010 Cover image legend: A model for cap-dependent translation initiation in sea urchin. The image shows the graph of the wiring diagram obtained for the model, as generated using Cytoscape software. Full details can be found in Bellé et al. (this issue). [source] Expanded PTFE bladder neck slings for incontinence in children: the long-term outcomeBJU INTERNATIONAL, Issue 1 2004P. Godbole OBJECTIVE To assess the long-term outcome of circumferential expanded PTFE (Gore-texTM, WL Gore Associates, Scotland) bladder neck slings for achieving urethral continence in children with a neuropathic bladder. PATIENTS AND METHODS The records were reviewed of 19 children undergoing bladder reconstruction (most with a neuropathic bladder) who had a Gore-tex sling placed circumferentially at the bladder neck, over a 5-year period. Of these, seven had spina bifida; two each spinal dysraphism, surgery for anorectal anomalies and an idiopathic neuropathic bladder; five who developed a neuropathic bladder from other causes, and one born with bladder exstrophy. All children had an uncompliant bladder with a low urethral leak-point pressure on preoperative urodynamics. In all children conventional clean intermittent catheterization and pharmacotherapy had failed. Four had had previous augmentation surgery while 15 had concomitant bladder augmentation and formation of a Mitrofanoff stoma. The main outcome measure was achieving dryness. The original intention of the procedure was also to maintain urethral catheterization. RESULTS Full details of the follow-up were available in 17 patients. Despite initial good short-term results, at a median follow up of 7 years, in 14 patients the sling had to be removed because of erosion, often with transient urethral leakage before the bladder neck subsequently closed. A bladder calculus was associated with each case of erosion except one. CONCLUSION Although in the short term this technique had favourable results, it was not a useful technique in the long term. [source] Principles of Corporate Governance in GreeceCORPORATE GOVERNANCE, Issue 2 2001Harilaos Mertzanis This article presents the reasons which led the business community in Greece to reconsider existing corporate governance practices of listed corporations in the Athens Stock Exchange, outlines the general rationale for the creation and adoption of specific recommendations for best corporate practice, presents the recommendations in full detail and finally provides suggestions for the required corporate legal reform. [source] The Laulimalide Family: Total Synthesis and Biological Evaluation of Neolaulimalide, Isolaulimalide, Laulimalide and a Nonnatural AnalogueCHEMISTRY - A EUROPEAN JOURNAL, Issue 24 2009Andreas Gollner Dipl.-Ing. Abstract A sensitive family: The first total synthesis of the antitumor agents neolaulimalide and isolaulimalide as well as a highly efficient route to laulimalide is described. A Kulinkovich reaction followed by a cyclopropyl,allyl rearrangement is used to install the exo -methylene group. The cytotoxicity of neolaulimalide could be confirmed for the first time since its original isolation and it could be shown that it induces tubulin polymerization as efficiently as laulimalide. We herein describe in full detail the first total synthesis of the antitumor agents neolaulimalide and isolaulimalide as well as a highly efficient route to laulimalide. A Kulinkovich reaction followed by a cyclopropyl,allyl rearrangement is used to install the exo -methylene group. The C2,C16 aldehyde fragment is coupled with the C17,C28 sulfone fragments by a highly (E)-selective Julia,Lythgoe,Kocienski olefination to deliver the key intermediates of all three syntheses. Various conditions for the Yamaguchi macrolactonization are applied to close the individual macrocycles. Finally a carefully elaborated endgame was developed to solve the problem of acyl migration in the case of neolaulimalide. All compounds were tested against several cell lines. The cytotoxicity of neolaulimalide could be confirmed for the first time since its original isolation and it could be shown that it induces tubulin polymerization as efficiently as laulimalide. [source] Borrowing Hydrogen: Indirect "Wittig" Olefination for the Formation of C,C Bonds from AlcoholsEUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 19 2006Phillip J. Black Abstract The successful development of an indirect three-step domino sequence for the formation of C,C bonds from alcohol substrates is described. An iridium-catalysed dehydrogenation of alcohol 1 affords the intermediate aldehyde 2. The desired C,C bond can then be formed by a facile Wittig olefination, yielding the intermediate alkene 3. In the final step the alkene is hydrogenated to afford the indirect Wittig product, the alkane 4. The key to this process is the concept of borrowing hydrogen; hydrogen removed in the initial dehydrogenation step is simply borrowed by the iridium catalyst. Functioning as a hydrogen reservoir, the catalyst facilitates C,C bond formation before subsequently returning the borrowed hydrogen in the final step. Herein we present full details of our examination into both the substrate and reaction scope and the limitations of the catalytic cycle. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006) [source] A rapid synthesis of new benzene-centered porphyrin trimersJOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 5 2007Cyril A. Papamicaël In connection with our study of the capability of forming ordered self-assembled monolayers on gold substrates, we described the full details concerning the rapid synthesis of two rigid, star-shaped D3 -symmetric arrays with a benzene core attached to three identical metalloporphyrins containing either ethyldisulfide functions or thienyl groups. [source] Treating missing values in INAR(1) models: An application to syndromic surveillance dataJOURNAL OF TIME SERIES ANALYSIS, Issue 1 2010Jonas Andersson Time-series models for count data have found increased interest in recent years. The existing literature refers to the case of data that have been fully observed. In this article, methods for estimating the parameters of the first-order integer-valued autoregressive model in the presence of missing data are proposed. The first method maximizes a conditional likelihood constructed via the observed data based on the k -step-ahead conditional distributions to account for the gaps in the data. The second approach is based on an iterative scheme where missing values are imputed so as to update the estimated parameters. The first method is useful when the predictive distributions have simple forms. We derive in full details this approach when the innovations are assumed to follow a finite mixture of Poisson distributions. The second method is applicable when there are no closed form expression for the conditional likelihood or they are hard to derive. The proposed methods are applied to a dataset concerning syndromic surveillance during the Athens 2004 Olympic Games. [source] ,J'y Suis, J'y Reste': The Parliamentary Statue of Oliver Cromwell by Hamo ThornycroftPARLIAMENTARY HISTORY, Issue 3 2009MELANIE UNWIN The conservation of the statue of Cromwell by Hamo Thornycroft in 2009 (for full details and images see http://www.parliament.uk/about/visiting/exhibitions/cromwell_conservation.cfm) provided an opportunity to review the history of this most controversial of parliamentary statues both within the context of the proposed statue programme for the new palace of Westminster and the development of British sculpture which the Royal Commission for the Fine Arts hoped to encourage with its commissioning programme. Whilst 2009 marked the 350th anniversary of Cromwell's death it was the tercentenary of his birth in 1899 which brought forward a clutch of statues, including parliament's, reflecting the Victorian reassessment, and indeed repopularisation of Cromwell, as a historical figure. [source] | ||||||||||