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Foscarnet Therapy (foscarnet + therapy)

Distribution by Scientific Domains

Medical Sciences	100%

Selected Abstracts

Penile Erosions Associated with Foscarnet Therapy in a Child

PEDIATRIC DERMATOLOGY, Issue 3 2010
Ryan W. Hick M.D.
We report the case of a boy with penile erosions associated with foscarnet therapy in the setting of umbilical cord blood transplantation (CBT). [source]

A case of immune recovery vitritis induced by donor leukocyte infusion for the treatment of cytomegalovirus retinitis

EUROPEAN JOURNAL OF HAEMATOLOGY, Issue 4 2005
Manabu Kawakami
Abstract:, Donor leukocyte infusion (DLI) has been successfully used for some life-threatening viral infections after stem cell transplantation (SCT). We describe here the first case of DLI treatment for cytomegalovirus (CMV) retinitis. A 49-year-old female patient with AML, M1 underwent SCT with a reduced-intensity conditioning regimen from HLA-haploidentical son. On day +140, the patient developed CMV retinitis of her left eye despite the continuing antiviral therapy. DLI at a dose of 1 × 105 CD3+ cells/kg was added to ganciclovir and foscarnet therapy. Eighteen days after the DLI, the funduscopic findings revealed improvement of the retinitis and the development of vitreous inflammation. Simultaneously, the number of CD4+ cells in the peripheral blood rapidly increased. Thus, we consider it likely that DLI induced a local immune response against CMV antigens, which resulted in the immune recovery vitritis. This case suggested the potentiality of DLI for the treatment of CMV retinitis. [source]

Penile Erosions Associated with Foscarnet Therapy in a Child

Acyclovir-resistant herpes simplex virus pneumonia post-unrelated stem cell transplantation: A word of caution

PEDIATRIC TRANSPLANTATION, Issue 8 2007
Haydar Frangoul
Abstract: HSV causes serious complications in immunocompromised patients, especially SCT recipients. Although ACV is an effective antiviral prophylaxis, the emergence of ACV resistance is a growing problem. The authors describe two cases of fatal ACV-resistant HSV in two pediatric patients following unrelated donor SCT. Despite the in vitro sensitivity of the HSV isolates to foscarnet, both patients failed to respond to foscarnet therapy. Other antiviral therapies should be considered in those patients who fail to show rapid clinical improvement. [source]