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Fetal Anaemia (fetal + anaemia)

Distribution by Scientific Domains

Life Sciences	60%

Selected Abstracts

Effect of fetal anaemia on myocardial ischaemia-reperfusion injury and coronary vasoreactivity in adult sheep

ACTA PHYSIOLOGICA, Issue 4 2008
Bohuslav OstadalArticle first published online: 11 NOV 200
No abstract is available for this article. [source]

Maternal serum alpha-fetoprotein, fetal middle cerebral artery blood flow velocity and fetal haemoglobin in pregnancies at risk of fetal anaemia

PRENATAL DIAGNOSIS, Issue 2 2006
Jose L. Bartha
Abstract Objectives To evaluate the relationships between maternal serum alpha-fetoprotein (MSAFP) levels and both middle cerebral artery (MCA) peak systolic velocity and fetal haemoglobin in women at risk of fetal anaemia. Methods Forty-one measurements of MSAFP were carried out in 22 women at risk of fetal anaemia (16 alloimmunised patients and 6 cases of parvovirus infection) who were monitored by using MCA Doppler measurements. The relationships between MSAFP (MoM) and both MCA peak systolic velocity (z -scores) and fetal haemoglobin (MoM) were studied. Results There were significant correlations between MSAFP and both MCA Doppler measurements (r = 0.56, p = 0.00017) and fetal haemoglobin (n = 13, r = ,0.71, p = 0.006). MSAFP was higher in cases with fetal anaemia (n = 10) than in those with normal haemoglobin levels (n = 3) (1.7 ± 0.4 vs 0.8 ± 0.1 MoM; p = 0.006). In cases of alloimmunised pregnancies with fetal anaemia, MSAFP elevations preceded the presence of increased MCA Doppler velocity by 2.7 weeks (range 0,9 weeks). Conclusion MSAFP is significantly correlated with both MCA Doppler measurements and fetal haemoglobin. Elevations of MSAFP may appear earlier than MCA Doppler abnormalities in cases of fetal anaemia associated with red blood cell alloimmunisation. Copyright © 2006 John Wiley & Sons, Ltd. [source]

Thrombocytopenia in hydropic fetuses with parvovirus B19 infection: incidence, treatment and correlation with fetal B19 viral load

BJOG : AN INTERNATIONAL JOURNAL OF OBSTETRICS & GYNAECOLOGY, Issue 1 2008
TR De Haan
Objective, To examine (1) the incidence of fetal thrombocytopenia in hydropic fetuses with congenital B19 virus infection, (2) the effect of intrauterine platelet transfusions and (3) the correlation between fetal B19 viral load and severity of thrombocytopenia. Design, Retrospective analysis of data from prospectively collected fetal blood samples. Setting, Leiden University Medical Centre, the national centre for management of intrauterine fetal disease in the Netherlands. Population, Thirty hydropic fetuses treated with intrauterine red blood cell and platelet transfusions for human B19 virus-induced severe fetal anaemia and thrombocytopenia over a 10-year period. Methods, Fetal blood samples (n= 30) taken before and after intrauterine transfusion were investigated. No cases were excluded, and there was no loss to follow up. Main outcome measures, Parameters recorded were gestational age, experienced fetal movements, gravidity and parity, severity of fetal hydrops, severity of fetal anaemia and thrombocytopenia and megakaryocyte and reticulocyte counts. Survival and procedure-associated complications were documented. Quantitative B19 viral load measurements were performed on all fetal samples. Results, Forty-six percent of all hydropic fetuses showed severe thrombocytopenia. No antenatal intracerebral haemorrhage or procedure-associated bleeding occurred. Overall, survival was 77%. Platelet counts increased following platelet transfusion and decreased significantly following red blood cell transfusion alone. No correlation was found between fetal viral loads and platelet counts. Conclusion, Thrombocytopenia was frequently encountered in fetal B19V infection, but fetal bleeding complications were not noted. Absence of a direct relationship between fetal B19 viral load and platelet counts suggests a temporal dissociation between these findings. Dilutional thrombocytopenia is frequently seen in the fetus following red blood cell transfusion alone. The clinical significance of this phenomenon is unclear. The risk of fluid overload by fetal platelet transfusion in a severely hydropic fetus should be weighed against the low incidence of fetal bleeding complications. [source]