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Fat Gain (fat + gain)
Selected AbstractsHormone Replacement Therapy Dissociates Fat Mass and Bone Mass, and Tends to Reduce Weight Gain in Early Postmenopausal Women: A Randomized Controlled 5-Year Clinical Trial of the Danish Osteoporosis Prevention Study,JOURNAL OF BONE AND MINERAL RESEARCH, Issue 2 2003LB Jensen MD Abstract The aim of this study was to study the influence of hormone replacement therapy (HRT) on weight changes, body composition, and bone mass in early postmenopausal women in a partly randomized comprehensive cohort study design. A total of 2016 women ages 45,58 years from 3 months to 2 years past last menstrual bleeding were included. One thousand were randomly assigned to HRT or no HRT in an open trial, whereas the others were allocated according to their preferences. All were followed for 5 years for body weight, bone mass, and body composition measurements. Body weight increased less over the 5 years in women randomized to HRT (1.94 ± 4.86 kg) than in women randomized to no HRT (2.57 ± 4.63, p = 0.046). A similar pattern was seen in the group receiving HRT or not by their own choice. The smaller weight gain in women on HRT was almost entirely caused by a lesser gain in fat. The main determinant of the weight gain was a decline in physical fitness. Women opting for HRT had a significantly lower body weight at inclusion than the other participants, but the results in the self-selected part of the study followed the pattern found in the randomized part. The change in fat mass was the strongest predictor of bone changes in untreated women, whereas the change in lean body mass was the strongest predictor when HRT was given. Body weight increases after the menopause. The gain in weight is related to a decrease in working capacity. HRT is associated with a smaller increase in fat mass after menopause. Fat gain protects against bone loss in untreated women but not in HRT-treated women. The data suggest that women's attitudes to HRT are more positive if they have low body weight, but there is no evidence that the conclusions in this study are skewed by selection bias. [source] Variation analysis of ,3 -adrenergic receptor and melanocortin-4 receptor genes in childhood obesityPEDIATRICS INTERNATIONAL, Issue 2 2007TOMOE KINOSHITA Abstract Background: Decreased energy expenditure and increased food intake are principal causes for obesity. In the present study, genotypes of ,3 -adrenergic receptor (,3AR) and of melanocortin-4 receptor (MC4R), both of which are believed to have a close link to the cause of obesity, were analyzed and compared with phenotypes of childhood obesity. Methods: Thirty-five obese children with moderate to severe obesity were enrolled. Direct sequencing of the MC4R coding region and pinpoint-polymerase chain reaction were used to detect genomic variation in the ,3AR gene using peripheral blood-derived DNA. Results: Allele frequency of Trp64Arg variation in the ,3AR gene in the obese subjects was 0.16, which is comparable with that in the healthy general population in eastern Asia. Comparison of phenotypical characteristics did not show a significant difference between Trp/Trp and Trp/Arg subjects. It was notable that body height SD was significantly higher in the Trp/Trp than the Trp/Arg subjects (0.93 ± 1.0 SD vs 0.07 ± 1.3 SD, P= 0.03). Annual weight gains were far beyond a hypothetical fat gain in an Arg64 heterozygote with decreased energy consumption, suggesting increased food intake in childhood obesity. There was, however, no variation in the MC4R gene despite thorough sequencing of the entire coding region. Conclusions: The Trp64Arg variation in the ,3AR gene has no relationship to the degree or the incidence of childhood obesity. The majority of childhood obesity can be characterized as tall stature, more rapid weight gain than that expected by decreased energy expenditure. Further investigation is necessary in regard to the increased food intake as a major cause of childhood obesity. [source] Moderate,vigorous physical activity and body fatness in Chinese urban school childrenPEDIATRICS INTERNATIONAL, Issue 2 2007LIUBAI LI Abstract Background: The exact relation between moderate,vigorous physical activity (MVPA) and body fatness in children has yet to be fully defined. This study examined the relationship between MVPA and body fatness in Chinese urban school children aged 9,11 years, in an 8 month longitudinal study. Methods: Two hundred and ten children (aged 9,11 years; 97 boys and 113 girls) were recruited from two public primary schools in the Beijing urban area. The baseline and the 8 month follow-up percent body fat (fat%), fat mass (FM), body mass index (BMI), waist size, hip size and the waist : hip ratio were investigated as measures of body fatness. Habitual MVPA level (activity-related energy expenditure, AEE) was measured using a validated self-report questionnaire recall. Results: Nine-year-old girls who were in the top quartile for MVPA had significantly lower fat% than other girls at the same age (P < 0.05); 10,11-years girls who were in the top quartile for MVPA had significantly less increase in all of the indices of body fatness (P < 0.05). There was no difference in fat% between the highly physically active (top quartile for MVPA) and less active 9,11 year boys in both cross-sectional and longitudinal statistical analyses. Conclusions: Highly physically active girls had lower fat% and less increase in body fatness. In light of world trends showing increasing childhood obesity, this study supports the hypothesis that MVPA might be effective in fighting excess body fat gain in Chinese school-age girls. [source] Body fat composition and weight changes during pregnancy and 6,8 months post-partum in primiparous and multiparous womenAUSTRALIAN AND NEW ZEALAND JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Issue 1 2009William W. K. TO Objective:, To compare changes in maternal weight and body fat composition from early to late pregnancy and 6,8 months postnatally between primiparous and multiparous patients Methods:, Maternal weight and body fat percentage were assessed in a cohort of low-risk uncomplicated women in a general antenatal clinic at 14,20 weeks gestation, after 36 weeks, and around six to eight months after delivery using a Tanita TBF 105 Fat Analyser. Maternal epidemiological and anthropometric data, as well as pregnancy characteristics and perinatal outcome, were derived from standard antenatal records after delivery. The cohort was stratified into primiparous and multiparous women for comparison. Results:, In a cohort of 104 women, 55 (52.8%) were primiparous and 49 (47.1%) were multiparous. A relatively good overall correlation between body fat percentage gain and weight gain was observed (correlation coefficient 0.33) from early to late pregnancy. Primiparous women had higher weight gain (12 kg) and higher body fat gain (7.7%) during the pregnancy compared to multiparous women (10.8 kg and 6%, respectively), and they also retained more of the fat accumulated during pregnancy (1.92% vs , 0.44%, P < 0.001) when assessed over six months after their delivery. Conclusion:, The findings could represent more exaggerated physiological responses to the pregnant state in the primiparous woman as compared to multiparous women. 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