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Distribution by Scientific Domains

Earth and Environmental Science	50%

Selected Abstracts

Assessment of Proliferating Cell Nuclear Antigen Activity Using Digital Image Analysis in Breast Carcinoma Following Magnetic Resonance-Guided Interstitial Laser Photocoagulation

THE BREAST JOURNAL, Issue 5 2003
Soheila Korourian MD
Abstract: This study examines proliferative activity in tumor cells of patients with histologically documented invasive breast carcinoma treated with magnetic resonance-guided interstitial laser photocoagulation (MR-GILP). Immunohistochemical marker for proliferating cell nuclear antigen (PCNA), a nuclear protein abundant in actively proliferating cells, is used. The study demonstrates the effectiveness of MR-GILP in ablating tumor cells of infiltrating breast cancer. The diagnosis of infiltrating breast carcinoma was confirmed by core needle biopsies. Using a specially designed magnetic resonance imaging (MRI) device, rotating delivery of excitation off-resonance (RODEO), tumors were measured ranging from 1.8 to 4.0 cm in greatest dimension. Seven formalin-fixed, paraffin-embedded archival tissues from seven patients with infiltrating carcinoma, status post-MR-GILP, were analyzed. Using PCNA immunoperoxidase (Biomeda Corp.), the proliferative capability of the remaining tumor cells around the focus of laser photocoagulation was determined. The lesions were digitally acquired using a Nikon Eclipse E800 microscope with an automated stage. Images were analyzed using Cool SNAP image editing software (version 1.0). Appropriate thresholds were set for positive staining and limited concentric radial measurements of equal area between all samples were compared at radial millimeter intervals from the center of laser ablation. The integrated area occupied by PCNA-positive cells per radial millimeter from the charcoal site (the center of the laser) increased as the distance from this site increased (a mean average at each radial measurement revealed: at the 1 mm radius the positive integrated area was 0.0024 mm2; at 2 mm, 0.0145 mm2; at 3 mm, 0.0351 mm2; at 4 mm, 0.0696 mm2; at 5 mm, 0.1025 mm2; and at 6 mm, 0.1263 mm2). MR-GILP is an effective mean of ablating breast carcinoma. This treatment option may represent an alternative to lumpectomy for a single lesion ,1 cm, or make patients with two separate lesions eligible for lumpectomy. [source]

Fibonacci grids: A novel approach to global modelling

THE QUARTERLY JOURNAL OF THE ROYAL METEOROLOGICAL SOCIETY, Issue 619 2006
Richard Swinbank
Abstract Recent years have seen a resurgence of interest in a variety of non-standard computational grids for global numerical prediction. The motivation has been to reduce problems associated with the converging meridians and the polar singularities of conventional regular latitude,longitude grids. A further impetus has come from the adoption of massively parallel computers, for which it is necessary to distribute work equitably across the processors; this is more practicable for some non-standard grids. Desirable attributes of a grid for high-order spatial finite differencing are: (i) geometrical regularity; (ii) a homogeneous and approximately isotropic spatial resolution; (iii) a low proportion of the grid points where the numerical procedures require special customization (such as near coordinate singularities or grid edges); (iv) ease of parallelization. One family of grid arrangements which, to our knowledge, has never before been applied to numerical weather prediction, but which appears to offer several technical advantages, are what we shall refer to as ,Fibonacci grids'. These grids possess virtually uniform and isotropic resolution, with an equal area for each grid point. There are only two compact singular regions on a sphere that require customized numerics. We demonstrate the practicality of this type of grid in shallow-water simulations, and discuss the prospects for efficiently using these frameworks in three-dimensional weather prediction or climate models. © Crown copyright, 2006. Royal Meteorological Society [source]

Nestedness, SLOSS and conservation networks of boreal herb-rich forests

APPLIED VEGETATION SCIENCE, Issue 3 2009
Päivi J. Hokkanen
Abstract Question: Herb-rich patches are biodiversity hotspots for vascular plants in boreal forests. We ask: Do species occurrences on herb-rich patches show a non-random, nested structure?; Does patch size relate to richness of edaphically demanding and red-listed species?; Does a set of small patches support more edaphically demanding and red-listed species than a few large patches of the equal area? Location: Eastern Finland (63°04,N, 29°52,E), boreal vegetation zone. Data: Vegetation mapping of 90 herb-rich sites, varying from 0.05 to 6.93 ha in size and belonging to six different, predetermined forest site types. Results: Using the RANDNEST procedure, only one site type showed a significantly nested pattern, and patch area was not related to "nestedness" in any of the site types. The number of edaphically demanding and red-listed plant species was positively correlated with a patch size in three forest site types. In all site types, a set of small patches had more edaphically demanding and red-listed species than did a few large patches of the equal total area. Conclusions: For conservation, it is essential to protect representative sets of different herb-rich forest site types because flora varies between the site types. Within herb-rich forest site types, several small areas may support representative species composition. However, successful conservation requires thorough species inventories, because of the high level of heterogeneity between the herb-rich patches. [source]

Determinants of preferred intertidal feeding habitat for Eastern Curlew: A study at two spatial scales

AUSTRAL ECOLOGY, Issue 2 2007
PAUL G. FINN
Abstract Broadscale habitat use by Eastern Curlews (Numenius madagascariensis) in their non-breeding range in eastern Australia was assessed using low tide surveys on feeding grounds, where 60 skilled volunteers made repeated counts of the birds on intertidal flats, across 41% (9500 ha) of the intertidal habitat within Moreton Bay, Australia. We analysed 32 defined sections of intertidal flat, of roughly equal area (mostly 200,400 ha), which varied greatly in their curlew density (2,47 birds per 100 ha) and also in substrate and other environmental features. Sites with the least resistant substrates had densities three times those with the most resistant substrates. Of 10 environmental characteristics measured for each site, substrate resistance was the best predictor of curlew density (r2 = 0.45). Characteristics that were poor predictors included distance to the nearest roost, level of human disturbance and distance to urban settlement. For a finer-scale assessment, microhabitat use and feeding behaviour were recorded during low tide within 12 intertidal flats, which varied in size (23,97 ha), substrate, topography and other features. Across all flats, curlews strongly preferred to feed relatively close (0,50 m) to the low-water line. They fed on a variety of substrates (including sand, sandy-mud, mud and seagrass) in broadly similar proportions to their occurrence in the habitat. There was a statistically significant preference for sand, although its magnitude was not strong. These results indicate that curlews select habitat most strongly at a between-flat rather than within-flat scale. [source]