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Engineering Purposes (engineering + purpose)

Distribution by Scientific Domains
Medical Sciences33%
Earth and Environmental Science22%

Kinds of Engineering Purposes

  • tissue engineering purpose
    		•

    Selected Abstracts

    CFD Sinflow Library: A framework to develop engineering educational codes in CFD and thermal sciences

    COMPUTER APPLICATIONS IN ENGINEERING EDUCATION, Issue 1 2004
    Romeu André Pieritz
    Abstract This work introduces the educational code development library "CFD Sinflow Library" specialized in 2D numerical methods in computational fluid dynamics (CFD) and termal science. This library is for research, educational, and engineering purposes like an open and platform independent architecture. The library was developed with C++ standard programming language using an object-oriented approach allowing educators and graduation/undergraduation students to access the numerical methods in a simplified way. The numerical capabilities and results quality are evaluated, where comparisons are made with benchmark and analytical solutions. © 2004 Wiley Periodicals, Inc. Comput Appl Eng Educ 12: 31,43, 2004; Published online in Wiley InterScience (www.interscience.wiley.com); DOI 10.1002/cae.10056 [source]

    Hierarchical Structure Recovery of Point-Sampled Surfaces

    COMPUTER GRAPHICS FORUM, Issue 6 2010
    Marco Attene
    I.3 COMPUTER GRAPHICS; I.3.5 Computational Geometry and Object Modeling,Object hierarchies Abstract We focus on the class of ,regular' models defined by Várady et al. for reverse engineering purposes. Given a 3D surface,,represented through a dense set of points, we present a novel algorithm that converts,,to a hierarchical representation,. In,, the surface is encoded through patches of various shape and size, which form a hierarchical atlas. If,,belongs to the class of regular models, then,,captures the most significant features of,,at all the levels of detail. In this case, we show that,,can be exploited to interactively select regions of interest on,,and intuitively re-design the model. Furthermore,,,intrinsically encodes a hierarchy of useful ,segmentations' of,. We present a simple though efficient approach to extract and optimize such segmentations, and we show how they can be used to approximate the input point sets through idealized manifold meshes. [source]

    The high-resolution gravimetric geoid of Iberia: IGG2005

    GEOPHYSICAL JOURNAL INTERNATIONAL, Issue 3 2005
    V. Corchete
    SUMMARY It is well known that orthometric heights can be obtained without levelling by using ellipsoidal and geoidal heights. For engineering purposes, these orthometric heights must be determined with high accuracy. For this reason, the determination of a high-resolution geoid is necessary. In Iberia, since the publication of the most recent geoid (IBERGEO95), a new geopotential model has become available (EIGEN-CG01C, released on 2004 October 29) and a new high-resolution digital terrain model (SRTM 90M obtained from the Shuttle Radar Topography Mission) has been developed for the Earth. Logically, these new data represent improvements that must be included in a new geoid of Iberia. With this goal in mind, we have carried out a new gravimetric geoid determination in which these new data are included. The computation of the geoid uses the Stokes integral in convolution form, which has been shown as an efficient method to reach the proposed objective. The terrain correction has been applied to the gridded gravity anomalies to obtain the corresponding reduced anomalies. The indirect effect has also been taken into account. Thus, a new geoid is provided as grid data distributed for Iberia from 35° to 44° latitude and ,10° to 4° longitude (extending to 9°× 14°) in a 361 × 561 regular grid with a mesh size of 1.5,× 1.5, and 202 521 points in the GRS80 reference system. This calculated geoid and previous geoids that exist for this study area (IBERGEO95, EGM96, EGG97 and EIGEN-CG01C) are compared to the geoid undulations corresponding to 16 points of the European Vertical Reference Network (EUVN) on Iberia. The new geoid shows an improvement in precision and reliability, fitting the geoidal heights of these EUVN points with more accuracy than the other previous geoids. [source]

    A brief study of applications of the generalized reciprocal method and of some limitations of the method

    GEOPHYSICAL PROSPECTING, Issue 5 2000
    Bengt Sjögren
    An analysis of the generalized reciprocal method (GRM), developed by Palmer for the interpretation of seismic refraction investigations, has been carried out. The aim of the present study is to evaluate the usefulness of the method for geotechnical investigations in connection with engineering projects. Practical application of the GRM is the main object of this study rather than the theoretical/mathematical aspects of the method. The studies are partly based on the models and field examples presented by Palmer. For comparison, some other refraction interpretation methods and techniques have been employed, namely the ABC method, the ABEM correction method, the mean-minus-T method and Hales' method. The comparisons showed that the results, i.e. the depths and velocities determined by Palmer, are partly incorrect due to some errors and misinterpretations when analysing the data from field examples. Due to the limitations of the GRM, some of which are mentioned here, stated by Palmer in his various publications, and other shortcomings of the method (e.g. the erasing of valuable information), the GRM must be regarded as being of limited use for detailed and accurate interpretations of refraction seismics for engineering purposes. [source]

    Solvent/non-solvent sintering: A novel route to create porous microsphere scaffolds for tissue regeneration

    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, Issue 2 2008
    Justin L. Brown
    Abstract Solvent/non-solvent sintering creates porous polymeric microsphere scaffolds suitable for tissue engineering purposes with control over the resulting porosity, average pore diameter, and mechanical properties. Five different biodegradable biocompatible polyphosphazenes exhibiting glass transition temperatures from ,8 to 41°C and poly (lactide- co -glycolide), (PLAGA) a degradable polymer used in a number of biomedical settings, were examined to study the versatility of the process and benchmark the process to heat sintering. Parameters such as: solvent/non-solvent sintering solution composition and submersion time effect the sintering process. PLAGA microsphere scaffolds fabricated with solvent/non-solvent sintering exhibited an interconnected porosity and pore size of 31.9% and 179.1 ,m, respectively which was analogous to that of conventional heat sintered PLAGA microsphere scaffolds. Biodegradable polyphosphazene microsphere scaffolds exhibited a maximum interconnected porosity of 37.6% and a maximum compressive modulus of 94.3 MPa. Solvent/non-solvent sintering is an effective strategy for sintering polymeric microspheres, with a broad spectrum of glass transition temperatures, under ambient conditions making it an excellent fabrication route for developing tissue engineering scaffolds and drug delivery vehicles. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008 [source]

    Bone morphogenetic proteins in tissue engineering: the road from the laboratory to the clinic, part I (basic concepts)

    JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Issue 1 2008
    P. C. Bessa
    Abstract Discovered in 1965, bone morphogenetic proteins (BMPs) are a group of cytokines from the transforming growth factor-, (TGF,) superfamily with significant roles in bone and cartilage formation. BMPs are used as powerful osteoinductive components of diverse tissue-engineering products for the healing of bone. Several BMPs with different physiological roles have been identified in humans. The purpose of this review is to cover the biological function of the main members of BMP family, the latest research on BMPs signalling pathways and advances in the production of recombinant BMPs for tissue engineering purposes. Copyright © 2008 John Wiley & Sons, Ltd. [source]

    Two isomorphous cobalt(II) complexes: poly[[diaqua-,-2,5-dicarboxybenzene-1,4-dicarboxylato-,-1,2-di-4-pyridylethene-cobalt(II)] 1,2-di-4-pyridylethene solvate] and the 1,2-di-4-pyridylethane analogue

    ACTA CRYSTALLOGRAPHICA SECTION C, Issue 1 2009
    Ana María Atria
    The two isomorphous title structures, formulated as {[Co(C10H4O8)(C12H10N2)(H2O)2]·C12H10N2}n, (I), and {[Co(C10H4O8)(C12H12N2)(H2O)2]·C12H12N2}n, (II), respectively, are reported. They crystallize in the space group P with only one formula unit in the asymmetric unit, so that the organic ligands lie about inversion centres and the Co atom lies on an inversion centre. The Co atoms are octahedrally coordinated by a carboxylate O atom from 2,5-dicarboxybenzene-1,4-dicarboxylate (H2btc), one N atom from 1,2-di-4-pyridylethene (L) in (I) or from 1,2-di-4-pyridylethane (L) in (II), and one coordinated water molecule, plus their inversion-related species. This particular coordination results in a two-dimensional array, with an elemental unit in the shape of a parallelogram having the CoII cations at the corners, linked in one direction by L bridges and in the opposite direction by H2btc groups. The L solvent molecules act as pillars between parallel planes, linking them by strong hydrogen bonds where the H atoms lie midway between the formal donor/acceptor atoms in a `shared' mode. Comparison is made with structures presenting the same structural motif, strongly suggesting that the two-dimensional arrangement reported here might be a very stable robust building block for molecular engineering purposes. [source]

    Detergent Decellularization of Heart Valves for Tissue Engineering: Toxicological Effects of Residual Detergents on Human Endothelial Cells

    ARTIFICIAL ORGANS, Issue 3 2010
    Serghei Cebotari
    Abstract Detergents are powerful agents for tissue decellularization. Despite this, the high toxicity of detergent residua can be a major limitation. This study evaluated the efficacy of detergent removal from decellularized pulmonary valves (PVs) and the consequences of repopulation with human endothelial cells (HECs). Porcine PVs were treated with 1% sodium deoxycholate (SDC), group A; 1% sodium dodecyl sulfate (SDS), group B; and a mixture of 0.5% SDC/0.5% SDS, group C (n = 5 each). After each of 10 succeeding wash cycles (WCs), samples of the washing solution (WS) were analyzed by solid phase extraction and high performance liquid chromatography for the presence of detergents. Metabolic activity of HEC was also assessed in the WS samples (cytotoxicity and MTS assays). Decellularized and washed PVs were reseeded with HEC. Histological analysis demonstrated efficient tissue decellularization in all groups. Detergents' concentration in all WSs decreased exponentially and was below 50 mg/L after 6, 8, and 4 WCs in groups A, B, and C, respectively. This concentration resulted in no significant toxic influence on cell cultures, and scaffolds could be efficiently reseeded with HEC. In conclusion, intensive washing of detergent decellularized valvular scaffolds lowers the residual contamination below a hazardous threshold and allows their successful repopulation with HEC for tissue engineering purposes. [source]

    Behavior of Cardiomyocytes and Skeletal Muscle Cells on Different Extracellular Matrix Components,Relevance for Cardiac Tissue Engineering

    ARTIFICIAL ORGANS, Issue 1 2007
    Karin Macfelda
    Abstract:, Myocardial cell transplantation in patients with heart failure is emerging as a potential therapeutic option to augment the function of remaining myocytes. Nevertheless, further investigations on basic issues such as ideal cell type continue to be evaluated. Therefore, the aim of our studies was to compare the performance of skeletal muscle cells and cardiomyocytes with respect to their proliferation rate and viability on different extracellular matrix components (EMCs). Rat cardiomyocytes (RCM) and rat skeletal muscle cells (RSMC) were cultured on EMCs such as collagen type I, type IV, laminin, and fibronectin. The components were used as "single coating" as well as "double coating." Proliferation rates were determined by proliferation assays on days 1, 2, 4, and 8 after inoculation of the cells. The most essential result is that collagen type I enhances the proliferation rate of RSMC but decreases the proliferation of RCM significantly. This effect is independent of the second EMC used for the double-coating studies. Other EMCs also influence cellular behavior, whereas the sequence of the EMCs is essential. Results obtained in our studies reveal the significant different proliferation behavior of RCM and RSMC under identical conditions. As skeletal muscle cells are also used in heart tissue engineering models, these results are essential and should be investigated in further studies to prove the applicability of skeletal muscle cells for heart tissue engineering purposes. [source]