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Efficiency Considerations (efficiency + consideration)
Selected AbstractsIdentifying and assessing environmentally harmful subsidies in Germany: an overview of studies and their underlying methodologies in the energy and transport sectorENVIRONMENTAL POLICY AND GOVERNANCE, Issue 1 2007Tilmann Rave Abstract The discussion on the reduction and reform of subsidies in Germany has gained momentum lately. It has repeatedly been suggested that environmental and wider efficiency consideration be taken into account in reform strategies. Yet, progress at reforming environmentally harmful subsidies seems to be slow overall. This paper provides an overview on monitoring and assessing environmentally harmful subsidies in selected German policy sectors and discusses the underlying study methodologies. For this purpose we first briefly deal with the concept of subsidy and the measurement of subsidies in general and illustrate the linkage between subsidies and their environmental effects. The main focus of the paper is then on the current state of subsidy impact assessment and/or related monitoring activities. We discuss studies relating to two different policy sectors, energy policy and transport policy. While no single best methodology exists, it is suggested that different approaches may fertilize each other. Copyright © 2007 John Wiley & Sons, Ltd and ERP Environment. [source] Adaptive patient enrichment designs in therapeutic trialsBIOMETRICAL JOURNAL, Issue 2 2009Sue-Jane Wang Abstract The utility of clinical trial designs with adaptive patient enrichment is investigated in an adequate and well-controlled trial setting. The overall treatment effect is the weighted average of the treatment effects in the mutually exclusive subsets of the originally intended entire study population. The adaptive enrichment approaches permit assessment of treatment effect that may be applicable to specific nested patient (sub)sets due to heterogeneous patient characteristics and/or differential response to treatment, e.g. a responsive patient subset versus a lack of beneficial patient subset, in all patient (sub)sets studied. The adaptive enrichment approaches considered include three adaptive design scenarios: (i) total sample size fixed and with futility stopping, (ii) sample size adaptation and futility stopping, and (iii) sample size adaptation without futility stopping. We show that regardless of whether the treatment effect eventually assessed is applicable to the originally studied patient population or only to the nested patient subsets; it is possible to devise an adaptive enrichment approach that statistically outperforms one-size-fits-all fixed design approach and the fixed design with a pre-specified multiple test procedure. We emphasize the need of additional studies to replicate the finding of a treatment effect in an enriched patient subset. The replication studies are likely to need fewer number of patients because of an identified treatment effect size that is larger than the diluted overall effect size. The adaptive designs, when applicable, are along the line of efficiency consideration in a drug development program. [source] Residential air exchange rates in three major US metropolitan areas: results from the Relationship Among Indoor, Outdoor, and Personal Air Study 1999,2001INDOOR AIR, Issue 1 2010N. Yamamoto Abstract, We report approximately 500 indoor,outdoor air exchange rate (AER) calculations based on measurements conducted in residences in three US metropolitan areas in 1999,2001: Elizabeth, New Jersey; Houston, Texas; and Los Angeles County, California. Overall, a median AER across these urban areas and seasons was 0.71 air changes per hour (ACH, or per hour; n = 509) while median AERs measured in California (n = 182), New Jersey (n = 163), and Texas (n = 164) were 0.87, 0.88, and 0.47 ACH, respectively. In Texas, the measured AERs were lower in the summer cooling season (median = 0.37 ACH) than in the winter heating season (median = 0.63 ACH), likely because of the reported use of room air conditioners as Houston is typically hot and humid during the summer. The measured AERs in California were higher in summer (median = 1.13 ACH) than in winter (median = 0.61 ACH). Because the summer cooling season in Los Angeles County is less humid than in New Jersey or Texas, natural ventilation through open windows and screened doors likely increased measured AER in California study homes. In New Jersey, AER were similar across heating and cooling seasons, although the median AER was relatively lower during the spring. Practical Implications Adequate ventilation or air exchange rate (AER) for an indoor environment is important for human health and comfort, and relevant to building design and energy conservation and efficiency considerations. However, residential AER data, especially measured by more accurate non-toxic tracer gas methodologies, are at present quite limited worldwide, and are insufficient to represent the variations across regions and seasons within and between homes, including apartments and condominiums in more densely populated urban areas. The present paper presents quantitative and qualitative data to characterize residential AERs in three US urban areas with different climate attributes. [source] The Effect of International Terrorism on EU Intelligence Co-operationJCMS: JOURNAL OF COMMON MARKET STUDIES, Issue 1 2008BJÖRN MÜLLER-WILLE While the US has revamped its intelligence community by creating the Department of Homeland Security, little seems to have happened at the European level. The article seeks to explain why some intelligence co-operation takes place within the EU and why the bulk does not. It uses a new model, the ,intelligence cube', to develop a discussion on co-operation in distinct areas. Following a functionalist approach, suggesting that collaboration is utility driven, it proposes that efficiency considerations offer the most convincing explanation why no new European Intelligence Agency has been created and why so little co-operation takes place within EU structures. [source] Consideration of regional difference in design and analysis of multi-regional trials,,PHARMACEUTICAL STATISTICS: THE JOURNAL OF APPLIED STATISTICS IN THE PHARMACEUTICAL INDUSTRY, Issue 3 2010H. M. James Hung Abstract Clinical trial strategy, particularly in developing pharmaceutical products, has recently expanded to a global level in the sense that multiple geographical regions participate in the trial simultaneously under the same study protocol. The possible benefits of this strategy are obvious, at least from the cost and efficiency considerations. The challenges with this strategy are many, ranging from trial or data quality assurance to statistical methods for design and analysis of such trials. In many regulatory submissions, the presence of regional differences in the estimated treatment effect, whether they are different only in magnitude or in direction, often presents great difficulty in interpretation of the global trial results, particularly for the acceptability by the local regulatory authorities. This article presents a number of useful statistical analysis tools for exploration of regional differences and a method that may be worth consideration in designing a multi-regional clinical trial. Published in 2010 by John Wiley & Sons, Ltd. [source] | |||||||||||||