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Equivocal Findings (equivocal + finding)
Selected AbstractsLiving with uncertainty: Equivocal Pap test results and the evolution of ASC terminologyDIAGNOSTIC CYTOPATHOLOGY, Issue 3 2010Lydia Pleotis Howell M.D. Abstract Communication of equivocal findings and their significance has been a significant challenge related to Pap testing throughout its history. Terminology to report these findings has changed considerably to accommodate the changes in understanding of cervical neoplasia, and to accommodate new management strategies, tests, and technologies. This article reviews the evolution of terminology for equivocal Pap test findings from the original Papanicolaou classification to the current the Bethesda System 2001 atypical squamous cells terminology, the implication and use of these terms, and the changing landscape of cervical neoplasia screening, which prompted these terminology changes. Emerging issues related to improving risk stratification through the introduction of additional terms and the impact of human papillomavirus testing may alter terminology of equivocal findings in the future. Diagn. Cytopathol. 2010. © 2009 Wiley-Liss, Inc. [source] Assessment of Family Functioning in Caucasian and Hispanic Americans: Reliability, Validity, and Factor Structure of the Family Assessment DeviceFAMILY PROCESS, Issue 4 2007GREGORY A. AARONS PH.D. The purpose of this study was to examine the factor structure, reliability, and validity of the Family Assessment Device (FAD) among a national sample of Caucasian and Hispanic American families receiving public sector mental health services. A confirmatory factor analysis conducted to test model fit yielded equivocal findings. With few exceptions, indices of model fit, reliability, and validity were poorer for Hispanic Americans compared with Caucasian Americans. Contrary to our expectation, an exploratory factor analysis did not result in a better fitting model of family functioning. Without stronger evidence supporting a reformulation of the FAD, we recommend against such a course of action. Findings highlight the need for additional research on the role of culture in measurement of family functioning. [source] Visual Cortex Excitability in Migraine With and Without AuraHEADACHE, Issue 6 2001Wim M. Mulleners MD Objectives.,Previous research using transcranial magnetic stimulation has produced equivocal findings concerning thresholds for the generation of visual phosphenes in migraine with aura. These studies were methodologically varied and did not systematically address cortical excitability in migraine without aura. We therefore studied magnetophosphene thresholds in both migraine with aura and migraine without aura compared with headache-free controls. Methods.,Sixteen subjects with migraine with aura and 12 subjects with migraine without aura were studied and compared with 16 sex- and age-matched controls. Using a standardized transcranial magnetic stimulation protocol of the occipital cortex, we assessed the threshold stimulation intensity at which subjects just perceived phosphenes via a method of alternating course and fine-tuning of stimulator output. Results.,There were no significant differences across groups in the proportion of subjects seeing phosphenes. However, the mean threshold at which phosphenes were reported was significantly lower in both migraine groups (migraine with aura=47%, migraine without aura=46%) than in controls (66%). Moreover, there was no significant correlation between individual phosphene threshold and the time interval to the closest migraine attack. Conclusion.,Our findings confirm that the occipital cortex is hyperexcitable in the migraine interictum, both in migraine with and without aura. [source] Calcium supplementation of breeding birds: directions for future researchIBIS, Issue 4 2004S. James Reynolds Calcium is an essential nutrient for avian reproduction. Calcium-rich foods are consumed by breeding birds for production of eggshells and for provisioning chicks that are mineralizing skeletal tissues. A number of studies have documented calcium-limited reproduction, and calcium supplementation has been employed over the last decade to demonstrate degrees, causes and consequences of calcium limitation. However, supplementation studies have produced equivocal findings resulting from an absence of calcium limitation in the study species, a poorly designed supplementation procedure or both. Prior to effective calcium supplementation, many factors need to be considered. Calcium-limited breeding in birds can only be detected by monitoring breeding attempts for more than one year and by ensuring that the measured breeding parameters are sensitive to calcium availability. Natural calcium availability needs to be estimated, and daily calcium budgets for the appropriate reproductive stages determined for the study species. Most crucially, if calcium limitation of breeding is caused by secondary calcium limitation (e.g. through heavy metal toxicity), calcium supplementation will probably be ineffective. Effective calcium supplementation will then be achieved through careful planning , a study over several years using appropriate supplements (i.e. naturally occurring ones used by breeding birds), applied at the appropriate time of year (i.e. prelaying and/or chick-rearing phases) and using a response variable that is highly sensitive to calcium availability. If properly planned and performed, calcium supplementation is a cost-effective and potent tool for the study of bird breeding biology. [source] The role of antenatal pelvic floor muscle exercises in prevention of postpartum stress incontinence: a randomised controlled trialJOURNAL OF CLINICAL NURSING, Issue 19-20 2010Linda Mason Aim., This article reports a randomised controlled trial to determine the efficacy of antenatal pelvic floor muscle exercises in the primary prevention of postpartum stress incontinence in primiparous women. Background., Pelvic floor muscle exercises are effective in treating stress incontinence, yet prevention studies demonstrate equivocal findings. Design., Randomised controlled trial. Method., Pregnant women recruited from two hospitals in North-west England were randomised to an intervention (n = 141) or control group (n = 145). Data were collected from 2005,2006. The intervention comprised four sessions of taught pelvic floor muscle exercise training during pregnancy and 8,12 maximal contractions repeated twice daily at home. A modified Bristol Female Lower Urinary Tract Symptom questionnaire, Leicester Impact Scale and Three Day Diary were administered at 20 and 36 weeks of pregnancy and three months postpartum. Results., The intervention group was more likely to exercise their pelvic floor muscles compared to controls at 36 weeks (p = 0·019) and three months (0·022), reporting fewer episodes of incontinence and a lower score on the Leicester Impact Scale. However, these differences were not statistically significant. Conclusion., Significant differences were not demonstrated between the groups in relation to incontinence episodes and degree of bother of symptoms postpartum, although trends indicate a positive effect. Further research is necessary to address issues of adherence and the effect of pelvic floor muscle exercise undertaken during pregnancy on postpartum stress urinary incontinence. Relevance to clinical practice., A proportion of women did not meet the required attendance at antenatal class, furthermore, few exercised their pelvic floor muscles during pregnancy according to instructions. Health professionals need to find ways to instruct and motivate women to perform pelvic floor muscles exercises regularly during pregnancy and the postpartum. [source] The Self,Concept of Students with Learning Disabilities: A Meta,Analysis of Comparisons Across Different PlacementsLEARNING DISABILITIES RESEARCH & PRACTICE, Issue 4 2002Batya ElbaumArticle first published online: 17 DEC 200 Although placement in less restrictive settings is generally believed to be associated with more positive social outcomes for students with disabilities, the empirical research has yielded equivocal findings. The purpose of this study was to synthesize the empirical research comparing the self,concept of students with learning disabilities (LD) in different educational placements. Meta,analysis revealed no overall association between self,concept and educational placement for four out of five comparisons: regular class vs. resource room, regular class vs. self,contained class, resource room vs. self,contained class, and regular class vs. special school. Students with LD receiving instruction in self,contained classrooms in regular schools exhibited lower self,concept compared to students with LD attending special schools. Follow,up analyses were conducted to explore whether the variability of effect sizes in regular class,resource room comparisons was associated with any of several potential moderator variables; the only variable for which the association approached significance was whether students in the regular classroom were provided with appropriate special education supports and services. The findings are discussed in light of documented individual variation in students' placement preferences. [source] Personal view: a potential novel treatment for fatigue complicating chronic liver disease , how should its efficacy be evaluated?ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Issue 8 2006E. A. JONES Summary Profound fatigue is a clinically significant complication of chronic liver disease. A mechanism of fatigue in experimental animals and male athletes appears to be increased serotoninergic neurotransmission in the brain. Recently, attempts have been made to assess the efficacy of a serotonin antagonist, specifically the 5-HT3 receptor subtype antagonist, ondansetron, in ameliorating fatigue in patients with chronic liver disease. However, the results of a randomized controlled trial of ondansetron for fatigue in patients with primary biliary cirrhosis did not indicate that ondansetron was either effective or ineffective. The reasons for the uncertain outcome of the randomized controlled trial are not clear. One contributing factor may have been the use of subjective indices of fatigue as primary efficacy endpoints. There is a need to develop objective quantitative primary efficacy endpoints for use in trials of therapy for fatigue. Another contributing factor may relate to the conduct of a randomized controlled trial not invariably being the optimal approach to resolve a specific clinical issue, particularly when the application of statistical methods yields equivocal findings. When the results of a randomized controlled trial are indecisive, findings based on clinical judgement, medicine's most important asset, should be carefully evaluated. [source] Role of FDG-PET in surgical management of patients with colorectal liver metastasesANZ JOURNAL OF SURGERY, Issue 8 2004Benjamin D. Teague Background: [ 18F]-fluorodeoxyglucose positron emission tomography (FDG-PET) is reported to change the management in 20,56% of patients with recurrent or metastatic colorectal cancer. It is not clear if FDG-PET has a role in all such patients or only a subgroup. The aim of the present study was to assess the influence of FDG-PET on the surgical management of patients with known or suspected colorectal liver metastases. Methods: Patients undergoing FDG-PET for investigation of known or suspected colorectal liver metastases were identified from a South Australian database. Case notes were reviewed retrospectively to determine the influence of FDG-PET findings on patient management. Findings from FDG-PET scanning were compared with findings from conventional diagnostic investigations and operative findings. Results: Overall, in four of 16 patients (25%) management was influenced by FDG-PET findings. FDG-PET altered management in four of eight (50%) patients with non-diagnostic liver lesions on computed tomography (CT) or with elevated carcinoembryonic antigen levels but no liver lesion on CT. In all eight patients with CT diagnosed resectable liver metastases, the addition of FDG-PET did not influence the management. Conclusions: The findings support the use of FDG-PET in the assessment of selected patients with suspected colorectal liver metastases and equivocal findings on conventional diagnostic investigation. [source] | ||||||||||