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Easy Target (easy + target)

Distribution by Scientific Domains

Chemistry	40%

Selected Abstracts

Increasing the thermal stability of euphauserase

FEBS JOURNAL, Issue 1 2001
A cold-active, multifunctional serine protease from Antarctic krill
A molecular model of Antarctic krill euphauserase based on the known crystal structure of its fiddler crab analog, collagenase I, indicates that the core structure of these enzymes is almost identical. Euphauserase is a cold-active and thermally sensitive enzyme with a high affinity for Lys, Arg and large hydrophobic amino acids. Residue Phe137 in euphauserase, localized in loop D (autolysis loop), is highly exposed on the surface of the molecule. Therefore, it appeared to be an easy target for autolysis. The broadly specific euphauserase has a low affinity for negatively charged residues. In order to increase the stability of the enzyme, two mutants were created in which residue Phe137 was replaced by a Glu and an Asp residue. Both mutations resulted in increased stability of the recombinant euphauserase towards thermal inactivation. [source]

Predatory boreholes in Tournaisian (Lower Carboniferous) spiriferid brachiopods

LETHAIA, Issue 3 2009
BERNARD MOTTEQUIN
A brachiopod fauna from the uppermost part of the Tournaisian Tournai Formation (Belgium) contains an undetermined species of Crurithyris (Spiriferida, Ambocoeliidae), which displays numerous bored shells. About 8% of the 432 specimens with conjoined valves display single, small (, 1 mm) boreholes, which are smooth-sided, cylindrical or weakly conical, circular to slightly elliptical in plan view, perpendicular to the shell surface and generally complete. Of the 35 bored articulated specimens, 27 were drilled on the ventral valve. Most of the boreholes are located in the posterior half of the shell, and no case of edge-drilling has been observed. The boreholes were drilled by a predator, or possibly a parasite, which selected individuals greater than 2.5 mm long. Crurithyris sp. may have represented an attractive (in terms of energy cost) and easy target for a small-sized predator because of its thin shell and ornament of minute spines. [source]

What should non-US behavioral health systems learn from the USA?: US behavior health services trends in the 1980s and 1990s

PSYCHIATRY AND CLINICAL NEUROSCIENCES, Issue 3 2006
YASUHIRO KISHI md
Abstract Several countries, such as the USA, inadvertently created a different behavioral health payment system from the rest of medicine through the introduction of diagnostic-related group exemptions for psychiatric care. This led to isolation in the administration and delivery of care for patients with mental health and substance abuse disorders from other medical services with significant, yet unintended, consequences. To insure an efficient and effective health-care system, it is necessary to recognize the problems introduced by segregating behavioral health from the rest of medical care. In this review, the authors assess trends in behavioral health services during the last two decades in the USA, a period in which independently managed behavioral health care has dominated administrative practices. During this time, behavioral health has been an easy target for aggressive cost cutting measures. There have been no clinically significant improvements in the number of adults receiving minimally adequate treatment or in the percentage of the population with behavior health problems receiving psychiatric care with the possible exception of depression. While decreased spending for behavioral health services has been well documented during this period, these savings are offset by costs shifted to greater medical service use with a net increase in the total cost of health care. Targeting behavioral health for reduction in health-care spending through independent management, starting with diagnostic procedure code or diagnostic-related group exemption may not be the wisest approach in addressing the increasing fiscal burden that medical care is placing on the national economy. [source]

LiveBench-1: Continuous benchmarking of protein structure prediction servers

PROTEIN SCIENCE, Issue 2 2001
Janusz M. Bujnicki
Abstract We present a novel, continuous approach aimed at the large-scale assessment of the performance of available fold-recognition servers. Six popular servers were investigated: PDB-Blast, FFAS, T98-lib, GenTHREADER, 3D-PSSM, and INBGU. The assessment was conducted using as prediction targets a large number of selected protein structures released from October 1999 to April 2000. A target was selected if its sequence showed no significant similarity to any of the proteins previously available in the structural database. Overall, the servers were able to produce structurally similar models for one-half of the targets, but significantly accurate sequence-structure alignments were produced for only one-third of the targets. We further classified the targets into two sets: easy and hard. We found that all servers were able to find the correct answer for the vast majority of the easy targets if a structurally similar fold was present in the server's fold libraries. However, among the hard targets,where standard methods such as PSI-BLAST fail,the most sensitive fold-recognition servers were able to produce similar models for only 40% of the cases, half of which had a significantly accurate sequence-structure alignment. Among the hard targets, the presence of updated libraries appeared to be less critical for the ranking. An "ideally combined consensus" prediction, where the results of all servers are considered, would increase the percentage of correct assignments by 50%. Each server had a number of cases with a correct assignment, where the assignments of all the other servers were wrong. This emphasizes the benefits of considering more than one server in difficult prediction tasks. The LiveBench program (http://BioInfo.PL/LiveBench) is being continued, and all interested developers are cordially invited to join. [source]

Nature, extent, and causes of bullying among personality-disordered patients in a high-secure hospital

AGGRESSIVE BEHAVIOR, Issue 3 2004
Jane L. Ireland
Abstract The present study explored the perceptions and experiences of the nature, extent and causes of bullying among personality-disordered patients, with a subsidiary aim of exploring differences in perceptions between staff and patients. The sample was selected from the Personality Disorder Unit of a high secure hospital. The total sample consisted of 60 participants, 30 patients and 30 staff. Participants engaged in a semi-structured interview based on that developed by Brookes [1993] and modified by Ireland and Archer [1996] and Ireland [2002a]. The interview assessed their perceptions and experiences of patient-to-patient bullying. One fifth of patients and staff reported that they had seen a patient being bullied in the previous week. One-fifth of patients reported that they had been bullied in the previous week and less than one tenth reported that they had bullied others. The most frequent types of bullying reported were theft-related, verbal abuse, being made to do chores, physical assaults and intimidation. One fifth of the sample reported that sexual abuse took place. Victims were generally perceived to be ,easy targets' that were vulnerable, either physically or emotionally. Staff identified a wider range of victim types than patients. The results highlight how patient-to-patient bullying does occur and is an important issue worthy of further research. A number of similarities were found between the current findings and those of prison-based research suggesting that both hospitals and prisons share a number of environmental similarities that help to explain why bullying takes placed in secure forensic settings. Aggr. Behav. 30:229,242, 2004. © 2004 Wiley-Liss, Inc. [source]