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Easy Synthesis (easy + synthesis)
Selected AbstractsEasy Synthesis of Hollow Polymer, Carbon, and Graphitized Microspheres,ANGEWANDTE CHEMIE, Issue 9 2010An-Hui Lu Dr. Kugeln in Massen! Ein neuer Ansatz wurde entwickelt, der die einfache Synthese von hohlen Mikrokügelchen mit amorphen oder graphitischen Mikrostrukturen ermöglicht. Ausgehend von einem einzelnen Typ von festen Polymerkügelchen führt die einfache Behandlung mit Wasser zur Bildung hohler Strukturen. Je nach weiterer Behandlung lassen sich verschiedene Produkte wie hohle Kohlenstoff- oder graphitische Kügelchen erhalten (siehe Bild). [source] Regioselective Ring Opening of Amino Epoxides with Nitriles: An Easy Synthesis of (2R,3S)- and (2S,3S)-1,3-Diaminoalkan-2-ols with Differently Protected Amine Functions.CHEMINFORM, Issue 2 2006Jose M. Concellon No abstract is available for this article. [source] An Easy Synthesis of Thermochromic Ethylenes under Microwave Irradiation.CHEMINFORM, Issue 2 2004Didier Villemin Abstract For Abstract see ChemInform Abstract in Full Text. [source] Easy Synthesis of (E)- or (Z)-Perfluorinated ,-Enaminoesters.CHEMINFORM, Issue 5 2003Gildas Prie Abstract For Abstract see ChemInform Abstract in Full Text. [source] ChemInform Abstract: An Easy Synthesis of Some 1,2,3,4-Tetrahydro-9-oxa-10-phospha-phenanthrene-10-oxides.CHEMINFORM, Issue 27 2001Peter Nesvadba Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: An Easy Synthesis of Enaminones in Water as Solvent.CHEMINFORM, Issue 2 2001Helio A. Stefani Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Synthesis, Physical, and Mechanical Properties of Bulk Zr3Al3C5 CeramicJOURNAL OF THE AMERICAN CERAMIC SOCIETY, Issue 4 2007Lingfeng He An in situ reactive hot-pressing process using zirconium (zirconium hydride), aluminum, and graphite as staring materials and Si and Y2O3 as additives was used to synthesize bulk Zr3Al3C5 ceramics. This method demonstrates the advantages of easy synthesis, lower sintering temperature, high purity and density, and improved mechanical properties of synthesized Zr3Al3C5. Its electrical and thermal properties were measured. Compared with ZrC, Zr3Al3C5 has a relatively low hardness (Vickers hardness of 12.5 GPa), comparable stiffness (Young's modulus of 374 GPa), but superior strength (flexural strength of 488 GPa) and toughness (fracture toughness of 4.68 MPa·m1/2). In addition, the stiffness decreases slowly with increasing temperature and at 1600°C remains 78% of that at ambient temperature, indicating that Zr3Al3C5 is a potential high-temperature structural ceramic. [source] Pyrazolo[3,4- d]pyrimidine Derivatives as COX-2 Selective Inhibitors: Synthesis and Molecular Modelling StudiesARCHIV DER PHARMAZIE, Issue 6 2009Demetrio Raffa Abstract The pyrazolo[3,4- d]pyrimidine system shows a multitude of interesting pharmacological properties. Owing to the potential anti-inflammatory activity of 5-benzamido-pyrazolo[3,4- d]pyrimidin-4-one derivatives and considering the easy synthesis of this class of compounds, a set of new 5-benzamido-1H -pyrazolo[3,4- d]pyrimidin-4-ones has been prepared in 42-80% yields by reacting 5-aminopyrazole-4(N -benzoyl)carbohydrazide derivatives and the opportune triethylorthoesters. Compounds 8a, b, 10a,d, and 11a, b revealed a superior inhibitory profile against COX-2, when compared to that of reference standards NS398 and indomethacin. Molecular modelling studies confirmed the obtained biological results. [source] Oligosaccharide Mimics Containing Galactose and Fucose Specifically Label Tumour Cell Surfaces and Inhibit Cell Adhesion to FibronectinCHEMBIOCHEM, Issue 2 2005Evelyn Y.-L. Abstract With the aim of establishing a versatile and easy synthesis of branched saccharides for biological applications, we used molecular-dynamics simulations to model Lewisyto two classes of di- or triantennary saccharide mimetics. One set of mimetics was based on 1,3,5-tris(hydroxymethyl)cyclohexane (TMC) as the core, the other on furan, and both were derivatised with galactose and/or fucose. The TMC-based saccharides were biotinylated, while the furan disaccharides were treated with maleimide-activated biotin in a Diels,Alder fashion to yield oxazatricyclodecanes (OTDs). These were then assayed as cell-surface labels in human colon (SW480 and CaCo-2), liver (PLC), Glia (U333,CG,343) and ovary (SKOV-3) tumour cell lines. Discrete staining patterns were observed in all cells, usually at one or two poles of the cells, particularly with the asymmetric 3-,- L -fucopyranosyloxymethyl-4-,- D -galactopyranosyloxymethyl-OTD. Normal SV40-transformed fibroblasts (SV80) showed no staining. Adhesion of the highly metastatic mouse melanoma line B16,F10 to fibronectin was inhibited by 80,% by the TMC-digalactoside and by 30,% by 3,4-bis-(,- D -galactopyranosyloxymethyl)furan. None of the saccharide mimetics inhibited the adhesion of the less metastatic B16,F1 line. Migration of B16,F10 cells through MatrigelTMwas greatly inhibited by the TMC-digalactoside and weakly inhibited by the TMC-trigalactoside. The saccharide mimetics that had shown the best structural agreements with the terminal saccharides of Lewisyin the molecular dynamics simulation were also the most biologically potent compounds; this underlines the predictive nature of molecular dynamics simulations. The use of the non-saccharide cores enabled us to adapt spacer lengths and terminal saccharides to optimise the structures to bind more avidly to cell-surface lectins. [source] Tetraamine-Derived Bifunctional Chelators for Technetium-99m Labelling: Synthesis, Bioconjugation and Evaluation as Targeted SPECT Imaging Probes for GRP-Receptor-Positive Tumours,CHEMISTRY - A EUROPEAN JOURNAL, Issue 7 2010Keelara Abiraj Dr. Abstract Owing to its optimal nuclear properties, ready availability, low cost and favourable dosimetry, 99mTc continues to be the ideal radioisotope for medical-imaging applications. Bifunctional chelators based on a tetraamine framework exhibit facile complexation with Tc(V)O2 to form monocationic species with high in vivo stability and significant hydrophilicity, which leads to favourable pharmacokinetics. The synthesis of a series of 1,4,8,11-tetraazaundecane derivatives (01,06) containing different functional groups at the 6-position for the conjugation of biomolecules and subsequent labelling with 99mTc is described herein. The chelator 01 was used as a starting material for the facile synthesis of chelators functionalised with OH (02), N3 (04) and O -succinyl ester (05) groups. A straightforward and easy synthesis of carboxyl-functionalised tetraamine-based chelator 06 was achieved by using inexpensive and commercially available starting materials. Conjugation of 06 to a potent bombesin-antagonist peptide and subsequent labelling with 99mTc afforded the radiotracer 99mTc-N4-BB-ANT, with radiolabelling yields of >97,% at a specific activity of 37,GBq,,mol,1. An IC50 value of (3.7±1.3),nM was obtained, which confirmed the high affinity of the conjugate to the gastrin-releasing-peptide receptor (GRPr). Immunofluorescence and calcium mobilisation assays confirmed the strong antagonist properties of the conjugate. In vivo pharmacokinetic studies of 99mTc-N4-BB-ANT showed high and specific uptake in PC3 xenografts and in other GRPr-positive organs. The tumour uptake was (22.5±2.6),% injected activity per gram (%,IA,g,1) at 1,h post injection (p.i.). and increased to (29.9±4.0),%,IA,g,1 at 4,h p.i. The SPECT/computed tomography (CT) images showed high tumour uptake, clear background and negligible radioactivity in the abdomen. The promising preclinical results of 99mTc-N4-BB-ANT warrant its potential candidature for clinical translation. [source] | ||||||||||