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Effects Independent (effects + independent)
Selected AbstractsRESEARCH REPORT Alcoholism treatment and medical care costs from Project MATCHADDICTION, Issue 7 2000Harold D. Holder Aims. This paper examines the costs of medical care prior to and following initiation of alcoholism treatment as part of a study of patient matching to treatment modality. Design Longitudinal study with pre- and post-treatment initiation. Measurements. The total medical care costs for inpatient and outpatient treatment for patients participating over a span of 3 years post-treatment. Setting. Three treatment sites at two of the nine Project MATCH locations (Milwaukee, WI and Providence, RI). Participants. Two hundred and seventy-nine patients. Intervention. Patients were randomly assigned to one of three treatment modalities: a 12-session cognitive behavioral therapy (CBT), a four-session motivational enhancement therapy (MET) or a 12-session Twelve-Step facilitation (TSF) treatment over 12 weeks. Findings. Total medical care costs declined from pre- to post-treatment overall and for each modality. Matching effects independent of clinical prognosis showed that MET has potential for medical-care cost-savings. However, patients with poor prognostic characteristics (alcohol dependence, psychiatric severity and/or social network support for drinking) have better cost-savings potential with CBT and/or TSF., Conclusions. Matching variables have significant importance in increasing the potential for medical-care cost-reductions following alcoholism treatment. [source] Growth hormone-releasing peptide 6 protection of hypothalamic neurons from glutamate excitotoxicity is caspase independent and not mediated by insulin-like growth factor IEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 11 2009A. Delgado-Rubín Abstract Treatment of the fetal hypothalamic neuronal cell line RCA-6 with growth hormone-releasing peptide 6, an agonist of the ghrelin receptor, or insulin-like growth factor I activates intracellular signalling cascades associated with anti-apoptotic actions. Abnormally high concentrations of glutamate provoke over-excitation of neurons leading to cell damage and apoptosis. Thus, the aim of this study was to investigate whether the administration of growth hormone-releasing peptide 6 and insulin-like growth factor I attenuates monosodium glutamate-induced apoptosis in RCA-6 neurons and the mechanisms involved. Two different mechanisms are involved in glutamate-induced cell death, one by means of caspase activation and the second through activation of a caspase-independent pathway of apoptosis mediated by the translocation of apoptosis-inducing factor. Growth hormone-releasing peptide 6 partially reversed glutamate-induced cell death but not the activation of caspases, suggesting blockage of the caspase-independent cell death pathway, which included interference with the translocation of apoptosis-inducing factor to the nucleus associated with the induction of Bcl-2. In contrast, the addition of insulin-like growth factor I to RCA-6 neurons abolished glutamate-induced caspase activation and cell death. These data demonstrate for the first time a neuroprotective role for growth hormone secretagogues in the caspase-independent cell death pathway and indicate that these peptides have neuroprotective effects independent of its induction of insulin-like growth factor I. [source] Repetition suppression of induced gamma band responses is eliminated by task switchingEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 9 2006Thomas Gruber Abstract The formation of cortical object representations requires the activation of cell assemblies, correlated by induced oscillatory bursts of activity >,20 Hz (induced gamma band responses; iGBRs). One marker of the functional dynamics within such cell assemblies is the suppression of iGBRs elicited by repeated stimuli. This effect is commonly interpreted as a signature of ,sharpening' processes within cell-assemblies, which are behaviourally mirrored in repetition priming effects. The present study investigates whether the sharpening of primed objects is an automatic consequence of repeated stimulus processing, or whether it depends on task demands. Participants performed either a ,living/non-living' or a ,bigger/smaller than a shoebox' classification on repeated pictures of everyday objects. We contrasted repetition-related iGBR effects after the same task was used for initial and repeated presentations (no-switch condition) with repetitions after a task-switch occurred (switch condition). Furthermore, we complemented iGBR analysis by examining other brain responses known to be modulated by repetition-related memory processes (evoked gamma oscillations and event-related potentials; ERPs). The results obtained for the ,no-switch' condition replicated previous findings of repetition suppression of iGBRs at 200,300 ms after stimulus onset. Source modelling showed that this effect was distributed over widespread cortical areas. By contrast, after a task-switch no iGBR suppression was found. We concluded that iGBRs reflect the sharpening of a cell assembly only within the same task. After a task switch the complete object representation is reactivated. The ERP (220,380 ms) revealed suppression effects independent of task demands in bilateral posterior areas and might indicate correlates of repetition priming in perceptual structures. [source] Neuroprotective effects of atorvastatin against glutamate-induced excitotoxicity in primary cortical neuronesJOURNAL OF NEUROCHEMISTRY, Issue 6 2005Julian Bösel Abstract Statins [3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors] exert cholesterol-independent pleiotropic effects that include anti-thrombotic, anti-inflammatory, and anti-oxidative properties. Here, we examined direct protective effects of atorvastatin on neurones in different cell damage models in vitro. Primary cortical neurones were pre-treated with atorvastatin and then exposed to (i) glutamate, (ii) oxygen,glucose deprivation or (iii) several apoptosis-inducing compounds. Atorvastatin significantly protected from glutamate-induced excitotoxicity as evidenced by propidium iodide staining, nuclear morphology, release of lactate dehydrogenase, and mitochondrial tetrazolium metabolism, but not from oxygen,glucose deprivation or apoptotic cell death. This anti-excitototoxic effect was evident with 2,4 days pre-treatment but not with daily administration or shorter-term pre-treatment. The protective properties occurred independently of 3-hydroxy-3-methylglutaryl-CoA reductase inhibition because co-treatment with mevalonate or other isoprenoids did not reverse or attenuate neuroprotection. Atorvastatin attenuated the glutamate-induced increase of intracellular calcium, which was associated with a modulation of NMDA receptor function. Taken together, atorvastatin exerts specific anti-excitotoxic effects independent of 3-hydroxy-3-methylglutaryl-CoA reductase inhibition, which has potential therapeutic implications. [source] Attachment to the Nation and International Relations: Dimensions of Identity and Their Relationship to War and PeacePOLITICAL PSYCHOLOGY, Issue 5 2009Richard K. Herrmann Since the rise of mass politics, the role national identities play in international relations has been debated. Do they produce a popular reservoir easily tapped for war or bestow dignity thereby fostering cooperation and a democratic peace? The evidence for either perspective is thin, beset by different conceptions of identity and few efforts to identify its effects independent of situational factors. Using data drawn from new national surveys in Italy and the United States, we advance a three-dimensional conception of national identity, theoretically connecting the dimensions to conflictive and cooperative dispositions as well as to decisions to cooperate with the United Nations in containing Iran's nuclear proliferation and Sudan's humanitarian crisis in Darfur. Attachment to the nation in Italy and the United States is found to associate with less support for militarist options and more support for international cooperation as liberal nationalists expect. This depends, however, on containing culturally exclusive conceptions of the nation and chauvinism. [source] PAPINEAU ON ETIOLOGICAL TELEOSEMANTICS FOR BELIEFSRATIO, Issue 3 2006Joseph Mendola Teleosemantics holds that the contents of psychological states depend crucially on the functions of such states. Etiological accounts of function hold that the functions of things depend on their histories, especially their evolutionary or learning histories. Etiological teleosemantics combines these two features. Consider the case of beliefs. Since selection rests on the stable effects of things, since beliefs have no obvious effects independent of unstable desires, and since desires themselves have mental content, beliefs may seem a hard case for etiological teleosemantics. But David Papineau deploys the effects of beliefs mediated by conation in an artful way to evade these difficulties. I argue that accounts with such an architecture are false. [source] Sex differences of chondrogenic progenitor cells in late stages of osteoarthritisARTHRITIS & RHEUMATISM, Issue 4 2010Sebastian Koelling Objective Osteoarthritis (OA), a mainly degenerative disease, is known to be multifactorial in origin. Gene expression patterns vary between populations and sexes. Sex hormone receptors have been described in the cartilage tissue of animals and humans. We undertook this study to determine whether the regenerative potential of chondrogenic progenitor cells (CPCs) present in the arthritic tissue during the late stages of human OA might also be subject to sex-specific differences and influenced by sex steroids. Methods We analyzed sex-specific differences in the regenerative potential of CPCs and the involvement of sex hormones in vitro in cartilage samples from patients with late-stage knee OA, using electrochemiluminescence immunoassay, microarray analysis, real-time reverse transcription,polymerase chain reaction, immunohistochemistry, Western blot analysis, fluorescence-activated cell sorting, and cell culture. Results We detected expression of estrogen and testosterone in the OA synovial fluid as well as CPCs positive for estrogen receptor , (ER,), ER,, and androgen receptor. Both hormones influenced the expression of all 3 receptor genes as well as the chondrogenic potential of CPCs by regulating gene expression of Sox9, Runx2, type II collagen, and type I collagen. We found regulatory effects on the collagens via Sox9 and Runx2 as well as regulatory effects independent of these transcription factors. These effects were sex-specific and relied on hormone concentrations. Conclusion Physiologic concentrations of testosterone in men and premenopausal concentrations of estrogen in women have a positive effect on the chondrogenic potential of CPCs in vitro. Therefore, strategies of hormone replacement in the synovial fluid of women and men might have beneficial effects on the regenerative potential of arthritic cartilage tissue in late stages of human OA. [source] | ||||||||||||||||