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Aggressive Behavior (aggressive + behavior)
Selected AbstractsSickness and Aggressive Behavior in Dominant and Subordinate Mice,ETHOLOGY, Issue 2 2009Daniel W. H. Cohn Sick animals show a set of organized behavioral changes (sickness behavior), which is the result of a motivational re-organization of the behavior as a whole. Sickness behavior display can be influenced by the social context. In this work, we sought to investigate the regulation of sickness behavior within a pair of mice in the presence of an intruder mouse. Dominant and subordinate mice were treated with the bacterial endotoxin lipopolysaccharide (LPS) and were challenged with the presence of an intruder mouse. LPS effects depended on ranking and social context. Even though dominant mice displayed more agonistic interaction towards the intruder, subordinate mice displayed agonistic behavior towards the intruder when their dominant companion was treated with LPS. The results show that, not only sickness behavior is differentially expressed among different social ranks, but also that sickness behavior is related to different reactions among surrounding animals. These data are relevant for a biological approach to the relation between sickness behavior and social behavior. [source] The Effects of Social Experience on Aggressive Behavior in the Green Anole Lizard (Anolis carolinensis)ETHOLOGY, Issue 9 2001Eun-Jin Yang To understand how context-specific aggression emerges from past experience, we examined how consecutive aggressive encounters influence aggressive behavior and stress responses of male green anole lizards (Anolis carolinensis). Animals were shown a video clip featuring an aggressively displaying conspecific male, which provoked aggressive responding, while control animals viewed a neutral video. After 5 d of interaction with the videos, both the subject and control groups were presented with a live conspecific. As a non-invasive assay of stress responses, we measured changes in body color and eyespot darkness, two features known to be strongly correlated with titers of stress hormones. Our results demonstrate that experience increased aggression in male anoles, but that increases in aggression to a repeated stimulus were transient. Tests with a novel conspecific indicate that the experienced animals remained aggressive when presented with novel stimuli. Although there were differences in the morphological indicators of the stress response between experimental and control groups during video presentations, there were no differences when presented with novel conspecifics. These data indicate that experience-dependent differences were not mediated by differences in the ,stressfulness' of aggressive interaction, as thought to be the case for animals in chronic subordinate/dominant dyads. We suggest that habituation and reinforcement interact to promote aggressive responding and to restrict it to novel individuals. Such context specificity is a hallmark of natural patterns of aggression in territorial species. [source] Establishing Independence in Low-Income Urban Areas: The Relationship to Adolescent Aggressive BehaviorJOURNAL OF MARRIAGE AND FAMILY, Issue 3 2003Kathleen M. Roche Although adolescents in poor urban areas often assume independent, adult-like roles, relatively little is known about the relationship between these roles and other adolescent behaviors. This research examines the association between independent roles occurring within different contexts (e.g. family, peer, work) and aggressive behavior among 516 low-income, urban middle school students. Overall, adolescent employment is related to increases in aggressive behavior. However, associations that familial and peer independent roles have with aggression differ by the extent of youth involvement in paid work. Greater engagement in familial independent roles is associated with decreased aggression among employed adolescents, but with increased aggression among unemployed youth. Also, peer independent roles are related to significantly greater increases in aggression among unemployed, compared with employed, adolescents. [source] Serotonin Transporter Promoter Polymorphism Genotype Is Associated With Behavioral Disinhibition and Negative Affect in Children of AlcoholicsALCOHOLISM, Issue 7 2001Geoffrey R. Twitchell Background : Serotonergic (5-HT) dysfunction has been implicated in the etiology of both behavioral disinhibition (BD) and negative affect (NA). This work extends our previous finding of relationships between whole blood 5-HT and both BD and NA in pubescent, but not prepubescent, children of alcoholics and continues examination of a hypothesized role of 5-HT dysfunction in alcoholism risk. The long and short (L and S) variants of the 5-HT transporter gene-linked polymorphic region (5-HTTLPR) are responsible for differing transcriptional efficiencies in 5-HT uptake. Although associations have been found between the SS 5-HTTLPR genotype and severe alcoholism and neuroticism, recent reports describe relationships between the LL genotype and both low level of response to alcohol and alcoholism diagnosis and a predominance of the LL genotype in early-onset alcoholics. Methods: This report is from an ongoing prospective study of the development of risk for alcoholism and other problematic outcomes in a sample of families classified by father's alcoholism subtype. This study examines relationships between 5-HTTLPR genotype and both child BD (Child Behavior Checklist Aggressive Behavior) and NA (Child Behavior Checklist Anxious/Depressed) in offspring from 47 families. Results: Results showed significantly higher levels of BD and NA in the 16 children with the LL genotype than the 46 SS or SL children. Conclusions: Behaviors of undercontrol, which occur at increased rates in children of alcoholics, may be genetically influenced through the regulation of the 5-HT transporter. Due to the small sample size and the preliminary nature of our findings, replication is necessary. [source] Aggressive Behavior in the Disabled: RevisitedPAIN MEDICINE, Issue 2 2000Rollin M. Gallagher MD First page of article [source] Evolution, Prevention, and Responses to Aggressive Behavior and ViolenceTHE JOURNAL OF LAW, MEDICINE & ETHICS, Issue 1 2004Robert M. Sade First page of article [source] Hostile Attribution of Intent and Aggressive Behavior: A Meta-AnalysisCHILD DEVELOPMENT, Issue 3 2002Bram Orobio De Castro A meta-analytic review was conducted to explain divergent findings on the relation between children's aggressive behavior and hostile attribution of intent to peers. Forty-one studies with 6,017 participants were included in the analysis. Ten studies concerned representative samples from the general population, 24 studies compared nonaggressive to extremely aggressive nonreferred samples, and 7 studies compared nonreferred samples with children referred for aggressive behavior problems. A robust significant association between hostile attribution of intent and aggressive behavior was found. Effect sizes differed considerably between studies. Larger effects were associated with more severe aggressive behavior, rejection by peers as one of the selection criteria, inclusion of 8- to-12-year-old participants, and absence of control for intelligence. Video and picture presentation of stimuli were associated with smaller effect sizes than was audio presentation. Staging of actual social interactions was associated with the largest effects. The importance of understanding moderators of effect size for theory development is stressed. [source] Aggressive behavior, related conduct problems, and variation in genes affecting dopamine turnoverAGGRESSIVE BEHAVIOR, Issue 3 2010Elena L. Grigorenko Abstract A number of dopamine-related genes have been implicated in the etiology of violent behavior and conduct problems. Of these genes, the ones that code for the enzymes that influence the turnover of dopamine (DA) have received the most attention. In this study, we investigated 12 genetic polymorphisms in four genes involved with DA functioning (COMT, MAOA and MAOB, and D,H) in 179 incarcerated male Russian adolescents and two groups of matched controls: boys without criminal records referred to by their teachers as (a) "troubled-behavior-free" boys, n=182; and (b) "troubled-behavior" boys, n=60. The participants were classified as (1) being incarcerated or not, (2) having the DSM-IV diagnosis of conduct disorder (CD) or not, and (3) having committed violent or nonviolent crimes (for the incarcerated individuals only). The findings indicate that, although no single genetic variant in any of the four genes differentiated individuals in the investigated groups, various linear combinations (i.e., haplotypes) and nonlinear combinations (i.e., interactions between variants within and across genes) of genetic variants resulted in informative and robust classifications for two of the three groupings. These combinations of genetic variants differentiated individuals in incarceration vs. nonincarcerated and CD vs. no-CD groups; no informative combinations were established consistently for the grouping by crime within the incarcerated individuals. This study underscores the importance of considering multiple rather than single markers within candidate genes and their additive and interactive combinations, both with themselves and with nongenetic indicators, while attempting to understand the genetic background of such complex behaviors as serious conduct problems. Aggr. Behav. 36:158,176, 2010. © 2010 Wiley-Liss, Inc. [source] Aggressive behavior in response to violence exposure: is it adaptive for middle-school children?,JOURNAL OF COMMUNITY PSYCHOLOGY, Issue 8 2008Suzanne Salzinger The role of aggression in adaptation to family and community violence was examined in a sample of 667 inner-city schoolchildren studied annually over three years in middle school. Regression analyses indicated that the association between Year 1 exposure to family and community violence and Year 2 aggression was mediated by aggression occurring contemporaneously with Year 1 exposure. Cognitive justification of aggression and friends' delinquency made small independent contributions to prediction of Year 2 aggression, delinquency, and externalizing behaviors. Year 2 aggression mediated the association between Year 1 community violence victimization and Year 3 negative adaptation (internalizing problems, anxiety, and depression). Year 2 aggression also mediated the negative association between Year 1 witnessing community violence and Year 3 positive adaptation (self-esteem). Cognitive justification of aggression and friends' delinquency made independent contributions to Year 3 negative adaptation. The pattern of relations among variables infrequently varied by gender. Implications for intervention are discussed. © 2008 Wiley Periodicals, Inc. [source] Aggressive behavior in children's dolls' house playAGGRESSIVE BEHAVIOR, Issue 6 2004*Article first published online: 25 OCT 200, Maria A. Tallandini Abstract The present study addressed the question of whether there are gender and age differences in aggressive behavior when it is studied as the spontaneous expression of mental contents and not as the result of immediate social interaction. This study also investigated whether aggression, in terms of mental content, is related to temperamental aspects. Aggressive behaviors were examined in make-believe play, in relation to age, gender, and temperament in a near-ecological context, i.e., the Dolls' House Play. The participants, 55 boys and 47 girls, subdivided into three age levels (4 years,4 years and 6 months; 5,6 years; and 7 years and 6 months,8 years and 6 months) were requested to represent what happens in their family 1) during Mealtimes; 2) at Bedtime; 3) on the Saddest day; and 4) the Happiest day; their Dolls' House Play was then recorded. Children's temperaments were measured with the TABC-Teachers' form [Martin, The Temperament Assessment Battery for Children, Brandon, VT: Clinical Psychology Publishing, 1998]. Data analysis was conducted considering aggressive behaviors in their distinct expressions,physical, verbal, direct, and indirect. Results revealed no statistical differences between boys and girls when all aggressive behaviors were compounded. However, when the distinct types of aggressiveness were considered, boys presented statistically higher levels of physical aggression than girls did. Moreover, boys and girls reacted with different types of aggression in the different emotional contexts created by the four episodes. Few age differences were observed. Surprisingly, there was a significantly greater presence of indirect verbal aggressiveness in younger children. With respect to temperament, a higher level of negative emotivity was significantly linked to a greater degree of aggressive behaviors in some of the episodes. In conclusion, this paper confirms gender differences in the type of aggressive behavior children display even in the absence of any immediate social interaction, which might itself trigger aggression. Aggr. Behav. 30:504,519, 2004. © 2004 Wiley-Liss, Inc. [source] Overt and covert aggression in work settings in relation to the subjective well-being of employeesAGGRESSIVE BEHAVIOR, Issue 5 2001Ari Kaukiainen Abstract Aggressive behavior was studied in workplaces having (1) predominantly male, (2) predominantly female, or (3) both male and female employees in equal or near equal frequencies. In addition to examining the occurrence of different types of aggression in these workplaces, the question of whether being a target of aggression is related to employees' subjective well-being was addressed. One hundred sixty-nine participants (mainly 30,50 years of age) employed in a wide range of organizations in the public sector completed a questionnaire measuring four types of observed and experienced aggression: direct overt, indirect manipulative, covert insinuative, and rational-appearing aggression. Indirect manipulative and rational-appearing aggression were perceived to be the most widely used aggression styles in the work context. In the predominantly male workplaces, the men were perceived to use more of all types of aggression than in the predominantly female workplaces. The women's aggression was not related to the relative number of females and males with whom they worked. Participants were divided into two groups on the basis of the extent to which they estimated themselves to be targets of workplace aggression. Those who considered themselves to be victims of workplace aggression suffered significantly more from psychosocial problems and physical symptoms than those who had been victimized to a lesser extent or not at all. The victimized group also considered the aggression they had suffered to be the reason for their psychosocial and health problems. Aggr. Behav. 27:360,371, 2001. © 2001 Wiley-Liss, Inc. [source] Aggressive behavior and Brunner Syndrome: No evidence for the C936T mutation in a population sampleAMERICAN JOURNAL OF MEDICAL GENETICS, Issue 4 2001Jose M. Mejia No abstract is available for this article. [source] Aggressive behavior in children's dolls' house playAGGRESSIVE BEHAVIOR, Issue 6 2004*Article first published online: 25 OCT 200, Maria A. Tallandini Abstract The present study addressed the question of whether there are gender and age differences in aggressive behavior when it is studied as the spontaneous expression of mental contents and not as the result of immediate social interaction. This study also investigated whether aggression, in terms of mental content, is related to temperamental aspects. Aggressive behaviors were examined in make-believe play, in relation to age, gender, and temperament in a near-ecological context, i.e., the Dolls' House Play. The participants, 55 boys and 47 girls, subdivided into three age levels (4 years,4 years and 6 months; 5,6 years; and 7 years and 6 months,8 years and 6 months) were requested to represent what happens in their family 1) during Mealtimes; 2) at Bedtime; 3) on the Saddest day; and 4) the Happiest day; their Dolls' House Play was then recorded. Children's temperaments were measured with the TABC-Teachers' form [Martin, The Temperament Assessment Battery for Children, Brandon, VT: Clinical Psychology Publishing, 1998]. Data analysis was conducted considering aggressive behaviors in their distinct expressions,physical, verbal, direct, and indirect. Results revealed no statistical differences between boys and girls when all aggressive behaviors were compounded. However, when the distinct types of aggressiveness were considered, boys presented statistically higher levels of physical aggression than girls did. Moreover, boys and girls reacted with different types of aggression in the different emotional contexts created by the four episodes. Few age differences were observed. Surprisingly, there was a significantly greater presence of indirect verbal aggressiveness in younger children. With respect to temperament, a higher level of negative emotivity was significantly linked to a greater degree of aggressive behaviors in some of the episodes. In conclusion, this paper confirms gender differences in the type of aggressive behavior children display even in the absence of any immediate social interaction, which might itself trigger aggression. Aggr. Behav. 30:504,519, 2004. © 2004 Wiley-Liss, Inc. [source] Brain mechanisms underlying emotional alterations in the peripartum period in ratsDEPRESSION AND ANXIETY, Issue 3 2003Inga D. Neumann Abstract In the period before and after parturition, i.e., in pregnancy and lactation, a variety of neuroendocrine alterations occur that are accompanied by marked behavioral changes, including emotional responsiveness to external challenging situations. On the one hand, activation of neuroendocrine systems (oxytocin, prolactin) ensures reproduction-related physiological processes, but in a synergistic manner also ensures accompanying behaviors necessary for the survival of the offspring. On the other hand, there is a dramatic reduction in the responsiveness of neuroendocrine systems to stimuli not relevant for reproduction, such as the hypothalamo-pituitary-adrenal (HPA) axis responses to physical or emotional stimuli in both pregnant and lactating rats. With CRH being the main regulator of the HPA axis, downregulation of the brain CRH system may result in various behavioral, in particular emotional, adaptations of the maternal organisms, including changes in anxiety-related behavior. In support of this, the lactating rat becomes less emotionally responsive to novel situations, demonstrating reduced anxiety, and shows a higher degree of aggressive behavior in the test for agonistic behavior as well as in the maternal defense test. These changes in emotionality are independent of the innate (pre-lactation) level of anxiety and are seen in both rats bred for high as well as low levels of anxiety. Both brain oxytocin and prolactin, highly activated at this time, play a significant role in these behavioral and possibly also neuroendocrine adaptations in the peripartum period. Depression and Anxiety 17:111,121, 2003. © 2003 Wiley-Liss, Inc. [source] Pilomatrix Carcinoma of the Back Treated by Mohs Micrographic SurgeryDERMATOLOGIC SURGERY, Issue 8 2004David Sable MD Background. Pilomatrix carcinoma (synonyms, matrical carcinoma or malignant pilomatrixoma) is a rare malignant neoplasm derived from the hair matrix first described in 1980. This neoplasm can exhibit local aggressive behavior and distant metastasis. Most pilomatrix carcinomas occur on the head and neck of elderly individuals with a predilection for males (M:F 5:1). Pilomatrix carcinoma is often clinically misdiagnosed as a sebaceous cyst and histologic difficulty can occur in differentiating this entity from the benign entity pilomatrixoma. Objective. The objective was to describe a case of pilomatrix carcinoma encountered in a Mohs micrographic surgery practice. We present the first case of this lesion treated by Mohs surgery. Methods. A case report and literature review are presented. Conclusion. Pilomatrix carcinoma is a rare malignant variant of pilomatrixoma. Given the rarity of this lesion there are no well-defined standards for surgical management. Wide local excision has been recommended given the high rate of reoccurrence. Mohs micrographic surgery may provide optimal treatment of this neoplasm given the ability to have 100% margin control. [source] Child to adult continuities of psychopathology: a 24-year follow-upACTA PSYCHIATRICA SCANDINAVICA, Issue 3 2009J. Reef Objective:, To determine continuities of mental health problems of children across a 24-year follow-up period. Method:, In 1983, parent ratings of emotional and behavioral problems were collected with the Child Behavior Checklist (CBCL) in a general population sample of 2076 children. Twenty-four years later, 1365 participants completed Adult Self-Reports (ASR) to assess emotional and behavioral problems. Results:, Of the participants who were classified as deviant in childhood, 22.2% were also classified as deviant in adulthood. Both homotypic and heterotypic continuity was found. Childhood aggressive, delinquent, and anxious/depressed problems were associated with most adult psychopathology. Attention problems did not predict later problems independently. Conclusion:, Even though assessed with parent-reports in childhood and analogous self-reports in adulthood, and over a large period of 24 years, continuity of psychopathology was found from childhood into adulthood. Anxious/depressed problems, delinquent behavior and aggressive behavior in childhood are core predictors for adult psychopathology. [source] Sex-role reversal is reflected in the brain of African black coucals (Centropus grillii)DEVELOPMENTAL NEUROBIOLOGY, Issue 12 2007Cornelia Voigt Abstract In most bird species males compete over access to females and have elevated circulating androgen levels when they establish and defend a breeding territory or guard a mate. Testosterone is involved in the regulation of territorial aggression and sexual display in males. In few bird species the traditional sex-roles are reversed and females are highly aggressive and compete over access to males. Such species represent excellent models to study the hormonal modulation of aggressive behavior in females. Plasma sex steroid concentrations in sex-role reversed species follow the patterns of birds with "traditional" sex-roles. The neural mechanisms modulating endocrine secretion and hormone,behavior interactions in sex-role reversed birds are currently unknown. We investigated the sex differences in the mRNA expression of androgen receptors, estrogen receptor ,, and aromatase in two brain nuclei involved in reproductive and aggressive behavior in the black coucal, the nucleus taeniae and the bed nucleus of the stria terminalis. In the bed nucleus there were no sex differences in the receptor or aromatase expression. In the nucleus taeniae, however, we show for the first time, that females have a higher mRNA expression of androgen receptors than males. These results suggest that the expression of agonistic and courtship behavior in females does not depend on elevated blood hormone levels, but may be regulated via increased steroid hormone sensitivity in particular target areas in the brain. Hence, aggression in females and males may indeed be modulated by the same hormones, but regulated at different levels of the neuroendocrine cascade. © 2007 Wiley Periodicals, Inc. Develop Neurobiol, 2007 [source] Social experience organizes parallel networks in sensory and limbic forebrainDEVELOPMENTAL NEUROBIOLOGY, Issue 3 2007Eun-Jin Yang Abstract Successful social behavior can directly influence an individual's reproductive success. Therefore, many organisms readily modify social behavior based on past experience. The neural changes induced by social experience, however, remain to be fully elucidated. We hypothesize that social modulation of neural systems not only occurs at the level of individual nuclei, but also of functional networks, and their relationships with behavior. We used the green anole lizard (Anolis carolinensis), which displays stereotyped, visually triggered social behaviors particularly suitable for comparisons of multiple functional networks in a social context, to test whether repeated aggressive interactions modify behavior and metabolic activity in limbic,hypothalamic and sensory forebrain regions, assessed by quantitative cytochrome oxidase (a slowly accumulating endogenous metabolic marker) histochemistry. We found that aggressive interactions potentiate aggressive behavior, induce changes in activities of individual nuclei, and organize context-specific functional neural networks. Surprisingly, this experiential effect is not only present in a limbic,hypothalamic network, but also extends to a sensory forebrain network directly relevant to the behavioral expression. Our results suggest that social experience modulates organisms' social behavior via modifying sensory and limbic neural systems in parallel both at the levels of individual regions and networks, potentially biasing perceptual as well as limbic processing. © 2007 Wiley Periodicals, Inc. Develop Neurobiol, 2007 [source] Brain aromatase, 5,-reductase, and 5,-reductase change seasonally in wild male song sparrows: Relationship to aggressive and sexual behaviorDEVELOPMENTAL NEUROBIOLOGY, Issue 3 2003Kiran K. Soma Abstract In many species, territoriality is expressed only during the breeding season, when plasma testosterone (T) is elevated. In contrast, in song sparrows (Melospiza melodia morphna), males are highly territorial during the breeding (spring) and nonbreeding (autumn) seasons, but not during molt (late summer). In autumn, plasma sex steroids are basal, and castration has no effect on aggression. However, inhibition of aromatase reduces nonbreeding aggression, suggesting that neural steroid metabolism may regulate aggressive behavior. In wild male song sparrows, we examined the neural distribution of aromatase mRNA and seasonal changes in the activities of aromatase, 5,-, and 5,-reductase, enzymes that convert T to 17,-estradiol, 5,-dihydrotestosterone (5,-DHT, a potent androgen), or 5,-DHT (an inactive metabolite), respectively. Enzyme activities were measured in the diencephalon, ventromedial telencephalon (vmTEL, which includes avian amygdala), caudomedial neostriatum (NCM), and the hippocampus of birds captured during spring, molt, or autumn. Aromatase and 5,-reductase changed seasonally in a region-specific manner. Aromatase in the diencephalon was higher in spring than in molt and autumn, similar to seasonal changes in male sexual behavior. Aromatase activity in the vmTEL was high in both spring and autumn but significantly reduced at molt, similar to seasonal changes in aggression. 5,-Reductase was not elevated during molt, suggesting that low aggression during molt is not a result of increased inactivation of androgens. These data highlight the relevance of neural steroid metabolism to the expression of natural behaviors by free-living animals. © 2003 Wiley Periodicals, Inc. J Neurobiol 56: 209,221, 2003 [source] Exploratory behavior in mice selectively bred for developmental differences in aggressive behaviorDEVELOPMENTAL PSYCHOBIOLOGY, Issue 1 2008Kathryn E. Hood Abstract The development and expression of exploratory behavior was assessed in the Cairns lines of Institute for Cancer Research (ICR) mice that were selectively bred for differences in aggressive behavior, with a high-aggressive 900 line, low-aggressive 100 line, and control 500 line. Four paradigms were employed. Developmental changes were evident in the complex novel arena, with older males faster to contact a novel object, and ambulating more than young males. Within the control 500 line, older males showed longer latency to emerge from the home cage, and shorter latency to contact novel objects. In the 900 line, younger males showed this same pattern. R. B. Cairns proposed that line differences in aggressive behavior arise through alterations in developmental timing [Cairns et al. [1983] Life-span developmental psychology (Vol. 5). New York: Academic Press; Gariépy et al. [2001] Animal Behaviour 61: 933,947]. The early appearance of mature patterns of exploratory behavior in 900 line males supports this interpretation. The 900 line males also appear to be behaviorally inhibited in novel settings such as the light,dark box and the neohypophagia paradigm, compared to the 500 and 100 lines (Experiments 1, 2, and 4). Moreover, in the most complex apparatus, the novel arena, 900 line males were slowest to exit the home cage, and fastest to contact a novel object. The apparent contrast in these parameters of exploratory behavior is discussed in relation to T. C. Schneirla's [1965 Advances in the study of behavior (Vol. 1). New York: PN Academic] approach,withdrawal theory. © 2007 Wiley Periodicals, Inc. Dev Psychobiol 50: 32,47, 2008. [source] Preparation of thyroid FNA material for routine cytology and BRAF testing: A validation studyDIAGNOSTIC CYTOPATHOLOGY, Issue 3 2010Giancarlo Troncone M.D., Ph.D. Abstract V600E BRAF mutation is emerging as an independent marker of papillary thyroid carcinoma aggressive behavior. Papillary thyroid carcinomas harboring this mutation should be extensively resected. However, this requires an unquestionable cytological diagnosis of malignancy. Thus, cytological specimens should be properly handled to provide both morphological and molecular information. Here, we assessed whether our method of preparation of fine-needle aspiration material is suitable for both tests. A series of 128, routinely performed, fine-needle aspirations was analyzed. Each nodule was punctured three times. A representative Diff-Quik smear prepared from the first two passages was evaluated onsite. When microscopy was diagnostic (n = 44), the third needle pass was dedicated to harvest material for BRAF testing; in the remaining cases (n = 84), additional direct smears for cytology were prepared and the remaining material in the needle plus the needle rinsing was collected for BRAF testing. Cellularity was adequate in 126/128 (98%) cases. Cytological diagnoses were inadequate (2%), benign (85%), follicular lesion of undetermined significance (5%), follicular neoplasms (2%), suspicious for malignancy (2%), and malignant (4%). Higher average of extracted DNA concentration was observed in the dedicated pass group (25.9 vs 7.95 ng/,l). However, the rate of successful exon 15 BRAF amplification was similar with (43/44; 97.7%) or without (79/84; 94%) the dedicated pass. Thus, our protocol is suitable for both tests. Whenever necessary BRAF testing may also be performed on the residual samples of thyroid nodules, without interfering with routine cytology. Diagn. Cytopathol. 2010. © 2009 Wiley-Liss, Inc. [source] The Effects of Social Experience on Aggressive Behavior in the Green Anole Lizard (Anolis carolinensis)ETHOLOGY, Issue 9 2001Eun-Jin Yang To understand how context-specific aggression emerges from past experience, we examined how consecutive aggressive encounters influence aggressive behavior and stress responses of male green anole lizards (Anolis carolinensis). Animals were shown a video clip featuring an aggressively displaying conspecific male, which provoked aggressive responding, while control animals viewed a neutral video. After 5 d of interaction with the videos, both the subject and control groups were presented with a live conspecific. As a non-invasive assay of stress responses, we measured changes in body color and eyespot darkness, two features known to be strongly correlated with titers of stress hormones. Our results demonstrate that experience increased aggression in male anoles, but that increases in aggression to a repeated stimulus were transient. Tests with a novel conspecific indicate that the experienced animals remained aggressive when presented with novel stimuli. Although there were differences in the morphological indicators of the stress response between experimental and control groups during video presentations, there were no differences when presented with novel conspecifics. These data indicate that experience-dependent differences were not mediated by differences in the ,stressfulness' of aggressive interaction, as thought to be the case for animals in chronic subordinate/dominant dyads. We suggest that habituation and reinforcement interact to promote aggressive responding and to restrict it to novel individuals. Such context specificity is a hallmark of natural patterns of aggression in territorial species. [source] Hypoxia-inducible factor-1, blocks differentiation of malignant gliomasFEBS JOURNAL, Issue 24 2009Huimin Lu Aberrant differentiation is a characteristic feature of neoplastic transformation, while hypoxia in solid tumors is believed to be linked to aggressive behavior and poor prognosis. However, the possible relationship between hypoxia and differentiation in malignancies remains poorly defined. Here we show that rat C6 and primary human malignant glioma cells can be induced to differentiate into astrocytes by the well-known adenylate cyclase activator forskolin. However, hypoxia-inducible factor-1, expression stimulated by the hypoxia mimetics cobalt chloride or deferoxamine blocks this differentiation and this effectiveness is reversible upon withdrawal of the hypoxia mimetics. Importantly, knockdown of hypoxia inducible factor-1, by RNA interference restores the differentiation capabilities of the cells, even in the presence of cobalt chloride, whereas stabilization of hypoxia-inducible factor-1, through retarded ubiquitination by von Hippel-Lindau tumor suppressor gene silence abrogates the induced differentiation. Moreover, targeting of HIF-1 using chetomin, a disrupter of HIF-1 binding to its transcriptional co-activator CREB-binding protein (CBP)/p300, abolishes the differentiation-inhibitory effect of hypoxia-inducible factor-1,. Administration of chetomin in combination with forskolin significantly suppresses malignant glioma growth in an in vivo xenograft model. Analysis of 95 human glioma tissues revealed an increase of hypoxia-inducible factor-1, protein expression with progressing tumor grade. Taken together, these findings suggest a key signal transduction pathway involving hypoxia-inducible factor-1, that contributes to a differentiation defect in malignant gliomas and sheds new light on the differentiation therapy of solid tumors by targeting hypoxia-inducible factor-1,. Structured digital abstract ,,MINT-7292117: CBP (uniprotkb:Q6JHU9) physically interacts (MI:0915) with Hif1a (uniprotkb:O35800) by anti bait coimmunoprecipitation (MI:0006) [source] Taking It to the Extreme: The Effect of Coalition Cabinets on Foreign PolicyFOREIGN POLICY ANALYSIS, Issue 1 2008Juliet Kaarbo Institutional constraints have been offered by some scholars as an explanation for why multiparty coalitions should be more peaceful than single-party cabinets. Yet others see the same institutional setting as a prescription for more aggressive behavior. Recent research has investigated these conflicting expectations, but with mixed results. We examine the theoretical bases for these alternative expectations about the effects of coalition politics on foreign policy. We find that previous research is limited theoretically by confounding institutional effects with policy positions, and empirically by analyzing only international conflict data. We address these limitations by examining cases of foreign policy behavior using the World Event/Interaction Survey (WEIS) dataset. Consistent with our observation that institutional constraints have been confounded with policy positions, we find that coalitions are neither more aggressive nor more peaceful, but do engage in more extreme foreign policy behaviors. These findings are discussed with regard to various perspectives on the role of institutions in shaping foreign policy behavior. [source] Individual vulnerability to escalated aggressive behavior by a low dose of alcohol: decreased serotonin receptor mRNA in the prefrontal cortex of male miceGENES, BRAIN AND BEHAVIOR, Issue 1 2010S. Chiavegatto Low to moderate doses of alcohol consumption induce heightened aggressive behavior in some, but not all individuals. Individual vulnerability for this nonadaptive behavior may be determined by an interaction of genetic and environmental factors with the sensitivity of alcohol's effects on brain and behavior. We used a previously established protocol for alcohol oral self-administration and characterized alcohol-heightened aggressive (AHA) mice as compared with alcohol non-heightened (ANA) counterparts. A week later, we quantified mRNA steady state levels of several candidate genes in the serotonin [5-hydroxytryptamine (5-HT)] system in different brain areas. We report a regionally selective and significant reduction of all 5-HT receptor subtype transcripts, except for 5-HT3, in the prefrontal cortex of AHA mice. Comparable gene expression profile was previously observed in aggressive mice induced by social isolation or by an anabolic androgenic steroid. Additional change in the 5-HT1B receptor transcripts was seen in the amygdala and hypothalamus of AHA mice. In both these areas, 5-HT1B mRNA was elevated when compared with ANA mice. In the hypothalamus, AHA mice also showed increased transcripts for 5-HT2A receptor. In the midbrain, 5-HT synthetic enzyme, 5-HT transporter and 5-HT receptors mRNA levels were similar between groups. Our results emphasize a role for postsynaptic over presynaptic 5-HT receptors in mice which showed escalated aggression after the consumption of a moderate dose of alcohol. This gene expression profile of 5-HT neurotransmission components in the brain of mice may suggest a vulnerability trait for alcohol-heightened aggression. [source] Female oxytocin gene-knockout mice, in a semi-natural environment, display exaggerated aggressive behaviorGENES, BRAIN AND BEHAVIOR, Issue 4 2005A. K. Ragnauth Compared to results from a generation of neuropharmacological work, the phenotype of mice lacking the oxytocin (OT) peptide gene was remarkably normal. An important component of the current experiments was to assay OT-knockout (OTKO) and wild-type (WT) littermate control mice living under controlled stressful conditions designed to mimic more closely the environment for which the mouse genome evolved. Furthermore, our experimental group was comprised of an all-female population, in contrast to previous studies which have focused on all-male populations. Our data indicated that aggressive behaviors initiated by OTKO during a food deprivation feeding challenge were considerably more intense and diverse than aggressive behaviors initiated by WT. From the measures of continuous social interaction in the intruder paradigm, it emerged that OTKO mice were more offensively aggressive (attacking rumps and tails) than WT. In a test of parental behaviors, OTKO mice were 100% infanticidal while WT were 16% infanticidal and 50% maternal. Finally, ,alpha females' (always OTKO) were identified in each experiment. They were the most aggressive, the first to feed and the most dominant at nesting behaviors. Semi-natural environments are excellent testing environments for elucidating behavioral differences between transgenic mice and their WT littermates which may not be ordinarily discernible. Future studies of mouse group behavior should include examining female groupings in addition to the more usual all-male groups. [source] Sentinel node biopsy and head and neck tumors,Where do we stand today?HEAD & NECK: JOURNAL FOR THE SCIENCES & SPECIALTIES OF THE HEAD AND NECK, Issue 12 2006FCAP, Kenneth O. Devaney MD Abstract Background. Sentinel lymph node sampling may be studied profitably in series of patients with 1 tumor type, such as breast carcinoma, in 1 anatomic locale. The present work analyzes the efficacy of sentinel node sampling in a pathologically diverse group of lesions from an anatomically diverse region such as the head and neck; however, there are risks conflating the findings in different tumors with radically different behaviors, in the process producing muddled data. This report reviews the head and neck experience with sentinel sampling and concludes that certain tumor types that have a known propensity for aggressive behavior are the best candidates for trials employing sentinel node sampling; candidates include many cutaneous melanomas of the head and neck, oropharyngeal squamous carcinomas, and selected thyroid carcinomas. Despite the growing popularity of sentinel node sampling in a variety of regions of the body, however, at this juncture this technique remains an investigational procedure, pending demonstration of a tangible improvement in patient outcome through its use. It is recommended that studies of the efficacy of this technique strive, whenever possible, to segregate results of different tumor types in different head and neck locales from one another so as to produce more focused findings for discrete types of malignancies, and not group together tumor types that may in reality exhibit different biological behaviors. © 2006 Wiley Periodicals, Inc. Head Neck, 2006 [source] Mothers' Trait Verbal Aggressiveness as a Predictor of Maternal and Child Behavior During Playtime InteractionsHUMAN COMMUNICATION RESEARCH, Issue 3 2008Steven R. Wilson This article explores associations between mothers' trait verbal aggressiveness (VA) and maternal and child behavior during playtime interactions. Forty mothers completed a 10-minute play period with one of their children (range = 3,8 years) and then responded to D. A. Infante and C. J. Wigley's (1986) trait VA scale. Mothers' trait VA was associated positively (r = .48) with their rate of directing and inversely (r =,.44) with their child's rated cooperation. Qualitative analyses of a subset (n = 8) of interactions suggest that mothers high in trait VA used directives to control the choice, rate, and duration of activities, and used physical negative touch along with directives, more than low-VA mothers. Behaviors associated with trait VA occur even during brief mother,child interactions in which triggers for aggressive behavior largely are absent. Résumé Le trait d,agressivité verbale des mères comme variable explicative des comportements maternels et infantiles lors d'interactions de jeu Cet article explore les associations entre le trait d,agressivité verbale (AV) des mères et le comportement maternel et infantile lors d'interactions de jeu. 40 mères ont participéà une période de jeu de 10 minutes avec l,un de leurs enfants (tranche d'âge = 3-8 ans) puis ont répondu à l'échelle de trait d'AV d,Infante et Wigley (1986). Le trait d'AV des mères fut associé positivement (r= 0,48) à leur taux de contrôle et inversement (r= -0,44) au taux de coopération de leur enfant. Des analyses qualitatives d,un sous-ensemble (n= 8) d'interactions donnent à penser que les mères au trait d,AV élevé ont fait usage de directives pour contrôle le choix, le rythme et la durée des activités et qu'elles ont utilisé le toucher physique négatif en même temps que les directives, plus que ne l,ont fait les mères au trait d'AV faible. Les comportements associés au trait d'AV surviennent même lors de brèves interactions mère-enfant au cours desquelles les déclencheurs de comportements agressifs étaient largement absents. Abstract Das Müttermerkmal verbale Aggression als Prädiktor für Mutter-Kind-Verhalten in spielerischen Interaktionen Dieser Artikel untersucht den Zusammenhang zwischen dem Müttermerkmal verbale Aggression (VA) und dem Mutter-Kind-Verhalten in spielerischen Interaktionen. 40 Mütter spielten 10 Minuten lang mit einem ihrer Kinder (zwischen 3-8 Jahren) und beantworteten dann die VA-Eigenschaftsskala nach Infante & Wigley (1986). Das Müttermerkmal VA war positiv assoziiert (r= .48) mit der Häufigkeit des führenden Eingreifens und umgekehrt assoziiert (r= -.44) mit der vom Kind beurteilten Kooperation. Qualitative Analysen eines Teils (n= 8) der Interaktionen deuten darauf hin, dass Mütter mit hoher VA führendes Eingreifen nutzen, um die Wahl, Häufigkeit und Dauer von Aktivitäten zu kontrollieren. Sie nutzten außerdem häufiger physisch negative Berührungen zusammen mit dem führenden Eingreifen als Mütter mit niedriger VA. Mit dem Merkmal VA verbundene Verhaltensweisen finden sogar in kurzen Mutter-Kind-Interaktionen statt bei denen Auslöser für aggressives Verhalten weitestgehend fehlen. Resumen El Rasgo de la Agresividad Verbal de las Madres como Vaticinador del Comportamiento Materno y del Niño Durante las Interacciones en el Recreo Este artículo explora la asociación entre el rasgo de agresividad verbal de las madres (VA) y el comportamiento maternal y del niño durante las interacciones en el recreo. Cuarenta madres completaron un período de 10-minutos de juego con uno de sus hijos (oscilando = 3-8 años) y luego respondieron a la escala sobre el rasgo VA de Infante y Wigley (1986). El rasgo VA de las madres fue asociado positivamente (r= .48) con el grado de direccionamiento e inversamente (r= -.44) con el grado de cooperación de su niño. Los análisis cualitativos de un subset (n= 8) de interacciones sugieren que las madres con rasgos altos de VA usaron directivas para controlar la selección, el tipo, y la duración de las actividades, y usaron el contacto físico negativo junto con directivas, más que las madres con rasgos bajos de VA. Los comportamientos asociados con el rasgo VA durante las interacciones breves entre la madre y su niño que provocan el comportamiento agresivo se encuentran mayormente ausentes. ZhaiYao Yo yak [source] Clinical, cellular, and neuropathological consequences of AP1S2 mutations: further delineation of a recognizable X-linked mental retardation syndrome,HUMAN MUTATION, Issue 7 2008Guntram Borck Abstract Mutations in the AP1S2 gene, encoding the ,1B subunit of the clathrin-associated adaptor protein complex (AP)-1, have been recently identified in five X-linked mental retardation (XLMR) families, including the original family with Fried syndrome. Studying four patients in two unrelated families in which AP1S2 nonsense and splice-site mutations segregated, we found that affected individuals presented, in addition to previously described features, with elevated protein levels in cerebrospinal fluid (CSF). Moreover, computed tomography scans demonstrated that the basal ganglia calcifications associated with AP1S2 mutations appeared during childhood and might be progressive. Based on these observations, we propose that AP1S2 mutations are responsible for a clinically recognizable XLMR and autism syndrome associating hypotonia, delayed walking, speech delay, aggressive behavior, brain calcifications, and elevated CSF protein levels. Using the AP-2 complex, in which the , subunit is encoded by one single gene, as a model system, we demonstrated that , subunits are essential for the stability of human AP complexes. By contrast, no major alteration of the stability, subcellular localization, and function of the AP-1 complex was observed in fibroblasts derived from a patient carrying an AP1S2 mutation. Similarly, neither macro- nor microscopic defects were observed in the brain of an affected fetus. Altogether, these data suggest that the absence of an AP-1 defect in peripheral tissues is due to functional redundancy among AP-1 , subunits (,1A, ,1B, and ,1C) and that the phenotype observed in our patients results from a subtle and brain-specific defect of the AP-1-dependent intracellular protein traffic. Hum Mutat 29(7), 966,974, 2008. © 2008 Wiley-Liss, Inc. [source] Selective cyclooxygenase-2 inhibitor downregulates the paracrine epithelial,mesenchymal interactions of growth in scirrhous gastric carcinomaINTERNATIONAL JOURNAL OF CANCER, Issue 3 2007Masakazu Yashiro Abstract The importance of cancer-mesenchymal interactions in the aggressive behavior of scirrhous gastric cancer is supported by experimental and clinical evidences. We have previously reported that gastric fibroblasts secretion of keratinocyte growth factor (KGF) underline the remarkable proliferation of scirrhous gastric cancer cells. Cyclooxygenase-2 (COX-2) is not only expressed in cancer cells, but also in interstitial fibroblasts in gastric carcinoma. To clarify the mechanisms responsible for the antiproliferation effect of COX-2 inhibitors, effect of COX-2 inhibitor on the paracrine epithelial,mesenchymal interactions of growth was examined. Scirrhous gastric cancer cell line, OCUM-2M, gastric fibroblasts, NF-21, and COX-2 inhibitor, JTE-522, were used. Growth-interaction was examined by calculating the number of cancer cells or by measuring [3H] thymidine incorporation of cancer cells. Effect of JTE-522 on KGF expression from NF-21 cells and OCUM-2M cells was analyzed by ELISA and RT-PCR. The conditioned medium from gastric fibroblasts significantly stimulated the growth of scirrhous gastric cancer cells. JTE-522 at the concentrations of 10,5 and 10,6 M significantly decreased the growth-stimulating activity of gastric fibroblasts. JTE-522 reduced the expression of KGF mRNA and the production of KGF from gastric fibroblasts. Oral administration of JTE-522 significantly decreased the size of xenografted tumor coinoculated with OCUM-2M cells and NF-21 cells in nude mice. JTE-522 decreased COX-2 expression and Ki67 labeling index within the coinoculated tumor. These findings suggested that a selective COX-2 inhibitor, JTE-522, downregulates KGF production from gastric fibroblasts, resulting in the inhibition of paracrine epithelial,mesenchymal interactions of proliferation between scirrhous gastric cancer cells and gastric fibroblasts. © 2006 Wiley-Liss, Inc. [source] | ||||||||||||||||||||||||||||||||||