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Fertile Ground (fertile + ground)
Selected AbstractsOn Fertile Ground: A Natural History of Human ReproductionAMERICAN ANTHROPOLOGIST, Issue 2 2002Nadine R. Peacock On Fertile Ground:. Natural History of Human Reproduction. Peter T. Ellison. Cambridge, MA: Harvard University Press, 2001. 358 pp. [source] Alcohol marketing on the internet: new challenges for harm reductionDRUG AND ALCOHOL REVIEW, Issue 1 2002TOM E. CARROLL While much has been made of the problems of regulating alcohol and other drug promotion in the traditional media of print, radio and newspapers, the ,new media' and in particular the world wide web, provides new fertile ground for alcohol advertisers. In this Harm Reduction Digest Tom Carroll and Rob Donovan apply the voluntary standards of the Alcohol Beverages Advertising Code to six websites for alcohol products available in Australia. They conclude that the internet provides an opportunity for alcohol marketing targeted at underage consumers, that some alcohol-related web pages would be in breach of the Code if it applied to the internet, and suggest that web marketing practices of alcohol beverage companies should be monitored and a code of practice developed to regulate alcohol promotion on the web. [source] Capillary Force Lithography: A Versatile Tool for Structured Biomaterials Interface Towards Cell and Tissue Engineering,ADVANCED FUNCTIONAL MATERIALS, Issue 17 2009Kahp-Yang Suh Abstract This Feature Article aims to provide an in-depth overview of the recently developed molding technologies termed capillary force lithography (CFL) that can be used to control the cellular microenvironment towards cell and tissue engineering. Patterned polymer films provide a fertile ground for controlling various aspects of the cellular microenvironment such as cell,substrate and cell,cell interactions at the micro- and nanoscale. Patterning thin polymer films by molding typically involves several physical forces such as capillary, hydrostatic, and dispersion forces. If these forces are precisely controlled, the polymer films can be molded into the features of a polymeric mold with high pattern fidelity and physical integrity. The patterns can be made either with the substrate surface clearly exposed or unexposed depending on the pattern size and material properties used in the patterning. The former (exposed substrate) can be used to adhere proteins or cells on pre-defined locations of a substrate or within a microfluidic channel using an adhesion-repelling polymer such as poly(ethylene glycol) (PEG)-based polymer and hyaluronic acid (HA). Also, the patterns can be used to co-culture different cells types with molding-assisted layer-by-layer deposition. In comparison, the latter (unexposed substrate) can be used to control the biophysical surrounding of a cell with tailored mechanical properties of the material. The surface micropatterns can be used to engineer cellular and multi-cellular architecture, resulting in changes of the cell shape and the cytoskeletal structures. Also, the nanoscale patterns can be used to affect various aspects of the cellular behavior, such as adhesion, proliferation, migration, and differentiation. [source] Regional Devolution and Regional Economic Success: Myths and Illusions about PowerGEOGRAFISKA ANNALER SERIES B: HUMAN GEOGRAPHY, Issue 2 2006Ray Hudson Abstract The proposition that regional devolution in and of itself will lead to economic success has become deeply embedded in beliefs and policy discourses about the determinants of regional prosperity, and in turn has led to political demands for such devolution. In this paper I seek critically to examine such claims, using the case of the north-east of England as the setting for this examination. The paper begins with some introductory comments on concepts of power, regions, the reorganization of the state and of multi-level governance, and governmentality, which help in understanding the issues surrounding regional devolution. I then examine the ways in which north-east England was politically and socially constructed as a particular type of region, with specific problems, in the 1930s , a move that has had lasting significance up until the present day. Moving on some six decades, I then examine contemporary claims about the relationship between regional devolution and regional economic success, which find fertile ground in the north-east precisely due to its long history of representation as a region with a unified regional interest. I then reflect on the processes of regional planning, regional strategies and regional devolution, and their relationship to regional economic regeneration. A brief conclusion follows, emphasizing that questions remain about the efficacy of the new governmentality and about who would be its main beneficiaries in the region. The extent to which devolution would actually involve transferring power to the region and the capacity of networked forms of power within the region to counter the structural power of capital and shape central state policies remains unclear. [source] Geographical Imaginations of ,New Asia-Singapore'GEOGRAFISKA ANNALER SERIES B: HUMAN GEOGRAPHY, Issue 3 2004T.C. Chang Abstract ,Geographical imaginations' constitute an important aspect in geographic research, enriching our understanding of places and societies as well as the contested meanings people have towards spaces. The marketing and development of tourist destinations offers a fertile ground for the exercise of geographical imagination. This paper explores how tourism marketing distils the essence of a place, and ,imagines' an identity that is attractive to tourists and residents alike. Such spatial identities, however, are seldom hegemonic and are often highly contested. Using the case of the ,New Asia-Singapore' (NAS) campaign launched by the Singapore Tourism Board, we explore the geographical imaginations involved in tourism marketing, and its consequent effects on people and place. Specifically we discuss the role and rationale of tourism planners in formulating the NAS campaign; the actions of tourism entrepreneurs in creating NAS commodities; and the reactions from tourists and local residents towards the NAS images. We argue that the nexus of policy intent, entrepreneurial actions and popular opinions yields invaluable insights into the highly contested processes of tourism development and identity formation. [source] Decolonising, Multiplicities and Mining in the Eastern Goldfields, Western AustraliaGEOGRAPHICAL RESEARCH, Issue 1 2003Leah M. Gibbs In this ,postcolonial' era, peoples and places around the globe continue to face ongoing colonisation. Indigenous peoples in particular experience colonisation in numerous forms. Despite recent attempts to ,decolonise' indigenous spaces, hegemonic systems of production, governance and thinking often perpetuate colonial structures and relationships, resulting in further entrenched colonisation or ,deep colonising' (Rose, 1999). The interface between indigenous communities and the mining industry provides fertile ground for the tensions emerging between decolonising and deep colonising. Gold mining operations at Placer Dome's Granny Smith mine in the Eastern Goldfields of Western Australia present a valuable case study for examining this tension. Changes taking place at the mine site are decolonising in intent, though outcomes may be deep colonising in effect. Recent discussions among cultural geographers over meanings of place, Ollman's (1993) notion of vantage point and a broadly postcolonial literature inform consideration of this tension. Acknowledgment and incorporation of multiple vantage points into new resource management systems allows current hegemonic approaches to be rethought, and provides insights for the shift towards genuinely decolonising processes. [source] Won't Get Fooled Again: The Paranoid Style in the National Security State1GOVERNMENT AND OPPOSITION, Issue 4 2003Thomas C. Ellington In meeting the threat posed by terrorism, the democratic state also faces a paradox: those practices best suited to defending the state are often least suited to democracy. Such is the case with official secrecy, which has received renewed attention. Military and intelligence operations frequently depend on secrecy for their success. At the same time, democracy depends on openness, a fact too often neglected by democratic theory. Official secrecy subverts citizen autonomy and in so doing creates fertile ground for paranoid-style thinking. For the United States, a history of secrets and lies has left a legacy of distrust and paranoia. [source] Neosecularization and Craft Versus Professional Religious Authority in a Nonreligious OrganizationJOURNAL FOR THE SCIENTIFIC STUDY OF RELIGION, Issue 3 2003Don Grant At the same time many religious organizations are apparently becoming more internally secularized, other nonreligious organizations appear to be going through a countervailing process of "sacralization" (Demerath). This study explores this development through a case study of a state university hospital that attempted to created a more "holistic" corporate culture. Extending research on the declining scope of religious authority (Chaves) and professional systems (Abbott), this study suggests that secular settings may be fertile ground for craft versions of religious authority to develop. Implications of the latter during an age when authority structures and caring tasks in general are being downsized and devolved are discussed. [source] The pharmacology and epidemiology of post-market surveillance for suicide: the case of gabapentinJOURNAL OF PHARMACEUTICAL HEALTH SERVICES RESEARCH, Issue 2 2010Jill E. Lavigne Abstract Objectives, To describe the challenges in measurement of suicidal thoughts and behaviours and any causal relationship to prescription drug exposures. Recent US Food and Drug Administration (FDA) investigations of potential provocation of suicidal ideation and behaviour have led to black-box warnings of suicidal thoughts and behaviour on drugs ranging from smoking cessation to urinary incontinence agents. We describe the challenges faced in studying the effects of specific drug exposures on suicidal thoughts and behaviours using gabapentin (Neurontin) as an example because it has been implicated by the FDA as a drug that may induce suicidal thoughts or behaviours, offers more than 20 diverse indications including several known to be associated with an increase in suicide risk, and derives its clinical effect from 2 divergent mechanisms. Key findings, Gabapentin has two primary mechanisms: GABAergic neurotransmission and interruption of sodium and calcium channels. An increase in GABAergic neurotransmission is expected to improve anxiety and essential tremor, but to have no effect on pain, specifically migraine and neuropathic pain. Improvements in pain after gabapentin exposure are likely the result of the interruption of calcium and sodium channels. Neither mechanism is expected to affect bipolar disorder or schizophrenia, serious mental illnesses associated with a risk of suicide. Conclusions, These two independent mechanisms are expected to have mutually exclusive effects on a wide range of indications, only some of which are associated with increased risk of suicide. This very complexity and heterogeneity may present fertile ground for research aimed at not only improving our understanding of drug action, but also at expanding our knowledge of suicidal thoughts and behaviours. [source] Using economic concepts in institutional research on higher education costsNEW DIRECTIONS FOR INSTITUTIONAL RESEARCH, Issue 132 2006Paul T. BrinkmanArticle first published online: 14 MAR 200 Economics provides fertile ground, both theoretical and empirical, for institutional researchers interested in higher education costs. [source] Is there a trade-off between fertility and longevity?AMERICAN JOURNAL OF HUMAN BIOLOGY, Issue 4 2009A comparative study of women from three large historical databases accounting for mortality selection Frontier populations provide exceptional opportunities to test the hypothesis of a trade-off between fertility and longevity. In such populations, mechanisms favoring reproduction usually find fertile ground, and if these mechanisms reduce longevity, demographers should observe higher postreproductive mortality among highly fertile women. We test this hypothesis using complete female reproductive histories from three large demographic databases: the Registre de la population du Québec ancien (Université de Montréal), which covers the first centuries of settlement in Quebec; the BALSAC database (Université du Québec à Chicoutimi), including comprehensive records for the Saguenay-Lac-St-Jean (SLSJ) in Quebec in the nineteenth and twentieth centuries; and the Utah Population Database (University of Utah), including all individuals who experienced a vital event on the Mormon Trail and their descendants. Together, the three samples allow for comparisons over time and space, and represent one of the largest set of natural fertility cohorts used to simultaneously assess reproduction and longevity. Using survival analyses, we found a negative influence of parity and a positive influence of age at last child on postreproductive survival in the three populations, as well as a significant interaction between these two variables. The effect sizes of all these parameters were remarkably similar in the three samples. However, we found little evidence that early fertility affects postreproductive survival. The use of Heckman's procedure assessing the impact of mortality selection during reproductive ages did not appreciably alter these results. We conclude our empirical investigation by discussing the advantages of comparative approaches. Am. J. Hum. Biol., 2009. © 2009 Wiley-Liss, Inc. [source] On fertile ground: A natural history of human reproductionAMERICAN JOURNAL OF HUMAN BIOLOGY, Issue 4 2002Michael GrimesArticle first published online: 21 JUN 200 No abstract is available for this article. [source] Social Influence on Political Judgments: The Case of Presidential DebatesPOLITICAL PSYCHOLOGY, Issue 2 2007Steven Fein Four experiments investigated the extent to which judgments of candidate performance in presidential debates could be influenced by the mere knowledge of others' reactions. In Experiments 1 and 2 participants watched an intact version of a debate or an edited version in which either "soundbite" one-liners or the audience reaction to those soundbites were removed. In Experiment 3 participants saw what was supposedly the reaction of their fellow participants on screen during the debate. Participants in Experiment 4 were exposed to the reactions of live confederates as they watched the last debate of an active presidential campaign. In all studies, audience reactions produced large shifts in participants' judgments of performance. The results illustrate the power of social context to strongly influence individuals' judgments of even large amounts of relevant, important information, and they support the categorization of presidential debates as ambiguous stimuli, fertile ground for informational social influence. [source] Faith and Reason: Schiller's "Die Sendung Moses"THE GERMAN QUARTERLY, Issue 3 2008Alexander Mathäs In Schiller's re-interpretation of Moses' life, Moses becomes the archetypical poet/writer who, like Schiller himself, was committed to converting his audience to "truth" by appealing to their base instincts and ingrained habits. In "Die Sendung Moses" Schiller uses a widely known biblical source to reinterpret the beginnings of monotheist religion in a way that supports his Enlightenment anthropology. The question is whether Schiller's elevation of reason to the status of a Vernunftreligion prepares the path for the tyranny of reason, and whether the concomitant devaluation of "bare life" (Agamben) paves the way for a political theology that justifies human sacrifice in the name of ethical ideals, thus creating a fertile ground for nineteenth-century imperialist and, even worse, racist fantasies. My reading of "Die Sendung Moses" suggests that while Schiller seems to favor an abstract universal truth over and against the particular rights of individuals, the text shows also the price that this favoring exacts from the individual and thus points to Schiller's own struggle with the Enlightenment's coercive potential. [source] Imaging the future of stroke: I. Ischemia,ANNALS OF NEUROLOGY, Issue 5 2009David S. Liebeskind MD Envisioning the future of stroke appears daunting considering the milestones already achieved in stroke imaging. A historical perspective on the developments in stroke care provides a striking narrative of how imaging has transformed diagnosis, therapy, and prognosis of cerebrovascular disorders. Multimodal imaging techniques such as CT and MRI, incorporating parenchymal depictions, illustration of the vasculature, and perfusion data, can provide a wealth of information regarding ischemic pathophysiology. Key elements of ischemic pathophysiology depicted with imaging include vascular occlusion, compensatory collateral flow, resultant hemodynamic conditions that reflect these sources of blood flow, and the neurovascular injury that ensues. The mantra of "time is brain" has been perpetuated, but this does not provide an entirely accurate reflection of ischemic pathophysiology and imaging insight shows far more than time alone. Maximizing the potential of perfusion imaging will continue to expand the nascent concept that cerebral ischemia may be completely reversible in certain scenarios. Novel modalities provide a fertile ground for discovery of therapeutic targets and the potential to assess effects of promising strategies. Beyond clinical trials, imaging has become a requisite component of the neurological examination enabling tailored stroke therapy with the use of detailed neuroimaging modalities. In this first article on ischemia, the focus is on the most recent imaging advances and exploring aspects of cerebral ischemia where imaging may yield additional therapeutic strategies. A subsequent article will review recent and anticipated imaging advances in hemorrhage. These thematic overviews underscore that imaging will undoubtedly continue to dramatically shape the future of stroke. Ann Neurol 2009;66:574,590 [source] Asian social psychology: Achievements, threats, and opportunitiesASIAN JOURNAL OF SOCIAL PSYCHOLOGY, Issue 1 2007Kwok Leung A scan of citation impact suggests that Asian social psychologists have made significant contributions in three areas: indigenous research, culture and social behaviour, and in several topics in social psychology. An analysis of the most cited articles published in Asian Journal of Social Psychology (AJSP) in 1998,2002 in March 2005 reveals that most papers are concerned with culture, with a focus on either popular topics in the West or indigenous concepts. Asian social psychology seems to be closely associated with cultural issues, but it still lacks unique theoretical contributions, and the number of internationally visible scholars is limited and is mostly confined to East Asia. However, Asian cultures provide a fertile ground for identifying new constructs. Many Asian universities are now under pressure to internationalize, which will motivate more academics to participate in Asian conferences and publish in AJSP. To develop Asian social psychology, effort should be focused on nurturing the next generation of Asian social psychologists, who not only need an international perspective, but also ambition and creativity. [source] Comparative insect developmental genetics: phenotypes without mutantsBIOESSAYS, Issue 5 2001Rob Denell The last decade has seen a dramatic increase in interest in the extent to which morphological evolution depends on changes in regulatory pathways. Insects provide a fertile ground for study because of their diversity and our high level of understanding of the genetic regulation of development in Drosophila melanogaster. However, comparable genetic approaches are presently possible in only a small number of non-Drosophilid insects. In a recent paper, Hughes and Kaufman(1) have used a new methodology, RNA interference, in the milkweed bug, Oncopeltus fasciatus, to phenocopy the effects of mutations in Hox genes. RNA interference involves the injection of double-stranded RNA of the same sequence as the relevant mRNA resulting in a depletion of that transcript.(2) Hughes and Kaufman focused on the gnathal segments, which elaborate specialized appendages important to feeding. Their results indicate that gnathal adaptations in this bug are correlated with changes in Hox gene functions and interactions. BioEssays 23:379,382, 2001. © 2001 John Wiley & Sons, Inc. [source] Leading the democratic enterpriseBUSINESS STRATEGY REVIEW, Issue 4 2003Lynda Gratton Over the last decade the forces of globalisation, competition and ever more demanding customers have made many companies flatter, less hierarchical, more fluid and more virtual. Lynda Gratton believes that the breakdown of hierarchies and the new approaches within such companies as BT, BP Amoco, Goldman Sachs, McKinsey and Sony provide us with fertile ground on which to create a more democratic way of working. This requires leaders to take on radically new roles. [source] A Transaction Cost Primer on Farm OrganizationCANADIAN JOURNAL OF AGRICULTURAL ECONOMICS, Issue 4 2000Douglas W. Allen Agricultural economists, with their knowledge of farming, are well positioned to take advantage of the fertile ground of economic organization. The transaction cost paradigm is particularly useful in addressing such questions and is outlined in this paper. The overriding theme in the transaction cost approach is that patterns of ownership and contracts are chosen to mitigate transaction costs, which result from attempts to establish and maintain property rights. In agriculture, transaction costs are heavily influenced by Mother Nature. Nature's uncertainty, via weather and pests, leads to moral hazard and seasonal forces impose constraints on production cycles that are not often found in the production of most other commodities. Applications in land contracts, asset control, and business organization are discussed. [source] Profiles in Patient Safety: A "Perfect Storm" in the Emergency DepartmentACADEMIC EMERGENCY MEDICINE, Issue 8 2007CCFP(EM), Samuel G. Campbell MB Correct and rapid diagnosis is pivotal to the practice of emergency medicine, yet the chaotic and ill-structured emergency department environment is fertile ground for the commission of diagnostic error. Errors may result from specific error-producing conditions (EPCs) or, more frequently, from an interaction between such conditions. These EPCs are often expedient and serve to shorten the decision making process in a high-pressure environment. Recognizing that they will inevitably exist, it is important for clinicians to understand and manage their dangers. The authors present a case of delayed diagnosis resulting from the interaction of a number of EPCs that produced a "perfect" situation to produce a missed or delayed diagnosis. They offer practical suggestions whereby clinicians may decrease their chances of becoming victims of these influences. [source] Telomere DNA content and allelic imbalance demonstrate field cancerization in histologically normal tissue adjacent to breast tumorsINTERNATIONAL JOURNAL OF CANCER, Issue 1 2006Christopher M. Heaphy Abstract Cancer arises from an accumulation of mutations that promote the selection of cells with progressively malignant phenotypes. Previous studies have shown that genomic instability, a hallmark of cancer cells, is a driving force in this process. In the present study, two markers of genomic instability, telomere DNA content and allelic imbalance, were examined in two independent cohorts of mammary carcinomas. Altered telomeres and unbalanced allelic loci were present in both tumors and surrounding histologically normal tissues at distances at least 1 cm from the visible tumor margins. Although the extent of these genetic changes decreases as a function of the distance from the visible tumor margin, unbalanced loci are conserved between the surrounding tissues and the tumors, implying cellular clonal evolution. Our results are in agreement with the concepts of "field cancerization" and "cancer field effect," concepts that were previously introduced to describe areas within tissues consisting of histologically normal, yet genetically aberrant, cells that represent fertile grounds for tumorigenesis. The finding that genomic instability occurs in fields of histologically normal tissues surrounding the tumor is of clinical importance, as it has implications for the definition of appropriate tumor margins and the assessment of recurrence risk factors in the context of breast-sparing surgery. © 2006 Wiley-Liss, Inc. [source] | |||||||||||||||||||||||||||||||||||||