Home About us Contact
|
Home About us Contact | ||
|
|
||
Extraneous Factors (extraneous + factor)
Selected AbstractsTopical dose delivery in the reptilian egg treatment modelENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 5 2007Jennifer K. Muller Abstract Developing assays to detect endocrine-mediated toxicity from in ovo or in utero exposure is a current challenge in regulatory toxicology. Some species of reptiles exhibiting a unique mode of sex determination, in which the incubation temperature during a critical period determines gonadal sex, have been explored as an in ovo model to screen environmental contaminants for endocrine effects. We critically review published egg-exposure studies and conclude that data regarding the pharmacokinetics of topically applied substances are insufficient to validate dose,response relationships for the effects of chemicals on in ovo endocrine function or gender determination in reptiles. The insufficiencies in these data largely result from methodological failures, including lack of measurement verification, failure to investigate and control extraneous factors affecting the measurements, and lack of independent replication of results. Considerable additional research will be necessary to alleviate these methodological inadequacies. Given the current status of the data, topical treatment of reptilian eggs cannot be considered to be a valid means of establishing causal relationships between chemical treatment and biological outcome. [source] NAFTA-ization: Regionalization and Domestic Political Adjustment in the North American Economic AreaJCMS: JOURNAL OF COMMON MARKET STUDIES, Issue 1 2009MARK ASPINWALL Europeanization is an example of initial bargains between states leading to ongoing political adjustment within the states. In this article I apply the concept to NAFTA and look at two of its member states, finding that despite the low level of institutionalization, NAFTA has set in motion new forms of political organization and behaviour, and new demands for political action. This is especially marked in Mexico, and in certain sectors. It is also clearly visible in the changing patterns of cross-border bureaucratic communication. The main conclusions are that: (1) even in a lightly institutionalized regional trade agreement, the institutional, legal and civil society capacity of less-developed members is strengthened; (2) despite the absence of a formal process of policy or institutional development and the lack of legislative instruments, NAFTA has begun a hidden process of domestic adjustment in technical and specialized areas; and (3) like the EU, pressures to expand and strengthen NAFTA have emerged as a result of the initial agreement as well as extraneous factors. These conclusions may offer lessons to the study and practice of regional organizations elsewhere. [source] Confounding Factors in Infant Pain Assessment During Recovery From AnesthesiaJOURNAL FOR SPECIALISTS IN PEDIATRIC NURSING, Issue 2 2003Madalynn Neu ISSUES AND PURPOSE. To investigate in what ways infant pain assessments differed between outpatient surgical recovery areas (OPSRA) and other clinical settings that included inpatient postsurgical recovery areas. METHODS. Using a qualitative descriptive design, 8 nurse participants working in OPSRA and 7 nurse participants working in other clinical settings were interviewed. RESULTS. The assessments of participants in the OPSRA differed from those of other participants and were confounded by effects of a short-acting anesthetic, lower expectations of pain, and several extraneous factors. PRACTICE IMPLICATIONS. Recognizing infant pain in OPSRA is complex. Nurses working in OPSRA may need to assume leadership to address issues relating to accurate identification of infant pain and alleviating extraneous factors that may influence adequate treatment of pain. [source] Non-invasive systemic drug delivery: Developability considerations for alternate routes of administrationJOURNAL OF PHARMACEUTICAL SCIENCES, Issue 1 2010Neil R. Mathias Abstract Over the past few decades alternate routes of administration have gained significant momentum and attention, to complement approved drug products, or enable those that cannot be delivered by the oral or parenteral route. Intranasal, buccal/sublingual, pulmonary, and transdermal routes being the most promising non-invasive systemic delivery options. Considering alternate routes of administration early in the development process may be useful to enable new molecular entities (NME) that have deficiencies (extensive first-pass metabolism, unfavorable physicochemical properties, gastro-intestinal adverse effects) or suboptimal pharmacokinetic profiles that are identified in preclinical studies. This review article describes the various delivery considerations and extraneous factors in developing a strategy to pursue an alternate route of administration for systemic delivery. The various delivery route options are outlined with their pros and cons; key criteria and physicochemical attributes that would make a drug a suitable candidate are discussed; approaches to assess delivery feasibility, toxicity at the site of delivery, and overall developability potential are described; and lastly, product trends and their disease implications are highlighted to underscore treatment precedence that help to build scientific rationale for the pursuit of an alternate route of administration. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:1,20, 2010 [source] Identification of individual tigers (Panthera tigris) from their pugmarksJOURNAL OF ZOOLOGY, Issue 1 2005Sandeep Sharma Abstract An objective multivariate technique is described for identification of individual tigers Panthera tigris from their pugmarks. Tracings and photographs of hind pugmarks were obtained from 23 pugmark-sets of 19 individually known tigers (17 wild and two captive tigers). These 23 pugmark-sets were then divided into two groups, one of 15 pugmark-sets for model building and another of eight pugmark-sets for model testing and validation. A total of 93 measurements were taken from each pugmark along with three gait measurements. We used CV ratio, F -ratio and removed highly correlated variables to finally select 11 variables from these 93 variables. These 11 variables did not differ between left and right pugmarks. Stepwise discriminant function analysis (DFA) based on these 11 variables correctly classified pugmark-sets to individual tigers. A realistic population estimation exercise was simulated using the validation dataset. The algorithms developed here correctly allocated each pugmark-set to the correct individual tiger. The effect of extraneous factors, i.e. soil depth and multiple tracers, was also tested and pugmark tracings compared with pugmark photographs. We recommend collecting pugmarks from soil depths ranging between 0.5 and 1.0 cm, and advocate the use of pugmark photographs rather than pugmark tracings to eliminate the chance of obtaining substandard data from untrained tracers. Our study suggests that tigers can be individually identified from their pugmarks with a high level of accuracy and pugmark-sets could be used for population estimation of tigers within a statistically designed mark,recapture framework. [source] Bimodal skin reactivity to histamine in atopic children in Singapore: influence of specific sensitizationsPEDIATRIC ALLERGY AND IMMUNOLOGY, Issue 6 2004Mona Iancovici Kidon Histamine skin prick test (SPT) is used as the ,golden standard' for positive control in in vivo immediate type hypersensitivity testing. The skin reactivity to histamine can, however, be modulated by a bevy of extraneous factors. We aimed to define whether histamine skin reactivity in atopic children in Singapore is influenced by age, ethnic origin, gender, environmental exposure or specific sensitization patterns. A retrospective analysis of children, with specific aeroallergen sensitization (as measured by at least one allergen-specific SPT with a wheal size >3 mm compared with the negative control) from the outpatient speciality clinic of the KK Children's Hospital, during 06/2002,06/2003. A total of 315 patients were included, 235 (75%) were males, 252 (80%) were Chinese, age mean was 7.7 yr (range: 2,15). Patients were referred to the SPT with a diagnosis of one or more of: allergic rhinitis 287 (91%), asthma 112 (36%) or atopic dermatitis 60 (19%). The mean histamine response showed a bimodal distribution, independent of age, ethnic origin, gender or phenotypical expression of allergic disease. Histamine skin reactivity was higher in atopic patients with polysensitization (mean 5.0 mm vs. 2.9 mm in monosensitized patients, p < 0.001), and in patients with mould sensitization (mean 5.1 mm vs. 3.3 mm in patient not sensitized to moulds, p < 0.001). The presence of passive smoking increased the likelihood of a diminished histamine skin response. Histamine skin response data strongly suggested the presence of two heterogeneous subpopulations. Children with polysensitization and mould sensitization were more likely to show a large significant histamine response, whereas children with passive smoke exposure, showed a diminished skin reactivity to histamine. [source] | |||||||||||||