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Epithelial Cell Interactions (epithelial + cell_interaction)
Selected AbstractsAndrogens and hair growthDERMATOLOGIC THERAPY, Issue 5 2008Valerie Anne Randall ABSTRACT:, Hair's importance in human communication means that abnormalities like excess hair in hirsutism or hair loss in alopecia cause psychological distress. Androgens are the main regulator of human hair follicles, changing small vellus follicles producing tiny, virtually invisible hairs into larger intermediate and terminal follicles making bigger, pigmented hairs. The response to androgens varies with the body site as it is specific to the hair follicle itself. Normally around puberty, androgens stimulate axillary and pubic hair in both sexes, plus the beard, etc. in men, while later they may also inhibit scalp hair growth causing androgenetic alopecia. Androgens act within the follicle to alter the mesenchyme,epithelial cell interactions, changing the length of time the hair is growing, the dermal papilla size and dermal papilla cell, keratinocyte and melanocyte activity. Greater understanding of the mechanisms of androgen action in follicles should improve therapies for poorly controlled hair disorders like hirsutism and alopecia. [source] The role of the gut flora in health and disease, and its modification as therapyALIMENTARY PHARMACOLOGY & THERAPEUTICS, Issue 8 2002A. L. Hart Summary The gut flora is a vast interior ecosystem whose nature is only beginning to be unravelled, due to the emergence of sophisticated molecular tools. Techniques such as 16S ribosomal RNA analysis, polymerase chain reaction amplification and the use of DNA microarrays now facilitate rapid identification and characterization of species resistant to conventional culture and possibly unknown species. Life-long cross-talk between the host and the gut flora determines whether health is maintained or disease intervenes. An understanding of these bacteria,bacteria and bacteria,host immune and epithelial cell interactions is likely to lead to a greater insight into disease pathogenesis. Studies of single organism,epithelial interactions have revealed the large range of metabolic processes that gut bacteria may influence. In inflammatory bowel diseases, bacteria drive the inflammatory process, and genetic predisposition to disease identified to date, such as the recently described NOD2/CARD15 gene variants, may relate to altered bacterial recognition. Extra-intestinal disorders, such as atopy and arthritis, may also have an altered gut milieu as their basis. Clinical evidence is emerging that the modification of this internal environment, using either antibiotics or probiotic bacteria, is beneficial in preventing and treating disease. This natural and apparently safe approach holds great appeal. [source] Eosinophil,epithelial cell interactions: an important facet of asthmatic inflammationCLINICAL & EXPERIMENTAL ALLERGY, Issue 6 2002Darren W. Sexton No abstract is available for this article. [source] Eosinophil,epithelial cell interactions: a special relationship?CLINICAL & EXPERIMENTAL ALLERGY, Issue 3 2001Garry M. Walsh [source] Dermatofibroma: a possible model of local fibrosis with epithelial/mesenchymal cell interactionJOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY & VENEREOLOGY, Issue 4 2009T Yamamoto Abstract Dermatofibromas are benign dermal nodules usually seen on the extremities; however, whether a dermatofibroma is a reactive fibrous hyperplasia or a true neoplasm is still unclear. Fibrous type dermatofibromas might be regarded as the symptom of local fibrotic processes and thus present a possible model of local fibrosis. Interaction between proliferated dermatofibroma fibroblasts and overlying elongated epidermis suggests a relationship between keratinocytes and mesenchymal cells. We herein describe current insights into the pathogenesis of dermatofibromas and explore the possible involvement of immunocytes around fibroblasts and effector cells which play an important role in the development of dermatofibromas. Conflicts of interest None declared [source] | ||||||||||