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Family Study (family + study)
Selected AbstractsPartnership Instability and Child Well-BeingJOURNAL OF MARRIAGE AND FAMILY, Issue 4 2007Cynthia Osborne We use data from three waves of the Fragile Families Study (N= 2,111) to examine the prevalence and effects of mothers' partnership changes between birth and age 3 on children's behavior. We find that children born to unmarried and minority parents experience significantly more partnership changes than children born to parents who are married or White. Each transition is associated with a modest increase in behavioral problems, but a significant number of children experience 3 or more transitions. The association between instability and behavior is mediated by maternal stress and lower quality mothering. The findings imply that policies aimed at reducing maternal stress and partnership instability may improve child well-being. [source] Marriage following the birth of a child among cohabiting and visiting parentsJOURNAL OF MARRIAGE AND FAMILY, Issue 1 2005Cynthia Osborne Approximately half of nonmarital births are to mothers in cohabiting relationships, and an additional 30% are to mothers in visiting relationships. I use data (N= 1,945) from the Fragile Families Study to investigate whether the determinants of marriage in the year following a child's birth are similar for cohabiting and visiting parents. The results show that mothers' education is predictive of marriage for cohabiting parents, whereas mothers' earnings are predictive of marriage for visiting parents. The findings imply that visiting mothers place a greater emphasis on economic independence and sufficient resources to establish an independent household before transitioning to marriage. No differences in the association of relationship quality or attitudes and marriage are found. [source] Maternal Self-Report of Oral Health in 4-Year-Old Pacific Children from South Auckland, New Zealand: Findings from the Pacific Islands Families StudyJOURNAL OF PUBLIC HEALTH DENTISTRY, Issue 2 2007Philip J. Schluter PhD Abstract Objectives: To report on the oral health risk in a disadvantaged group of 4-year-old Pacific children and their mothers living in South Auckland, New Zealand. Methods: The Pacific Islands Families study follows a cohort of Pacific infants born in 2000. Maternal self-report of mother and child's oral health practices and child's filling and extraction experience was undertaken at interview approximately 4 years postpartum. Results: Overall, 1,048 mothers of children were interviewed. Children's reported oral health practices were generally poor, with 47 percent brushing ,1/day, 47 percent having no adult assistance with brushing, 57 percent routinely snacking or drinking immediately prior to bed, and 26 percent yet to receive their first dental checkup. Maternal practices were also poor, with 34 percent brushing ,1/day and 50 percent having never seen or last visiting a dentist over 5 years ago. Significant differences were seen in many practices between the major ethnic subgroups. Of children attending the school dental service, 22 percent were reported having at least one filling and/or extraction. In multivariable analyses, variables corresponding to mother's toothbrushing frequency, child snacking or drinking prior to bed, and duration of breastfeeding were significantly associated with reported filling and/or extraction experience; but no difference was seen between the three major maternal ethnic subgroups. Conclusions: Many mothers and their Pacific children have poor basic oral hygiene and dietary practices that increase the oral health risk in these children. Culturally appropriate and targeted strategies aimed at these modifiable practices need to be widely promoted so that the oral health burden carried by Pacific children can be reduced. [source] Pacific Islands Families Study: behavioral problems among two-year-old Pacific children living in New ZealandTHE JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY AND ALLIED DISCIPLINES, Issue 5 2007Janis Paterson Background:, The aim of this study was to determine (1) the prevalence of behavioral problems among two-year-old Pacific children living in New Zealand, (2) ethnic differences in behavioral problems, and (3) relationships between maternal and socio-demographic variables and problem child behavior. Methods:, Data were gathered from the Pacific Islands Families (PIF) Study. Mothers of a cohort of 1398 Pacific infants born in Auckland, New Zealand during 2000 were interviewed when the children were two years of age. Maternal reports (1028) of child behavior were obtained using the Child Behavior Checklist (CBCL). Results:, In the PIF cohort, 15.6% of children were in the clinical range with one or more deviant scores from the seven syndrome scales, and 14% were in the borderline range. The prevalence rate of internalizing problems was 17.1% in the clinical range and 8.9% in the borderline range. The prevalence rate of externalizing problems was 6.6% in the clinical range and 13.7% in the borderline range. The prevalence rate of total problems was 14.2% in the clinical range and 9.6% in the borderline range. Discipline and maternal education were significantly associated with elevated externalizing scores. Household size, maternal education, cultural orientation, and number of years living in New Zealand were significantly associated with internalizing scores. Child ethnicity was significantly associated with internalizing, externalizing and total problem behavior scores. In the clinical range, child ethnicity and gender were significantly associated with the prevalence of problem behavior. Conclusions:, Cross-ethnicity differences in CBCL scores were found, which illustrates the diversity in the Pacific population in New Zealand. Such findings highlight the way in which preschool behavior problems may vary within specific cultural settings and underscore the need for in-depth research to explore these unique contexts. [source] More Kin, Less Support: Multipartnered Fertility and Perceived Support Among MothersJOURNAL OF MARRIAGE AND FAMILY, Issue 1 2007Kristen Harknett Recent research has documented the high prevalence of having children with more than 1 partner, termed multipartnered fertility. Because childbearing is an important mechanism for building kin networks, we theorize that multipartnered fertility will influence the availability of social support for mothers. Analyzing 3 waves of data from the Fragile Families study (N = 12,259), we find that multipartnered fertility is negatively associated with the availability of financial, housing, and child-care support. Our longitudinal evidence suggests a bidirectional relationship in which multipartnered fertility reduces the availability of support, and the availability of support inhibits multipartnered fertility. We conclude that smaller and denser kin networks seem to be superior to broader, but weaker kin ties in terms of perceived instrumental support. [source] Infant care practices associated with sudden infant death syndrome: Findings from the Pacific Islands Families studyJOURNAL OF PAEDIATRICS AND CHILD HEALTH, Issue 5 2007Philip J Schluter Aim: To report infant care practice prevalence for known modifiable sudden infant death syndrome (SIDS) risk factors among a generally disadvantaged yet low-SIDS rate population of mothers with Pacific infants. Methods: The Pacific Islands Families study follows a cohort of Pacific infants born at a large tertiary hospital in South Auckland, between 15 March and 17 December 2000. Maternal self-report of infant care practices was undertaken at interview 6 weeks post-partum. Results: Overall, 1376 mothers self-reported upon their care practices for infants with median age of 7 weeks. Current maternal smoking was reported by 29%. Of infants: 50% were fully breastfed; 1% were placed prone to sleep; 50% usually bed-shared with their mother and 12% usually bed-shared with a mother who smoked; and 94% usually and 1% occasionally slept in the same room as their mother. Except for room sharing (P = 0.09), there were significant differences in these practices between the three major Pacific Island ethnic subgroups (all P < 0.001). Conclusion: Adoption of bed-sharing and room-sharing practices appears to be saving Pacific infants' lives, even though the New Zealand Cot Death Association has discouraged bed-sharing and not actively promoted room sharing. Mothers need to receive adequate information antenatally about the risks and benefits of room-sharing, bed-sharing and safe-sleeping practices and environments should they decide or have no option but to bed-share. [source] Cancer patterns in nasopharyngeal carcinoma multiplex families in TaiwanINTERNATIONAL JOURNAL OF CANCER, Issue 7 2009Kelly J. Yu Abstract Genetic and environmental factors have been implicated in the etiology of nasopharyngeal carcinoma (NPC), a tumor known to be closely associated with Epstein-Barr virus (EBV) infection. Studies have reported familial aggregation of NPC and have suggested the possible aggregation of NPC and other cancers. We evaluated familial aggregation of cancer in 358 high-risk families with two or more NPC cases enrolled in a NPC genetics study in Taiwan. Participants were linked to the Taiwan National Cancer Registry to identify incident cancers diagnosed after study enrollment (started in 1996) and before December 31, 2005, or death. In total, 2,870 individuals from the NPC Multiplex Family Study contributed 15,151 person-years over an average of 5.3 years of follow-up. One hundred ten incident cancers were identified. Multiple-primary standardized incidence ratios (MP-SIRs) were computed to evaluate overall cancer risk associated with infectious agents and with other tumors. The overall MP-SIR was 1.3 (95% CI: 1.1,1.6), which was largely explained by an excess in NPC (MP-SIR = 15; 95% CI: 10,23). Exclusion of incident NPC diagnoses led to an overall MP-SIR of 1.0 (95% CI: 0.83,1.3). Similarly, the observed excess risk of cancers associated with infectious agents (MP-SIR = 2.0; 95% CI: 1.5,2.6) was driven by the excess in NPC; exclusion of NPC cases led to a reduced MP-SIR that did not differ from 1.0. Analysis of the largest NPC multiplex family study to date confirms the presence of coaggregation of NPC within families in Taiwan but does not provide evidence for a broader familial syndrome involving NPC and other tumors. © 2008 Wiley-Liss, Inc. [source] New ideas and fertility limitation: The role of mass mediaJOURNAL OF MARRIAGE AND FAMILY, Issue 5 2004Jennifer S. Barber This article investigates the mass media as a social change that shapes individual behavior primarily via ideational mechanisms. We construct a theoretical framework drawing on social demography and social psychology to explain how mass media may affect behavior via attitudinal change. Empirical analyses of 1,091 couples in the Chitwan Valley Family Study, using detailed measures of social change from rural Nepal, show that exposure to the mass media is related to childbearing behavior, and to preferences for smaller families, weaker son preferences, and tolerance of contraceptive use. This result should motivate greater research attention to the influence of changing ideas on behavioral changes, particularly in the study of families. [source] The University of California, San Francisco Family Alcoholism Study.ALCOHOLISM, Issue 10 2004Background: The University of California, San Francisco (UCSF) Family Alcoholism Study is a project designed to identify genetic loci that influence susceptibility to alcohol dependence and related phenotypes. Evidence supports a substantial genetic contribution to alcoholism susceptibility. However, the genetic epidemiology of alcoholism is complex, and its clinical manifestation is heterogeneous, making phenotype definition and demonstration of linkage difficult. Despite these challenges, some progress has been made toward identifying genes. Methods: The UCSF Family Alcoholism Study used a small family design, focusing primarily on sibling pairs and parent-child trios for linkage and association studies. Alcoholism-related phenotypes were assessed through interview and self-report questionnaires, with a focus on unidimensional and subphenotypical traits. Data-driven approaches to determining the most promising phenotypes for genetic analysis are being used. Both genome-wide scan and candidate gene approaches were used. Results: The study enrolled 2154 individuals from 970 families from December 1995 through January 2003. Test-retest and interrater reliability for clinical data are very good, and power estimates suggest that this study will have adequate power by linkage analysis to detect loci with moderate effects. Design, methods, and sample demographics of the UCSF Family Study are presented, along with intrafamilial correlations for primary diagnostic phenotypes. Conclusions: Plans for genetic analysis, novel approaches to phenotype refinement, and the implications of ascertainment bias for heritability estimates are discussed. [source] Drinks of the Father: Father's Maximum Number of Drinks Consumed Predicts Externalizing Disorders, Substance Use, and Substance Use Disorders in Preadolescent and Adolescent OffspringALCOHOLISM, Issue 12 2002Stephen M. Malone Background The maximum number of drinks consumed in 24 hr seems to be an interesting phenotype related to alcoholism. The goal of the present study was to determine in an epidemiologic sample whether this measure of drinking history in fathers predicted externalizing behavioral disorders, substance use, and substance abuse in preadolescent and adolescent offspring and whether any such associations would be independent of paternal alcohol dependence diagnoses. Methods Subjects were male and female twins from both age cohorts of the Minnesota Twin Family Study, a population-based longitudinal study, and were approximately 11 or 17 years of age, respectively, upon study enrollment. In both age cohorts, diagnoses of conduct disorder, oppositional defiant disorder, and attention-deficit/hyperactivity disorder served as outcome measures. In addition, measures of lifetime substance use and of the presence of symptoms of substance abuse were derived for the 11-year-old cohort when subjects were approximately 14 years old and diagnoses of substance abuse were derived for the older cohort at age 17. An extension of logistic regression using generalized estimating equations served to assess whether paternal maximum alcohol consumption predicted filial outcome measures. Results Paternal maximum alcohol consumption was consistently associated with conduct disorder, substance use, and substance abuse or dependence in male and female offspring. These associations were not mediated by a primary effect of paternal alcoholism. Conclusions Paternal maximum alcohol consumption was uniquely associated with those offspring characteristics most reliably found in adolescent children of alcoholic parents. This phenotype might supplement DSM diagnoses of alcohol dependence to reduce the number of false positives in genetic research. [source] Posttraumatic stress symptom trajectories in children living in families reported for family violence,JOURNAL OF TRAUMATIC STRESS, Issue 5 2009Nicole R. Nugent The present study examined latent class trajectories of posttraumatic stress disorder (PTSD) and associations between demographics, prior trauma, and reason for referral on class membership. Children ages 7,18 (n=201) were recruited for participation in the Navy Family Study following reports to the U.S. Navy's Family Advocacy Program (FAP). Initial interviews were conducted 2,6 weeks following FAP referral, with follow-ups conducted at 9,12, 18,24, and 36,40 months. Growth mixture modeling revealed two latent class trajectories: a resilient class and a persistent symptom class. Relative to youth in the resilient class, participants in the persistent symptom class were more likely to be older and to report exposure to a greater number of trauma experiences at Time 1. [source] Error rate on the antisaccade task: Heritability and developmental change in performance among preadolescent and late-adolescent female twin youthPSYCHOPHYSIOLOGY, Issue 5 2002Stephen M. Malone We examined heritability of error rate on the antisaccade task among female twin youths. This task appears to be sensitive to prefrontal functioning, providing a measure of individual differences in inhibitory control associated with genetic risk for schizophrenia. The sample consisted of 674 11-year-olds and 616 17-year-olds, comprising the two cohorts of female twins from the Minnesota Twin Family Study, a population-based investigation of substance abuse and related psychopathology. We used biometric model-fitting methods to determine the relative magnitude of genetic and environmental influences on performance. In both age cohorts, the best fitting model contained additive genes and nonshared environment. Despite substantial age-related differences in mean performance levels (effect size = .81), additive genes accounted for greater than half the variance in performance in both age cohorts. These results are consistent with the hypothesis that antisaccade error rate might serve as an endophenotype for behavior disorders reflecting frontal lobe dysfunction or problems with inhibitory control. [source] Mutations in the first MyTH4 domain of MYO15A are a common cause of DFNB3 hearing lossTHE LARYNGOSCOPE, Issue 4 2009A. Eliot Shearer BSc Abstract Objectives. To use clinical and genetic analyses to determine the mutation causing autosomal recessive nonsyndromic hearing loss (ARNSHL) segregating in two consanguineous Iranian families. Study Design. Family study. Methods. Members of each family received otologic and audiometric examination for the type and extent of hearing loss. Linkage mapping using Affymetrix 50K GeneChips and short tandem repeat (STRP) analysis localized the hearing loss in both families to the DFNB3 locus. Direct sequencing of the MYO15A gene was completed on affected members of both families. Results. Family L-3165 segregated a novel homozygous missense mutation (c.6371G>A) that results in a p.R2124Q amino acid substitution in the myosin XVa protein, while family L-896 segregated a novel homozygous missense (c.6555C>T) mutation resulting in a p.P2073S amino acid change. Conclusions. These are the first MYO15A mutations reported to cause DFNB3 sensorineural hearing loss in the Iranian population. Like other mutations located in the myosin tail homology 4 (MyTH4) domain, the p.R2124Q and p.P2073S mutations are predicted to disrupt the function of the myosin XVa protein, which is integral to the mechanosensory activity of hair cells in the inner ear. Laryngoscope, 2009 [source] Robustness of inference on measured covariates to misspecification of genetic random effects in family studiesGENETIC EPIDEMIOLOGY, Issue 1 2003Ruth M.Pfeiffer Abstract Family studies to identify disease-related genes frequently collect only families with multiple cases. It is often desirable to determine if risk factors that are known to influence disease risk in the general population also play a role in the study families. If so, these factors should be incorporated into the genetic analysis to control for confounding. Pfeiffer et al. [2001 Biometrika 88: 933,948] proposed a variance components or random effects model to account for common familial effects and for different genetic correlations among family members. After adjusting for ascertainment, they found maximum likelihood estimates of the measured exposure effects. Although it is appealing that this model accounts for genetic correlations as well as for the ascertainment of families, in order to perform an analysis one needs to specify the distribution of random genetic effects. The current work investigates the robustness of the proposed model with respect to various misspecifications of genetic random effects in simulations. When the true underlying genetic mechanism is polygenic with a small dominant component, or Mendelian with low allele frequency and penetrance, the effects of misspecification on the estimation of fixed effects in the model are negligible. The model is applied to data from a family study on nasopharyngeal carcinoma in Taiwan. Genet Epidemiol 24:14,23, 2003. © 2003 Wiley-Liss, Inc. [source] Cancer patterns in nasopharyngeal carcinoma multiplex families in TaiwanINTERNATIONAL JOURNAL OF CANCER, Issue 7 2009Kelly J. Yu Abstract Genetic and environmental factors have been implicated in the etiology of nasopharyngeal carcinoma (NPC), a tumor known to be closely associated with Epstein-Barr virus (EBV) infection. Studies have reported familial aggregation of NPC and have suggested the possible aggregation of NPC and other cancers. We evaluated familial aggregation of cancer in 358 high-risk families with two or more NPC cases enrolled in a NPC genetics study in Taiwan. Participants were linked to the Taiwan National Cancer Registry to identify incident cancers diagnosed after study enrollment (started in 1996) and before December 31, 2005, or death. In total, 2,870 individuals from the NPC Multiplex Family Study contributed 15,151 person-years over an average of 5.3 years of follow-up. One hundred ten incident cancers were identified. Multiple-primary standardized incidence ratios (MP-SIRs) were computed to evaluate overall cancer risk associated with infectious agents and with other tumors. The overall MP-SIR was 1.3 (95% CI: 1.1,1.6), which was largely explained by an excess in NPC (MP-SIR = 15; 95% CI: 10,23). Exclusion of incident NPC diagnoses led to an overall MP-SIR of 1.0 (95% CI: 0.83,1.3). Similarly, the observed excess risk of cancers associated with infectious agents (MP-SIR = 2.0; 95% CI: 1.5,2.6) was driven by the excess in NPC; exclusion of NPC cases led to a reduced MP-SIR that did not differ from 1.0. Analysis of the largest NPC multiplex family study to date confirms the presence of coaggregation of NPC within families in Taiwan but does not provide evidence for a broader familial syndrome involving NPC and other tumors. © 2008 Wiley-Liss, Inc. [source] Promoter polymorphism of the IL-18 gene is associated with atopic asthma in Tunisian childrenINTERNATIONAL JOURNAL OF IMMUNOGENETICS, Issue 1 2008J. Lachheb Summary Several lines of evidence point to a relevant role of IL-18 in the process of asthma. Some studies suggest that the polymorphism in the gene of IL-18 can be involved in many inflammatory and atopic diseases such as asthma. The aim of our study is to estimate the frequency of the IL-18- 607 C/A (rs 1946518) promoter polymorphism in Tunisian children with asthma. We investigated whether the presence of this polymorphism -607 C/A was associated with asthma or atopy and whether this polymorphism influenced the severity of asthma in affected children. We examined also the relationship between the IL-18 gene polymorphism and the serum total IgE level. The IL-18/-607 C/A polymorphism was analysed by polymerase chain reaction and restriction fragment-length polymorphism (PCR-RFLP) analysis. A total of 105 asthma patients and 112 controls as part of the whole children population were studied in a case-control study. Among the 105 children with asthma, 40 were also studied for linkage analyses with their respective parents. We noted that the A allele was associated with statistically significant increases in the risk of asthma in the case-control study (odd ratio (OR) = 1.55, 95% confidence interval (CI) 1.03,2.33. Moreover, the A allele was also associated with atopic asthma (P = 0.008), but not with asthma severity. The transmission disequilibrium test (TDT) analysis in this family study did not suggest a preferential transmission of the IL-18/ -607 C/A polymorphism to affected children. There is no correlation between the IgE level and the IL-18 - 607 C/A promoter polymorphism. Our data indicate that IL-18 - 607 C/A promoter polymorphism is associated with susceptibility to developing asthma in Tunisian population. [source] Haemoglobin H disease due to (,,,SEA) ,-globin gene deletion and ,2-codon 30 (,GAG) mutation: a family studyINTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, Issue 5 2001S.K. Ma A Chinese family in which two siblings suffer from haemogloblin (Hb) H disease due to (,,,SEA) ,-globin gene deletion and ,2-codon 30 (,GAG) mutation is described. Both siblings are transfusion-independent and have survived to adulthood. In contrast to previous report of hydrops fetalis associated with ,-,-thal-1 and ,2-codon 30 (,GAG) mutation, the ,-globin genes are intact in the two siblings, which most probably alleviates the ,-chain excess and protects the fetus from severe anaemia. Correlation of genotype with phenotype in Hb H disease is important for genetic counselling, especially in the antenatal setting. [source] Families and family study in international perspectiveJOURNAL OF MARRIAGE AND FAMILY, Issue 5 2004Bert N. Adams Many changes are occurring in the world's families. Some observers feel that the changes are destructive, whereas others see them as leading to new opportunities and understanding. Issues in international family studies include regional limitations and the various aspects of doing research cross-culturally. Knowledge regarding certain categories of families, inheritance, and the social psychology of families is incomplete. There are, however, some universals and universal or worldwide changes, including movement toward individual partner choice, more divorces, lower fertility, and greater opportunities for women. [source] Heritability of serum iron measures in the hemochromatosis and iron overload screening (HEIRS) family studyAMERICAN JOURNAL OF HEMATOLOGY, Issue 2 2010Christine E. McLaren Heritability is the proportion of observed variation in a trait among individuals in a population that is attributable to hereditary factors. The Hemochromatosis and Iron Overload Screening family study estimated heritability of serum iron measures. Probands were HFE C282Y homozygotes or non-C282Y homozygotes with elevated transferrin saturation (TS > 50%, men; TS > 45%, women) and serum ferritin concentration (SF > 300 ,g/L, men; SF > 200 ,g/L, women). Heritability (h2) was estimated by variance component analysis of TS, natural logarithm (ln) of SF, and unsaturated iron-binding capacity (UIBC). Participants (N = 942) were 77% Caucasians, 10% Asians, 8% Hispanics, and 5% other race/ethnicities. Average age (SD) was 49 (16) years; 57% were female. For HFE C282Y homozygote probands and their family members, excluding variation due to HFE C282Y and H63D genotype and measured demographic and environmental factors, the residual h2 (SE) was 0.21 (0.07) for TS, 0.37 (0.08) for ln SF, and 0.34 (0.08) for UIBC (all P < 0.0004 for comparisons with zero). For the non-C282Y homozygote proband group, residual h2 was significant with a value of 0.64 (0.26) for ln SF (P = 0.0096). In conclusion, serum iron measures have significant heritability components, after excluding known genetic and nongenetic sources of variation. Am. J. Hematol. 85:101,105, 2010. © 2009 Wiley-Liss, Inc. [source] | |||||||||||||