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Enantioselective Approach (enantioselective + approach)

Distribution by Scientific Domains
Chemistry100%
Distribution within Chemistry
Organic Chemistry60%
General & Introductory Chemistry40%

Selected Abstracts

Rhodium-Catalyzed Asymmetric Hydroformylation of N -Allylamides: Highly Enantioselective Approach to ,2 -Amino Aldehydes,

ANGEWANDTE CHEMIE, Issue 24 2010
Xiaowei Zhang
N -Allylamide undN -Allylsulfonamide wurden mithilfe eines Rhodium-Yanphos-Katalysators asymmetrisch hydroformyliert. Dabei wurden ,2 -Aminoaldehyde, -säuren und -alkohole mit ausgezeichneten Enantioselektivitäten erhalten (siehe Schema; TON=Umsatzzahl, acac=Acetylacetonat). [source]

A Concise and Enantioselective Approach to the Total Synthesis of (-)-Lasubine I.

CHEMINFORM, Issue 7 2007
Shengyang Liu
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

Quinine/Selectfluor Combination Induced Asymmetric Semipinacol Rearrangement of Allylic Alcohols: An Effective and Enantioselective Approach to ,-Quaternary ,-Fluoro Aldehydes.

CHEMINFORM, Issue 11 2006
Min Wang
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

An Asymmetric Approach towards (,)-Aphanorphine and Its Analogues

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 6 2009
Pavel A. Donets
Abstract A short enantioselective approach towards the alkaloid(,)-aphanorphine and its substituted analogues is described. The enantiomerically pure starting material for the synthesis was obtained by asymmetric hydrogenation in the presence of the Rh,(S)-PipPhos complex. Microwave-assisted Heckcyclization selectively provided the seven-membered 3-benzazepine ring. Further, the assembly of the tricyclic core of the alkaloid was accomplished by intramolecular radical cyclization. The X-ray structure confirming the absolute configuration of the obtained products is described. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009) [source]

Enantioselective Organocatalytic Addition of Oxazolones to 1,1-Bis(phenylsulfonyl)ethylene: A Convenient Asymmetric Synthesis of Quaternary ,-Amino Acids

CHEMISTRY - A EUROPEAN JOURNAL, Issue 18 2010
Andrea-Nekane
Abstract A new, easy, and highly enantioselective method for the synthesis of quaternary ,-alkyl-,-amino acids based on organocatalysis is reported. The addition of oxazolones to 1,1-bis(phenylsulfonyl)ethylene is efficiently catalyzed by simple chiral bases or thioureas. The reaction affords ,,,-disubstituted ,-amino acid derivatives with complete C4 regioselectivity and with excellent yields and enantioselectivities. This methodology is complementary to previously reported enantioselective approaches to quaternary ,-amino acids and allows the synthesis of ,-phenyl-,-alkyl-,-amino acids and ,- tert -butyl-,-alkyl-,-amino acids. It has distinct advantages in terms of operational simplicity, enviromentally friendly conditions, and suitability for large-scale reactions. [source]