Home About us Contact
|
Home About us Contact | ||
|
|
||
Fresh Look (fresh + look)
Selected AbstractsA Fresh Look at Dickinsonia: Removing It from VendobiontaACTA GEOLOGICA SINICA (ENGLISH EDITION), Issue 5 2006ZHANG Xingliang Abstract: The Ediacaran Dickinsonia is well-known for being the only fossil to be assigned to many phyla, ranging from lichens, Cnidaria, Platyhelminthes, Annelida, and a phylum of its own to a nonmetazoan kingdom. A new specimen from the Ediacaran fine-grained sandstone on the Winter Coast of the White Sea in northern Russia, which has an age of ,555 million years ago, preserved convincing internal anatomies of definite animals, comparable with meridional canals of extant ctenophores (comb jellies). Additionally, we reconsidered Dickinsonia as a biradially symmetrical animal rather than a bilateral one as previously thought. The animal nature of Dickinsonia is, thus, well established and its affinities are most probably allied to ctenophores. This research is not only removing Dickinsonia from Vendobionta, but also bringing the fossil record of ctenophores forward to 20 million years before the Cambrian "explosion". [source] A CRITICAL LOOK AT PAP ADEQUECY: ARE OUR CRITERIA SATISFACTORY?CYTOPATHOLOGY, Issue 2006D.R. Bolick Liquid based Pap (LBP) specimen adequacy is a highly documented, yet poorly understood cornerstone of our GYN cytology practice. Each day, as cytology professionals, we make adequacy assessments and seldom wonder how the criteria we use were established. Are the criteria appropriate? Are they safe? What is the scientific data that support them? Were they clinically and statistically tested or refined to achieve optimal patient care? In this presentation, we will take a fresh look at what we know about Pap specimen adequacy and challenge some of the core assumptions of our daily practice. LBP tests have a consistent, well-defined surface area for screening, facilitating the quantitative estimates of slide cellularity. This provides an unprecedented opportunity to establish reproducible adequacy standards that can be subjected to scientific scrutiny and rigorous statistical analysis. Capitalizing on this opportunity, the TBS2001 took the landmark step to define specimen adequacy quantitatively, and set the threshold for a satisfactory LBP at greater than 5,000 well visualized squamous epithelial cells. To date, few published studies have attempted to evaluate the validity or receiver operator characteristics for this threshold, define an optimal threshold for clinical utility or assess risks of detection failure in ,satisfactory' but relatively hypocellular Pap specimens. Five years of cumulative adequacy and cellularity data of prospectively collected Pap samples from the author's laboratory will be presented, which will serve as a foundation for a discussion on ,Pap failure'. A relationship between cellularity and detection of HSIL will be presented. Risk levels for Pap failure will be presented for Pap samples of different cellularities. The effect of different cellularity criterion on unsatisfactory Pap rates and Pap failure rates will be demonstrated. Results from this data set raise serious questions as to the safety of current TBS2001 adequacy guidelines and suggest that the risk of Pap failure in specimens with 5,000 to 20 000 squamous cells on the slide is significantly higher than those assumed by the current criteria. TBS2001 designated all LBP to have the same adequacy criterion. Up to this point, it has been assumed that ThinPrep, SurePath, or any other LBP would be sufficiently similar that they should have the same adequacy criteria. Data for squamous cellularity and other performance characteristics of ThinPrep and SurePath from the author's laboratory will be compared. Intriguing data involving the recently approved MonoPrep Pap Test will be reviewed. MonoPrep clinical trial data show the unexpected finding of a strong correlation between abundance of endocervical component and the detection of high-grade lesions, provoking an inquiry of a potential new role for a quantitative assessment of the transition zone component. The current science of LBP adequacy criteria is underdeveloped and does not appear to be founded on statistically valid methods. This condition calls us forward as a body of practitioners and scientists to rigorously explore, clarify and define the fundamental nature of cytology adequacy. As we forge this emerging science, we will improve diagnostic performance, guide the development of future technologies, and better serve the patients who give us their trust. Reference:, Birdsong GG: Pap smear adequacy: Is our understanding satisfactory? Diagn Cytopathol. 2001 Feb; 24(2): 79,81. [source] A fresh look at an early theory of evolution and development: a new translation of Schmalhausen's Factors of EvolutionACTA ZOOLOGICA, Issue 4 2010Rainer R. Schoch No abstract is available for this article. [source] Standard-Setting Methods as Measurement ProcessesEDUCATIONAL MEASUREMENT: ISSUES AND PRACTICE, Issue 1 2010Paul Nichols Some writers in the measurement literature have been skeptical of the meaningfulness of achievement standards and described the standard-setting process as blatantly arbitrary. We argue that standard setting is more appropriately conceived of as a measurement process similar to student assessment. The construct being measured is the panelists' representation of student performance at the threshold of an achievement level. In the first section of this paper, we argue that standard setting is an example of stimulus-centered measurement. In the second section, we elaborate on this idea by comparing some popular standard-setting methods to the stimulus-centered scaling methods known as psychophysical scaling. In the third section, we use the lens of standard setting as a measurement process to take a fresh look at the two criticisms of standard setting: the role of judgment and the variability of results. In the fourth section, we offer a vision of standard-setting research and practice as grounded in the theory and practice of educational measurement. [source] Jonson's Joyless Economy: Theorizing Motivation and Pleasure in VolponeENGLISH LITERARY RENAISSANCE, Issue 1 2008Oliver Hennessey Departing from a tradition of expedient, often pious, interpretations of Volpone as a straightforward fable of avarice, miserliness, and material misappropriation, this essay takes a fresh look at old Volp's actions in the light of radical reconsiderations of consumer motivation by the contemporary economist, Tibor Scitovsky. Scitovsky's The Joyless Economy broke with conventional economic doxa by asking whether modern consumer behavior was in fact irrational, and, further, whether Americans are encouraged to pursue styles of life that foster ennui. Applying the Scitovskian paradigm to another commodity culture, Volpone's seventeenth-century Venice, forces us to confront an aspect of the play most usually finessed: the joy of gulling. Volpone, and early modern city comedy more generally, offers us a chance to examine the multi-faceted response of individuals in the early Seventeenth Century coming to terms with Europe's expanding commercial scene and the commodity culture to which the playhouse responded, and within which it was implicated. [source] A fresh look at dry weightHEMODIALYSIS INTERNATIONAL, Issue 4 2008Jochen RAIMANN Abstract The concept of dry weight (DW) is central to dialysis therapy. The most commonly used definition of DW is the weight below which patients become hypotensive on dialysis. However, this definition is dependent on patient symptoms. A more rigorous definition of DW is the body weight at a physiological extracellular volume (ECV) state. Overhydration is an excess in ECV above that found in healthy subjects. In healthy subjects, within extremes of salt intake, ECV may vary between 280 and 340 mL/kg lean body mass. Sodium accumulation is one of the many consequences of renal failure; it results in increased water intake and an increase in ECV, and an accompanying rise in blood pressure with its clinical sequelae, most prominently cardiovascular and cerebrovascular diseases. Recently characterized endogenous digitalis-like factors which are released in response to ECV expansion have extended this traditional picture. Efforts to reduce a positive sodium balance include dietary counseling and avoidance of iatrogenic intradialytic sodium loading, such as dialysate sodium exceeding serum levels, sodium profiling, and intravenous saline. Excess ECV is predominantly located in the interstitial compartment and must be removed during dialysis therapy by ultrafiltration. During this process, interstitial fluid redistributes to the intravascular space via uptake in the capillary bed. In addition to that mechanism, we propose that increased lymphatic flow into the venous system contributes to plasma refilling. Both clinical and technical means are used to assess the presence of DW. Continuous segmental calf bioimpedance is a promising new technology for intradialytic DW diagnosis. [source] Green supply-chain management: A state-of-the-art literature reviewINTERNATIONAL JOURNAL OF MANAGEMENT REVIEWS, Issue 1 2007Samir K. Srivastava There is a growing need for integrating environmentally sound choices into supply-chain management research and practice. Perusal of the literature shows that a broad frame of reference for green supply-chain management (GrSCM) is not adequately developed. Regulatory bodies that formulate regulations to meet societal and ecological concerns to facilitate growth of business and economy also suffer from its absence. A succinct classification to help academicians, researchers and practitioners in understanding integrated GrSCM from a wider perspective is needed. Further, sufficient literature is available to warrant such classification. This paper takes an integrated and fresh look into the area of GrSCM. The literature on GrSCM is covered exhaustively from its conceptualization, primarily taking a ,reverse logistics angle'. Using the rich body of available literature, including earlier reviews that had relatively limited perspectives, the literature on GrSCM is classified on the basis of the problem context in supply chain's major influential areas. It is also classified on the basis of methodology and approach adopted. Various mathematical tools/techniques used in literature vis-à-vis the contexts of GrSCM are mapped. A timeline indicating relevant papers is also provided as a ready reference. Finally, the findings and interpretations are summarized, and the main research issues and opportunities are highlighted. [source] Family policy and social order , comparing the dynamics of family policy-making in Scandinavia and Confucian AsiaINTERNATIONAL JOURNAL OF SOCIAL WELFARE, Issue 1 2003Ka Lin This article compares family policies in two Scandinavian and three Confucian Asian countries. Through a general survey on schemes of child allowance and parental leave, it seeks explaining factors for cross-regime diversity of the welfare systems. In focus are the agents affecting the family policy-making process, including social classes, the state, women and families. In order to assess the roles these agents have played, this study retraces the preconditions of family policy development and its associated socio-cultural backgrounds. Results from such an examination will illustrate how the social order determines the patterns of family policy, which offers a new path to travel to these different cultural ,worlds'. Taking the Confucian Asian states into its frame of reference, the study will take a fresh look at Scandinavian welfare systems, which still have some general implications for the study of the dynamics, model and outcome of family policy in an international context. [source] Avian molecular systematics on the rebound: a fresh look at modern shorebird phylogenetic relationshipsJOURNAL OF AVIAN BIOLOGY, Issue 3 2004Marcel Van Tuinen The study of avian molecular systematics currently lags behind that of mammals in several ways. Little phylogenetic resolution is observed among orders and phylogenetic studies below the ordinal level largely remain based on fast evolving mitochondrial sequences. New papers by Paton et al., Ericson et al., and Thomas et al. provide avian molecular systematics with a badly needed boost. These studies indicate that sampling more taxa and slower evolving nuclear genes yields strong phylogenetic resolution among the major shorebird (order Charadriiformes) families. The new data show surprising overall consensus and converge on certain novel clades. If correct, this newly obtained phylogenetic framework has tremendous implications for our understanding of the evolution of shorebird morphology, ecology and behaviour. [source] Skin ageing, a fresh look at an old storyJOURNAL OF COSMETIC DERMATOLOGY, Issue 1 2004G E Piérard [source] A Retrospective Look at the Water Resource Management Policies in Nassau County, Long Island, New York,JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION, Issue 5 2008Daniel J. St. Germain Abstract:, The residents of Nassau County Long Island, New York receive all of their potable drinking water from the Upper Glacial, Jameco/Magothy (Magothy), North Shore, and Lloyd aquifers. As the population of Nassau County grew from 1930 to 1970, the demand on the ground-water resources also grew. However, no one was looking at the potential impact of withdrawing up to 180 mgd (7.9 m3/s) by over 50 independent water purveyors. Some coastal community wells on the north and south shores of Nassau County were being impacted by saltwater intrusion. The New York State Legislature formed a commission to look into the water resources in 1972. The commission projected extensive population growth and a corresponding increase in pumping resulting in a projected 93.5 to 123 mgd (4.1 to 5.5 m3/s) deficit by 2000. In 1986, the New York Legislature passed legislation to strengthen the well permit program and also establish a moratorium on new withdrawals from the Lloyd aquifer to protect the coastal community's only remaining supply of drinking water. Over 30 years has passed since the New York Legislature made these population and pumping projections and it is time to take a look at the accuracy of the projections that led to the moratorium. United States Census data shows that the population of Nassau County did not increase but decreased from 1970 to 2000. Records show that pumping in Nassau County was relatively stable fluctuating between 170 and 200 mgd (7.5 to 8.8 m3/s) from 1970 to 2004, well below the projection of 242 to 321 mgd (10.6 to 14.1 m3/s). Therefore, the population and water demand never grew to projected values and the projected threat to the coastal communities has diminished. With a stable population and water demand, its time to take a fresh look at proactive ground-water resource management in Nassau County. One example of proactive ground-water management that is being considered in New Jersey where conditions are similar uses a ground-water flow model to balance ground water withdrawals, an interconnection model to match supply with demand using available interconnections, and a hydraulic model to balance flow in water mains. New Jersey also conducted an interconnection study to look into how systems with excess capacity could be used to balance withdrawals in stressed aquifer areas with withdrawals in unstressed areas. Using these proactive ground-water management tools, ground-water extraction could be balanced across Nassau County to mitigate potential impacts from saltwater intrusion and provide most water purveyors with a redundant supply that could be used during water emergencies. [source] Analysis of ancient human genomesBIOESSAYS, Issue 5 2010000-year-old human from Greenland has been obtained, 20-fold coverage of the genome of a , Using next generation sequencing Abstract High-capacity sequencing technologies have dramatically reduced both the cost and time required to generate complete human genome sequences. Besides expanding our knowledge about existing diversity, the nature of these technologies makes it possible to extend knowledge in yet another dimension: time. Recently, the complete genome sequence of a 4,000-year-old human from the Saqqaq culture of Greenland was determined to 20-fold coverage. These data make it possible to investigate the population affinities of this enigmatic culture and, by identifying several phenotypic traits of this individual, provide a limited glimpse into how these people may have looked. While undoubtedly a milestone in ancient DNA research, the cost to generate an ancient genome, even from such an exceptionally preserved specimen, remains out of reach for most. Nonetheless, recently developed DNA capture methods, already applied to Neanderthal and fossil human mitochondrial DNA, may soon make large-scale genome-wide analysis of ancient human diversity a reality, providing a fresh look at human population history. [source] An Undercover Angiosperm from the Jurassic of ChinaACTA GEOLOGICA SINICA (ENGLISH EDITION), Issue 4 2010ZHENG Shaolin Abstract: Searching for early angiosperms is a riveting activity in botany because it helps to resolve the phylogenetic relationships among seed plants and among angiosperms themselves. One of the challenges for this job is what the target fossils look like. Most possibly early angiosperms may elude our scrutiny with gymnospermous appearances. This possibility becomes a reality in a Jurassic plant, Solaranthus gen. nov, which bears a peltaspermalean appearance and enclosed ovules. According to knowledge available hitherto, the latter feature makes it an angiosperm. However, such a feature is more likely to be eclipsed by its gymnospermous appearance. The early age and unexpected character assemblage of Solaranthus urge for a fresh look on the assumed-simple relationship between angiosperms and gymnosperms. Its resemblance to the order Peltaspermales favors the Mostly Male Theory. [source] | ||||||||||||||||