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Easy Route (easy + route)

Distribution by Scientific Domains

Chemistry	83%

Distribution within Chemistry

Organic Chemistry	60%
General & Introductory Chemistry	39%

Selected Abstracts

Direct Amination of meso -Tetraarylporphyrin Derivatives , Easy Route to A3B-, A2BC-, and A2B2 -Type Porphyrins Bearing Two Nitrogen-Containing Substituents at the meso -Positioned Phenyl Groups

HELVETICA CHIMICA ACTA, Issue 10 2007
Stanis, aw Ostrowski
Abstract meso -Tetraarylporphyrinato complexes 1a,g (ZnII, CuII, and NiII) bearing one or two nitro-substituted aryl moieties react with 1,1,1-trimethylhydrazinium iodide in the presence of tBuOK in THF at 0,5° or in the presence of KOH in DMSO at 60,70° according to a nucleophilic substitution of an H-atom, thus affording porphyrins 2a,g and 3f,g with amino-functionalized meso -positioned aryl substituents in yields up to 73% (Scheme,1 and Table). The products obtained are attractive intermediates for further derivatization of porphyrins and may be of potential use as sensitizers in photodynamic cancer therapy. [source]

An Easy Route to 4-Substituted 2-Oxazolidinones from Prochiral-1,3-diols.

CHEMINFORM, Issue 34 2004
Hocine Allali
Abstract For Abstract see ChemInform Abstract in Full Text. [source]

Dancing with the Devil: Partnering with Industry but Publishing in Academia,

DECISION SCIENCES, Issue 4 2007
V. Daniel R. Guide Jr
ABSTRACT We believe that partnering with industry can lead to research that is relevant, rigorous, and refreshing. Our experiences show that the potential benefits of partnering with industry are enormous, but that this is not an easy route for academics interested in operations research modeling or empirical methods. The need for grounded business research is greater now than ever, and, while academics have made great progress, there are still numerous opportunities to demonstrate the relevance of our research. We discuss how to establish industry contacts, identify fruitful academic,industry projects, and publish the resulting research. [source]

Back to Natural Cinchona Alkaloids: Highly Enantioselective Michael Addition of Malononitrile to Enones

ADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 18 2009
Alessio Russo
Abstract An efficient and convenient highly enantioselective Michael addition of malononitrile to enones has been developed by using quinine as the organocatalyst. The adducts were isolated in excellent yield and high asymmetric induction (up to 95% ee). An easy route to difficultly accessible ester derivatives has been also disclosed. [source]

An easy route to 2-substituted-2,3-dihydro-5(7)H -oxazolo[3,2- a]pyrimidin-5-ones and 7-ones starting from the corresponding 2-amino-2-oxazolines

JOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 4 2001
I. Forfar
The isomeric 2-substituted-7(5)-methyl-2,3-dihydro-5(7)H -oxazolo[3,2- a]pyrimidin-5-ones 3a-b and 7-ones 2a-b,7a were synthesized by cyclocondensation from the 5-substituted-2-amino-2-oxazolines 1a-b with biselectrophiles. In boiling ethanol, the reaction of 1a-b with acetylenic esters led to a mixture of 2a-b,7a with a small amount of (E)-2- N -(2-ethoxycarbonylethylene)-5-substituted-2-iminooxazolines 5a-b. The ring annulation between 1a-b and diketene gave the 2-substituted-7-hydroxy-7-methyl-2,3,6,7-tetrahydro-5H -oxazolo[3,2- a]pyrimidin-5-ones 4a-b which can be easily dehydrated to provide the 2-substituted-7-methyl-2,3-dihydro-5H -oxazolo[3,2- a]pyrimidin-5-ones 3a-b. [source]

Biologically Active Compounds through Catalysis: Efficient Synthesis of N -(Heteroarylcarbonyl)- N,-(arylalkyl)piperazines

CHEMISTRY - A EUROPEAN JOURNAL, Issue 3 2004
Kamal Kumar Dr.
Abstract A practical route for the synthesis of new biologically active 5-HT2,A receptor antagonists has been developed. In only three catalytic steps, this class of central nervous system (CNS) active compounds can be synthesized efficiently with high diversity. As the initial step, an anti -Markovnikov addition of amines to styrenes provides an easy route to N -(arylalkyl)piperazines, which constitute the core structure of the active molecules. Here, base-catalyzed hydroamination reactions of styrenes with benzylated piperazine proceeded in high yield even at room temperature. After catalytic debenzylation, the free amines were successfully carbonylated with different aromatic and heteroaromatic halides and carbon monoxide to yield the desired compounds in good to excellent yields. The two key reactions, base-catalyzed hydroamination of styrenes and palladium-catalyzed aminocarbonylation of haloarenes/heterocycles, showed tolerance towards various functional groups, thereby demonstrating the potential to synthesize a wide variety of new derivatives of this promising class of pharmaceuticals. [source]