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Selected AbstractsTHE NARROWING GENDER GAP IN ARRESTS: ASSESSING COMPETING EXPLANATIONS USING SELF-REPORT, TRAFFIC FATALITY, AND OFFICIAL DATA ON DRUNK DRIVING, 1980,2004,CRIMINOLOGY, Issue 3 2008JENNIFER SCHWARTZ We evaluate two alternative explanations for the converging gender gap in arrest,changes in women's behavior versus changes in mechanisms of social control. Using the offense of drunk driving and three methodologically diverse data sets, we explore trends in the DUI gender gap. We probe for change across various age groups and across measures tapping DUI prevalence and chronicity. Augmented Dickey-Fuller time-series techniques are used to assess changes in the gender gap and levels of drunk driving from 1980 to 2004. Analyses show women of all ages making arrest gains on men,a converging gender gap. In contrast, self-report and traffic data indicate little or no systematic change in the DUI gender gap. Findings support the conclusion that mechanisms of social control have shifted to target female offending patterns disproportionately. Little support exists for the contention that increased strain and liberalized gender roles have altered the gender gap or female drunk-driving patterns. [source] SOCIAL DISORGANIZATION OUTSIDE THE METROPOLIS: AN ANALYSIS OF RURAL YOUTH VIOLENCE,CRIMINOLOGY, Issue 1 2000D. WAYNE OSGOOD In order to extend the study of community social disorganization and crime beyond its exclusive focus on large urban centers, we present an analysis of structural correlates of arrest rates for juvenile violence in 264 nonmetropolitan counties of four states. Findings support the generality of social disorganization theory: Juvenile violence was associated with rates of residential instability, family disruption, and ethnic heterogeneity. Though rates of poverty were not related to juvenile violence, this is also in accord with social disorganization theory because, unlike urban settings, poverty was negatively related to residential instability. Rates of juvenile violence varied markedly with population size through a curvilinear relationship in which counties with the smallest juvenile populations had exceptionally low arrest rates. Analyses used negative binomial regression (a variation of Poisson regression) because the small number of arrests in many counties meant that arrest rates would be ill suited to least-squares regression. [source] In 12-step groups, helping helps the helperADDICTION, Issue 8 2004Sarah E. Zemore ABSTRACT Aims The helper therapy principle suggests that, within mutual-help groups, those who help others help themselves. The current study examines whether clients in treatment for alcohol and drug problems benefit from helping others, and how helping relates to 12-step involvement. Design Longitudinal treatment outcome. Participants An ethnically diverse community sample of 279 alcohol- and/or drug-dependent individuals (162 males, 117 females) was recruited through advertisement and treatment referral from Northern California Bay Area communities. Participants were treated at one of four day-treatment programs. Measurements A helping checklist measured the amount of time participants spent, during treatment, helping others by sharing experiences, explaining how to get help and giving advice on housing and employment. Measures of 12-step involvement and substance use outcomes were administered at baseline and a 6 month follow-up. Findings Helping and 12-step involvement emerged as important and related predictors of treatment outcomes. In the general sample, total abstinence at follow-up was strongly and positively predicted by 12-step involvement at follow-up, but not by helping during treatment; still, helping positively predicted subsequent 12-step involvement. Among individuals still drinking at follow-up, helping during treatment predicted a lower probability of binge drinking, whereas effects for 12-step involvement proved inconsistent. Conclusions Findings support the helper therapy principle and clarify the process of 12-step affiliation. [source] Does cannabis use encourage other forms of illicit drug use?ADDICTION, Issue 4 2000David M. Fergusson Aims. To examine the relationship between cannabis use in adolescence and the onset of other illicit drug use. Method. Data were gathered over the course of a 21-year longitudinal study of a birth cohort of 1265 New Zealand children. Measures analysed included: (a) frequency of cannabis use and other illicit drugs from 15-21; (b) family, social, educational and behavioural backgrounds of cohort members prior to 15; and (c) adolescent life-style variables. Findings. (i) By 21, nearly 70% of cohort members and used cannabis and 26% had used other illicit drugs. (ii) In all but three cases, the use of cannabis had preceded the use of illicit drugs. (iii) Those using cannabis on more than 50 occasions a year had hazards of other illicit drug use that were 140 times higher than non-users. (iv)After adjustment for covariate factors, including childhood factors, family factors and adolescent life-style factors, cannabis use remained strongly related to the onset of other forms of illicit drug use. Those using cannabis on more than 50 occasions per year had hazards of other illicit drug use that were 59.2 times higher than non-users. Conclusions. Findings support the view that cannabis may act as a gateway drug that encourages other forms of illicit drug use. None the less, the possibility remains that the association is non-causal and reflects factors that were not adequately controlled in the analysis. [source] Applying the Infant-Toddler Social & Emotional Assessment (ITSEA) and Brief-ITSEA in early interventionINFANT MENTAL HEALTH JOURNAL, Issue 6 2007Margaret J. Briggs-Gowan To examine the internal consistency and validity of the Infant-Toddler Social and Emotional Assessment (ITSEA) and Brief-ITSEA (BITSEA) parent-report questionnaires in an early intervention sample. A sociodemographically diverse sample of 192 parents of 11- to 36-month-old children referred to early intervention programs completed surveys containing the ITSEA, BITSEA, and Child Behavior Checklist (CBCL). Parents were interviewed with the Vineland Adaptive Behavior Scales. Evaluators blind to children's status on the ITSEA and BITSEA rated child behavior during developmental assessments. Finally, a subsample of 71 children was administered the Mullen Scales of Early Learning. Findings support the internal consistency of the ITSEA and BITSEA, with the majority of Cronbach's alphas above .70. Supporting validity, ITSEA and BITSEA problem scores correlated significantly with CBCL Internalizing and Externalizing scores (rs=.28 to .78), as well as with observational ratings of problem behaviors on constructs paralleling the ITSEA domains (rs=.21 to .45). In contrast, ITSEA Competence and BITSEA Competence demonstrated moderate negative associations with CBCL scores (rs=,.39 to ,.43). Finally, ITSEA Competence and BITSEA Competence correlated significantly with developmental level on the Mullen, Vineland Socialization, and observational ratings of competence (rs=.25 to .43). Emphasizing the importance of addressing social-emotional issues in early intervention settings, 58.6% of children had high social-emotional/behavioral problems and/or low competence on the ITSEA; 39.8% had high ITSEA Problems and 38.5% had low ITSEA Competence. Results indicate the need to assess social-emotional adjustment in early intervention settings and support the use of the ITSEA and BITSEA for this purpose. [source] An integration of cognitive-behavioral therapy and interpersonal psychotherapy for bulimia nervosa: A case study using the case formulation methodINTERNATIONAL JOURNAL OF EATING DISORDERS, Issue 2 2005Peter S. Hendricks MA Abstract Objective The current study provides an illustration of an integration of cognitive-behavioral therapy (CBT) and interpersonal psychotherapy (IPT) for the treatment of bulimia nervosa (BN), based on the case formulation strategy. Method A 25-year-old Hispanic female referred herself for the treatment of eating difficulties and depressed mood. Diagnostic criteria were met for BN, major depressive episode, and alcohol abuse. Components of both CBT and IPT were utilized throughout the course of treatment. Results CBT techniques appeared to be most effective in eliminating binge eating and binge drinking behavior, whereas IPT techniques seemed to be most effective in reducing purging behavior. Results revealed that the client was no longer experiencing clinically significant symptoms of BN, depression, or alcohol abuse at end of treatment and follow-up (18 months after treatment onset). Discussion Findings support the integration of CBT and IPT for the treatment of BN and, potentially, other eating disorders. © 2005 by Wiley Periodicals, Inc. [source] Screening for major depression in persons with HIV infection: the concurrent predictive validity of the Profile of Mood States Depression-Dejection ScaleINTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH, Issue 2 2006Katherine Patterson Abstract Major Depressive Disorder (MDD) is among the most prevalent but underdiagnosed psychiatric disorders in persons with HIV infection. Given the known adverse impact of comorbid MDD on HIV disease progression and health-related quality of life, it is important both for research and for efficient, effective clinical care, to validate existing screening measures that may discriminate between MDD and the somatic symptoms of HIV (such as fatigue). In the current study, we evaluated the concurrent predictive validity of the Profile of Mood States (POMS) Depression-Dejection scale in detecting current MDD in 310 persons with HIV infection. The Structured Clinical Interview for DSM-IV (SCID) diagnosis of MDD and the Cognitive-Affective scale from the Beck Depression Inventory (BDI-CA) served as comparative diagnostic and severity measures of depression, respectively. Results demonstrated that the POMS Depression-Dejection scale accurately classified persons with and without MDD SCID diagnoses, with an overall hit rate of 80%, sensitivity of 55%, specificity of 84%, and negative predictive power of 91% using a recommended cutpoint of 1.5 standard deviations above the normative mean. Moreover, the POMS performed comparably to the BDI-CA in classifying MDD. Findings support the predictive validity of the POMS Depression-Dejection scale as a screening instrument for MDD in persons with HIV disease. Copyright © 2006 John Wiley & Sons, Ltd. [source] The Effect of Active Support Interactive Training on the Daily Lives of Adults with an Intellectual DisabilityJOURNAL OF APPLIED RESEARCH IN INTELLECTUAL DISABILITIES, Issue 2 2010Vasiliki Totsika Background, Interactive training (IT) is one of the two staff training components of the active support (AS) model. The present study explores how effective IT is when offered to staff divorced in time from the AS workshops, the other training component. We explored the effects of IT on resident activity engagement, challenging behaviours and staff assistance. Materials and Methods, Twenty-one adults with an intellectual disability living in residential settings participated. Observations and ratings of staff and resident behaviours were obtained before, immediately after the training sessions, and at 6 months follow-up. Results, Group-level analyses indicated a short-lived improvement in quality of staff support but, in general, there was an overall lack of change in staff behaviours, resident engagement and , observed and rated , challenging behaviours. However, subgroup analyses indicated that there was a significant improvement in engagement immediately after IT for a distinct subgroup of participants; those who had significantly higher aggressive behaviour ratings at the beginning of the study. Conclusions, Findings support the combination of the training components of AS for improvements in the quality of life for people with intellectual disability. IT may also be worthy of future study as a potential stand-alone intervention for people with the most difficult challenging behaviours. [source] Intellectual and adaptive behaviour functioning in pantothenate kinase-associated neurodegenerationJOURNAL OF INTELLECTUAL DISABILITY RESEARCH, Issue 6 2007K. Freeman Abstract Background Pantothenate kinase-associated neurodegeneration (PKAN), an extremely rare autosomal recessive disorder resulting in iron accumulation in the brain, has a diverse phenotypic expression. Based on limited case studies of one or two patients, intellectual impairment is considered part of PKAN. Investigations of cognitive functioning have utilized specific neuropsychological tests, without attention to general intellectual skills or adaptive behaviour. Methods Sixteen individuals with PKAN completed measures of global intellectual functioning, and participants or care providers completed measures of adaptive behaviour skills and day-to-day functional limitations. Clinicians provided global ratings of condition severity. Results Testing with standardized measures documented varied phenotypic expression, with general cognitive skills and adaptive behaviour ranging from high average to well below average. Age of disease onset correlated with measures of intellectual functioning, adaptive functioning and disease severity. Conclusions Findings support previously described clinical impressions of varied cognitive impairment and the association between age of onset and impairment. Further, they add important information regarding the natural history of the disease and suggest assessment strategies for use in treatment trials. [source] Cumulative Environmental Risk and Youth Problem BehaviorJOURNAL OF MARRIAGE AND FAMILY, Issue 3 2004Jean M. Gerard Using data from Wave 1 (n = 5,070) and Wave 2 (n = 4,404) of the National Longitudinal Study of Adolescent Health, we examined the relationship between cumulative risk exposure and youth problem behavior. Cross-sectional analyses revealed a positive, linear association between cumulative risk and problem behaviors. The association between cumulative risk and externalizing problems was stronger for White youth than for Black youth. The association between cumulative risk and internalizing problems was stronger for girls than for boys, and stronger for White youth than for Black and Hispanic youth. Cumulative risk predicted change over time in internalizing problems. Findings support the theoretical notion that adolescents experience diminished psychological comfort when risk factors are present across several social domains. [source] Sources of science self-efficacy beliefs of middle school studentsJOURNAL OF RESEARCH IN SCIENCE TEACHING, Issue 5 2006Shari L. Britner The purpose of this study was to investigate the degree to which A. Bandura's (1997) hypothesized sources of self-efficacy predict the science self-efficacy beliefs of middle school students (N,=,319), to replicate previous findings that science self-efficacy predicts science achievement, and to explore how science self-efficacy and its antecedents differ by gender. Significant correlations were found between mastery experiences, vicarious experiences, social persuasions, physiological arousal, and self-efficacy. Only mastery experiences significantly predicted science self-efficacy. Girls reported stronger science self-efficacy than did boys. Findings support and extend the theoretical tenets of Bandura's social cognitive theory. © 2006 Wiley Periodicals, Inc. J Res Sci Teach 43: 485,499, 2006 [source] The Deal Structuring Stage of the Venture Capitalist Decision-Making Process: Exploring Confidence and Control,JOURNAL OF SMALL BUSINESS MANAGEMENT, Issue 2 2009G. Tyge Payne This exploratory study examines the deal structuring stage of the venture capitalist decision-making process. Here, the primary issues of concern are investor confidence and potential control of a venture in relation to the level of financing the investor provides and the structure with which the funding is delivered. Confidence comes in support of the entrepreneur, the venture itself, or a combination of the two, prior to capital transfer, but after the initial "invest or not invest" decision has already occurred. Findings support a multicriteria perspective of the pre-investment decision-making process and a distinct difference between entrepreneur confidence and venture confidence in the deal structuring stage. [source] Anxious solitude/withdrawal and anxiety disorders: Conceptualization, co-occurrence, and peer processes leading toward and away from disorder in childhoodNEW DIRECTIONS FOR CHILD & ADOLESCENT DEVELOPMENT, Issue 127 2010Heidi Gazelle This chapter contains (1) an analysis of commonalities and differences in anxious solitude and social anxiety disorder, and a review of empirical investigations examining (2) correspondence among childhood anxious solitude and anxiety and mood diagnoses and (3) the relation between peer difficulties and temporal stability of anxious solitude and depressive symptoms. Findings support a diathesis-stress model in which anxious solitude forecasts symptoms of psychopathology primarily in the context of interpersonal stress. Additionally, evidence for individual and environmental factors which moderate risk for peer difficulties among anxious solitary children is reviewed. Implications for intervention are discussed. © Wiley Periodicals, Inc. [source] The link between sociotropy/autonomy and dimensions of relationship commitment: Evidence from gay and lesbian couplesPERSONAL RELATIONSHIPS, Issue 2 2000LAWRENCE A. KURDEK The tendency to be excessively concerned about either interpersonal relationships (sociotropy) or self-reliance (autonomy) has been regarded as increasing one's susceptibility to experience symptoms of depression. In this study, both one's own and one's partner's scores for each tendency were linked to two dimensions of one's own appraisal of relationship commitment (attractions to the relationship and constraints against leaving the relationship) in a sample of both partners from 29 gay and 35 lesbian cohabiting couples. One's own high autonomy was linked to perceiving few attractions to the relationship, whereas one's own high sociotropy was linked to perceiving many constraints to leaving the relationship under two conditions: when one's partner's sociotropy was low or when one regarded the partner as highly dependable. Findings support the view that individual differences variables may serve as either risk factors for or protective factors against difficulties in maintaining a close relationship and underscore the need to examine cross-partner effects and moderating effects in identifying the individual differences variables linked to relationship functioning. [source] Body size and shape and glycemic control among Maya women in rural YucatánAMERICAN JOURNAL OF HUMAN BIOLOGY, Issue 6 2003Penelope A. Mclorg Studies on relationships between aspects of physique and glucose physiology generally focus on clinical glucose tolerance or on fasting glucose or insulin assays showing glycemic status at the time of testing. Little work has examined the associations between body variables and glycemic control, or average past glucose levels in regular living conditions. The aim of this research was to investigate connections between body size and shape and glycemic control. The sample consists of 60 nondiabetic Maya women, ages 40,85 years, residing in 16 rural villages around Mérida, Yucatán. Body morphology was assessed through anthropometric and derived measures of size and shape, including indicators of fat distribution and general adiposity. Glycemic control was measured through microvenous samples analyzed for glycated blood proteins HbA1c and fructosamine to demonstrate average circulating glucose under customary living conditions during the previous several months and weeks. Four-variable regression models explain 17% of the variance in HbA1c and 25% of the variance in fructosamine. Arm circumference has the largest positive effect on HbA1c, while weight has the greatest positive impact on fructosamine. The predictor with the largest negative effect on both glycated blood proteins is calf circumference. In general, variables reflecting overall adiposity and central adiposity demonstrate positive associations with HbA1c and fructosamine, whereas lean body measures exhibit negative associations. Findings support the value of glycated blood proteins and of less common anthropometric measures, such as calf circumference, in population research on morphological relations with glycemia. Am. J. Hum. Biol. 15:746,757, 2003. © 2003 Wiley-Liss, Inc. [source] An examination of communication behaviors as mediators in individual-level interorganizational exchangesPSYCHOLOGY & MARKETING, Issue 1 2006Chickery J. Kasouf This research attempts to address some of the gaps in our understanding of individual-level interorganizational exchanges. To this end, a conceptual framework that integrates cooperative norms, communication behaviors, and perceived problem-solving efficacy is developed. Qualitative and quantitative methodologies were employed to explore relevance and significance of proposed constructs and relationships. Findings support the viability of constructs and proposed relationships. Specifically, communication behaviors were found to mediate the relationship between cooperative norms and problem-solving confidence to resolve conflict. These results hold implications for future research and management practice. © 2006 Wiley Periodicals, Inc. [source] Empathy and error processingPSYCHOPHYSIOLOGY, Issue 3 2010Michael J. Larson Abstract Recent research suggests a relationship between empathy and error processing. Error processing is an evaluative control function that can be measured using post-error response time slowing and the error-related negativity (ERN) and post-error positivity (Pe) components of the event-related potential (ERP). Thirty healthy participants completed two measures of empathy, the Interpersonal Reactivity Index (IRI) and the Empathy Quotient (EQ), and a modified Stroop task. Post-error slowing was associated with increased empathic personal distress on the IRI. ERN amplitude was related to overall empathy score on the EQ and the fantasy subscale of the IRI. The Pe and measures of empathy were not related. Results remained consistent when negative affect was controlled via partial correlation, with an additional relationship between ERN amplitude and empathic concern on the IRI. Findings support a connection between empathy and error processing mechanisms. [source] Model test of the relationship between self-help-promoting nursing interventions and self-care and health status outcomesRESEARCH IN NURSING & HEALTH, Issue 2 2004Grace J. Kreulen Abstract In this study of a nursing intervention outcomes model was tested. Path analysis techniques were used to examine predicted relationships between self-help-promoting interventions and patient outcomes of self-care practice and client morbidity at three times. A sample of 307 women receiving medical treatment for breast cancer provided data for the study. The average participant was White, middle-aged, married, educated, and in stage I or stage II disease. Findings support the hypothesized model linking these nursing interventions directly to self-care outcomes and self-care to client morbidity outcomes. Client factors of age, social network size, disease stage, receipt of chemotherapy, resourcefulness, and uncertainty significantly influenced predicted relationships. Examination of specific patterns of relationships for the sample revealed delayed behavioral responses to the interventions, variability in predictors of each outcome at the three measurement times and a more strongly predictive model when patient outcomes were considered within the context of client factors. © 2004 Wiley Periodicals, Inc. Res Nurs Health 27:97,109, 2004 [source] Teen pregnancy, motherhood, and unprotected sexual activity,RESEARCH IN NURSING & HEALTH, Issue 1 2003Deborah Koniak-Griffin Abstract The sexual behaviors and attitudes toward condom use of adolescent mothers (N,=,572) from ethnic minority groups were examined. Constructs from social cognitive theory (SCT), the theory of reasoned action (TRA), and the theory of planned behavior (TPB; e.g., intentions to use condoms, self-efficacy, outcome expectancies) were measured with questionnaires. Measures of AIDS and condom-use knowledge and selected psychosocial, behavioral, and demographic variables were included. Many adolescents reported early onset of sexual activity, multiple lifetime sexual partners, substance use, and childhood sexual or physical abuse. Only 18% stated a condom was used at last intercourse. Using hierarchical regression analysis, 13% of the variance for factors associated with unprotected sex was accounted for by TRA constructs. Other variables contributed an additional 17% of the variance. Unprotected sex was associated with behavioral intentions to use condoms, pregnancy, having a steady partner, more frequent church service attendance, and ever having anal sex. Findings support the urgent need for broad-based HIV prevention efforts for adolescent mothers that build on theoretical concepts and address the realities of their lives. © 2003 Wiley Periodicals, Inc. Res Nurs Health 26:4,19, 2003 [source] Assessment of child problem behaviors by multiple informants: a longitudinal study from preschool to school entryTHE JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY AND ALLIED DISCIPLINES, Issue 10 2007David C.R. Kerr Background:, Children's early problem behavior that manifests in multiple contexts is often more serious and stable. The concurrent and predictive validity of ratings of externalizing and internalizing by four informants was examined at preschool and early school age in an at-risk sample. Methods:, Two hundred forty children were assessed by mothers and fathers (Child Behavior Checklist (CBCL)), and teachers and laboratory examiners (Teacher Report Form (TRF)) at ages 3 and 5 years. Results:, All informants' ratings of externalizing converged on a common factor at ages 3 and 5 that showed strong stability over time (, = .80). All informants' age 3 externalizing ratings significantly predicted the problem factor at age 5; mothers', fathers', and teachers' ratings were independently predictive. Ratings of internalizing (except by examiners at age 3) also converged at both ages; the problem factor showed medium stability (, = .39) over time. Only fathers' ratings of age 3 internalizing predicted the age 5 problem factor. Conclusions:, Findings support the value of multi-informant assessment, uphold calls to include fathers in childhood research, and suggest that examiners provide valid, though non-unique assessment data. Examiner contributions may prove useful in many research contexts. [source] The Informal Economy in Non-Metropolitan Canada*CANADIAN REVIEW OF SOCIOLOGY/REVUE CANADIENNE DE SOCIOLOGIE, Issue 1 2006BILL REIMER L'auteur de cet article examine la relation existant entre les économies formelle et informelle, avec des apergus provenant de la recherche sur le Canada rural. L'économie informelle comprend la production, la distribution et la consommation de biens et services ayant une valeur économique, mais qui ne sont ni protégés par un code de loi formel ni enregistrés par des organismes de réglementation endossés par le gouvernement. Plusieurs allégations concernant l'interdépendance des deux économies sont formulées et testées en utilisant les données des Enquêtes sociales générates de 1992 et de 1998 sur l'emploi du temps. Les résultats confirment l'importance de l'economie informelle en tant que filet protecteur, tampon des changements structurels, constructeur de capacités et soutien de l'inclusion sociale. This paper discusses the relationship between the formal and the informal economies with insights derived from research on rural Canada. The informal economy is considered to be the production, distribution and consumption of goods and services that have economic value, but are neither protected by a formal code of law nor recorded for use by government-backed regulatory agencies. Several claims regarding the interdependence of both economies are developed and tested with time budget data from the 1992 and 1998 General Social Surveys. Findings support the importance of the informal economy as a safety net, buffer for structural changes, capacity builder, and support for social inclusion. [source] To be or not to be a cog: the Bremen Cog in perspectiveINTERNATIONAL JOURNAL OF NAUTICAL ARCHAEOLOGY, Issue 2 2000Ole Crumlin-Pedersen Following on from Thijs Maarleveld's paper in 1995 on type-names for archaeological finds of ships, the use of the term cog has been questioned by Timm Weski, who suggested the archaeological term Ijsselmeer-type instead. The present paper surveys a total of 18 ship-finds of this type with respect to date, origin and year of investigation, without finding support for the proposed change in terminology. Instead, the archaeological term cog should be restricted to seagoing vessels of the 12th,15th centuries which share the structural features of the lower part of hull with the Bremen Cog. Recent results of dendroanalysis point to the root of the Jutland peninsula as a more likely area than the former Zuiderzee for the transformation of a hypothetical older,proto-cog'-type for navigation on rivers and in the Waddensee into the proper seagoing medieval cog-type. Impulses for this transformation were found, most likely, in the need to circumnavigate Cape Skagen already in the 12th century, and technical features were probably taken over from large Scandinavian cargo ships of that period. © 2000 The Nautical Archaeology Society [source] Hypocretin-1 Dose-Dependently Modulates Maternal Behaviour in MiceJOURNAL OF NEUROENDOCRINOLOGY, Issue 8 2006K. L. D'Anna Increases in neuronal activity of hypocretin (HCRT), a peptide involved in arousal, and in HCRT-1 receptor mRNA expression have recently been identified in association with lactation. HCRT is released within brain regions regulating maternal behaviour and it is possible that increased HCRT neurotransmission during lactation supports maternal care. The present study examined for the first time the behavioural effects of HCRT on lactating mice. At intermediate doses, intracerebroventricular (i.c.v.) injections of HCRT-1 (0.06 and 0.1 µg) elevated levels of licking and grooming of pups (but not self-grooming) and number of nursing bouts without affecting other behaviours. At the highest dose, HCRT-1 (0.3 µg, i.c.v) delayed latency to nurse, decreased nursing, increased time off nest, and decreased maternal aggression. Intraperitoneal injections of the HCRT-1 receptor antagonist, SB-334867, exhibited a general trend towards increasing time spent low-arched back nursing (P = 0.053) and decreasing licking and grooming of pups while high-arched back nursing (P = 0.052). This suggests that the endogenous release of HCRT, working independently or dependently with other neuromodulators, may be necessary for full maternal behaviour expression. Possible sites of HCRT action in enhancing and impairing maternal care were identified via examinations of c,Fos immunoreactivity in association with i.c.v. HCRT injections. Together, these finding support the idea of HCRT modulating maternal behaviour, with intermediate levels (0.06 and 0.1 µg) supporting (even augmenting) some behaviours, but with levels that are too high (0.3 µg HCRT, i.c.v.), maternal behaviour and aggression are suppressed. [source] Childhood growth and age at diagnosis with Type 1 diabetes in Colorado young peopleDIABETIC MEDICINE, Issue 10 2009K. Vehik Abstract Objective, Studies have suggested that the age at diagnosis of Type 1 diabetes (T1D) is decreasing over time. The overload hypothesis postulates that risk factors, such as accelerated growth, may be responsible for this decrease. We assessed changes in age, body mass index (BMI), weight and height at diagnosis with T1D in non-Hispanic white (NHW) and Hispanic (HISP) young people from Colorado, using data from the IDDM Registry and SEARCH Study. Methods, In three time periods, 656 (1978,1983), 562 (1984,1988) and 712 (2002,2004) young people aged 2,17 years were newly diagnosed with T1D. Age, weight, height and presence of diabetic ketoacidosis (DKA) at diagnosis with T1D were obtained from medical records. Trends over the three time periods were assessed with regression analyses. Results, Age at diagnosis decreased by 9.6 months over time (P = 0.0002). Mean BMI standard deviation score (SDS), weight SDS and height SDS increased over time (P < 0.0001), while prevalence of DKA decreased (P < 0.0001). Increasing height over time accounted for 15% (P = 0.04) of the decreasing age at diagnosis with T1D. Conclusions, Our study provides evidence that increased linear growth, but not increased BMI or weight over time, may account, at least in part, for the younger age at diagnosis of T1D in Colorado children. This finding supports the hypothesis that increasing environmental pressure resulting from changes in potentially preventable risk factors may accelerate the onset of T1D in children. [source] Seropositivity to Helicobacter pylori heat shock protein 60 is strongly associated with intensity of chronic inflammation, particularly in antrum mucosa: an extension of an 18-year follow-up study of chronic gastritis in Saaremaa, EstoniaFEMS IMMUNOLOGY & MEDICAL MICROBIOLOGY, Issue 2 2001Tamara Vorobjova Abstract Helicobacter pylori is a cause of chronic gastritis and leads to development of atrophy in some cases. There is evidence that the heat shock protein 60 (HSP60) of H. pylori is involved in induction of chronic inflammation. Seroprevalence of IgG antibodies to H. pylori HSP60 in an adult cohort from Saaremaa, Estonia (68 persons, median age 57 years), with a high prevalence of antibodies to cell surface proteins of H. pylori (92%) and a well characterized dynamics of chronic gastritis in an 18-year follow-up study, was tested using purified H. pylori HSP60 at a concentration of 1 ,g ml,1 with ELISA. The state of the gastric mucosa and the presence of H. pylori in histological sections in the samples of 1979 and 1997 were assessed in accordance with the Sydney system. Seropositivity for H. pylori HSP60 was 65%. Immunological response to H. pylori HSP60 is associated with the morphological presence of H. pylori in the antrum and corpus (P=0.01) and is strongly correlated with the grade of chronic inflammation, particularly in the antrum mucosa (r=0.34; P=0.003; OR=5.97 (95% CI 1.21,29.3)), but is not associated with development of atrophy during 18 years of follow-up, or with the activity of gastritis. This finding supports the evidence that immunological response to H. pylori HSP60 may play a role in triggering of the inflammatory process in the gastric mucosa. [source] Informed Trading around Merger Announcements: An Empirical Test Using Transaction Volume and Open Interest in Options MarketFINANCIAL REVIEW, Issue 2 2001Narayanan Jayaraman G14/G34 Abstract This paper provides empirical evidence on the level of trading activity in the stock options market prior to the announcement of a merger or an acquisition. Our analysis shows that there is a significant increase in the trading activity of call and put options for companies involved in a takeover prior to the rumor of an acquisition or merger. This result is robust to both the volume of option contracts traded and the open interest. The increased trading suggests that there is a significant level of informed trading in the options market prior to the announcement of a corporate event. In addition, abnormal trading activity in the options market appears to lead abnormal trading volume in the equity market. This finding supports the hypothesis that the options market plays an important role in price discovery. [source] Roles of mammalian sterile 20-like kinase 2-dependent phosphorylations of Mps one binder 1B in the activation of nuclear Dbf2-related kinasesGENES TO CELLS, Issue 12 2009Yijun Bao Mammalian nuclear Dbf2-related (NDR) kinases (LATS1, LATS2, NDR1 and NDR2) play a role in cell proliferation, apoptosis and morphological changes. Mammalian sterile 20-like (MST) kinases and Mps one binder (MOB) proteins are important in the activation of NDR kinases. MOB1 is phosphorylated by MST1 and MST2 and this phosphorylation enhances the ability of MOB1 to activate NDR kinases. The phosphorylated MOB1 can be more effective as a scaffold protein to facilitate the MST-dependent phosphorylation of NDR kinases and/or as a direct activator of NDR kinases. We previously reported that Thr74 of MOB1B is phosphorylated by MST2. Thr12 and Thr35 have also been identified as phosphorylation sites. In this study, we quantified the phosphorylation of Thr74 using the phosphorylated Thr74-specific antibody. Thr74 is indeed phosphorylated by MST2, but the efficiency is low, suggesting that MOB1B can activate NDR kinases without the phosphorylation of Thr74. We also showed that the phosphorylated MOB1B activates NDR1 T444D and LATS2 T1041D, in which threonine residues phosphorylated by MST kinases are replaced with phosphorylation-mimicking aspartic acid, more efficiently than the unphosphorylated MOB1B does. This finding supports that the phosphorylation of MOB1B enhances its ability as a direct activator of NDR kinases. [source] Usefulness of follow-up after pancreatoduodenectomy for carcinoma of the ampulla of VaterHPB, Issue 2 2007LAURENCE CHICHE Abstract Background: The prognosis for carcinoma of the ampulla of Vater (CAV) is better than for pancreatic cancer. The 5-year survival median rate after resection of CAV is 45%, but late recurrences remain possible. Several survival factors have been identified (lymph nodes, perineural invasion), but few data are available on the type of recurrences, their impact and their management. Patients and methods: A total of 41 patients treated by pancreatoduodenectomy (PD) for CAV from 1980 to 2003 were studied retrospectively. Patient selection, long-term survival recurrence rate and recurrence treatment were reviewed. Univariate and multivariate proportional hazards analysis were conducted on this series. Results: The mean follow-up was 48 months. Five-year survival was 62.8%. Eleven patients had recurrences (6,67 months). Recurrence was associated with time to all-causes death (hazard ratio [HR] 4.3, p=0.003). Factors predictive of recurrence were perineural invasion (HR 5.3, p=0.02), lymph node invasion (HR 5.3, p=0.02) and differentiation (HR 0.2, p=0.05). Three patients underwent surgical R0 treatment of their recurrences. Two who presented with solitary liver metastasis are alive and disease-free. Conclusions: Recurrence represents a serious threat in the prognosis of CAV after surgery. Some of these recurrences, in particular liver metastases, are accessible for a curative treatment. This finding supports the usefulness of a close and long-term follow-up after surgery to improve survival of patients with CAV, especially in the group of patients with a good prognosis. [source] Disease Status in Autosomal Dominant Osteopetrosis Type 2 Is Determined by Osteoclastic Properties,JOURNAL OF BONE AND MINERAL RESEARCH, Issue 7 2006Kang Chu Abstract Asymptomatic gene carriers and clinically affected ADO2 subjects have the same ClCN7 mutation. We examined osteoclastic bone resorption in vitro as well as osteoclast formation, several markers, acid secretion, and cytoskeletal structure. We found that ADO2 expression results from osteoclast specific properties. Introduction: Autosomal dominant osteopetrosis type II (ADO2) is a heritable osteosclerotic disorder that results from heterozygous mutations in the ClCN7 gene. However, of those individuals with a ClCN7 mutation, one third are asymptomatic gene carriers who have no clinical, biochemical, or radiological manifestations. Disease severity in the remaining two thirds is highly variable. Materials and Methods: Human peripheral blood mononuclear cells were isolated and differentiated into osteoclasts by stimulation with hRANKL and human macrophage-colony stimulating factor (hM-CSF). Study subjects were clinically affected subjects, unaffected gene carriers, and normal controls (n = 6 in each group). Pit formation, TRACP staining, RANKL dose response, osteoclast markers, acid secretion, F-actin ring, and integrin ,v,3 expression and co-localization were studied. Results: Osteoclasts from clinically affected subjects had severely attenuated bone resorption compared with those from normal controls. However, osteoclasts from unaffected gene carriers displayed similar bone resorption to those from normal controls. In addition, the resorption lacunae from both unaffected gene carriers and normal controls appeared much earlier and spread much more rapidly than those from clinically affected subjects. As time progressed, the distinction between clinically affected subjects and the other two groups increased. No significant difference was found in acidic secretion or osteoclast formation between the three groups. Osteoclast cytoskeletal organization showed no difference between the three groups but there was low cellular motility in clinically affected subjects. Conclusions: Osteoclasts from the unaffected gene carriers, in contrast to those from the clinically affected subjects, functioned normally in cell culture. This finding supports the hypothesis that intrinsic osteoclast factors determine disease expression in ADO2. Further understanding of this mechanism is likely to lead to the development of new approaches to the treatment of clinically affected patients. [source] Male genital leiomyomas showing androgen receptor expressionJOURNAL OF CUTANEOUS PATHOLOGY, Issue 12 2007José Manuel Suárez-Peñaranda Genital leiomyoma in men include those superficial leiomyomas arising in the scrotum and the areola. They are unusual neoplasms: few cases have been reported in the literature and they usually escape clinical diagnosis. Three cases of male genital leiomyomas are reported: two in the scrotum and one in the areola. They were all conservatively excised and the behaviour was completely benign in all cases. Histopathological examination showed the typical findings of superficial leiomyomas, with some minor differences between cases arising in the scrotum and those from the areola. Immunohistochemical findings not only confirmed the smooth muscle nature of all cases but also showed unequivocal immunostaining for androgen receptors in the leiomyomas from the scrotum. Immunostaining for androgen receptors in scrotal leiomyomas is, as far as we are aware, a previously unknown characteristic of male genital leiomyomas. This finding supports the role of steroid hormones in the growth of genital leiomyomas, similar to leiomyomas found in other locations. [source] | ||||||||||||||||||||||||||||||||||||||||||||||