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First Issue (first + issue)

Distribution by Scientific Domains

Medical Sciences	33%
Humanities and Social Sciences	33%

Selected Abstracts

ROLE OF ENDOSCOPY IN SCREENING OF EARLY PANCREATIC CANCER AND BILE DUCT CANCER

DIGESTIVE ENDOSCOPY, Issue 2009
Kiyohito Tanaka
In the screening of early pancreatic cancer and bile duct cancer, the first issue was ,what are the types of abnormality in laboratory data and symptoms in case of early pancreatic cancer and bile duct cancer?' Early cancer in the pancreaticobiliary region has almost no symptoms, however epigastralgia without abnormality in the gastrointestinal (GI) tract is a sign of early stage pancreaticobiliary cancer. Sudden onset and aggravation of diabetes mellitus is an important change in the case of pancreatic cancer. Extracorporeal ultrasonography is a very useful procedure of checking up changes of pancreatic and biliary lesions. As the role of endoscopy in screening, endoscopic ultrasonography (EUS) is the most effective means of cancer detection of the pancreas, and endoscopic retrograde cholangiopancreatography (ERCP) is most useful of diagnosis tool for abnormalities of the common bile duct. Endoscopic retrograde cholangiopancreatography is an important modality as the procedure of sampling of diagnostic materials. Endoscopic ultrasonography-fine needle aspiration (EUS-FNA) has the role of histological diagnosis of pancreatic mass lesion also. Especially, in the case of pancreas cancer without evidence of cancer by pancreatic juice cytology and brushing cytology, EUS-FNA is essential. Intra ductal ultrasonography (IUDS) and perotral cholangioscopy (POCS) are useful for determination of mucosal extent in extrahepatic bile duct cancer. Further improvements of endoscopical technology, endoscopic procedures are expected to be more useful modalities in detection and diagnosis of early pancreatic and bile duct cancers. [source]

Notes on the origins of Epilepsia and the International League Against Epilepsy

EPILEPSIA, Issue 3 2009
Simon D. Shorvon
Summary The recent discovery of archival material has shed interesting light on the origins of Epilepsia and also the International League Against Epilepsy (ILAE). The idea of an international journal devoted to epilepsy seems first to have arisen from talks between Dr. L. J. J. Muskens and Dr. W. Aldren Turner in 1905. A protracted series of subsequent letters between Muskens and a Haarlem publisher show how the idea slowly took shape. The committee of patronage, editorial board, and editorial assistants was probably first approached at the First International Congress of Psychiatry, Neurology, Psychology, and Nursing of the Insane, held in Amsterdam in 1907. At this meeting, the concept of an international organization to fight epilepsy (to become the ILAE) was also first proposed in public, again by Muskens. The concept of the ILAE was clearly modeled on another international organization,the International Commission for the Study of the Causes of Mental Diseases and Their Prophylaxis. This Commission had been first publicly proposed in 1906 by Ludwig Frank, at the Second International Congress for the Care and Treatment of the Insane. The proposed Commission and ILAE shared many features, aims, and personnel. Despite an auspicious start, the International Commission was prevented by personal and political differences from ever actually coming into being. However, the first issue of Epilepsia appeared in March 1909 and the ILAE was inaugurated in August 1909; and both have flourished and celebrate their centenaries this year. [source]

The Return on Investment of the Guggenheim Museum Bilbao

INTERNATIONAL JOURNAL OF URBAN AND REGIONAL RESEARCH, Issue 2 2006
BEATRIZ PLAZA
The city of Bilbao has made use of a museum as one of the multiple means to restructure its former industrial base. However, the effectiveness of this costly formula is not always clear. Three major issues have arisen: the effects of Guggenheim Museum Bilbao on Bilbao's image, the effects on overnight stays, and the effects on the local economy. There is little debate about the first issue, and room for more evidence on the second and third issues. The aim is to quantify the museum's impact on tourism and employment and to calculate its yield (Return on Investment and Net Present Value). The approach adopted is the quantitative analysis of statistical data to try to isolate the economic contribution of the Guggenheim. [source]

The Second Generation in Europe

INTERNATIONAL MIGRATION REVIEW, Issue 4 2003
Maurice Crul
The study of integration processes has now reached a crucial stage in most Western European countries with the emergence of the second generation. The oldest children born to postwar immigrants on European soil have recently entered the job market, and we can now investigate their performance in both education and employment. This opens a unique opportunity to compare the situations of second generation migrants across countries. Ostensibly the children all have the same starting position, being born in the country of settlement. The intriguing question is how differences between immigrant groups, and also differences in national contexts, work to the benefit or detriment of the second generation. We discuss the first issue briefly, confining ourselves here to Turkish and Moroccan immigrants. In addressing the issue of national contexts, we focus primarily on policies and practices rather than on broad-reaching national integration models. We examine in detail the integration process itself in the context of vital institutional arrangements such as the education system and the mechanisms for transition to the labor market. How do such arrangements differ between countries, and how do they affect the outcomes for the second generation? [source]

Phylogeographical structure and temporal complexity in American sweetgum (Liquidambar styraciflua; Altingiaceae)

MOLECULAR ECOLOGY, Issue 17 2008
ASHLEY B. MORRIS
Abstract Eastern North American plant biogeography has traditionally focused on two primary issues: (i) the location of temperate Pleistocene refugia and their proximity to the southern margin of the ice sheet during the last glacial maximum, and (ii) the origin of the temperate element of northern Latin America. While numerous population genetic and phylogeographical studies have focused on the first issue, few (if any) have considered the second. We addressed these issues by surveying 117 individuals from 24 populations of Liquidambar styraciflua (American sweetgum; Altingiaceae) across the southeastern USA, eastern Mexico, and Guatemala, using more than 2200 bp of chloroplast DNA sequence data. To specifically address the issue of timing, we estimated intraspecific divergence times on the basis of multiple fossil-based calibration points, using taxa from Altingiaceae (Liquidambar and Altingia) and Hammamelidaceae (Hamamelis) as outgroups. More than half of the sampled localities exhibited multiple haplotypes. Remarkably, the greatest variation was observed within the USA, with Mexico and Guatemala sharing widespread haplotypes with Texas, Mississippi, Kentucky, Ohio, and northern Virginia. This lack of differentiation suggests shared ancestral polymorphisms, and that the genetic signal we observed is older than the disjunction itself. Our data provide support for previously proposed hypotheses of Pleistocene refugia in peninsular Florida and along the eastern Atlantic, but also for deeper divergences (~8 million years ago) within the USA. These patterns reflect a dynamic biogeographical history for eastern North American trees, and emphasize the importance of the inclusion of a temporal component in any phylogeographical study. [source]

JCPP , The Journal of Child Psychology and Psychiatry: a history from the inside

THE JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY AND ALLIED DISCIPLINES, Issue 1-2 2009
Michael Berger
As the JCPP marks its 50th year of publication, this paper revisits the founding philosophy and traces the journey from the first issue through to the present. The history of the JCPP reflects the many changes that have come about in the fields of developmental psychology and child and adolescent psychiatry and the changes introduced both to meet the needs and shape the practices of clinicians and researchers. It documents the achievements of the Journal and the contributions made by many in enabling its success. As the JCPP moves forward it will enjoy the benefits of the major technological and other advances being made in research, in the evolving and expanding knowledge base, and in the modes of publication, as well as needing to manage the associated challenges that will inevitably impact on its future. [source]