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Essential Nature (essential + nature)
Selected AbstractsIsolation and functional identification of a novel human hepatic growth factor: Hepatopoietin Cn,HEPATOLOGY, Issue 3 2008Chun-Ping Cui Hepatic stimulating substance (HSS) was first isolated from weanling rat liver in 1975 and found to stimulate hepatic DNA synthesis both in vitro and in vivo. Since then, mammalian and human HSS have been investigated for their potential to treat hepatic diseases. However, the essential nature in composition and structure of HSS remain puzzling because HSS has not been completely purified. Heating, ethanol precipitation, and ion-exchange chromatographies had been carried out to isolate the protein with specific stimulating activity from newborn calf liver, and [3H]thymidine deoxyribose (TdR)/bromodeoxyuridine (BrdU) incorporation and carboxyfluorescein diacetate succinimidyl ester (CFSE)-based proliferation assay to determine the bioactivity in vitro and in vivo. We report the purification of a novel 30-kDa protein from a crude extract of calf liver HSS. This protein is a member of the leucine-rich acidic nuclear protein family (LANP) and has been named hepatopoietin Cn (HPPCn). Studies of partially hepatectomized (PH) mice show that levels of HPPCn messenger RNA (mRNA) increase after liver injury. Furthermore, the recombinant human protein (rhHPPCn) was shown to stimulate hepatic DNA synthesis and activate signaling pathways involved in hepatocyte proliferation in vitro and in vivo. Conclusion: HPPCn is a novel hepatic growth factor that plays a role in liver regeneration. (HEPATOLOGY 2008;47:986,995.) [source] Dynamic Interracial/Intercultural Processes: The Role of Lay Theories of RaceJOURNAL OF PERSONALITY, Issue 5 2009Ying-yi Hong ABSTRACT This paper explores how the lay theory approach provides a framework beyond previous stereotype/prejudice research to understand dynamic personality processes in interracial/ethnic contexts. The authors conceptualize theory of race within the Cognitive,Affective Personality System (CAPS), in which lay people's beliefs regarding the essential nature of race sets up a mind-set through which individuals construe and interpret their social experiences. The research findings illustrate that endorsement of the essentialist theory (i.e., that race reflects deep-seated, inalterable essence and is indicative of traits and ability) versus the social constructionist theory (i.e., that race is socially constructed, malleable, and arbitrary) are associated with different encoding and representation of social information, which in turn affect feelings, motivation, and competence in navigating between racial and cultural boundaries. These findings shed light on dynamic interracial/intercultural processes. Relations of this approach to CAPS are discussed. [source] Jonathan Edwards and the Language of Nature: The Re-Enchantment of the World in the Age of Scientific ReasoningJOURNAL OF RELIGIOUS HISTORY, Issue 1 2002Avihu Zakai For a long time Jonathan Edwards (1703-58) was thought of more as a preacher of hellfire and revival than as a theologian, and rather as a Calvinist theologian than a philosopher of importance, and he was dismissed accordingly. Yet Edwards was more than a hellfire preacher, more than a theologian. This New England divine was one of the rare individuals anywhere to recognize and answer the challenges posed to traditional Christian belief by the emergence of new modes of thought in early modern history - the new ideas of the scientific thought and the Enlightenment. His force of mind is evident in his exposition of the poverty of mechanical philosophy, which radically transformed the traditional Christian dialectic of God's utter transcendence and divine immanence by gradually dimin-ishing divine sovereignty with respect to creation, providence, and redemption, thus leading to the disenchantment of the world. Edwards constructed a teleological and theological alternative to the prevailing mechanistic interpretation of the essential nature of reality, whose ultimate goal was the re-enchantment of the world by reconstituting the glory of God's majestic sovereignty, power, and will within the order of creation. [source] Staphylococcus aureus primase has higher initiation specificity, interacts with single-stranded DNA stronger, but is less stimulated by its helicase than Escherichia coli primaseMOLECULAR MICROBIOLOGY, Issue 6 2008Scott A. Koepsell Summary The study of primases from model organisms such as Escherichia coli, phage T7 and phage T4 has demonstrated the essential nature of primase function, which is to generate de novo RNA polymers to prime DNA polymerase. However, little is known about the function of primases from other eubacteria. Their overall low primary sequence homology may result in functional differences. To help understand which primase functions were conserved, primase and its replication partner helicase from the pathogenic Gram-positive bacteria Staphylococcus aureus were compared in detail with that of E. coli primase and helicase. The conserved properties were to primer initiation and elongation and included slow kinetics, low fidelity and poor sugar specificity. The significant differences included S. aureus primase having sixfold higher kinetic affinity for its template than E. coli primase under equivalent conditions. This naturally higher activity was balanced by its fourfold lower stimulation by its replication fork helicase compared with E. coli primase. The most significant difference between the two primases was that S. aureus helicase stimulation did not broaden the S. aureus primase initiation specificity, which has important biological implications. [source] The case against neuropsychoanalysis: On fallacies underlying psychoanalysis' latest scientifi c trend and its negative impact on psychoanalytic discourseTHE INTERNATIONAL JOURNAL OF PSYCHOANALYSIS, Issue 1 2007RACHEL B. BLASS The authors offer a critical examination of the claims of the proponents of the growing neuropsychoanalytic trend, that neuroscientifi c fi ndings are relevant and important for the development and justifi cation of psychoanalytic theory and practice. They bring to light some of the intuitions that have led to the popularity of the neuropsychoanalytic claims and the fallacies that underlie these claims and intuitions. They argue that it is crucial at this time to articulate the case against the neuropsychoanalytic trend because, underlying the debate over the relevance of neuroscience to psychoanalysis, there lies a struggle over the essential nature of psychoanalytic theory and practice. Relying on a biologistic perspective, whereby only what is biological is real, this new trend in effect offers a vision of psychoanalysis that limits the signifi cance of the unique psychoanalytic concern with the understanding of meanings and the role of discourse in discerning and justifying these meanings. [source] | ||||||||||