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Favourable Results (favourable + result)
Selected AbstractsGuidelines for practical use of MAL-PDT in non-melanoma skin cancerJOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY & VENEREOLOGY, Issue 5 2010E Christensen Abstract Methyl aminolaevulinate photodynamic therapy is increasingly practiced in the treatment of actinic keratoses, Bowen's disease and basal cell carcinomas. This method is particularly suitable for treating multiple lesions, field cancerization and lesions in areas where a good cosmetic outcome is of importance. Good treatment routines will contribute to a favourable result. The Norwegian photodynamic therapy (PDT) group consists of medical specialists with long and extensive PDT experience. With support in the literature, this group presents guidelines for the practical use of topical PDT in non-melanoma skin cancer. [source] Teaching the Fuzzy Front End of Innovation: Experimenting with Team Learning and Cross-Organizational IntegrationCREATIVITY AND INNOVATION MANAGEMENT, Issue 3 2009Miia Martinsuo How can the extremely uncertain front end of innovation , managing the fuzzy front end , be taught to graduate students? This paper describes and analyses experiments with experiential, problem-based learning focused on the front end of innovation. The focus is on the learning and cross-organizational integration of student teams; factors that have been identified as central to the success of teams involved in the front end of innovation. An experiential course, ,From an idea to a business plan in product development', was developed in conjunction with an actual company, and piloted with four student groups in 2007 and 2008. Data on this novel course were collected through participant observation, team self-assessment and questionnaires. This paper reports favourable results for the effectiveness of the course design; it discusses the impact of team size and cross-organizational team composition on team performance; and identifies the implications for teaching the front end of innovation. [source] Populating the Galaxy with low-mass X-ray binariesMONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, Issue 3 2006Paul D. Kiel ABSTRACT We perform binary population-synthesis calculations to investigate the incidence of low-mass X-ray binaries (LMXBs) and their birth rate in the Galaxy. We use a binary-evolution algorithm that models all the relevant processes including tidal circularization and synchronization. Parameters in the evolution algorithm that are uncertain and may affect X-ray binary formation are allowed to vary during the investigation. We agree with previous studies that under standard assumptions of binary evolution the formation rate and number of black hole (BH) LMXBs predicted by the model are more than an order of magnitude less than what is indicated by observations. We find that the common-envelope process cannot be manipulated to produce significant numbers of BH LMXBs. However, by simply reducing the mass-loss rate from helium stars adopted in the standard model, to a rate that agrees with the latest data, we produce a good match to the observations. Including LMXBs that evolve from intermediate-mass systems also leads to favourable results. We stress that constraints on the X-ray binary population provided by observations are used here merely as a guide as surveys suffer from incompleteness and much uncertainty is involved in the interpretation of results. [source] Glycoproteomics of N -glycosylation by in-gel deglycosylation and matrix-assisted laser desorption/ionisation-time of flight mass spectrometry mapping: Application to congenital disorders of glycosylationPROTEINS: STRUCTURE, FUNCTION AND BIOINFORMATICS, Issue 10 2005Dijana Abstract A general strategy for the structural evaluation of N -glycosylation, a common post-translational protein modification, is presented. The methods for the release of N -linked glycans from the gel-separated proteins, their isolation, purification and matrix-assisted laser desorption/ionisation-mass spectrometry (MALDI-MS) analysis of their mixtures were optimised. Since many glycoproteins are available only at low quantities from sodium dodecyl sulphate-polyacrylamide gel electrophoresis or two-dimensional gels, high attention was paid to obtain N -glycan mixtures representing their actual composition in human plasma by in-gel deglycosylation. The relative sensitivity of solid MALDI matrices for MS analysis of acidic N -glycans was compared. The most favourable results for native acidic N -glycans were obtained with 2,4,6-trihydroxyacetophenone monohydrate/diammoniumcitrate as a matrix. This matrix provided good results for both neutral and acidic mixtures as well as for methylated N -glycans. In the second part of this paper the potential of such an optimised MS strategy alone or in combination with high pH anion-exchange chromatography profiling for the clinical diagnosis of congenital disorders of glycosylation is presented. [source] The Diamedica Draw-Over Vaporizer: a comparison of a new vaporizer with the Oxford Miniature VaporizerANAESTHESIA, Issue 1 2009W. A. English Summary The Diamedica Draw-Over Vaporizer (DDV) has been developed as an alternative to the Oxford Miniature Vaporizer (OMV). Both can function as draw-over or plenum vaporizers. The performances of these two vaporizers were compared under conditions simulating intermittent positive pressure ventilation (IPPV) and continuous flow (CF). Series 1 experiments were conducted with the vaporizers in water baths at 20, 25 and 30 °C. Vaporizers were tested at dial settings of 1,4% over a range of minute volumes (1.75,6 l.min,1) and flow rates (3,8 l.min,1). Series 2 experiments compared output of the vaporizers over time at ambient temperatures of 20, 25 and 30 °C. A minute volume of 6 l.min,1 (IPPV) and a gas flow of 8 l.min,1 (CF) were used with a vaporizer setting of 2%. Vapour concentrations were recorded at 5-min intervals. In series 1 IPPV experiments, the DDV vaporizer was more accurate, producing significantly fewer vapour concentrations 0.5% more than or less than setting (p = 0.013). The OMV tended to produce more favourable results under continuous flow (p = 0.42). In series 2 experiments, the accuracy of both vaporizers was similar but consistency of output over time was better for the DDV and consistency of output according to differences in ambient temperature was better for the DDV. The OMV produced more vapour concentrations that were markedly higher than dial setting, particularly at high ambient temperatures. The DDV is a suitable alternative to the OMV with some distinct advantages. These include a larger reservoir, tendency towards greater accuracy during IPPV and improved consistency of output. [source] Expanded PTFE bladder neck slings for incontinence in children: the long-term outcomeBJU INTERNATIONAL, Issue 1 2004P. Godbole OBJECTIVE To assess the long-term outcome of circumferential expanded PTFE (Gore-texTM, WL Gore Associates, Scotland) bladder neck slings for achieving urethral continence in children with a neuropathic bladder. PATIENTS AND METHODS The records were reviewed of 19 children undergoing bladder reconstruction (most with a neuropathic bladder) who had a Gore-tex sling placed circumferentially at the bladder neck, over a 5-year period. Of these, seven had spina bifida; two each spinal dysraphism, surgery for anorectal anomalies and an idiopathic neuropathic bladder; five who developed a neuropathic bladder from other causes, and one born with bladder exstrophy. All children had an uncompliant bladder with a low urethral leak-point pressure on preoperative urodynamics. In all children conventional clean intermittent catheterization and pharmacotherapy had failed. Four had had previous augmentation surgery while 15 had concomitant bladder augmentation and formation of a Mitrofanoff stoma. The main outcome measure was achieving dryness. The original intention of the procedure was also to maintain urethral catheterization. RESULTS Full details of the follow-up were available in 17 patients. Despite initial good short-term results, at a median follow up of 7 years, in 14 patients the sling had to be removed because of erosion, often with transient urethral leakage before the bladder neck subsequently closed. A bladder calculus was associated with each case of erosion except one. CONCLUSION Although in the short term this technique had favourable results, it was not a useful technique in the long term. [source] Accuracy of a newly developed integrated system for dental implant planningCLINICAL ORAL IMPLANTS RESEARCH, Issue 11 2009Timo Dreiseidler Abstract Objectives: To evaluate the accuracy of the first integrated system for cone-beam CT (CBCT) imaging, dental implant planning and surgical template-aided implant placement. Materials and methods: On the basis of CBCT scans, a total of 54 implant positions were planned for 10 partially edentulous anatomical patient-equivalent models. Surgical guides were ordered from the manufacturer (SICAT). Two different types of guidance were assessed: for assessment of the SICAT system inherent accuracy vendor's titanium sleeves of 2 mm internal diameter and 5 mm length were utilized for pilot drills. The guide sleeves of the NobelGuide system were implemented for fully guided surgery and implant insertion. Deviations perpendicular to the implant axes at the crestal and apical end, as well as the angle deviations between the virtual planning data and the surgical results, were measured utilizing a follow-up CBCT investigation and referential marker-based registration. Results: The SICAT system inherent mean deviation rates for the drilled pilot osteotomies were determined to be smaller than 500 ,m even at the apical end. Mean angle deviations of 1.18° were determined. Utilizing the NobelGuide sleeve-in-sleeve system for fully guided implant insertion in combination with the investigated template technology enabled to insert dental implants with the same accuracy. Crestal deviations, in general, were significantly lower than the apical deviations. Conclusion: Although hardly comparable due to different study designs and measurement strategies, the investigated SICAT system's inherent accuracy corresponds to the most favourable results for computer-aided surgery systems published so far. In combination with the NobelGuide surgical set for fully guided insertion, the same accuracy level could be maintained for implant positioning. [source] | ||||||||||