Efficient Total Synthesis (efficient + total_synthesis)

Distribution by Scientific Domains


Selected Abstracts


An Efficient Total Synthesis of Decarestrictine D,

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 7 2008
Priti Gupta
Abstract An efficient total synthesis of decarestrictine D has been achieved using cross-metathesis or ring-closing metathesis and Yamaguchi macrolactonization as key steps. The stereogenic centres were generated by means of hydrolytic kinetic resolution (HKR) and Sharpless asymmetric dihydroxylation (AD). ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008) [source]


Efficient Total Synthesis of (,)-(3S,6R)-3,6-Dihydroxy-10-methylundecanoic Acid

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 2 2007
Satyendra Kumar Pandey
Abstract An efficient enantioselective synthesis of (,)-(3S,6R)-3,6-dihydroxy-10-methylundecanoic acid (1) from epichlorohydrin is described. The key steps include Jacobsen's HKR, Sharpless asymmetric dihydroxylation, regioselective opening of epoxide and cyclic sulfate. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007) [source]


An Efficient Total Synthesis of 9-Methoxycarbazole-3-carbaldehyde Based on a Novel Methodology for the Preparation of Methoxyindoles.

CHEMINFORM, Issue 52 2003
N. Selvakumar
Abstract For Abstract see ChemInform Abstract in Full Text. [source]


An Efficient Total Synthesis of Optically Active Tetrodotoxin,from,Levoglucosenone

CHEMISTRY - AN ASIAN JOURNAL, Issue 1-2 2006
Daisuke Urabe
Abstract Tetrodotoxin, a toxic principal of puffer-fish poisoning, is one of the most famous marine natural products, and has been known as a formidable synthetic target in synthesis owing to its multifunctional structure and unusual chemical properties. From the perspective of supplying tetrodotoxin derivatives such as labeled molecules for biochemical research, we have completed our second total synthesis of tetrodotoxin from a synthetic intermediate for 11-deoxytetrodotoxin, which was previously prepared from levoglucosenone as a chiral starting material in this laboratory. This paper discloses the details of the total synthesis with special reference to significant influences on the neighboring functional groups found in the installation of guanidine. The established route should allow us to prepare the tetrodotoxin-related compounds required for biochemical studies. [source]


The New Metabolite (S)-Cinnamoylphosphoramide from Streptomyces sp. and Its Total Synthesis

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 30 2008
Melanie Quitschau
Abstract The tunicate-associated strain Streptomyces sp. JP90 produces the unprecedented metabolite cinnamoylphosphoramide (1) among several other compounds. Structure elucidation was accomplished by NMR spectroscopic studies and efficient total synthesis. The absolute configuration at phosphorus was determined by synthesis of both enantiomers of 1 performing a resolution of the corresponding diastereomeric phosphoramides of L -phenylalanine ethyl ester. Unusual cinnamic acid derivative 1 represents the first bacterial organophosphoramide. As it matches the Schrader's formula for insecticidal organophosphates, its biological activity was investigated. A weak inhibition of acetylcholinesterase was observed in in vitro tests, and water-soluble analogues of 1 were prepared. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008) [source]


An Efficient Total Synthesis of Decarestrictine D,

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 7 2008
Priti Gupta
Abstract An efficient total synthesis of decarestrictine D has been achieved using cross-metathesis or ring-closing metathesis and Yamaguchi macrolactonization as key steps. The stereogenic centres were generated by means of hydrolytic kinetic resolution (HKR) and Sharpless asymmetric dihydroxylation (AD). ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008) [source]