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Dual Mode (dual + mode)
Selected AbstractsVasopressin modulates lateral septal network activity via two distinct electrophysiological mechanismsEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 9 2007G. Allaman-Exertier Abstract The lateral septal area is rich in vasopressin V1A receptors and is densely innervated by vasopressinergic axons, originating mainly from the bed nucleus of the stria terminalis and the amygdala. Genetic and behavioral studies provide evidence that activation of vasopressin receptors in this area plays a determinant role in promoting social recognition. What could be the neuronal mechanism underlying this effect? Using rat brain slices and whole-cell recordings, we found that lateral septal neurons are under the influence of a basal GABAergic inhibitory input. Vasopressin, acting via V1A but not V1B receptors, greatly enhanced this input in nearly all neurons. The peptide had no effect on miniature inhibitory postsynaptic currents, indicating that it acted on receptors located in the somatodendritic membrane, rather than on axon terminals, of GABAergic interneurons. Cell-attached recordings showed that vasopressin can cause a direct excitation of a subpopulation of lateral septal neurons by acting via V1A but not V1B receptors. The presence in the lateral septum of V1A but not of V1B receptors was confirmed by competition binding studies using light microscopic autoradiography. In conclusion, vasopressin appears to act in the lateral septum in a dual mode: (i) by causing a direct excitation of a subpopulation of neurons, and (ii) by causing an indirect inhibition of virtually all lateral septal neurons. This modulation by vasopressin of the lateral septal circuitry may be part of the neuronal mechanism by which the peptide, acting via V1A receptors, promotes social recognition. [source] Report of a new technique for enhanced non-invasive skin rejuvenation using a dual mode pulsed light and radio-frequency energy source: selective radio-thermolysisJOURNAL OF COSMETIC DERMATOLOGY, Issue 3 2002Patrick Bitter Jr [source] Synthesis of new 5-substitutedbenzo[b]thiophene derivativesJOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 5 2001S. Pérez-Silanes Previous works of our group have dealt with the synthesis of 1-(aryl)-3-[4-(aryl)piperazin-1-yl]propane derivatives in the search for new and efficient antidepressants with a dual mode of action: serotonin reuptake inhibition and 5-HT1A receptor afinity [1-4]. From these studies we concluded that the 3-[4-(aryl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propane derivatives led to the best results. The continuation of this research project required the preparation of some new 3-acyl-5-substituted benzo[b]thiophenes with a wide variety of substituents at the 5 position, ranging from nitro to hydroxyl derivatives. To obtain these derivatives we acylated the corresponding 5-substituted benzo[b]thiophenes when it was possible. [source] Lacosamide: new adjunctive treatment for partial seizuresPRESCRIBER, Issue 10 2009MRPharmS, Steve Chaplin MSc Lacosamide (Vimpat), which is hypothesised to have a novel dual mode of action, is a new antiepileptic drug licensed as adjunctive therapy for partial seizures. In our New products review Steve Chaplin presents the clinical data relating to its efficacy and adverse effects, and Dr Yvonne Hart comments on its place in treatment. Copyright © 2009 Wiley Interface Ltd [source] | ||||||||||