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Few Years (few + year)
Selected AbstractsThe future: genes, physical activity and healthACTA PHYSIOLOGICA, Issue 4 2010F. W. Booth Abstract The assigned title for the Lindhard presentation was to examine the future of genes, physical activity and health. The current review is a summary of this presentation. Caution is expressed that technology is improving so rapidly that a future view is limited to a few years as opposed to the 100 years passing since Lindhard's achievements. The near futuristic opportunities and challenges for four major topic topics are reviewed here. Concerns are expressed over current usage of the terms ,control' group and ,non-responders' in exercise research. Our view is that ,control' needs to be differentiated between its usage for treatments of exercise to restore natural functions in individuals with less than healthy levels of physical activity and the inherited genome's expectation for physical activity levels to maintain normal function. For the second discussed topic, it is proposed that the term ,non-responders' should be replaced by the term ,low sensitivity' as there may be no such human who is a non-responder to every exercise adaptation. The third futuristic topic is exercise prescription as envisioned for individualized medicine. However, numerous limitations and challenges exist to truly optimal exercise medicine at the level of one individual. Finally, preventative physical activity medicine is discussed. Physical activity as a therapy now exists to prevent most of the chronic diseases. The future needs to understand the molecular basis for how the body becomes dysfunctional when its level of physical activity does not match the norm of physical activity that selected our inherited genome. [source] Grazing Intensity and the Diversity of Grasshoppers, Butterflies, and Trap-Nesting Bees and WaspsCONSERVATION BIOLOGY, Issue 6 2002Andreas Kruess The reduction of management intensity can be a useful tool for the long-term conservation of the biological diversity of grasslands. We analyzed floral and faunal diversity on intensively and extensively (unintensively) grazed pastures and on 5- to 10-year-old ungrazed grasslands in northern Germany. Each of the three grassland habitats differing in grazing intensity was replicated six times. We related diverse taxa such as grasshoppers, butterfly adults and lepidopteran larvae, and trap-nesting solitary bees and wasps to vegetation structure. There was an increase of species richness and abundance from pastures to ungrazed grasslands. The percentage of parasitism of the most abundant trap-nesting species, the digger-wasp ( Trypoxylon figulus), was also higher on ungrazed grasslands. Decreased grazing on pastures enhanced species richness for adult butterflies only, whereas the abundance of adult butterflies, solitary bees and wasps, and their natural enemies increased. Although the differences in insect diversity between pastures and ungrazed grassland could be attributed to a greater vegetation height and heterogeneity ( bottom-up effects) on ungrazed areas, the differences between intensively and extensively grazed pastures could not be explained by changes in vegetation characteristics. Hence, intensive grazing appeared to affect the insect communities through the disruption of plant-insect interactions. A mosaic of extensively grazed grassland and grassland left ungrazed for a few years may be a good means by which to maintain biodiversity and the strength of trophic interactions. Resumen: El mantenimiento de pastizales como hábitats distintos depende del manejo regular, generalmente, por medio de pastoreo o segado, pero se sabe que la diversidad de especies declina con el incremento de intensidad de manejo. La reducción de la intensidad de manejo puede ser una herramienta útil para la conservación a largo plazo de la biodiversidad de pastizales. Analizamos la diversidad florística y faunística en pastizales pastoreados intensiva y extensivamente (no intensivos) y en pastizales de 5 a 10 años no pastoreados en el norte de Alemania. Cada uno de los tres hábitats de pastizal diferentes en el grado de pastoreo fue replicado seis veces. Relacionamos diversos taxones como chapulines, mariposas adultas, larvas de lepidópteros y abejas y avispas solitarias con la estructura de la vegetación. Hubo un incremento en la riqueza y abundancia de especies de pastizales pastoreados a no pastoreados. El porcentaje de parasitismo de la especie de avispa más abundante ( Trypoxylon figulus) también fue mayor en pastizales no pastoreados. La reducción del pastoreo incrementó la riqueza de especies de mariposas adultas solamente, mientras que incrementó la abundancia de mariposas adultas, abejas y avispas solitarias y sus enemigos naturales. Aunque las diferencias en la diversidad de insectos entre pastizales pastoreados y no pastoreados pudiera atribuirse a la mayor altura de la vegetación y a la heterogeneidad (efectos abajo-arriba) en áreas no pastoreadas, las diferencias entre pastizales pastoreados intensiva y extensivamente no podría explicarse por cambios en las características de la vegetación. Por consiguiente, el pastoreo intensivo aparentemente afectó a las comunidades de insectos por la disrupción de las interacciones planta-animal. Un mosaico de pastizales pastoreados extensivamente y pastizales sin pastoreo por varios años puede ser una buena estrategia para mantener la biodiversidad y la vigencia de las interacciones tróficas. [source] Development of the use of standardized environmental management systems (EMSs) in local authoritiesCORPORATE SOCIAL RESPONSIBILITY AND ENVIRONMENTAL MANAGEMENT, Issue 3 2005Sara Emilsson Abstract Local authorities have used EMSs to structure their environmental efforts for some time now, and this paper studies the development over time of the use of EMSs in some Swedish local authorities. The analyses depart from three development indicators: dissemination of the EMS work, the progress in the EMS cycle and the use of EMS standards. The results show that EMSs are more widely used within the local authorities today compared with a few years ago. Before, it was mainly the technical sector that was subject to EMS implementation, but today there is a stronger emphasis on the successfulness of EMS implementation in departments within the soft sector. The study also shows that local authorities have shifted from using ISO 14001 and/or EMAS to using less formal, often locally adapted and designed standards. The paper concludes by discussing the usefulness of standards for EMS implementation in local authorities. Copyright © 2005 John Wiley & Sons, Ltd and ERP Environment. [source] Fate of developing tooth buds located in relation to mandibular fractures in three infancy casesDENTAL TRAUMATOLOGY, Issue 4 2010Kazuhiko Yamamoto Three infants, 2 girls and a boy, aged from 1 year and 5-months old to 2 years and 6-months old, were treated for dislocated mandibular fracture in the symphyseal region by manual reduction and fixation with a thermoforming splint and circumferential wiring under general anesthesia. Fracture healing was uneventful in all cases. A few years later, no obvious deformity of the jaw or malocclusion was observed; however, malformation of the crown was found in one of the permanent teeth on the fracture line in the first case. In the second case, no abnormality was observed in one of the permanent teeth on the fracture line, but the effect on the other tooth could not be evaluated due to abnormality of the tooth probably not related to the injury. In the third case, root formation was arrested in one of the permanent teeth on the fracture line and the tooth was lost early after eruption. The development of tooth buds on the fracture line is not predictable and therefore, should be monitored by regular follow up. [source] Pulp capping with adhesive resin-based composite vs. calcium hydroxide: a reviewDENTAL TRAUMATOLOGY, Issue 6 2000A. H. B. Schuurs Abstract , The results of some short-term experiments suggest that direct capping of a vital pulp with the modern resin-based composite systems may be as effective as capping with calcium hydroxide. Total cavity etching with 10% phosphoric acid seems to be safe for the exposed pulp, but unless annulled by calcium hydroxide 35% phosphoric acid may be disastrous. For hemostasis and cleaning of the pulp wound both sodium hypochlorite and saline seem suitable, whereas the effectiveness of a 2% chlorhexidine solution is questionable. Although hard-setting calcium hydroxide cements may induce the formation of dentin bridges, they appear not to provide an effective long-term seal against bacterial factors. Within a few years, the majority of mechanically exposed and capped pulps show infection and necrosis due to microleakage of such capping materials and tunnel defects in the dentin bridges. It is unknown whether newer types of resin containing calcium-hydroxide-products will act as a permanent barrier. The cytotoxicity of the resin-based composites and the temperature rise during polymerisation may not be of concern, but microleakage, sensitisation and allergic reactions may pose problems. Based on available data, pulp capping with resin-based composites may be said to be promising, but more and long-term research is mandatory before the method can be recommended. [source] The History of Sclerosing FoamsDERMATOLOGIC SURGERY, Issue 5 2004Jan-Christoph G. R. Wollmann MD Background. The use of foamed sclerosants in phlebology is undergoing a renaissance. The use of foam sclerotherapy was relaunched only a few years ago. Despite this, the early developments, pioneer findings, and improvements, especially in foaming techniques, are not widely recognized. Objective. The objective of this study was to give an overview from the very beginnings of foam sclerotherapy until the most recent and progressive techniques, as described by Tessari or the double syringe system technique. Results. The publications found after a thorough research for literature about foam sclerotherapy allow us to examine what has been invented between Orbach's work in 1944 and now and,surprisingly,even before 1944. The contributions of greatly reputed and also of unknown colleagues, such as Orbach, Sigg, Mayer, or Flückiger, are presented, giving a historical overview from the very beginnings of foam sclerotherapy until the most recent techniques. Basically, the literature shows that remarkable work was carried out in the field of noncommercial foam sclerotherapy and that sclerosing foams have been used by numerous doctors continuously for the past six decades, especially for the treatment of varicose veins of the lower limbs. Conclusion. The use of foamed sclerosing agents in therapy of large or small varicose veins is not new. It started as early as 1939 and has continuously been improved in the past decades. [source] Medical imaging and MRI in nail disorders: report of 119 cases and review of the literatureDERMATOLOGIC THERAPY, Issue 2 2002Bertrand Richert Radiographs remain the golden standard for exploration of the bony structures located beneath the nail plate, but they provide no information on the perionychium. Until a few years ago the nail apparatus was deprived of investigative medical imaging. Glomus tumor was the only condition that was explored using invasive techniques such as angiography or scintigraphy. High-frequency ultrasound rapidly came up against technical limits. High-resolution magnetic resonance imaging (MRI) offers a superior alternative in detection of distal lesions as well as their relationship with the adjacent structures. MRI provides an accurate analysis of the nail apparatus with detection of lesions as small as 1 mm. This noninvasive technique will allow us to better understand, diagnose, and treat pathologies of the distal phalanx. [source] Six3 promotes the formation of ectopic optic vesicle-like structures in mouse embryosDEVELOPMENTAL DYNAMICS, Issue 3 2001Oleg Lagutin Abstract A few years ago, three novel murine homeobox genes closely related to the Drosophila sine oculis (so) gene (Six1-3) were isolated and were all included in the Six/so gene family. Because of its early expression in the developing eye field, Six3 was initially thought to be the functional ortholog of the Drosophila so gene. This hypothesis was further supported by the demonstration that ectopic Six3 expression in medaka fish (Oryzias latipes) promotes the formation of ectopic lens and retina tissue. Here, we show that similar to Drosophila, where the eyeless/Pax6 gene regulates the eye-specific expression of so, Six3 expression in the murine lens placodal ectoderm is also controlled by Pax6. We also show that ectopic Six3 expression promotes the formation of ectopic optic vesicle-like structures in the hindbrain-midbrain region of developing mouse embryos. © 2001 Wiley-Liss, Inc. [source] Effect of weight-reducing agents on glycaemic parameters and progression to Type 2 diabetes: a reviewDIABETIC MEDICINE, Issue 10 2008C. Lloret-Linares Abstract Weight loss is associated with improvements in glycaemic control and cardiovascular disease risk factors. However, in the diabetic population, weight management is more challenging, in part because of the weight-promoting effects of the majority of glucose-lowering therapies. This review summarizes evidence from 23 placebo-controlled randomized trials, of at least 1 year duration, on the effects of drugs promoting weight loss (orlistat, sibutramine and rimonabant) on glycaemic variables, diabetes incidence and diabetes control. Fifteen studies of non-diabetic subjects were found, eight of which included a longer treatment period. Eight studies in diabetic patients were reviewed. In non-diabetic subjects, weight loss agents led to a significant improvement in fasting glucose, fasting insulin and insulin resistance. In the diabetic population, glycated haemoglobin decreased by 0.28,1.1% with orlistat and 0.6% with sibutramine and rimonabant. Orlistat reduces progression to diabetes in patients with glucose intolerance treated for 4 years (risk reduction of 45%). In summary, despite leading to only modest weight loss after 12 months, agents promoting weight loss have beneficial effects on glycaemic parameters, glycaemic control and progression to diabetes. These additional benefits of weight loss agents need to be highlighted in order to increase their judicious use in clinical practice, although this may be limited by their well-known adverse side effects. The longer-term safety of these agents beyond a few years is yet to be established. [source] Type 2 diabetes mellitus: a disease of the innate immune system?DIABETIC MEDICINE, Issue 3 2004An update Abstract A few years ago a hypothesis was proposed suggesting that elements of the innate immune system, such as acute phase reactants, contribute to the development of Type 2 diabetes mellitus. Acute phase reactants such as C-reactive protein and sialic acid may thus predict risk of developing Type 2 diabetes mellitus, as well as being markers of diabetes microvascular and macrovascular complications. This article discusses these issues. [source] Novel agents to override imatinib resistance mechanismsDRUG DEVELOPMENT RESEARCH, Issue 7 2008Asumi Yokota Abstract Chronic myelogenous leukemia (CML) is a disorder of hematopoietic stem cells that results from the Philadelphia chromosome (Ph) created through translocation of human chromosomes 9 and 22. The resulting Bcr-Abl fusion protein has constitutively high tyrosine kinase activity that causes transformation of hematopoietic stem cells. Imatinib mesylate (IM) was developed as a specific Bcr-Abl kinase inhibitor and is efficacious in treating Ph-chromosome-positive (Ph+) leukemias such as CML and Ph+ acute lymphoblastic leukemia (ALL). Within a few years of its introduction to the clinic, IM has dramatically altered the first-line therapy for CML. Although most newly diagnosed CML patients in the chronic phase (CP) achieved durable responses when treated with IM, resistance to IM has become a major problem in patients with advanced-stage disease. The most important mechanism of IM resistance are point mutations within the Abl kinase domain; therefore, there is an urgent need for novel agents that can inhibit mutated Bcr-Abl. In this review, we describe novel Bcr-Abl tyrosine kinase inhibitors, the so-called "Super Gleevec" inhibitors. Drug Dev Res 69:398,406, 2008. © 2008 Wiley-Liss, Inc. [source] Iatrogenic Creutzfeldt,Jakob disease subsequent to dural graft: persisting risk after 1987EUROPEAN JOURNAL OF NEUROLOGY, Issue 5 2003C. Boutoleau The first case of Creutzfeldt,Jakob disease (CJD) related to the use of a dura mater graft of cadaveric origin was identified in 1987 and this procedure is now considered as one of the main causes of iatrogenic CJD. Although the decontamination procedure for the preparation of graft material was modified, the product was withdrawn from the market in many countries a few years later and replaced by synthetic material. In this context, two patients treated in our institution developed CJD following a cadaveric dural graft performed after cerebral and lumbar trauma. Their clinical presentation, showing predominant cerebellar symptoms, late deterioration and myoclonic jerks, and a rapid disease course until death, was similar to that of previously reported cases involving the iatrogenic form. As the graft for one of the patients was performed in 1991 (several years after modification of the decontamination procedure), this fourth reported case suggests that the risk of iatrogenic CJD may have persisted in some patients treated after 1987, when grafts of cadaveric origin were totally abandoned. [source] Learning and re-learning regime support: The dynamics of post-communist regimesEUROPEAN JOURNAL OF POLITICAL RESEARCH, Issue 1 2002William Mishler The political support of citizens of new democracies reflects two sets of experiences. Initially, people are socialized into an undemocratic regime; then, they must re-learn political support in relation to a new regime. In an established democracy, it is difficult to disentangle the effect of early socialization and current performance because both refer to the same regime. However, this is both possible and necessary in countries where there has been a change in regime. Critical questions then arise: When, whether and how do citizens determine their support for their new regime? At the start of a new regime past socialization should be more important but, after a few years, current performance should become more important. We draw on 47 Barometer surveys between 1991 and 1998 in ten more or less democratic post-communist regimes of Central and Eastern Europe and the former Soviet Union to test the relative importance of early socialization influences, the legacy of the communist past, and the political and economic performance of new regimes. We find that economic and political performance explains the most variance in support and, secondarily, the communist legacy. Early socialization is insignificant. However, contrary to economic theories of voting, the impact of political performance is greater than the impact of economic performance in post-communist countries , and its impact is increasing. [source] Comparing the hydrology of grassed and cultivated catchments in the semi-arid Canadian prairiesHYDROLOGICAL PROCESSES, Issue 3 2003G. van der Kamp Abstract At the St Denis National Wildlife Area in the prairie region of southern Saskatchewan, Canada, water levels in wetlands have been monitored since 1968. In 1980 and 1983 a total of about one-third of the 4 km2 area was converted from cultivation to an undisturbed cover of brome grass. A few years after this conversion all the wetlands within the area of grass dried out; they have remained dry since, whereas wetlands in adjacent cultivated lands have held water as before. Field measurements show that introduction of undisturbed grass reduces water input to the wetlands mainly through a combination of efficient snow trapping and enhanced infiltration into frozen soil. In winter, the tall brome grass traps most of the snowfall, whereas in the cultivated fields more wind transport of snow occurs, especially for short stubble and fallow fields. Single-ring infiltration tests were conducted during snowmelt, while the soil was still frozen, and again in summer. The infiltrability of the frozen soil in the grassland is high enough to absorb most or all of the snowmelt, whereas in the cultivated fields the infiltration into the frozen soil is limited and significant runoff occurs. In summer, the infiltrability increases for the cultivated fields, but the grassland retains a much higher infiltrability than the cultivated land. The development of enhanced infiltrability takes several years after the conversion from cultivation to grass, and is likely due to the gradual development of macropores, such as root holes, desiccation cracks, and animal burrows. Copyright ©2002 Crown in the right of Canada. Published by John Wiley & Sons, Ltd. [source] Quantitative structural damage detection using high-frequency piezoelectric signatures via the reverberation matrix methodINTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING, Issue 5 2007W. Yan Abstract High-frequency structural analysis so far has been a major issue in dynamic analysis, for which many conventional methods such as finite element method and transfer matrix method are unable to perform well. Since the electromechanical impedance technique for structural health monitoring (SHM) operates at very high frequencies, the reverberation matrix method (RMM), which was just developed a few years ago, is employed to study dynamics of the monitored structures, which are bonded with piezoelectric lead zirconate titanate (PZT) patches. A piecewisely homogeneous Euler,Bernoulli beam model is introduced to approximate the non-homogeneous beam and only one-dimensional axial vibration of PZT wafers is considered. The imperfect interfacial bonding between PZT patches and the host beam is investigated based on a shear lag model. Using a hybrid technique combining electromechanical impedance method and RMM, an analytical expression of impedance (or admittance) related to the response of the coupled model of PZT patch-bonding layer-host beam system is derived for SHM. The proposed method is examined by comparing with other theoretical methods as well as by means of a test on an intelligent system using a steel beam with two symmetrically installed PZT wafers. It could be further applied to predicting the dynamics of monitored Timoshenko beams, continuous beams, and framed structures as well. Copyright © 2006 John Wiley & Sons, Ltd. [source] The effect of income growth on the mix of purchases between disposable goods and reusable goodsINTERNATIONAL JOURNAL OF CONSUMER STUDIES, Issue 3 2007John McCollough Abstract With each passing year consumers find more and more disposable goods for sale in the market place. Even goods that were considered to be reusable goods just a few years back are now disposable goods. As a result the American economy has been labelled a ,throwaway society'. This paper examines a main underlying cause for this trend by linking growth in consumer income with the purchases of disposable goods. More specifically, the model proposes that as incomes rise, consumers will purchase more of both reusable goods and disposable goods. However, as incomes rise, consumers will naturally substitute purchases away from reusable goods and into disposable goods. The shift towards disposable goods occurs because it becomes too costly for consumers to spend their time repairing and maintaining products. Their time is better spent in more productive endeavours. It is simply cheaper (in terms of opportunity cost of time) to dispose of old products and replace them with new products. [source] Finding an Adequate Job: Employment and Income of Recent Immigrants to IsraelINTERNATIONAL MIGRATION, Issue 2 2003Haya Stier Summary The study examines the early market experience of recent immigrants to Israel from the former Soviet Union (FSU) and their mobility patterns a few years after migration. The Labour Utilization Framework, proposed by Clogg and Sullivan (1983), was analysed to identify the employment difficulties immigrants experienced upon arrival, their short-term mobility in the labour market, and the income consequences of their disadvantaged position in the market. Using a panel study of immigrants who arrived in Israel during 1990, we found that although most of them found employment, only a minority did not experience employment hardships. Four years after their arrival, most immigrants were still employed in occupations for which they were over-qualified, and only a small portion of the group managed to find adequate employment. Women had more severe employment hardships and a lower rate of mobility into the better positions. For men and women alike, almost any deviation from a stable adequate employment entailed wage penalties. [source] FHA Domains as Phospho-Threonine Binding Modules in Cell SignalingIUBMB LIFE, Issue 1 2003Andrew Hammet Abstract Forkhead-associated (FHA) domains are present in <200 diverse proteins in all phyla from bacteria to mammals and seem to be particularly prevalent in proteins with cell cycle control functions. Recent work from several laboratories has considerably improved our understanding of the structure and function of these domains that were virtually unknown a few years ago, and the first disease associations of FHA domains have now emerged. FHA domains form 11-stranded beta-sandwiches that contain some 100-180 amino acid residues with a high degree of sequence diversity. FHA domains act as phosphorylation-dependent protein-protein interaction modules that preferentially bind to phospho-threonine residues in their targets. Interestingly, point mutations in the human CHK2 gene that lead to single-residue amino acid substitutions in the FHA domain of this cell cycle checkpoint kinase have been found to cause a subset of cases of the Li-Fraumeni multi-cancer syndrome. IUBMB Life, 55: 23-27, 2003 [source] The equilibrium assumption in estimating the parameters of metapopulation modelsJOURNAL OF ANIMAL ECOLOGY, Issue 1 2000Atte Moilanen 1.,The construction of a predictive metapopulation model includes three steps: the choice of factors affecting metapopulation dynamics, the choice of model structure, and finally parameter estimation and model testing. 2.,Unless the assumption is made that the metapopulation is at stochastic quasi-equilibrium and unless the method of parameter estimation of model parameters uses that assumption, estimates from a limited amount of data will usually predict a trend in metapopulation size. 3.,This implicit estimation of a trend occurs because extinction-colonization stochasticity, possibly amplified by regional stochasticity, leads to unequal numbers of observed extinction and colonization events during a short study period. 4.,Metapopulation models, such as those based on the logistic regression model, that rely on observed population turnover events in parameter estimation are sensitive to the implicit estimation of a trend. 5.,A new parameter estimation method, based on Monte Carlo inference for statistically implicit models, allows an explicit decision about whether metapopulation quasi-stability is assumed or not. 6.,Our confidence in metapopulation model parameter estimates that have been produced from only a few years of data is decreased by the need to know before parameter estimation whether the metapopulation is in quasi-stable state or not. 7.,The choice of whether metapopulation stability is assumed or not in parameter estimation should be done consciously. Typical data sets cover only a few years and rarely allow a statistical test of a possible trend. While making the decision about stability one should consider any information about the landscape history and species and metapopulation characteristics. [source] Lichen acclimatization on retention trees: a conservation physiology lessonJOURNAL OF APPLIED ECOLOGY, Issue 4 2009Kadi Jairus Summary 1.,Green-tree retention (GTR) has been suggested as a means to effectively support epiphytic lichen species in managed forests, given the low lichen mortality on retention trees in the short term. However, a long-term perspective requires a physiological understanding of lichen responses to logging. This study compares anatomical, morphological and physiological traits of lichens on retention trees and on intact forest trees. 2.,Thalli of nine taxa (Buellia griseovirens, Cladonia digitata, Hypogymnia physodes, Lecanora allophana, Lecanora pulicaris, Lepraria spp., Peltigera praetextata, Pertusaria amara and Phlyctis argena) were sampled from birch Betula spp. and aspen Populus tremula in GTR cuts, where they had previously been reported to survive well, and in adjacent managed forests. In the laboratory, chlorophyll fluorescence parameter Fv/Fm, thickness of the upper cortex, photobiont to mycobiont ratio and (in Lecanora species) the relative area of the apothecia were measured. 3.,All the lichen samples collected from GTR cuts appeared alive, but their Fv/Fm was significantly lower, relative areas of the apothecia were larger and the upper cortices of thalli were thicker compared with the samples from adjacent forests. No difference in photobiont to mycobiont ratio was found. These patterns were broadly consistent among species, indicating a common mechanism: while suffering from photoinhibition, the lichens had acclimatized to the open conditions and increased their investment to sexual reproduction in a few years. 4.,Synthesis and applications. The study highlights the value of a morpho-physiological framework for conservation management by pointing out that, in GTR areas, lichen survival is high-irradiation limited and heavily dependent on phenotypic plasticity. A thin upper cortex may be a common feature of the most sensitive species. To sustain epiphyte populations in managed forests, precautionary harvesting strategies (gradual felling; group-retention; extended rotations) should be preferred and large-enough populations should be preserved, even though short-term studies suggest a high survival of lichens in cut areas. [source] Degradation of aramid fibers under alkaline and neutral conditions: Relations between the chemical characteristics and mechanical propertiesJOURNAL OF APPLIED POLYMER SCIENCE, Issue 5 2010G. Derombise Abstract Aramid fibers are high-performance materials that have been used in various applications such as heat and cut protection, composites, rubber reinforcement, ropes and cables, and fabrics; today their use is proposed in geotextiles for alkaline ground reinforcement, and they have been used in cables for marine applications for a few years. However, there is a lack of experience with the long-term behavior of aramid fibers in wet and alkaline environments. Aging studies were therefore performed on Twaron 1000 fibers under different conditions (sea water, deionized water, pH 9, and pH 11). Hydrolytic degradation was evaluated with Fourier transform infrared and viscosimetry measurements, which were correlated with tensile test measurements. The tensile strength followed a logarithmic evolution with the aging time, whereas the modulus remained constant. A linear relation between the tensile strength and the reduced viscosity of the hydrolytically aged fibers is highlighted. Aging indicators are proposed that allow the hydrolytic degradation to be quantified. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010 [source] Early changes in renal hemodynamics in children with diabetes: Doppler sonographic findingsJOURNAL OF CLINICAL ULTRASOUND, Issue 6 2008Piernicola Pelliccia MD Abstract Purpose Although clinically evident diabetes-related microvascular complications are extremely rare in childhood, early functional and structural abnormalities may be present a few years after the onset of the disease. Renal Doppler resistance index (RI) is widely used for the evaluation of blood flow in renal parenchymal diseases. This study was designed to investigate the possible alteration of intrarenal Doppler RI in children with diabetes compared with healthy children. Methods The study was performed in 42 children with diabetes (age range, 6,18 years) and in 41 age-matched healthy controls, all having normal renal function. RI was measured with Doppler sonography in interlobular renal arteries. Results RI values were significantly greater in children with diabetes than in age-matched healthy controls (0.64 ± 0.03 versus 0.60 ± 0.04, P < 0.035). RI correlated positively with HbA1c (P < 0.001, r = 0.42) and diabetes duration (P < 0.05, r = 0.39). Conclusion Early changes in renal hemodynamics are detectable on Doppler sonography in children with diabetes without any evidence of renal dysfunction and may suggest a preclinical stage of diabetic nephropathy. © 2008 Wiley Periodicals, Inc. J Clin Ultrasound, 2008. [source] Ultrastructural study of the temporomandibular joint after unilateral meniscectomy in Wistar ratsJOURNAL OF ORAL REHABILITATION, Issue 10 2006D. T. MARTINI summary, Meniscectomy of the temporomandibular joint (TMJ) was frequently performed until a few years ago but now is seldom employed. This procedure induces important articular modifications but the complete extent of ultrastructural changes is still unknown. Twenty-one Wistar rats were submitted to unilateral meniscectomy. Animals were randomly divided into three groups and followed for 15, 35 or 60 days. After killing both meniscectomized and contralateral TMJ specimens were sectioned sagittally and prepared for light and scanning electron microscopy studies. Normal TMJs are characterized by glenoid fossa and condylar process with distinct conjunctive layers in which regularly arranged type 1 collagen fibres predominate. Meniscectomized animals initially exhibit a different tissue covering the eroded articular surface of the condyle with the prevalence of type 3 collagen fibres but type 1 fibres predominate in the late postoperative period. Subchondral cysts are clearly visible. A complex remodelling process of the TMJ after meniscectomy is evident with important ultrastructural modifications that may correlate to unsatisfactory clinical results. The dynamic nature of this process is also observed when specimens from different postoperative periods are compared. Surgeons should always bear in mind these alterations when indicating this procedure. [source] Structural transformations in organic crystals during photochemical reactionsJOURNAL OF PHYSICAL ORGANIC CHEMISTRY, Issue 10 2004Ilona Turowska-Tyrk Abstract In the 1980s and 1990s, x-ray studies of the photochemical reaction course in crystals dealt with the analysis of changes in cell constants or movements of atom groups inside molecules. This review presents the results of crystallographic studies on the monitoring of the behaviour of whole molecules in organic crystals during photochemical reactions. Papers on this subject started to appear only a few years ago. The studies showed quantitatively that reactant and product molecules do not take a fixed position in a crystal during the reaction. The product molecules move smoothly to a position assumed in the pure product crystal and the reactant molecules move from a position occupied in the pure reactant crystal. Moreover, with the reaction progress the adjacent reactant molecules gradually come closer and change their mutual orientation to resemble the product. The analysis of the photoreaction kinetics in crystals is also presented. Copyright © 2004 John Wiley & Sons, Ltd. [source] Musings about the development of XAFSJOURNAL OF SYNCHROTRON RADIATION, Issue 2 2001Edward A. Stern A personal recollection of the development of X-ray absorption fine structure (XAFS) into a structure-determination technique is presented. Because of confusion in the theoretical explanation of the `Kronig structure', now called EXAFS, the extended XAFS, its explanation remained unresolved for about 40 years. As I was introduced to the EXAFS phenomenon by Farrel Lytle and saw his impressive data, the thought came to me that scattering of the photoelectron from surrounding atoms could be the mechanism of the effect. My graduate student, Dale Sayers, agreed to work on developing the theory under my supervision and to make EXAFS measurements under Lytle's supervision as his PhD thesis. The theory led to the idea of a Fourier transform of the EXAFS, which showed peaks from surrounding atoms, proving the validity of the theory and suggesting the method of structure determination by using standards from known structures. Within a few years, facilities at synchrotron sources were developed to measure XAFS, opening up the technique to the general scientific community. In spite of some initial growing pains, XAFS has matured into a powerful technique for local structure and has been applied to obtain magnetic structure, in addition to distribution of atoms. Other related techniques have been spawned from XAFS, expanding the impact of the original phenomenon. [source] Polymer Chain Collapse in Supercritical Fluids.MACROMOLECULAR SYMPOSIA, Issue 1 2009Abstract A few years ago we reported the first observation, by computer simulations, of polymer chain collapse near the lower critical solution temperature (LCST).1 In the present work, we extended the above study to understand the underlying physics of a single polymer chain collapse near LCST and its relationship to phase boundaries in the T-x plane. Effects of solvent and monomer sizes, and solvent and monomer energetic interactions are studied. Using Monte Carlo simulations, the mean end-to-end distance (R) and gyration radius (Rg) are calculated for a single chain in a supercritical fluid solvent over a broad range of densities, pressures and temperatures. In general, the chain collapses as temperature increases at constant pressure. Upon a further temperature increase, the chain expands again to approach the athermal limit provided that the temperature is sufficiently high. The collapse is related to an LCST phase boundary while the expansion represents the signature of an upper-critical solution temperature (UCST) suggesting the existence of a closed-immiscibility loop. By manipulating the strength of the energetic interactions as well as the solvent-to-monomer size ratio, the size of the size of the immiscibility loop can be fine-tuned. The relationship among size and the segment-solvent energetic interaction are correlated by a conformational parameter (,) for the first time. By monitoring the , behavior, it is possible to predict solution's phase behavior, transition zone from LCST-UCST in a closed-loop miscibility behavior. The above relationship between chain conformation to phase boundaries may be useful in understanding phase stability in compressible polymer-solvent mixtures. [source] Cladosporium fulvum (syn. Passalora fulva), a highly specialized plant pathogen as a model for functional studies on plant pathogenic MycosphaerellaceaeMOLECULAR PLANT PATHOLOGY, Issue 4 2005BART P. H. J. THOMMA SUMMARY Taxonomy:,Cladosporium fulvum is an asexual fungus for which no sexual stage is currently known. Molecular data, however, support C. fulvum as a member of the Mycosphaerellaceae, clustering with other taxa having Mycosphaerella teleomorphs. C. fulvum has recently been placed in the anamorph genus Passalora as P. fulva. Its taxonomic disposition is supported by its DNA phylogeny, as well as the distinct scars on its conidial hila, which are typical of Passalora, and unlike Cladosporium s.s., which has teleomorphs that reside in Davidiella, and not Mycosphaerella. Host range and disease symptoms:, The presently known sole host of C. fulvum is tomato (members of the genusLycopersicon). C. fulvum is mainly a foliar pathogen. Disease symptoms are most obvious on the abaxial side of the leaf and include patches of white mould that turn brown upon sporulation. Due to stomatal clogging, curling of leaves and wilting can occur, leading to defoliation. C. fulvum as a model pathogen:, The interaction between C. fulvum and tomato is governed by a gene-for-gene relationship. A total of eight Avr and Ecp genes, and for four of these also the corresponding plant Cf genes, have been cloned. Obtaining conclusive evidence for gene-for-gene relationships is complicated by the poor availability of genetic tools for most Mycosphaerellaceae,plant interactions. Newly developed tools, including Agrobacterium -mediated transformation and RNAi, added to the genome sequence of its host tomato, which will be available within a few years, render C. fulvum attractive as a model species for plant pathogenic Mycosphaerellaceae. Useful websites:,http://www.sgn.cornell.edu/help/about/index.html; http://cogeme.ex.ac.uk [source] Long-term monitoring in IC4665: fast rotation and weak variability in very low mass objectsMONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, Issue 3 2009Alexander Scholz ABSTRACT We present the combined results of three photometric monitoring campaigns targeting very low mass (VLM) stars and brown dwarfs in the young open cluster IC4665 (age ,40 Myr). Each of our observing runs covers time-scales of ,5 d in the seasons 1999, 2001 and 2002, respectively. In all three runs, we observe ,100 cluster members, allowing us for the first time to put limits on the evolution of spots and magnetic activity in fully convective objects on time-scales of a few years. For 20 objects covering masses from 0.05 to 0.5 M,, we detect a periodic flux modulation, indicating the presence of magnetic spots co-rotating with the objects. The detection rate of photometric periods (,20 per cent) is significantly lower than in solar-mass stars at the same age, which points to a mass dependence in the spot properties. With two exceptions, none of the objects exhibits variability and thus spot activity in more than one season. This is contrary to what is seen in solar-mass stars and indicates that spot configurations capable of producing photometric modulations occur relatively rarely and are transient in VLM objects. The rotation periods derived in this paper range from 3 to 30 h, arguing for a lack of slow rotators among VLM objects. The periods fit into a rotational evolution scenario with pre-main sequence contraction and moderate (40,50 per cent) angular momentum losses due to wind braking. By combining our findings with literature results, we identify two regimes of rotational and magnetic properties, called C- and I-sequence. Main properties on the C-sequence are fast rotation, weak wind braking, H, emission and saturated activity levels, while the I-sequence is characterized by slow rotation, strong wind braking, no H, emission and linear activity-rotation relationship. Rotation rate and stellar mass are the primary parameters that determine in which regime an object is found. We outline a general scheme to understand rotational evolution for low-mass objects in the context of these two regimes and discuss the potential as well as the problems of this picture. [source] Motor fluctuations and dyskinesias in Parkinson's disease: Clinical manifestationsMOVEMENT DISORDERS, Issue S11 2005Joseph Jankovic MD Abstract Fluctuations in the symptoms of Parkinson's disease (PD), such as wearing-off and on,off effects, and dyskinesias are related to a variety of factors, including duration and dosage of levodopa, age at onset, stress, sleep, food intake, and other pharmacokinetic and pharmacodynamic mechanisms. The majority of patients, particularly those with young onset of PD, experience these levodopa-related adverse effects after a few years of treatment. Assessment of these motor complications is difficult because of the marked clinical variability between and within patients. Daily diaries have been used in clinical trials designed to assess the effects of various pharmacological and surgical interventions on motor fluctuations and dyskinesias. The most common type of dyskinesia, called "peak-dose dyskinesia", usually consists of stereotypical choreic or ballistic movements involving the head, trunk, and limbs, and occasionally, the respiratory muscles, whereas tremor and punding are less-common complications. Dystonia is also typically seen in patients with diphasic dyskinesia and wearing-off effect. Recognition of the full spectrum of clinical phenomenology of levodopa-related motor complications is essential for their treatment and prevention. © 2005 Movement Disorder Society [source] Which traits promote persistence of feral GM crops?OIKOS, Issue 1 2005Part 2: implications of metapopulation structure Transgenes may spread from crops into the environment via the establishment of feral populations, often initiated by seed spill from transport lorries or farm machinery. Locally, such populations are often subject to large environmental variability and usually do not persist longer than a few years. Because secondary feral populations may arise from seed dispersal to adjacent sites, the dynamics of such populations should be studied in a metapopulation context. We study a structured metapopulation model with local dispersal, mimicking a string of roadside subpopulations of a feral crop. Population growth is assumed to be subject to local disturbances, introducing spatially random environmental stochasticity. Our aim is to understand the role of dispersal and environmental variability in the dynamics of such ephemeral populations. We determine the effect of dispersal on the extinction boundary and on the distribution of persistence times, and investigate the influence of spatially correlated disturbances as opposed to spatially random disturbances. We find that, given spatially random disturbances, dispersal slows down the decline of the metapopulation and results in the occurrence of long-lasting local populations which remain more or less static in space. We identify which life history traits, if changed by genetic modification, have the largest impact on the population growth rate and persistence times. For oilseed rape, these are seed bank survival and dormancy. Combining our findings with literature data on transgene-induced life history changes, we predict that persistence is promoted by transgenes for oil-modifications (high stearate or high laurate) and, possibly, for insect resistence (Bt). Transgenic tolerance to glufosinate herbicide is predicted to reduce persistence. [source] | |||||||||||||||||||||||||||||||||||||||||||