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Enhanced Understanding (enhanced + understanding)
Selected AbstractsPrejudice and schizophrenia: a review of the ,mental illness is an illness like any other' approachACTA PSYCHIATRICA SCANDINAVICA, Issue 5 2006J. Read Objective:, Many anti-stigma programmes use the ,mental illness is an illness like any other' approach. This review evaluates the effectiveness of this approach in relation to schizophrenia. Method:, The academic literature was searched, via PsycINFO and MEDLINE, to identify peer-reviewed studies addressing whether public espousal of a biogenetic paradigm has increased over time, and whether biogenetic causal beliefs and diagnostic labelling are associated with less negative attitudes. Results:, The public, internationally, continues to prefer psychosocial to biogenetic explanations and treatments for schizophrenia. Biogenetic causal theories and diagnostic labelling as ,illness', are both positively related to perceptions of dangerousness and unpredictability, and to fear and desire for social distance. Conclusion:, An evidence-based approach to reducing discrimination would seek a range of alternatives to the ,mental illness is an illness like any other' approach, based on enhanced understanding, from multi-disciplinary research, of the causes of prejudice. [source] Psychodrama: helping families to adapt to childhood diabetesEUROPEAN DIABETES NURSING, Issue 3 2006B Bektas RN. Abstract Effective management of diabetes in children requires a holistic approach that takes into account the roles of diabetes education, treatment and disease management, and the integral role of family relationships. Psychodrama is a group-based psychological support technique that aims to improve the acceptance and understanding of diabetes within the families of diagnosed children. Through group improvisation, role plays and feedback sessions, the families of children with diabetes participate in a cathartic process that helps them to share their problems, benefit from others' insight and feedback and to discuss behavioural changes that will avoid similar problems in the future. The families that participated in this study reported an enhanced understanding of the contribution that relationships with their children have on the successful management of their diabetes. Through recognition of the reasons for their anxieties about their children's diabetes, they were able to address fixed behavioural patterns in a supportive, non-judgmental arena, and to work towards positive change. Their children benefited indirectly through changes in their parents' behaviour and improved communication within their families. A reduction in the children's HbA1c levels was observed through the course of the study, although this could not be considered a direct result of psychodrama. Copyright © 2006 FEND. [source] Reducing complexity in Qualitative Comparative Analysis (QCA): Remote and proximate factors and the consolidation of democracyEUROPEAN JOURNAL OF POLITICAL RESEARCH, Issue 5 2006CARSTEN Q. SCHNEIDER However, real-world research situations might make the application of fs/QCA difficult in two respects , namely, the complexity of the results and the phenomenon of limited diversity. We suggest a two-step approach as one possibility to mitigate these problems. After introducing the difference between remote and proximate factors, the application of a two-step fs/QCA approach is demonstrated analyzing the causes of the consolidation of democracy. We find that different paths lead to consolidation, but all are characterized by a fit of the institutional mix chosen to the societal context in terms of power dispersion. Hence, we demonstrate that the application of fs/QCA in a two-step manner helps to formulate and test equifinal and conjunctural hypotheses in medium-size N comparative analyses, and thus to contribute to an enhanced understanding of social phenomena. [source] Migraine: A Chronic Sympathetic Nervous System DisorderHEADACHE, Issue 1 2004Stephen J. Peroutka MD Objective.,To determine the degree of diagnostic and clinical similarity between chronic sympathetic nervous system disorders and migraine. Background.,Migraine is an episodic syndrome consisting of a variety of clinical features that result from dysfunction of the sympathetic nervous system. During headache-free periods, migraineurs have a reduction in sympathetic function compared to nonmigraineurs. Sympathetic nervous system dysfunction is also the major feature of rare neurological disorders such as pure autonomic failure and multiple system atrophy. There are no known reports in the medical literature, however, comparing sympathetic nervous system function in individuals with migraine, pure autonomic failure, and multiple system atrophy. Methods.,A detailed review of the literature was performed to compare the results of a wide variety of diagnostic tests and clinical signs that have been described in these 3 heretofore unrelated disorders. Results.,The data indicate that migraine shares significant diagnostic and clinical features with both pure autonomic failure and multiple system atrophy, yet represents a distinct subtype of chronic sympathetic dysfunction. Migraine is most similar to pure autonomic failure in terms of reduced supine plasma norepinephrine levels, peripheral adrenergic receptor supersensitivity, and clinical symptomatology directly related to sympathetic nervous system dysfunction. The peripheral sympathetic nervous system dysfunction is much more severe in pure autonomic failure than in migraine. Migraine differs from both pure autonomic failure and multiple system atrophy in that migraineurs retain the ability, although suboptimal, to increase plasma norepinephrine levels following physiological stressors. Conclusions.,The major finding of the present study is that migraine is a disorder of chronic sympathetic dysfunction, sharing many diagnostic and clinical characteristics with pure autonomic failure and multiple system atrophy. However, the sympathetic nervous system dysfunction in migraine differs from pure autonomic failure and multiple system atrophy in that occurs in an anatomically intact system. It is proposed that the sympathetic dysfunction in migraine relates to an imbalance of sympathetic co-transmitters. Specifically, it is suggested that a migraine attack is characterized by a relative depletion of sympathetic norepinephrine stores in conjunction with an increase in the release of other sympathetic cotransmitters such as dopamine, prostaglandins, adenosine triphosphate, and adenosine. An enhanced understanding of the sympathetic dysfunction in migraine may help to more effectively diagnose, prevent, and/or treat migraine and other types of headache. [source] Telling stories from everyday practice, an opportunity to see a bigger picture: a participatory action research project about developing discharge planningHEALTH & SOCIAL CARE IN THE COMMUNITY, Issue 6 2009Pia Petersson RN Abstract In spite of laws, rules and routines, findings from Swedish as well as international research show that discharge planning is not a simple matter. There is considerable knowledge about discharge planning, but the quality of the actual process in practice remains poor. With this in mind, a research and developmental health and social care network decided to use participation action research to explore the discharge planning situation in order to generate new ideas for development. This paper reports on the research process and the findings about our enhanced understanding about the discharge planning situation. Story dialogue method was used. The method is based on stories from everyday practice. The stories are used as ,triggers' to ask probing questions in a dialogical and structured form. Local theory is developed to help the participants to find solutions for action in the practice. Our findings were that the discharge planning situation could be seen as a system including three interconnected areas: patient participation, practitioners' competence and organizational support. To reach good quality in discharge planning, all these three issues need to be developed, but not only as routines and forms. Rather, when developing a discharge planning situation, a system where relational aspects such as confidence and continuity are essential and thus needs to be considered. To achieve a change, the core problem needs to be clarified. When the issue is complex, the solution needs to consider the bigger picture and not just the parts. Telling stories from everyday practice, and to systematically reflect and analyse those in interprofessional groups can create opportunities for enhanced understanding, as well as be a vehicle for future change of practice. [source] The hunting of the Leveller: the sophistication of parliamentarian propaganda, 1647,53HISTORICAL RESEARCH, Issue 199 2005Jason Peacey This article explores the propaganda produced against the Leveller John Lilburne by his enemies in Whitehall and Westminster. Based upon a wide range of civil war pamphlets and newspapers, as well as official sources and private papers, it contextualizes anti-Lilburne literature in terms of the complex political developments of the period, demonstrates the extent to which parliamentarians and Rumpers learnt to marshal ,civil service' resources, and assesses the conceptual appreciation of the ways in which print could be employed. As such, it contributes to an enhanced understanding of the political appropriation of popular polemic during the early modern ,print revolution'. [source] The riverscape of Western Amazonia , a quantitative approach to the fluvial biogeography of the regionJOURNAL OF BIOGEOGRAPHY, Issue 8 2007Tuuli Toivonen Abstract Aim, To provide a quantitative spatial analysis of the riverscape (open-water bodies and their surrounding areas) of the Western Amazonian lowlands using a consistent surface of remotely sensed imagery. Taking into account the essential significance of fluvial environments for the Amazonian biota, we propose that an enhanced understanding of the Amazonian riverscape will provide new insight for biogeographical studies in the region and contribute to the understanding of these megadiverse tropical lowlands. Location, An area of 2.2 million km2 covering the Western Amazonian lowlands of the Andean foreland region, i.e. the upper reaches of the Amazon river system. Areas in Colombia, Venezuela, Ecuador, Peru, Brazil and Bolivia between longitudes 83 °W and 65 °W and latitudes 5 °N and 12 °S are included. Methods, A mosaic of 120 Landsat TM satellite images was created with 100-m resolution, and water areas of over 1 ha in size or c. 60 m in width were extracted using a simple ratio threshold applicable to a large set of data. With this method, 99.1% of the water areas present in 30-m imagery were mapped with images with 100-m resolution. Water pixels of distinct river segments were assigned to river classes on the basis of their channel properties, and islands and lakes were distinguished separately and classified. Measures of water patterns such as structure, composition, richness and remoteness were provided for various spatial units. Riverine corridors were computed from the open-water mask by outer limits of active channels and floodplain lakes. Analytical results are shown as both thematic maps and statistics. Results, A total of 1.1% of Western Amazonia is covered by open-water bodies over 1 ha in size or 60 m in width. River-bound waters comprise 98% of the total water surface. Whilst isolated lakes are scarce, river-bound oxbow and backchannel lakes are plentiful, comprising 17.5% of all waters. They are particularly frequent along meandering channels, which dominate both in area and length. The riverine corridors including active channels and floodplain lakes cover 17% of the land area. The average distance from any point of land to the nearest water is 12 km. Geographically speaking, the distribution of waters is uneven across the region, and the detailed characteristics of the riverscape are geographically highly variable. Three major, fluvially distinct regions can be identified: central Western Amazonia, the south, and the north-east. The proportional surface areas of the riverine corridors, numbers of lakes, sizes of islands and their distributions depend largely on the types and sizes of the rivers. Main conclusions, Our results support the notion of Western Amazonia as a dynamic, highly fluvial environment, highlighting and quantifying considerable internal variation within the region in terms of fluvial patterns and the processes that they reflect and control. Biogeographically, the variety of types of fluvial environments and their characteristics are important constituents of what influences the distribution of species and dynamics of terrestrial habitats. Spatially consistent riverscape data can serve as a consistent and scalable source of relevant information for other biogeographical approaches in the region. [source] Applying a ,stages of change' model to enhance a traditional evaluation of a research transfer courseJOURNAL OF EVALUATION IN CLINICAL PRACTICE, Issue 4 2003Leslie L. Buckley MD MPH Abstract The aim of this study was to utilize an evaluation tool based on Prochaska's model of change in order to assess behaviour change as part of an evaluation process for a research transfer training programme (RTTP). The RTTP was a training programme offered to scientists in a psychiatry department and research institute to gain skills in research transfer. In addition to a traditional course evaluation framework evaluating overall satisfaction with the course and whether or not learning objectives were met, an additional ,stages of change' evaluation tool designed to assess change along a continuum was utilized. This instrument measured change in participants' attitudes, intentions and actions with respect to research transfer practice and consisted of a 12-question survey completed by participants prior to taking the course and 3 months post-course. In two out of the three categories, attitudes and intention to practice, there was positive change from pre- to post-course (P < 0.05). Although there was a trend of increased RT-related action, this was less robust and did not reach significance. For the RTTP transfer course, a ,stages of change' model of evaluation provided an enhanced understanding by showing changes in participants that would otherwise have been overlooked if only changes in RT behaviour were measured. Additionally, evaluating along a change continuum specifically identifies areas for improvement in future courses. The instrument developed for this study could also be used as a pre-course, participant needs assessment to tailor a course to the change needs of participants. Finally, this ,stages of change' approach provides insight into where barriers to change may exist for research transfer action. [source] Chitinolytic activity of endophytic Streptomyces and potential for biocontrolLETTERS IN APPLIED MICROBIOLOGY, Issue 6 2008M.C. Quecine Abstract Aims:, Biological sources for the control of plant pathogenic fungi remain an important objective for sustainable agricultural practices. Actinomycetes are used extensively in the pharmaceutical industry and agriculture owing to their great diversity in enzyme production. In the present study, therefore, we evaluated chitinase production by endophytic actinomycetes and the potential of this for control of phytopathogenic fungi. Methods and Results:, Endophytic Streptomyces were grown on minimum medium supplemented with chitin, and chitinase production was quantified. The strains were screened for any activity towards phytopathogenic fungi and oomycetes by a dual-culture in vitro assay. The correlation between chitinase production and pathogen inhibition was calculated and further confirmed on Colletotrichum sublineolum cell walls by scanning electron microscopy. Conclusions:, This paper reports a genetic correlation between chitinase production and the biocontrol potential of endophytic actinomycetes in an antagonistic interaction with different phytopathogens, suggesting that this control could occur inside the host plant. Significance and Impact of the Study:, A genetic correlation between chitinase production and pathogen inhibition was demonstrated. Our results provide an enhanced understanding of endophytic Streptomyces and its potential as a biocontrol agent. The implications and applications of these data for biocontrol are discussed. [source] Binding interactions between peptides and proteins of the class II Major Histocompatibility ComplexMEDICINAL RESEARCH REVIEWS, Issue 2 2002Benjamin J. McFarland Abstract The activation of helper T cells by peptides bound to proteins of the class II Major Histocompatibility Complex (MHC II) is pivotal to the initiation of an immune response. The primary functional requirement imposed on MHC II proteins is the ability to efficiently bind thousands of different peptides. Structurally, this is reflected in a unique architecture of binding interactions. The peptide is bound in an extended conformation within a groove on the membrane distal surface of the protein that is lined with several pockets that can accommodate peptide side-chains. Conserved MHC II protein residues also form hydrogen bonds along the length of the peptide main-chain. Here we review recent advances in the study of peptide-MHC II protein reactions that have led to an enhanced understanding of binding energetics. These results demonstrate that peptide-MHC II protein complexes achieve high affinity binding from the array of hydrogen bonds that are energetically segregated from the pocket interactions, which can then add to an intrinsic hydrogen bond-mediated affinity. Thus, MHC II proteins are unlike antibodies, which utilize cooperativity among binding interactions to achieve high affinity and specificity. The significance of these observations is discussed within the context of possible mechanisms for the HLA-DM protein that regulates peptide presentation in vivo and the design of non-peptide molecules that can bind MHC II proteins and act as vaccines or immune modulators. © 2002 John Wiley & Sons, Inc. Med Res Rev, 22, No. 2, 168,203, 2002; DOI 10.1002/med.10006 [source] Development of polymorphic markers for the root pathogen Thielaviopsis basicola using ISSR-PCRMOLECULAR ECOLOGY RESOURCES, Issue 4 2004MARIA M. GELDENHUIS Abstract Thielaviopsis basicola is a soil-borne fungal pathogen affecting many important agricultural crops. Little is known regarding the population biology or origin of this pathogen. Polymorphic markers developed for Ceratocystis fimbriata, a species complex phylogenetically closely related to T. basicola, were tested and found not to be useful for T. basicola. In this study 14 primer pairs, seven of which resulted in the amplification of single polymorphic fragments in T. basicola were developed. These primers will enable further studies on this economically important pathogen, and will result in an enhanced understanding of its population structure in different parts of the world. [source] Stretching the Effectiveness of Analogical Training in Negotiations: Teaching Diverse Principles for Creating ValueNEGOTIATION AND CONFLICT MANAGEMENT RESEARCH, Issue 2 2008Simone Moran Abstract The present research adapts analogical training to teach negotiators broad concepts of creating value. Recent research has shown specific analogical training, wherein negotiators draw analogies between different cases involving the same strategy, to be effective for learning and transferring specific value-creating strategies. The current results endorse the approach that analogical training can be a valuable tool for teaching negotiation, but argue that it can be enhanced by considering the breadth of the negotiation concepts that are learned. Diverse analogical training, wherein negotiators compare several different value-creating strategies, was shown to be more effective for learning broad underlying value-creating principles. This method facilitated transfer to a distinctive task and improved performance on a variety of value-creating strategies, including some that were not previously trained. The improved performance was also accompanied by enhanced understanding of the potential to create value. [source] Developing an audit tool to assess genetic servicesNURSING & HEALTH SCIENCES, Issue 2 2005Heather Skirton phd The aim of this study was to use clients' accounts and factor analysis to develop a robust assessment and audit tool for clinical genetic services. Qualitative data abstracted from published studies were used to generate a number of statements (n = 57) related to outcomes of genetic services. The resulting questionnaire was mailed to clients of the Wales genetic service, who were asked to rank each statement on a 7-point Likert type scale. Ninety-seven anonymised responses were received (73% response rate) and subjected to factor analysis. Six main factors were found to contribute to the outcome of the service and were labeled (i) enhanced understanding; (ii) positive psychological change; (iii) respect for autonomy; (iv) adaptation; (v) disequilibrium; and (vi) value of contact. The tool will be validated for use in clinical and research contexts. [source] Three-dimensional seismic characterisation of large-scale sandstone intrusions in the lower Palaeogene of the North Sea: completely injected vs. in situ remobilised sandbodiesBASIN RESEARCH, Issue 4 2010Ewa Szarawarska ABSTRACT A large number of km-scale, saucer-shaped sandstone bodies of enigmatic origin have recently been documented in the North Sea and the Faroe Shetland Basin. This study utilises three-dimensional seismic data, calibrated by well data, to examine two such bodies that exhibit very similar saucer-shaped geometries in cross-section. The Volund and Danica structures, located 250 km apart are interpreted as end members of a spectrum of large-scale remobilised and injected sandstones present in the North Sea Palaeogene. Both are characterised by a central 1,2 km-wide low area surrounded by a discordant, 2,300 m tall inclined dyke complex, that tips out into a bedding concordant body interpreted as a shallow-level sill and/or partly extruded sandstone. The origin of the central concordant sandstone body as either injected (laccolith) or depositional is of key importance to a complete understanding of the origin and prospectivity of these structures. The key criteria for recognising an injected vs. depositional origin for the central concordant sandbody are: (1) a flat, nonerosional base; (2) ,jack-up' of the overburden equal to the underlying sand thickness; (3) equally thick layers of encasing mudstones; and (4) paleogeographic context. This study suggests that the Danica structure was deposited as a channel sandstone and remobilised in situ; this led to the formation of wing-like intrusions along the channel margins. In contrast, the Volund structure overburden displays a forced-fold geometry, arguably a diagnostic feature of an intrusive origin. The ability to recognise and differentiate completely injected vs. in situ remobilised sandbodies is important both from a basin analysis, hydrocarbon exploration and rock mechanics points of view. An improved understanding of these aspects will lead to a reduction of risks associated with the exploration and development of such a sandbody and an enhanced understanding of sediment remobilisation and fluid flow on a basin scale. [source] Taming the fierce roller: an "enhanced" understanding of cellular differentiation in VolvoxBIOESSAYS, Issue 1 2002Stephen M. Miller Few organisms offer a better opportunity to explore the mechanisms of cellular differentiation, and their origins, than Volvox. Volvox consists of just two cell types, germ and soma, and is the most complex member of a family of green algae that includes unicellular and multicellular relatives. At the heart of the cell-fate determination program of Volvox carteri is the regA gene, which encodes a putative transcriptional repressor that prevents somatic cells from expressing reproductive functions. Stark et al.(1) have dissected the regA gene to determine how its expression is restricted to somatic cells. Their results suggest that regA expression is controlled by multiple enhancers, the most important of which prevents transcription in reproductive cells. While these findings shed light on Volvox development, they also raise a new set of questions about the mechanisms that control the germ,soma dichotomy in this organism. BioEssays 24:3,7, 2002. © 2002 John Wiley & Sons, Inc. 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