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Early Involvement (early + involvement)
Selected AbstractsThe use of technical knowledge in European water policy-makingENVIRONMENTAL POLICY AND GOVERNANCE, Issue 5 2010Perry J. M. van Overveld Abstract Environmental policy-making often involves a mix of technical knowledge, normative choice and uncertainty. Numerous actors, each with their own distinct objectives, are involved in these policy-making processes. One question these actors face, is how they can effectively communicate their technical knowledge and represent their interests in policy-making. The objective of this paper is to identify the factors that influence the use of technical knowledge and its impact on decision-making in the European Union. This is done for case of water policy-making for organic micropollutants, such as pesticides and pharmaceuticals. These pollutants enter the surface water in many ways and although concentrations are low, adverse effects cannot be ruled out. Via the EU Water Framework Directive, legislation has been developed to reduce the emissions of pollutants that pose a risk to ecology or public health. Using the advocacy coalition framework, the formal EU decision-making processes are analyzed for the identification of priority pollutants (Priority Substances) and the derivation of maximum allowable concentrations (Environmental Quality Standards). To enable a detailed analysis, the focus is on three specific micropollutants that pose health risks via drinking water supply. The findings show the extent to which actors can influence the decision-making process with technical knowledge. Early involvement in the drafting process that is led by the European Commission is important to influence decision-making outcomes. For this, organizational capacity in coalitions to mobilize and coordinate the required targeted contribution of technical knowledge is crucial. Copyright © 2010 John Wiley & Sons, Ltd and ERP Environment. [source] Understanding the Advantages of Open Innovation Practices in Corporate Venturing in Terms of Real OptionsCREATIVITY AND INNOVATION MANAGEMENT, Issue 4 2008Wim Vanhaverbeke Part of the advantages of using open innovation (compared to closed innovation) in corporate venturing can be explained by applying the real options approach. Open innovation in risk-laden activities such as corporate venturing has the following advantages: (i) benefits from early involvement in new technologies or business opportunities; (ii) delayed financial commitment; (iii) early exits reducing the downward losses; and (iv) delayed exit in case it spins off a venture. We furthermore argue that these benefits do not automatically materialize. Innovative firms have to learn new skills and routines to develop the full ,real option' potential of open innovation practices. [source] E-cadherin abnormalities resulting from CPG methylation promoter in metastatic and nonmetastatic oral cancerHEAD & NECK: JOURNAL FOR THE SCIENCES & SPECIALTIES OF THE HEAD AND NECK, Issue 1 2008Renato Vieira de Moraes MSc Abstract Background. This study aims to compare the alterations in the methylation profiles of E-cadherin in oral cancer, especially in tumors with lowest metatastic potential. Methods. Nine oral verrucous carcinomas (VCs), 20 oral well-differentiated squamous cell carcinomas without lymph node involvement (SCC-pN0), and 17 with lymph node involvement (SCC-pN+) were analyzed using methylation-specific polymerase chain reaction and immunohistochemical expression of E-cadherin gene. Results. The immunohistochemical expression of E-cadherin in VC was significantly higher (p = .016) when compared with SCC-pN0 and SCC-pN+ groups. The E-cadherin gene methylation was not correlated with its abnormal immunohistochemical expression in VC and SCC-pN0. All tumors of the SCC-pN+ group with unmethylated E-cadherin gene showed significant loss of E-cadherin immunoexpression (p = .044). Conclusions. The E-cadherin gene methylation presence in tumors with lowest invasive and metastatic potential, such as VC, suggests the early involvement of this epigenetic event in the multistep progression of the oral carcinogenesis. © 2007 Wiley Periodicals, Inc. Head Neck, 2008 [source] Enamel hypoplasia of the primary dentition in a 4-year-old with intestinal lymphangiectasiaINTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY, Issue 5 2005P. ARROW Summary. Intestinal lymphangiectasia (IL) is a rare disorder, and its incidence and prevalence is unknown for either Australia or world-wide. It is characterized by diarrhoea, mild steatorrhoea, oedema, enteric loss of protein (protein-losing enteropathy) and abnormal dilated lymphatic channels in the small intestine. Whilst oedema and diarrhoea are the predominant clinical features, other observed features include hypoalbuminemia, hypogammaglobulinemia, trace metal deficiency, hypocalcemia and chylous pleural effusions. While medical presentation of the condition has been reported widely, few descriptions of oral findings have been published. A search of Medline found two reports of dental findings in the permanent dentition in patients with IL. To date, there have been no reports on dental findings in the primary dentition. The primary dentition of a 4-year-old boy with IL had teeth with enamel defects which reflected the timing of enamel development and the period in which the disease was active. The present report highlights the need for early involvement of the dental team in the dental management of children with IL. [source] When does Parkinson's disease begin?,MOVEMENT DISORDERS, Issue S2 2009Carles Gaig MD Abstract Pathological and neuroimaging studies have shown that in Parkinson's disease (PD) there is a "subclinical" or "premotor" period during which dopaminergic neurons in the substantia nigra (SN) degenerate but typical motor symptoms have not yet developed. Post-mortem studies based on nigral cell counts and evaluating dopamine levels in the striata, and imaging studies assessing the nigrostriatal pathway in vivo, have estimated that this time period could last 3 to 6 years. In addition, emerging evidence indicates that the neuropathological process of PD does not start in the SN but more likely elsewhere in the nervous system: in the lower brainstem and the olfactory bulb, or even more distant from the SN, such as in the peripheral autonomic nervous system. Patients with PD frequently can present non-motor symptoms, such as hyposmia or constipation, years before the development of classical motor signs. The physiopathology of these "premotor" symptoms, though still unclear, is currently thought to be related to early involvement by the pathological process underlying PD of non-dopaminergic lower brainstem structures or autonomic plexuses. However, the answer to the question "when does PD start" remains uncertain. Here, we review clinical, pathological, and neuroimaging data related to the onset of the pathological process of PD, and propose that its onset is non-motor and that non-motor symptoms could begin in many instances 10 and 20 years before onset of motor symptoms. The variable course of the disorder once the motor symptoms develop, suggests that the start and progression of premotor PD is also highly variable andgiven the heterogeneous nature of PD, may differ depending on the cause/s of the syndrome. When and where the neuropathological process develops in PD remains uncertain. © 2009 Movement Disorder Society [source] Neural control of the gastrointestinal tract: Implications for Parkinson diseaseMOVEMENT DISORDERS, Issue 8 2008Maria G. Cersosimo MD Abstract Disorders of swallowing and gastrointestinal motility are prominent nonmotor manifestations of Parkinson disease (PD). Motility of the gut is controlled both by extrinsic inputs from the dorsal motor nucleus of the vagus (DMV) and paravertebral sympathetic ganglia and by local reflexes mediated by intrinsic neurons of the enteric nervous system (ENS). Both the ENS and the DMV are affected by Lewy body pathology at early stages of PD. This early involvement provides insights into the pathophysiology of gastrointestinal dysmotility in this disorder and may constitute an important step in the etiopathogenesis of Lewy body disease. © 2008 Movement Disorder Society. [source] Does Alzheimer's disease begin in the brainstem?NEUROPATHOLOGY & APPLIED NEUROBIOLOGY, Issue 6 2009G. Simic Although substantial evidence indicates that the progression of pathological changes of the neuronal cytoskeleton is crucial in determining the severity of dementia in Alzheimer's disease (AD), the exact causes and evolution of these changes, the initial site at which they begin, and the neuronal susceptibility levels for their development are poorly understood. The current clinical criteria for diagnosis of AD are focused mostly on cognitive deficits produced by dysfunction of hippocampal and high-order neocortical areas, whereas noncognitive, behavioural and psychological symptoms of dementia such as disturbances in mood, emotion, appetite, and wake,sleep cycle, confusion, agitation and depression have been less considered. The early occurrence of these symptoms suggests brainstem involvement, and more specifically of the serotonergic nuclei. In spite of the fact that the Braak and Braak staging system and National Institutes of Aging , Reagan Institute (NIA-RI) criteria do not include their evaluation, several recent reports drew attention to the possibility of selective and early involvement of raphe nuclei, particularly the dorsal raphe nucleus (DRN), in the pathogenesis of AD. Based on these findings of differential susceptibility and anatomical connectivity, a novel pathogenetic scheme of AD progression was proposed. Although the precise mechanisms of neurofibrillary degeneration still await elucidation, we speculated that cumulative oxidative damage may be the main cause of DRN alterations, as the age is the main risk factor for sporadic AD. Within such a framework, ,-amyloid production is considered only as one of the factors (although a significant one in familial cases) that promotes molecular series of events underlying AD-related neuropathological changes. [source] Forty-five years in climatology,a personal odysseyTHE CANADIAN GEOGRAPHER/LE GEOGRAPHE CANADIEN, Issue 1 2008WAYNE R. ROUSE This article presents a personal perspective on an academic and research vocation spanning a period of over 45 years. It starts with my early involvement in geography and climatology and terminates with my recent experience in a large interdisciplinary research venture. The presentation highlights, with specific examples, the importance of mentors. Also emphasized is the indispensable input of colleagues and graduate students to successful research endeavours. Most of my career has been centred on McMaster University, and I naturally draw on my experiences there. There have been great changes in the research world over the past few decades. Although the number of faculty and graduate students at McMaster remained relatively constant, the research output per person more than doubled. This is attributed in large part to the accelerating technological advancements in our ability to measure and our ability to process and manipulate data. In the environmental sciences, this has revolutionized the spatial and temporal scope of the scientific questions that can be addressed. Such major changes have stimulated a marked trend towards interdisciplinary research that has evolved from mainly wishful talking to active pursuit in a search to understand complex environmental interactions. Important among these is gaining insights into the processes and feedbacks driving climate change, whether natural or anthropologically induced. Equally important is gaining an understanding of the potential impacts resulting from climate change. My perception of my successes, failures and near misses divides chronologically into three periods that cover research in the early years, research in the central subarctic and research in the Mackenzie River Basin. Quarante-cinq ans en climatologie , une odyssée personnelle Cet article propose un regard personnel sur une carrière universitaire et en recherche échelonnée sur plus de 45 ans, de mes premières contributions à la géographie et la climatologie à mes expériences actuelles au sein d'un projet de recherche interdisciplinaire. L'importance du rôle des mentors est illustrée par des exemples. Le concours indispensable apporté par les collègues et les étudiants des cycles supérieurs au succès des démarches de recherche est également souligné. La majeure partie de mes expériences professionnelles s'est déroulée à l'université McMaster et c'est pourquoi il est naturel pour moi d'y faire référence. De grands changements ont bouleversé le monde de la recherche depuis quelques décennies. Malgré le fait que le nombre de professeurs et d'étudiants des cycles supérieurs soit demeuré relativement stable, la publication de résultats de recherche par personne a plus que doublé. Ceci est attribuable en grande partie au développement rapide des technologies qui nous permettent d'évaluer, de traiter et de manipuler les données. Nous assistons donc à une révolution dans le domaine des sciences environnementales au niveau des dimensions spatiales et temporelles des questions scientifiques que nous pouvons aborder. Ces changements d'envergure alimentent une tendance nette en faveur de la recherche interdisciplinaire qui a évolué d'un v,u pieux à une entreprise active visant à comprendre les interactions environnementales d'un haut niveau de complexité. Il est essentiel de mieux prendre conscience des processus et rétroactions qui interviennent dans les changements climatiques naturels ou d'origine anthropiques. Il est aussi très important de mieux comprendre les effets induits par les changements climatiques. Ma manière de percevoir mes réussites, échecs et quasi-succès se divise chronologiquement en trois époques: les recherches durant les premières années, les recherches menées dans le subarctique, et les recherches sur le bassin du fleuve Mackenzie. [source] Clinical progression in Parkinson disease and the neurobiology of axonsANNALS OF NEUROLOGY, Issue 6 2010Hsiao-Chun Cheng PhD Despite tremendous growth in recent years in our knowledge of the molecular basis of Parkinson disease (PD) and the molecular pathways of cell injury and death, we remain without therapies that forestall disease progression. Although there are many possible explanations for this lack of success, one is that experimental therapeutics to date have not adequately focused on an important component of the disease process, that of axon degeneration. It remains unknown what neuronal compartment, either the soma or the axon, is involved at disease onset, although some have proposed that it is the axons and their terminals that take the initial brunt of injury. Nevertheless, this concept has not been formally incorporated into many of the current theories of disease pathogenesis, and it has not achieved a wide consensus. More importantly, in view of growing evidence that the molecular mechanisms of axon degeneration are separate and distinct from the canonical pathways of programmed cell death that mediate soma destruction, the possibility of early involvement of axons in PD has not been adequately emphasized as a rationale to explore the neurobiology of axons for novel therapeutic targets. We propose that ongoing degeneration of axons, not cell bodies, is the primary determinant of clinically apparent progression of disease, and that future experimental therapeutics intended to forestall disease progression will benefit from a new focus on the distinct mechanisms of axon degeneration. ANN NEUROL 2010;67:715,725 [source] Unusual case of lymphoedema in a morbidly obese patientAUSTRALASIAN JOURNAL OF DERMATOLOGY, Issue 2 2007Stephanie Weston SUMMARY A morbidly obese 57-year-old woman presented with dermatological complications of obesity including cellulitis and severe localized lymphoedema of the right leg. There were two large pedunculated masses on the right lateral thigh with early involvement of the left and overlying skin changes of chronic lymphoedema. Our patient's condition is clinically consistent with a new entity recently described in the surgical pathology literature as massive localized lymphoedema. [source] Urinary incontinence after radical retropubic prostatectomy: the outcome of a surgical techniqueBJU INTERNATIONAL, Issue 4 2003A. Moinzadeh It is a reflection of the many manuscripts submitted on urological oncology in general, and prostate cancer in particular, that I am publishing 10 papers in this section this month. Seven of these relate to the latter subject. The authors from the Lahey Clinic describe their technique of radial prostatectomy and include a novel method of posterior bladder plication. They report an early return to continence and conclude that the technique is important in achieving their excellent results. In another study the group from Stockport show that patients often make decisions about types of treatment for prostate cancer having been strongly influenced by their partner, who in turn may have had pre-existing conceptions about this. They recommend early involvement of the partner to help in this very important decision-making. The two papers on bladder cancer describe possible prognostic factors, both clinical and laboratory-based, from a large experience in Hamburg and Mansoura. OBJECTIVE To analyse the incidence of incontinence after radical retropubic prostatectomy (RRP) and the time to return of continence, using an RRP technique including a novel posterior bladder plication PATIENTS AND METHODS We retrospectively reviewed the medical records of 200 consecutive patients who underwent RRP between September 1995 and February 1997, by one surgeon, at our institution. Patient characteristics including age, preoperative prostate-specific antigen (PSA) level and Gleason grade, were assessed. Continence was assessed before and after RRP by either a third-party patient interview or a prospective validated questionnaire. Continence was defined as not requiring the use of any sanitary pads or diapers. The continence rate was determined immediately after catheter removal, and at 3, 6, 12 and 15 months after RRP. RESULTS The mean age of the patients was 59.4 years, the preoperative PSA level 8.5 ng/mL and the Gleason grade 6.1. The time to continence and percentage of continent patients was 63.5% immediately, 82% at 3 months, 91% at 6 months, and 98.5% at 12 months after RRP. At 15 months, 199 of 200 consecutive patients were continent (99.5%). CONCLUSION With our technique there was an early return to continence and only a minor incontinence rate at 15 months. The cumulative effect of sequential technical manoeuvres in our RRP technique, including posterior bladder plication, is critical for continence after RRP. [source] Delineation of Early Changes in Cases with Progressive Supranuclear Palsy-Like Pathology.BRAIN PATHOLOGY, Issue 2 2009Astrocytes in Striatum are Primary Targets of Tau Phosphorylation, GFAP Oxidation Abstract Progressive supranuclear palsy (PSP) is a complex tauopathy usually confirmed at post-mortem in advanced stages of the disease. Early PSP-like changes that may outline the course of the disease are not known. Since PSP is not rarely associated with argyrophilic grain disease (AGD) of varible intensity, the present study was focused on AGD cases with associated PSP-like changes in an attempt to delineate early PSP-like pathology in this category of cases. Three were typical clinical and pathological PSP. Another case presented with cognitive impairment, abnormal behavior and two falls in the last three months. One case suffered from mild cognitive impairment, and two had no evidence of neurological abnormality. Neuropathological study revealed, in addition to AGD, increased intensity and extent of lesion in three groups of regions, striatum, pallidus/subthalamus and selected nuclei of the brain stem, correlating with neurological impairment. Biochemical studies disclosed oxidative damage in the striatum and amygdala. Together the present observations suggest (i) early PSP-like lesions in the striatum, followed by the globus pallidus/subthalamus and selected nuclei of the brain stem; (ii) early involvement of neurons and astrocytes, but late appearance of tufted astrocytres; and (iii) oxidative damage of glial acidic protein in the striatum. [source] | |||||||||||||||||||||||||