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Emphasis Being (emphasis + being)
Selected AbstractsLong-term Hydrological Forecasting in Cold Regions: Retrospect, Current Status and ProspectGEOGRAPHY COMPASS (ELECTRONIC), Issue 5 2009Alexander N. Gelfan The influence of long-term snow accumulation on the runoff conditions several months afterwards is a distinct hydrological characteristic of cold regions, which creates opportunities for long-term (seasonal and subseasonal) hydrological forecasting in these regions. We consider evolution of the long-term forecasting approaches from the deterministic data-based index methods to the hydrological model-based ensemble approaches. Of key interest in this review are the methods developed and used in operational practice in Russia and in the USA, with the emphasis being placed on the methods used in Russia, which may be less familiar to international hydrological society. Following a description of the historical context, we review recent developments that place emphasis on problems relating to the uncertainty of the weather conditions for the lead time of the forecast. We conclude with a personal view of the prospects for the future development of long-term hydrological forecasting techniques. [source] Fourier analysis methodology of trabecular orientation measurement in the human tibial epiphysisJOURNAL OF ANATOMY, Issue 2 2001M. HERRERA Methods to quantify trabecular orientation are crucial in order to assess the exact trajectory of trabeculae in anatomical and histological sections. Specific methods for evaluating trabecular orientation include the ,point counting' technique (Whitehouse, 1974), manual tracing of trabecular outlines on a digitising board (Whitehouse, 1980), textural analysis (Veenland et al. 1998), graphic representation of vectors (Shimizu et al. 1993; Kamibayashi et al. 1995) and both mathematical (Geraets, 1998) and fractal analysis (Millard et al. 1998). Optical and computer-assisted methods to detect trabecular orientation of bone using the Fourier transform were introduced by Oxnard (1982) later refined by Kuo & Carter (1991) (see also Oxnard, 1993, for a review), in the analysis of planar sections of vertebral bodies as well as in planar radiographs of cancellous bone in the distal radius (Wigderowitz et al. 1997). At present no studies have applied this technique to 2-D images or to the study of dried bones. We report a universal computer-automated technique for assessing the preferential orientation of the tibial subarticular trabeculae based on Fourier analysis, emphasis being placed on the search for improvements in accuracy over previous methods and applied to large stereoscopic (2-D) fields of anatomical sections of dried human tibiae. Previous studies on the trajectorial architecture of the tibial epiphysis (Takechi, 1977; Maquet, 1984) and research data about trabecular orientation (Kamibayashi et al. 1995) have not employed Fourier analysis. [source] Non-covalent molecular imprinting with emphasis on its application in separation and drug development,JOURNAL OF MOLECULAR RECOGNITION, Issue 4 2006Huiqi Zhang Abstract The molecular imprinting technique can be defined as the formation of specific nano-sized cavities by means of template-directed synthesis. The resulting molecularly imprinted polymers (MIPs), which often have an affinity and a selectivity approaching those of antibody-antigen systems, have thus been coined "artificial antibodies." MIPs are characterized by their high specificity, ease of preparation, and their thermal and chemical stability. They have been widely studied in connection with many potential applications, including their use for separation and isolation purposes, as antibody mimics (biomimetic assays and sensors), as enzyme mimics, in organic synthesis, and in drug delivery. The non-covalent imprinting approach, developed mainly in Lund, has proven to be more versatile than the alternative covalent approach because of its preparation being less complicated and of the broad selection of functional monomers and possible target molecules that are available. The paper presents a review of studies of this versatile technique in the areas of separation and drug development, with emphasis being placed on work carried out in our laboratory. Copyright © 2006 John Wiley & Sons, Ltd. [source] Thinking about Generations: Conceptual Positions and Policy ImplicationsJOURNAL OF SOCIAL ISSUES, Issue 4 2007Simon Biggs Three traditions of social theory are examined in this article, with a special emphasis being given to the ways that the concept of "generation" has been conceived and developed over time. These include Psychodynamic, Sociological, and Gerontological approaches with attention drawn to the similarities and differences among them. It is concluded that while conceptual development has been uneven, taken together, they provide a rich basis for a critical examination of contemporary social problems with implications for policy toward intergenerational relationships. [source] Acrylamide: An Update on Current Knowledge in Analysis, Levels in Food, Mechanisms of Formation, and Potential Strategies of ControlNUTRITION REVIEWS, Issue 12 2004Richard H. Stadler PhD This review summarizes the research to date on acrylamide levels in food, analytical methods, main sources of dietary exposure, mechanisms of formation, and mitigation research in the major food categories. Significant progress in the research has been made over the past 18 months, as reflected by the numerous publications and national and international workshops on the subject. This rapid pace of developments is mainly attributable to the coordinated and collaborative efforts of all of those concerned: the food industry, academia, private/enforcement laboratories, and national authorities. Most of the information gaps identified since the findings in early 2002 on the occurrence of acrylamide in foods and exposure assessments have been addressed, and public databases have been established by several authorities. Today, the performance of analytical methods, particularly for "difficult" food matrices, is adequate, and any modifications made over the past 12 to 18 months in analytical procedures did not significantly impact the initial exposure calculations. Several avenues into mitigation have been explored in the different food categories, with much emphasis being placed on potato-based products, and empirical trials (mostly pilot studies) have provided better knowledge of the key parameters that influence acrylamide formation. However, despite these intensive efforts, only marginal reductions have been achieved by the food industry, and any further progress will entail long-term studies at the primary production level. Any measures devised to reduce exposure to acrylamide in commercial foods must be carefully assessed in terms of food safety and quality. A hitherto poorly addressed concern is the formation of acrylamide in foods prepared by consumers in the home, and more guidance on this by national authorities is warranted. [source] For the good of the patient: risks and benefits of medicines,PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, Issue 2 2003Alasdair Breckenridge Abstract The basis of regulation of medicines is an assessment of risk and benefit. As the process of drug development has evolved with the advances in scientific knowledge, new and more precise methods of measuring drug efficacy have been created. Pharmacovigilance must also change with as much emphasis being placed on demonstrating the safety of a medicine as on preventing harm. Communication of these issues to interested parties remains problematical with room for considerable improvement. Copyright © 2003 John Wiley & Sons, Ltd. 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