Home About us Contact
|
Home About us Contact | ||
|
|
||
Find Ways (find + way)
Selected AbstractsChanging the Subject: Conversation in SupermaxCULTURAL ANTHROPOLOGY, Issue 3 2005Lorna A. Rhodes Although supermaximum prisons in the United States impose an extreme social exclusion designed to prevent interaction among inmates, some do find ways to talk with one another. Drawing on ethnographic research conducted in Washington State, I describe conversation in supermax and focus on a theme of persecution of child sex criminals that emerges from prisoners' accounts. I suggest that these facilities constitute a hidden and problematic public sphere in which a discourse of excluded citizenship develops around the figure of the victimized child. In conclusion, I offer a brief "to-do" list for considering the politics of bare life in the supermax prison. [source] Adding a caveat to the urgent clinical notification of anaemia does not reduce inappropriate emergency room referral ratesINTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, Issue 3 2003P. Froom Summary Background: Urgent clinician notification of low haemoglobin values might influence the clinicians' decision to refer patients to the emergency room (ER). Methods: We compared the effects of urgent clinician notification for low haemoglobin values with and without an added statement, that an urgent visit to the ER is not required if the patient has a haemoglobin value of 50 g/l or more and is clinically stable. We compared the referral rates and outcomes of 100 consecutive cases reported previously to that of 99 consecutive new cases with the added caveat. Results: Overall 47 (47%) of the historical control patients were referred to the ER compared with 45 (45.5%) in the study group (relative risk, 0.97, 95% CI, 0.72,1.3). Five patients were inappropriately transfused and almost none of the ER visits were an emergency. Conclusions: Adding a caveat to the urgent clinician notification that anaemia in clinically stable patients is not a medical emergency does not decrease the rate of ER referrals. Further studies are needed in order to find ways to decrease the number of inappropriate ER referrals. [source] Current practice in the management of children with cerebral palsy: a national survey of paediatric dietitiansJOURNAL OF HUMAN NUTRITION & DIETETICS, Issue 4 2003Hilary Hartley Abstract Background Dietitians play a key role in the clinical management of children with cerebral palsy. This survey was conducted with the aim of establishing an overview of current dietetic practice in the management of these children. Method A questionnaire which asked for information on aspects of dietetic practice relating to children with cerebral palsy was circulated to members of the British Dietetic Association during May to October 2000. Results Many respondents had a small caseload size. However, a larger caseload was linked to membership of a multi-disciplinary team, a greater proportion of severely disabled children and use of a wider range of anthropometric measurements. Dietitians who were members of a multi-disciplinary team were more likely to visit children at home. Conclusions This survey provides an overview of current dietetic practice in the UK regarding the management of children with cerebral palsy. There is a potential shortfall in specialist dietitians and this survey highlights some of the gaps in service provision. Children with cerebral palsy benefit from dietetic input and there is an increasing need for specialist dietitians to be involved in their management. It will be necessary to continue to identify any gaps and find ways to overcome them. [source] The Psycho-Ecology of Armed ConflictJOURNAL OF SOCIAL ISSUES, Issue 1 2006Deborah Du Nann Winter As natural resources are depleted and global population grows, environmental security is becoming an increasingly salient dimension of long-term peace. In this article, we discuss current views of environmental security and go on to argue that the social psychological dimensions of resource-based conflict should also be addressed. We briefly describe six examples of such conflicts, and conclude that psychologists can play an important role in promoting peace, by bringing attention to, and helping find ways to mitigate, the psycho-ecological dimensions of armed conflict. [source] Radio frequency identification (RFID) performance: the effect of tag orientation and package contentsPACKAGING TECHNOLOGY AND SCIENCE, Issue 1 2006Robert H. Clarke Abstract The objective of this research was to determine the relationship between different product types and tag orientations on the readability of RFID tags on shipping containers in a palletload that is driven through a portal type reader. This research finds that the content of packages can dramatically reduce the read rate. Only 25% of the tags on shipping containers containing water-filled bottles could be read. Rice-filled jars had a higher read rate (80.6%). Even empty boxes did not have a 100% read rate. For the variables without appreciable package contents, only 74,79% of loads had all of their tags read. The orientation of the tag does make a difference, especially when coupled with a filled package between it and the reader antennae. Tags facing outwards, towards the reader antennae, had the highest likelihood of a successful read. When tags for the boxes of water-filled bottles were all facing downwards, no tags were read. Supply chain managers need to understand these limitations of the technology and find ways to overcome them before RFID can be successfully implemented in supply chains. Copyright © 2005 John Wiley & Sons, Ltd. [source] A study of monoclonal antibody-producing CHO cell lines: What makes a stable high producer?,BIOTECHNOLOGY & BIOENGINEERING, Issue 4 2009Janet Chusainow Abstract Generating stable, high-producing cell lines for recombinant protein production requires an understanding of the potential limitations in the cellular machinery for protein expression. In order to increase our understanding of what makes a stable high producer, we have generated a panel of 17 recombinant monoclonal antibody expressing Chinese hamster ovary subclones (CHO-mAb) with specific productivities ranging between 3 and 75 pg,cell,1,day,1 using the dihydrofolate reductase (dhfr) expression system and compared the molecular features of these high- and low-producer clones. The relative heavy chain (HC) and light chain (LC) transgene copy numbers and mRNA levels were determined using real-time quantitative PCR (RT qPCR). We observed that not only higher transgene copy numbers and mRNA levels of both HC and LC were characteristic for the high-producer clones as compared to the low-producer clones but also a more favorable HC to LC transgene copy numbers ratio. By studying the long-term stability of the CHO-mAb subclones in the absence of methotrexate (MTX) selective pressure over 36 passages we observed a 35,92% decrease in volumetric productivity, primarily caused by a significant decrease in HC and LC mRNA levels with little change in the transgene copy numbers. Using Southern blot hybridization we analyzed the HC and LC transgene integration patterns in the host chromosome and their changes in course of gene amplification and long-term culturing. We observed that MTX-induced gene amplification caused chromosomal rearrangements resulting in clonal variability in regards to growth, productivity, and stability. No further obvious DNA rearrangements occurred during long-term culturing in the absence of MTX, indicating that other mechanisms were responsible for the decreased transcription efficiency. Our results implicate that the amplified transgene sequences were arranged in tandem repeats potentially triggering repeat-induced gene silencing. We hypothesize that the decline in transgene mRNA levels upon long-term culturing without MTX was mainly caused by transgene silencing consequently leading to a loss in mAb productivity. The exact molecular mechanisms causing production instability are not yet fully understood. The herein described extensive characterization studies could help understand the limitations to high-level, stable recombinant protein production and find ways to improving and accelerating the process for high-producer cell line generation and selection. Biotechnol. Bioeng. 2009;102: 1182,1196. © 2008 Wiley Periodicals, Inc. [source] | ||||||||||