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Final Compound (final + compound)

Distribution by Scientific Domains

Chemistry	83%

Selected Abstracts

Synthesis and Physicochemical Characterization of meso -Functionalized Corroles: Precursors of Organic,Inorganic Hybrid Materials

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 21 2005
Jean-Michel Barbe
Abstract Cobalt(III) corroles exhibit an infinite selectivity for the coordination of carbon monoxide towards dioxygen and dinitrogen. This peculiar property thus allows their use as sensing devices for CO detection. Here are described the syntheses and physico-chemical characterization of meso mono-, bis- and tris(triethoxysilyl)-functionalized corroles, precursors of organic,inorganic materials. The corrole ring formation was achieved in every case using the "2+1" method involving the reaction of two equivalents of an encumbered dipyrromethane with one equivalent of an aromatic aldehyde in the presence of a catalytic amount of trifluoroacetic acid. The functionalization of the corrole by triethoxysilyl chains was carried out by a condensation reaction of an isocyanate, bearing a triethoxysilyl termination, either on an amino or hydroxy group. Each final compound and intermediate were characterized by various physico-chemical techniques such as 1H NMR, UV/Vis, MALDI/TOF or EI mass spectrometry and elemental analysis. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005) [source]

Synthesis of 3H and fluorescence-labelled poly (DL -Lactic acid)

JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, Issue 10 2001
S. Ponsart
Abstract The novel polymer modification method based on the activation of an aliphatic polyester chain by using lithium diisopropylamide at low temperature to form a polycarbanion bearing nucleophilic sites in a position , to the carbonyl groups was applied to rac -poly (lactic acid), PLA50, to label this polymer with radioactive tritium atoms or with a fluorescent dye. Despite simultaneous partial chain degradation, radioactive PLA50 and fluorescent PLA50 with Mn=14000 g mol,1, Mw/Mn=1.9 and Mn=32 000 g mol,1, Mw/Mn=2.4, respectively, were obtained. The specific activity of the final compound was 3.7 µCi g,1 that squared with 0.3, substitution reaction. The fluorescent polymer was substituted with 0.25% ratio. This work shows that the LDA activation method appears to have considerable potential. Copyright © 2001 John Wiley & Sons, Ltd. [source]

Disubstituted 4(3H) Quinazolones: A Novel Class of Antitumor Agents

CHEMICAL BIOLOGY & DRUG DESIGN, Issue 3 2009
Vikas Srivastava
A series of disubstituted 4(3H) quinazolines were designed for potential application in tumors. Firstly, N -benzoyl anthranilic acid is formed, which undergoes cyclization in the presence of pyridine. Subsequently, nucleophilic attack by semicarbazide on the carbonyl carbon gives 2-substituted 3-carbamido 4(3H) quinazolones, which gives final compound with appropriate substitution. The final as well as intermediate products were confirmed by NMR, FT-IR, and mass spectrometry. In vitro toxicity was performed with different cell lines and showed that the connection of hydrophilic styryl to quinazoline moiety increases its efficacy. [source]

A Facile Method for the Preparation of Gold Glyconanoparticles from Free Oligosaccharides and Their Applicability in Carbohydrate-Protein Interaction Studies,

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 17 2005
Koen M. Halkes
Abstract The weak binding affinity of monomeric oligosaccharides with carbohydrate-binding proteins are hampering their use in in-vivo and in-vitro bio-assays. Gold glyconanoparticles (GNPs), prepared from synthetic oligosaccharides, have been used to overcome this weak binding affinity. In this paper, a convenient method for the preparation of GNPs from free oligosaccharides is presented. The reductive amination of saccharides with trityl-protected cysteamine, followed by de-tritylation, afforded cysteamine-extended saccharides that could be used for the preparation of GNPs under reducing conditions in water. The robust chemistry and facile purification of intermediate and final compounds ensure high yields and reproducible results and the, subsequent, preparation of GNPs proceeded smoothly, even with minute quantities (nanomolar scale) of the cysteamine-extended saccharide. The described method was used to synthesize a series of gluco - and manno -oligosaccharide-containing GNPs. The prepared GNPs were validated in interaction studies with Con A, using either surface plasmon resonance (SPR), UV/Vis spectroscopy, or transmission electron microscopy (TEM). The described method for the preparation of water-soluble gold glyconanoparticles can be used for the identification of carbohydrate ligands for novel carbohydrate-binding proteins, and can find application as inhibitors of pathological interactions. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005) [source]

Reactions of 6-aminopyrimidines with 2-dimethylaminomethylenetetralone.

JOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 2 2001
5- b] quinolines, 6-Dihydrobenzo [h]pyrimido [, Regiospecific Synthesis Of
Benzo[h]pyrimido[4,5- b]quinolines (3) have been synthesized via a regiospecific cyclocondensation reaction between 6-aminopyrimidines (1) and 2-dimethylaminomethylentetralone hydrochloride (2). The linear structure of the final compounds were determined by nmr measurements, especially by 1H,1H, 1H,13C COSY and DEPT experiments. [source]

Synthesis of the lipid peroxidation product 4-hydroxy-2(E)-nonenal with 13C stable isotope incorporation

JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, Issue 2 2008
I. Jouanin
Abstract The aim of this work was to synthesize 13C internal standards for the quantification of 4-hydroxy-2(E)-nonenal (HNE), a lipid peroxidation product, and of the etheno-adducts possibly formed by HNE damage to DNA nucleobases. We designed an eight-step synthesis starting from ethyl 2-bromoacetate and giving access to 4-[(tetrahydro- 2H -pyran-2-yl)oxy]-2(E)-nonenal. This compound is a precursor of HNE. The scheme was then used to produce the 13C precursor [1,2- 13C2]-4-[(tetrahydro- 2H -pyran-2-yl)oxy]-2(E)-nonenal. [1,2- 13C2]-HNE was obtained by acid deprotection. All the intermediary and final compounds were fully characterized by IR, HRMS, 1H and 13C NMR. It is the first synthesis of HNE which enables the incorporation of two 13C labels at determined positions. Copyright © 2008 John Wiley & Sons, Ltd. [source]