Founders

Distribution by Scientific Domains
Distribution within Life Sciences

Kinds of Founders

  • common founder

  • Terms modified by Founders

  • founder effect
  • founder effects
  • founder event
  • founder mutation
  • founder population

  • Selected Abstracts


    James Madison: Philosopher, Founder, and Statesman , Edited by John R. Vile, William D. Pederson, and Frank J. Williams

    PRESIDENTIAL STUDIES QUARTERLY, Issue 3 2010
    Peter C. Messer
    No abstract is available for this article. [source]


    Citizen Hamilton: The Wit and Wisdom of an American Founder , By Donald R. Hickey and Connie D. Clark

    THE HISTORIAN, Issue 3 2007
    Peter McNamara
    No abstract is available for this article. [source]


    Slavery and the Founding

    HISTORY COMPASS (ELECTRONIC), Issue 5 2006
    Matthew Mason
    One of the oldest but hottest debates over the U.S. Constitution has concerned its relationship to slavery, a dispute that goes right to the heart of the meaning of the founding of the republic. Some observers have portrayed slavery as a , even the , vital problem of the Founding, and denounced the Constitution as a proslavery document. Other scholars contend that this picture unduly elevates the importance of slavery in the contest over the Constitution and distorts the intent of the Founders. This essay reviews recent entries in this debate to frame its argument that slavery figured largely as a weapon that Federalists and Antifederalists wielded to press their more primary points. It examines the debates over , and using , the various slavery clauses in the document to conclude that slavery was a versatile tool in rather than a core concern of the Constitutional Convention and ratification debates. [source]


    Identification of five chromosomal regions involved in predisposition to melanoma by genome-wide scan in the MeLiM swine model

    INTERNATIONAL JOURNAL OF CANCER, Issue 1 2004
    Claudine Geffrotin
    Abstract In human familial melanoma, 3 risk susceptibility genes are already known, CDKN2A, CDK4 and MC1R. However, various observations suggest that other melanoma susceptibility genes have not yet been identified. To search for new susceptibility loci, we used the MeLiM swine as an animal model of hereditary melanoma to perform a genome scan for linkage to melanoma. Founders of the affected MeLiM stock were crossed with each other and with healthy Duroc pigs, generating MeLiM, F1 and backcross families. As we had previously excluded the MeLiM CDKN2A gene, we paid special attention to CDK4 and MC1R, as well as to other candidates such as BRAF and the SLA complex, mapping them on the swine radiation hybrid map and/or isolating close microsatellite markers to introduce them into the genome scan. The results revealed, first, that swine melanoma was inherited as an autosomal dominant trait with incomplete penetrance, preferably in black animals. Second, 4 chromosomal regions potentially involved in melanoma susceptibility were identified on Sus Scrofa chromosomes (SSC) 1, 2, 7 and 8, respectively, in intervals 44,103, 1.9,18, 59,73 and 47,62 cM. A fifth region close to MC1R was revealed on SSC 6 by analyzing an individual marker located at position 7.5 cM. Lastly, CDK4 and BRAF were unlikely to be melanoma susceptibility genes in the MeLiM swine model. The 3 regions on SSC 1, 6 and 7, respectively, have counterparts on human chromosomes (HSA) 9p, 16q and 6p, harboring melanoma candidate loci. The 2 others, on SSC 2 and 8, have counterparts on HSA 11 and 4, which might therefore be of interest for human studies. © 2004 Wiley-Liss, Inc. [source]


    Support for Rapid-Growth Firms: A Comparison of the Views of Founders, Government Policymakers, and Private Sector Resource Providers

    JOURNAL OF SMALL BUSINESS MANAGEMENT, Issue 4 2003
    Eileen Fischer
    The paper contrasts the perspectives of firm owners, government policy advisers, and external resource providers on how rapid-growth firms should be supported. Qualitative data were analyzed to identify similarities and differences in groups' perspectives. The research indicates that each group sees its roles as critical. Policymakers and external resources providers have incentives to interact with rapid-growth firms. Rapid-growth firms have incentives to obtain advice from government sources and external resource providers but prefer to obtain advice from their peers. These findings suggest a network-based approach to the support of rapid growth that is consistent with a new Ontario-based program, the Innovators Alliance. [source]


    Constitutionalism and Presidential Prerogative: Jeffersonian and Hamiltonian Perspectives

    AMERICAN JOURNAL OF POLITICAL SCIENCE, Issue 3 2004
    Clement Fatovic
    Scholars, the courts, and the public have been ambivalent about prerogative, the power of presidents to take extraordinary actions without explicit legal authorization in emergencies, because it seems to defy core principles of liberal constitutionalism. This article examines the relation between prerogative and liberal constitutionalism by comparing the approaches of two Founders with different conceptions of executive power, Jefferson and Hamilton. Although they both endorsed a Lockean conception of prerogative that makes it possible to secure vital substantive ends that might be imperiled by strict adherence to ordinary legal forms in an emergency, they disagreed over the constitutionality of prerogative. Whereas Hamilton located the authority for prerogative within the implied powers of the Constitution, Jefferson expected presidents to admit wrongdoing and seek post-hoc approval from the public, a difference with important implications for both democracy and constitutional practice that can be traced back to ambiguities in Locke's theory of prerogative. [source]


    Occupational therapy using a sensory integrative approach for children with developmental disabilities

    DEVELOPMENTAL DISABILITIES RESEARCH REVIEW, Issue 2 2005
    Roseann C. Schaaf
    Abstract This article provides an introduction and overview of sensory integration theory as it is used in occupational therapy practice for children with developmental disabilities. This review of the theoretical tenets of the theory, its historical foundations, and early research provides the reader with a basis for exploring current uses and applications. The key principles of the sensory integrative approach, including concepts such as "the just right challenge" and "the adaptive response" as conceptualized by A. Jean Ayres, the theory's founder, are presented to familiarize the reader with the approach. The state of research in this area is presented, including studies underway to further delineate the subtypes of sensory integrative dysfunction, the neurobiological mechanisms of poor sensory processing, advances in theory development, and the development of a fidelity measure for use in intervention studies. Finally, this article reviews the current state of the evidence to support this approach and suggests that consensual knowledge and empirical research are needed to further elucidate the theory and its utility for a variety of children with developmental disabilities. This is especially critical given the public pressure by parents of children with autism and other developmental disabilities to obtain services and who have anecdotally noted the utility of sensory integration therapy for helping their children function more independently. Key limiting factors to research include lack of funding, paucity of doctorate trained clinicians and researchers in occupational therapy, and the inherent heterogeneity of the population of children affected by sensory integrative dysfunction. A call to action for occupational therapy researchers, funding agencies, and other professions is made to support ongoing efforts and to develop initiatives that will lead to better diagnoses and effective intervention for sensory integrative dysfunction, which will improve the lives of children and their families. © 2005 Wiley-Liss, Inc. MRDD Research Reviews 2005;11:143,148. [source]


    "There Must be Mouse Dirt with the Pepper": A Lutheran Approach to Choosing Songs1

    DIALOG, Issue 4 2009
    Gertrud Tönsing
    Abstract:, This paper stems from my doctoral research on the question, "What is a good song?" It is a response to the Praise and Worship movement, which started within the charismatic churches, but also has spread to many mainline churches, including my own in South Africa. While I am supportive of much that is good in this movement, I am also critical of the content and theology of many of the songs. This paper focuses on what we as Lutherans can learn from our founder when it comes to choosing what and how to sing in our services. [source]


    The Founding of the American Epilepsy Society: 1936,1971

    EPILEPSIA, Issue 1 2007
    Howard P. Goodkin
    Summary:, In December 1946, a joint meeting devoted to epilepsy research and care was held by the Association for the Research in Nervous and Mental Disease and the American Chapter of the International League Against Epilepsy. The American Epilepsy Society (AES) has chosen this date and this meeting to mark its founding and recognizes Dr. Charles D. Aring as the organization's first president. However, the founding process of the AES actually began a decade earlier with a dinner meeting held during the American Medical Association's annual meeting. Based on this historical review, it is recommended that the AES recognize 1936 as the year of its founding and Dr. William G. Lennox as its founder and first president. [source]


    The Importance of Board Quality in the Event of a CEO Death

    FINANCIAL REVIEW, Issue 3 2006
    Kenneth A. Borokhovich
    G34 Abstract We examine board quality and executive replacement decisions around deaths of senior executives. Stock price reactions to executive deaths are positively related to board independence. Controlling for such factors as the deceased's stockholdings, outside blockholdings, board size, and whether the deceased was a founder, board independence is the most significant factor explaining abnormal returns. Board independence is particularly important when there is no apparent successor and firm performance is poor. The results are consistent with independent boards being reluctant to discipline poorly performing incumbent managers, but nevertheless using the opportunity of an executive death to improve the quality of management. [source]


    On the Future of Reanimatology,

    ACADEMIC EMERGENCY MEDICINE, Issue 1 2000
    Peter Safar MD
    Abstract: This article is adapted from a presentation given at the 1999 SAEM annual meeting by Dr. Peter Safar. Dr. Safar has been involved in resuscitation research for 44 years, and is a distinguished professor and past initiating chairman of the Department of Anesthesiology and Critical Care Medicine at the University of Pittsburgh. He is the founder and director of the Safar Center for Resuscitation Research at the University of Pittsburgh, and has been the research mentor of many critical care and emergency medicine research fellows. Here he presents a brief history of past accomplishments, recent findings, and future potentials for resuscitation research. Additional advances in resuscitation, from acute terminal states and clinical death, will build upon the lessons learned from the history of reanimatology, including optimal delivery by emergency medical services of already documented cardiopulmonary cerebral resuscitation, basic-advanced,prolonged life support, and future scientific breakthroughs. Current controversies, such as how to best educate the public in life-supporting first aid, how to restore normotensive spontaneous circulation after cardiac arrest, how to rapidly induce mild hypothermia for cerebral protection, and how to minimize secondary insult after cerebral ischemia, are discussed, and must be resolved if advances are to be made. Dr. Safar also summarizes future technologies already under preliminary investigation, such as ultra-advanced life support for reversing prolonged cardiac arrest, extending the "golden hour" of shock tolerance, and suspended animation for delayed resuscitation. [source]


    A large Norwegian family with inherited malignant melanoma, multiple atypical nevi, and CDK4 mutation

    GENES, CHROMOSOMES AND CANCER, Issue 1 2005
    Anders Molven
    Mutations in two loci encoding cell-cycle-regulatory proteins have been shown to cause familial malignant melanoma. About 20% of melanoma-prone families bear a mutation in the CDKN2A locus, which encodes two unrelated proteins, p16INK4A and p14ARF. Mutations in the other locus, CDK4, are much rarer and have been linked to the disease in only three families worldwide. In the 1960s, a large Norwegian pedigree with multiple atypical nevi and malignant melanomas was identified. Subsequently, six generations and more than 100 family members were traced and 20 cases of melanoma verified. In this article, we report that CDK4 codon 24 is mutated from CGT to CAT (Arg24His) in this unusually large melanoma kindred. Intriguingly, one of the family members had ocular melanoma, but the CDK4 mutation could not be detected in archival tissue samples from this subject. Thus, the case of ocular melanoma in this family was sporadic, suggesting an etiology different from that of the skin tumors. The CDK4 mutation in the Norwegian family was identical to that in melanoma families in France, Australia, and England. Haplotype analysis using microsatellite markers flanking the CDK4 gene and single-nucleotide polymorphisms within the gene did not support the possibility that there was a common founder, but rather indicated at least two independent mutational events. All CDK4 melanoma families known to date have a substitution of amino acid 24. In addition to resulting from selection pressure, this observation may be explained by the CG dinucleotide of codon 24 representing a mutational hot spot in the CDK4 gene. © 2005 Wiley-Liss, Inc. [source]


    English University Benefactors in the Middle Ages

    HISTORY, Issue 283 2001
    Alan B. Cobban
    The medieval universities of Oxford and Cambridge owed an enormous debt to the generosity of a plurality of benefactors of diverse social origins. Given their limited incomes, the universities could not have functioned at a successful level without the substantial material aid of benefactors. Although the English monarchy made a valuable contribution to several areas of university and collegiate life, it nevertheless appears that this monarchical beneficence was less extensive than might have been supposed. The English male nobility gave the occasional gift of property and made donations to loan-chests but before 1500 only one nobleman was a principal founder of a secular academic college. This opened the way for queens consort and female members of the greater aristocracy to emerge as significant benefactresses in both the university and collegiate spheres. Indeed, it could be argued that women from the upper echelons of society came to rank in importance as university and college benefactors with lesser ecclesiastics, knights, burgesses, merchants, current and former members of colleges and university servants. However, taking the donations of the episcopate in the round, it is probably true to say that the English bishops made the most decisive contribution [source]


    A multicenter study on the prevalence and spectrum of mutations in the otoferlin gene (OTOF) in subjects with nonsyndromic hearing impairment and auditory neuropathy,

    HUMAN MUTATION, Issue 6 2008
    Montserrat Rodríguez-Ballesteros
    Abstract Autosomal recessive nonsyndromic hearing impairment (NSHI) is a heterogeneous condition, for which 53 genetic loci have been reported, and 29 genes have been identified to date. One of these, OTOF, encodes otoferlin, a membrane-anchored calcium-binding protein that plays a role in the exocytosis of synaptic vesicles at the auditory inner hair cell ribbon synapse. We have investigated the prevalence and spectrum of deafness-causing mutations in the OTOF gene. Cohorts of 708 Spanish, 83 Colombian, and 30 Argentinean unrelated subjects with autosomal recessive NSHI were screened for the common p.Gln829X mutation. In compound heterozygotes, the second mutant allele was identified by DNA sequencing. In total, 23 Spanish, two Colombian and two Argentinean subjects were shown to carry two mutant alleles of OTOF. Of these, one Colombian and 13 Spanish subjects presented with auditory neuropathy. In addition, a cohort of 20 unrelated subjects with a diagnosis of auditory neuropathy, from several countries, was screened for mutations in OTOF by DNA sequencing. A total of 11 of these subjects were shown to carry two mutant alleles of OTOF. In total, 18 pathogenic and four neutral novel alleles of the OTOF gene were identified. Haplotype analysis for markers close to OTOF suggests a common founder for the novel c.2905_2923delinsCTCCGAGCGCA mutation, frequently found in Argentina. Our results confirm that mutation of the OTOF gene correlates with a phenotype of prelingual, profound NSHI, and indicate that OTOF mutations are a major cause of inherited auditory neuropathy. Hum Mutat 29(6), 823,831, 2008. © 2008 Wiley-Liss, Inc. [source]


    Syndrome-causing mutations of the BLM gene in persons in the Bloom's Syndrome Registry,,

    HUMAN MUTATION, Issue 8 2007
    James German
    Abstract Bloom syndrome (BS) is caused by homozygous or compound heterozygous mutations in the RecQ DNA helicase gene BLM. Since the molecular isolation of BLM, characterization of BS-causing mutations has been carried out systematically using samples stored in the Bloom's Syndrome Registry. In a survey of 134 persons with BS from the Registry, 64 different mutations were identified in 125 of them, 54 that cause premature protein-translation termination and 10 missense mutations. In 102 of the 125 persons in whom at least one BLM mutation was identified, the mutation was recurrent, that is, it was shared by two or more persons with BS; 19 of the 64 different mutations were recurrent. Ethnic affiliations of the persons who carry recurrent mutations indicate that the majority of such persons inherit their BLM mutation identical-by-descent from a recent common ancestor, a founder. The presence of widespread founder mutations in persons with BS points to population genetic processes that repeatedly and pervasively generate mutations that recur in unrelated persons. Hum Mutat 28(8), 743,753, 2007. Published 2007 Wiley-Liss, Inc. [source]


    Tau (MAPT) mutation Arg406Trp presenting clinically with Alzheimer disease does not share a common founder in Western Europe,

    HUMAN MUTATION, Issue 5 2003
    R. Rademakers
    No abstract is available for this article. [source]


    D90A- SOD1 mediated amyotrophic lateral sclerosis: A single founder for all cases with evidence for a Cis -acting disease modifier in the recessive haplotype,,

    HUMAN MUTATION, Issue 6 2002
    Matthew J. Parton
    Abstract More than 100 different heterozygous mutations in copper/zinc superoxide dismutase (SOD1) have been found in patients with amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Uniquely, D90A- SOD1 has been identified in recessive, dominant and apparently sporadic pedigrees. The phenotype of homozygotes is stereotyped with an extended survival, whereas that of affected heterozygotes varies. The frequency of D90A- SOD1 is 50 times higher in Scandinavia (2.5%) than elsewhere, though ALS prevalence is not raised there. Our earlier study indicated separate founders for recessive and dominant/sporadic ALS and we proposed a disease-modifying factor linked to the recessive mutation. Here we have doubled our sample set and employed novel markers to characterise the mutation's origin and localise any modifying factor. Linkage disequilibrium analysis indicates that D90A homozygotes and heterozygotes share a rare haplotype and are all descended from a single ancient founder (alpha 0.974) c.895 generations ago. Homozygotes arose subsequently only c.63 generations ago (alpha 0.878). Recombination has reduced the region shared by recessive kindreds to 97-265 kb around SOD1, excluding all neighbouring genes. We propose that a cis -acting regulatory polymorphism has arisen close to D90A- SOD1 in the recessive founder, which decreases ALS susceptibility in heterozygotes and slows disease progression. © 2002 Wiley-Liss, Inc. [source]


    "Singing for Our Lives": Women's Music and Democratic Politics

    HYPATIA, Issue 4 2002
    NANCY S. LOVE
    Although democratic theorists often employ musical metaphors to describe their politics, musical practices are seldom analyzed as forms of political communication. In this article, I explore how the music of social movements, what is called "movement music," supplements deliberative democrats' concept of public discourse as rational argument. Invoking energies, motions, and voices beyond established identities and institutions anticipates a different, more musical democracy. I argue that the "women's music" of Holly Near, founder of Redwood Records and Redwood Cultural Work, exemplifies this transformative power of musical sound. [source]


    Is Thabo Mbeki Africa's Saviour?

    INTERNATIONAL AFFAIRS, Issue 4 2003
    Gerrit Olivier
    Foreign relations are the main preoccupation of South African president, Thabo Mbeki. His role perception is dominated by a mission to improve the plight of Africa, and second to that, to act as the Third World's überdiplomat. Under his administration, South Africa's foreign policy has become almost an adjunct of his more holistic diplomatic pursuits. The New Partnership for Africa's Development (NEPAD) is the magnum opus of Mbeki's foreign policy, and the success or failure of this grand design for an African renaissance will determine his legacy and make or break his leadership in South Africa and in the rest of Africa. The success of his NEPAD diplomacy is a daunting task, requiring the support of his African peers, his South African constituency, and the leadership of the developed nations of the world. Dealing with these diverse elements, Mbeki's policy-making oscillates between realism and idealism, and between ideology and interests, giving the impression of a style of a prudent bureaucrat rather than that of a single-minded reformer. In the end, his diplomacy seems to founder because it fails to satisfy the contradictory demands of any of these three constituencies. However, even if NEPAD should fail as a project, its role could be that of a harbinger of a new political and economic era in Africa and the movement away from post-colonial orthodoxy. [source]


    A high proportion of founder BRCA1 mutations in Polish breast cancer families

    INTERNATIONAL JOURNAL OF CANCER, Issue 5 2004
    Bohdan Górski
    Abstract Three mutations in BRCA1 (5382insC, C61G and 4153delA) are common in Poland and account for the majority of mutations identified to date in Polish breast and breast,ovarian cancer families. It is not known, however, to what extent these 3 founder mutations account for all of the BRCA mutations distributed throughout the country. This question has important implications for health policy and the design of epidemiologic studies. To establish the relative contributions of founder and nonfounder BRCA mutations, we established the entire spectrum of BRCA1 and BRCA2 mutations in a large set of breast,ovarian cancer families with origins in all regions of Poland. We sequenced the entire coding regions of the BRCA1 and BRCA2 genes in 100 Polish families with 3 or more cases of breast cancer and in 100 families with cases of both breast and ovarian cancer. A mutation in BRCA1 or BRCA2 was detected in 66% of breast cancer families and in 63% of breast,ovarian cancer families. Of 129 mutations, 122 (94.6%) were in BRCA1 and 7 (5.4%) were in BRCA2. Of the 122 families with BRCA1 mutations, 119 (97.5%) had a recurrent mutation (i.e., one that was seen in at least 2 families). In particular, 111 families (91.0%) carried one of the 3 common founder mutations. The mutation spectrum was not different between families with and without ovarian cancer. These findings suggest that a rapid and inexpensive assay directed at identifying the 3 common founder mutations will have a sensitivity of 86% compared to a much more costly and labor-intensive full-sequence analysis of both genes. This rapid test will facilitate large-scale national epidemiologic and clinical studies of hereditary breast cancer, potentially including studies of chemoprevention. © 2004 Wiley-Liss, Inc. [source]


    Evolving Empire: America's "Emirates" Strategy in the Persian Gulf1

    INTERNATIONAL STUDIES PERSPECTIVES, Issue 2 2007
    MARC J. O'REILLY
    This article examines U.S. policy in the Persian Gulf and juxtaposes American efforts in Iraq with those in the Gulf Cooperation Council states. As the U.S.-led effort to pacify and democratize Iraq continues to founder and with civil war underway in parts of the country, Washington pursues another imperial strategy in the Persian Gulf better suited to American security preferences and more likely to succeed, at least in the short term. In pursuing an "emirates" strategy, Washington seeks to indulge its historic preference for an informal empire in the Gulf that relies on cooperation with pro-American monarchs. While the Bush administration has touted Iraq's potential to remake the Middle East into a democratic haven, America seems prepared to rely on familiar autocrats to help it tackle terrorists in Southwest Asia and preserve Western access to critical supplies of hydrocarbons should Iraq's democratic rehabilitation prove unsuccessful. [source]


    Sexuality, intimacy and subjectivity in social psychoanalytic thought of the 1920s and 1930s

    JOURNAL OF COMMUNITY & APPLIED SOCIAL PSYCHOLOGY, Issue 2 2008
    Naoko Wake
    Abstract Homosexuality has been one of the most contested issues in the history of social psychoanalysis. To better understand the issue's medical and social significance, we need a micro-historical analysis illuminating doctor-patient interactions in changing historical contexts. This paper sheds light on the clinical practice of the well-known founder of interpersonal theory, Harry Stack Sullivan (1892,1949), with a focus on four patients: two from the 1920s and two from the 1930s. During these decades, many psychiatrists, including neo-Freudians like Sullivan, considered homosexuality a mental illness. But Sullivan himself was a gay man, and he attempted to create efficacious therapeutic relationships amid a generally homophobic medicine. This comported with his effort to create professional coalitions with social psychologists and sociologists. In both clinical and non-clinical settings, he tried to find solutions to individual problems by redefining a limiting socio-cultural environment of therapy. Ambitious as this plan was, his patients' response to his approach varied from cautious cooperation to apparent rejection, as his actions became more immersed in the ambiguous realm of sexual subjectivity. In examining this change, I raise the question of what constituted ethically sound, professionally acceptable behaviours and efficacious therapeutic relationships, particularly in the historical context of the emerging collaboration between psychoanalysis and social psychology. Copyright © 2008 John Wiley & Sons, Ltd. [source]


    Leadership training for managers: An Adlerian approach

    JOURNAL OF LEADERSHIP STUDIES, Issue 1 2007
    Amy Preiss
    Adlerian theory,a social model of human behavior,provides an effective framework to improve managerial practices and enhance organizational leadership. Developed by Alfred Adler (1870,1937), founder of the influential school of individual psychology, Adlerian theory promotes principles of social interest, democracy, and encouragement. These principles may guide leaders in building collaborative, productive workforces through participative management, coaching, and employee engagement. Experiential training exercises that integrate Adlerian principles can help managers expand their interpersonal competencies and increase leadership effectiveness. [source]


    Genotypic analysis of two hypervariable human cytomegalovirus genes

    JOURNAL OF MEDICAL VIROLOGY, Issue 9 2008
    Amanda J. Bradley
    Abstract Most human cytomegalovirus (HCMV) genes are highly conserved in sequence among strains, but some exhibit a substantial degree of variation. Two of these genes are UL146, which encodes a CXC chemokine, and UL139, which is predicted to encode a membrane glycoprotein. The sequences of these genes were determined from a collection of 184 HCMV samples obtained from Africa, Australia, Asia, Europe, and North America. UL146 is hypervariable throughout, whereas variation in UL139 is concentrated in a sequence encoding a potentially highly glycosylated region. The UL146 sequences fell into 14 genotypes, as did all previously reported sequences. The UL139 sequences grouped into 8 genotypes, and all previously reported sequences fell into a subset of these. There were minor differences among continents in genotypic frequencies for UL146 and UL139, but no clear geographical separation, and identical nucleotide sequences were represented among communities distant from each other. The frequent detection of multiple genotypes indicated that mixed infections are common. For both genes, the degree of divergence was sufficient to preclude reliable sequence alignments between genotypes in the most variable regions, and the mode of evolution involved in generating the genotypes could not be discerned. Within genotypes, constraint appears to have been the predominant mode, and positive selection was detected marginally at best. No evidence was found for linkage disequilibrium. The emerging scenario is that the HCMV genotypes developed in early human populations (or even earlier), becoming established via founder or bottleneck effects, and have spread, recombined and mixed worldwide in more recent times. J. Med. Virol. 80:1615,1623, 2008. © 2008 Wiley-Liss, Inc. [source]


    Member Experience, Use of External Assistance and Evaluation of Business Ideas

    JOURNAL OF SMALL BUSINESS MANAGEMENT, Issue 1 2010
    Maw-Der Foo
    How do members' experience and external interactions shape evaluation of the team's business idea? With a sample of 74 teams that participated in a business idea competition, we showed that experience as defined by size, mean work experience, and assistance from individuals with business founding experience related positively to the teams' business idea evaluations. The benefits of external founders are more pronounced for smaller than for larger teams. Having a founder in the team did not relate to idea evaluation but interaction effects showed smaller sized teams had worse evaluations if they did not have a founder in the team. [source]


    Delineating Publicly Listed Family and Nonfamily Controlled Firms: An Approach for Capital Market Research in Australia,

    JOURNAL OF SMALL BUSINESS MANAGEMENT, Issue 3 2007
    Nicholas A. Mroczkowski
    Recent capital market research evidence suggests that a large proportion of public companies worldwide are characterized by controlling stockholders who are more often families, usually the founder(s) or their descendants. There has been considerable debate on whether "family" firms can indeed be accurately delineated from nonfamily firms given the diversity and abundance of family business definitions in the literature. This paper provides a robust definition of family business for the purposes of capital market research. Using an accounting-based definition of family business, the paper outlines a four-step procedure that provides validation for identifying family controlled companies listed on the Australian Stock Exchange. A significant feature of the research methodology was reliance on data collected from the Australian Securities and Investments Commission. Having access to the corporate regulator's restricted data enabled the researchers to establish important links between directors and their private related entities. [source]


    Issues in Growing a Family Business: A Strategic Human Resource Model

    JOURNAL OF SMALL BUSINESS MANAGEMENT, Issue 1 2001
    Sandra W. King
    The conceptual literature on family businesses suggests that family businesses have difficulty managing their human resources, especially when it concerns a family member or the transition from the founder to the successor. The authors empirically examined the assumptions raised in the conceptual literature regarding whether family businesses were experiencing human resource problems in growing their business and what factors enabled or constrained the ability of their businesses to grow. The authors used in-depth interviewing to collect data in order to emphasize the depth of the issue. Using content analysis with subject matter experts coding the data, the authors sought to mine the richness of data. Finally, the authors analyzed the data using Elliot Jaques' Stratified Systems Theory as a model to examine the strategic human resource issues and to draw some tentative conclusions. [source]


    Using the h -index to rank influential British researchers in information science and librarianship

    JOURNAL OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE AND TECHNOLOGY, Issue 2 2007
    Charles Oppenheim
    The recently developed h -index has been applied to the literature produced by senior British-based academics in librarianship and information science. The majority of those evaluated currently hold senior positions in UK information science and librarianship departments; however, a small number of staff in other departments and retired "founding fathers" were analyzed as well. The analysis was carried out using the Web of Science (Thomson Scientific, Philadelphia, PA) for the years from 1992 to October 2005, and included both second-authored papers and self-citations. The top-ranking British information scientist, Peter Willett, has an h -index of 31. However, it was found that Eugene Garfield, the founder of modern citation studies, has an even higher h -index of 36. These results support other studies suggesting that the h -index is a useful tool in the armory of bibliometrics. [source]


    "A brilliant and many-sided personality": Jessie Margaret Murray, founder of the Medico-Psychological Clinic

    JOURNAL OF THE HISTORY OF THE BEHAVIORAL SCIENCES, Issue 2 2009
    Elizabeth R. Valentine
    This paper outlines the life and career of Jessie Margaret Murray, the moving spirit behind the foundation of the Medico-Psychological Clinic, the first public clinic in Britain to offer psychoanalytic therapy and training in psychoanalysis. Biographical details of Murray and her close friend and collaborator, Julia Turner, are presented, and possible routes by which the two women may have met are explored. Murray's role in the suffragist movement is described, as well as other networks and professional societies in which she was involved, in particular the British Society for the Study of Sex Psychology, and her relationship with Marie Stopes. An account is given of events leading up to the founding of the Clinic, its activities, Murray's death, and other factors contributing to its demise. Finally, the Clinic's heritage and implications of the personalities of Murray and Turner for understanding the subsequent development of psycho-analysis in Britain are considered. [source]


    Opening Up Ownership: Community Belonging, Belongings, and the Productive Life of Property

    LAW & SOCIAL INQUIRY, Issue 3 2007
    Davina Cooper
    Drawing on empirical data and property theory, this article explores the property structure of a "free school" and the work property performs there. At Summerhill, we can see a tension between two property registers. On the one hand, the founder and present members stress the importance of individual ownership; at the same time the school's property regime involves property-limitation rules, a dispersal of rights, collective forms of property, and cross-cutting, pluralized sites of institutional recognition. In exploring how this tension is manifested through property's work, the article focuses on property's contribution to a variegated social life at the school, analyzed in terms of personal, civic, and boundary relations. With belonging treated as the central component of property rather than exclusion or control, ways of understanding what constitutes property and how it works shift. [source]