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Enormous Progress (enormous + progress)
Selected AbstractsThe paediatrician , past, present and future , a conversation with Nils Rosén von RosensteinACTA PAEDIATRICA, Issue 9 2009Ingemar Kjellmer Abstract An imagined conversation takes place with the author of the first textbook of Paediatrics, Nils Rosén von Rosenstein. Enormous progress in the prevention and treatment of diseases of children is demonstrated. But a different spectrum of diseases has replaced the old one. And in spite of unprecedented material well-being a substantial minority of our children cannot make full use of their capabilities. Conclusion:, We must resume the full responsibility for our children and act as their advocates in society. [source] Alois Alzheimer and Alzheimer's disease: a centennial perspectiveJOURNAL OF NEUROCHEMISTRY, Issue 3 2006David H. Small The year 2006 is the centenary of the famous presentation of Alois Alzheimer which first described the neuropathology of Alzheimer's disease (AD). Since this presentation, enormous progress has been made in understanding the biology of AD. The central role of the ,-amyloid protein (A,) in the pathogenesis of AD and the relationship between plaque and tangle pathology is now much better understood. In this article, we review the current status of the amyloid hypothesis of AD and its role in the development of future therapy. [source] Eukaryotic ribosomal proteins lacking a eubacterial counterpart: important players in ribosomal functionMOLECULAR MICROBIOLOGY, Issue 6 2006John Dresios Summary The ribosome is a macromolecular machine responsible for protein synthesis in all organisms. Despite the enormous progress in studies on the structure and function of prokaryotic ribosomes, the respective molecular details of the mechanism by which the eukaryotic ribosome and associated factors construct a polypeptide accurately and rapidly still remain largely unexplored. Eukaryotic ribosomes possess more RNA and a higher number of proteins than eubacterial ribosomes. As the tertiary structure and basic function of the ribosomes are conserved, what is the contribution of these additional elements? Elucidation of the role of these components should provide clues to the mechanisms of translation in eukaryotes and help unravel the molecular mechanisms underlying the differences between eukaryotic and eubacterial ribosomes. This article focuses on a class of eukaryotic ribosomal proteins that do not have a eubacterial homologue. These proteins play substantial roles in ribosomal structure and function, and in mRNA binding and nascent peptide folding. The role of these proteins in human diseases and viral expression, as well as their potential use as targets for antiviral agents is discussed. [source] Ultra-cool and extra-vigorous: Rotation and activity in Mand L dwarfsASTRONOMISCHE NACHRICHTEN, Issue 10 2007A. Reiners, Article first published online: 27 DEC 200 Abstract The study of rotation and activity in low-mass stars or brown dwarfs of spectral classes M and L has seen enormous progress during the last years. I summarize the results from different works that measured activity, rotation, and sometimes magnetic fields. The generation of magnetic activity seems to be unchanged at the threshold to completely convective stars, i.e. no change in the efficiency of the magnetic dynamos is observed. On the other hand, a sudden change in the strength of rotational braking appears at the threshold mass to full convection, and strong evidence exists for rotational braking weakening with lower mass. A probable explanation is that the field topology changes from dipolar to small scale structure as the objects become fully convective. (© 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] | ||||||||||