Home About us Contact
|
Home About us Contact | ||
|
|
||
Dogma
Selected AbstractsTHE FUTURE OF BIOETHICS: THREE DOGMAS AND A CUP OF HEMLOCKBIOETHICS, Issue 5 2010ANGUS DAWSON ABSTRACT In this paper I argue that bioethics is in crisis and that it will not have a future unless it begins to embrace a more Socratic approach to its leading assumptions. The absence of a critical and sceptical spirit has resulted in little more than a dominant ideology. I focus on three key issues. First, that too often bioethics collapses into medical ethics. Second, that medical ethics itself is beset by a lack of self-reflection that I characterize here as a commitment to three dogmas. Third, I offer a more positive perspective by suggesting how bioethics may benefit from looking towards public health ethics as a new source of inspiration and direction. [source] VISUAL ANTHROPOLOGY: Chinese Documentaries: From Dogma to Polyphony by Yingchi ChuAMERICAN ANTHROPOLOGIST, Issue 3 2010Paola Iovene No abstract is available for this article. [source] Utah Medical Products Inc. and the FDA: Regulatory Dogma versus Flexible InterpretationQUALITY ASSURANCE JOURNAL, Issue 2 2006C. Burgess Abstract This paper reviews the regulatory compliance background and the 2005 court case between the Food and Drug Administration (FDA) and Utah Medical Products Incorporated which supported the company's and not the Agency's interpretation of 21 Code of Federal Regulations (CFR) Part 820, the Quality System Regulations (QSR). This is the first time that the Agency has lost such a court case; the key issues in the case are presented and discussed. The judgement also shows the value of re-reading the regulations to interpret what is actually required rather than custom and practice. Copyright © 2006 John Wiley & Sons, Ltd. [source] Inputs and Outcomes of Outdoor Management Development: Of Design, Dogma and DissonanceBRITISH JOURNAL OF MANAGEMENT, Issue 4 2007Philip J. Jones Although it is now a multi-million pound international industry, there is continuing scepticism about the benefits of Outdoor Management Development (OMD). This study investigates the impact of participation in an archetypal example of OMD on a cohort of junior managers (n=19). Participants reported changes in a variety of attitudes including, their opinions of themselves, team-working and the theoretical frameworks used to underpin the programme. Analysis of individuals' accounts found associations between participation in particular forms of outdoor training activities and changes in certain categories of attitude. Cognitive dissonance theory is used as a framework to explain these changes. More specifically, we contend that task selection and review-style choices made by providers and sponsors significantly influenced the reactions, sense-making processes and training outcomes reported by participants. This study challenges the design of contemporary OMD programmes that privileges a linear, incremental view of development where one starts with simple tasks of short duration and gradually progresses to longer and more complex activities. [source] ,To Live and Die Upon a Dogma': Newman and Post/Modern FaithNEW BLACKFRIARS, Issue 986 2003Gerard Loughlin First page of article [source] Arabidopsis pathology breathes new life into the necrotrophs-vs.-biotrophs classification of fungal pathogensMOLECULAR PLANT PATHOLOGY, Issue 4 2004RICHARD P. OLIVER SUMMARY Fungal plant pathologists have for many decades attempted to classify pathogens into groups called necrotrophs, biotrophs and, more recently, hemibiotrophs. Although these terms are well known and frequently used, disagreements about which pathogens fall into which classes, as well as the precise definition of these terms, has conspired to limit their usefulness. Dogmas concerning the properties of the classes have been progressively eroded. However, the genetic analysis of disease resistance, particularly in the model plant Arabidopsis thaliana, has provided a biologically meaningful division based on whether defence against fungal pathogens is controlled via the salicylate or jasmonate/ethylene pathways. This mode-of-defence division distinguishes necrotrophs and biotrophs but it limits the biotroph class to pathogens that possess haustoria. The small number and limited range of pathogens that infect Arabidopsis means that several interesting questions are still unanswered. Do hemibiotrophs represents a distinct class or a subclass of the necrotrophs? Does the division apply to other plant families and particularly to cereals? and does this classification help us understand the intricacies of either fungal pathogenicity or plant defence? [source] Two Dogmas of Neo-EmpiricismPHILOSOPHY COMPASS (ELECTRONIC), Issue 4 2006Edouard Machery This article critically examines the contemporary resurgence of empiricism (or "neo-empiricism") in philosophy, psychology, neuropsychology, and artificial intelligence. This resurgence is an important and positive development. It is the first time that this centuries-old empiricist approach to cognition is precisely formulated in the context of cognitive science and neuroscience. Moreover, neo-empiricists have made several findings that challenge amodal theories of concepts and higher cognition. It is argued, however, that the theoretical foundations of and the empirical evidence for neo-empiricism are not as strong as is usually claimed by its proponents. The empirical evidence for and against neo-empiricism is discussed in detail. [source] Chronic lung disease: oxygen dogma revisitedACTA PAEDIATRICA, Issue 2 2001O D Saugstad Since the discovery of retrolental fibroplasia, and the role of oxygen in its development, oxygen has been considered a double-edged sword in neonatal medicine, the utmost care being exercised in order not to give too much oxygen (1). However, the important observation that hypoxaemia might induce pulmonary vasoconstriction (2) and airway constriction (3) in infants at risk for bronchopulmonary dysplasia has resulted in only a minor upward adjustment of oxygen supplementation in many neonatal units. Since oxygen toxicity has long been linked not only to retinopathy of prematurity but also to bronchopulmonary dysplasia (4), it is relevant to ask whether an increased FiO2 might have any detrimental effects on babies. [source] Consumer Control of Salt Marshes Driven by Human DisturbanceCONSERVATION BIOLOGY, Issue 3 2008MARK D. BERTNESS control de consumidor; impactos humanos; conservación de pantano de sal; cascadas de trophic Abstract:,Salt marsh ecosystems are widely considered to be controlled exclusively by bottom,up forces, but there is mounting evidence that human disturbances are triggering consumer control in western Atlantic salt marshes, often with catastrophic consequences. In other marine ecosystems, human disturbances routinely dampen (e.g., coral reefs, sea grass beds) and strengthen (e.g., kelps) consumer control, but current marsh theory predicts little potential interaction between humans and marsh consumers. Thus, human modification of top,down control in salt marshes was not anticipated and was even discounted in current marsh theory, despite loud warnings about the potential for cascading human impacts from work in other marine ecosystems. In spite of recent experiments that have challenged established marsh dogma and demonstrated consumer-driven die-off of salt marsh ecosystems, government agencies and nongovernmental organizations continue to manage marsh die-offs under the old theoretical framework and only consider bottom,up forces as causal agents. This intellectual dependency of many coastal ecologists and managers on system-specific theory (i.e., marsh bottom,up theory) has the potential to have grave repercussions for coastal ecosystem management and conservation in the face of increasing human threats. We stress that marine vascular plant communities (salt marshes, sea grass beds, mangroves) are likely more vulnerable to runaway grazing and consumer-driven collapse than is currently recognized by theory, particularly in low-diversity ecosystems like Atlantic salt marshes. Resumen:,Se ha considerado extensamente que los ecosistemas de marismas son controlados exclusivamente por dinámicas abajo-arriba, pero se ha acumulado evidencia de que las perturbaciones humanas están provocando el control por consumidores en marismas del Atlántico occidental, a menudo con consecuencias catastróficas. En otros ecosistemas marinos, las perturbaciones humanas rutinariamente disminuyen (e.g., arrecifes de coral, pastos marinos) y refuerzan (e.g., varec) el control por consumidores, pero la teoría de marismas actual predice una leve interacción potencial entre humanos y consumidores en las marismas. Por lo tanto, las modificaciones humanas al control arriba-abajo en las marismas no estaba anticipada y aun era descontada en la teoría de marismas actual, a pesar de advertencias sobre el potencial de impactos humanos en cascada en trabajos en otros ecosistemas marinos. No obstante los experimentos recientes que han desafiado el dogma de marismas establecido y que han demostrado la desaparición gradual de marismas conducida por consumidores, las agencias gubernamentales y las organizaciones no gubernamentales continúan manejando la disminución de marismas en el marco de la teoría vieja y sólo consideran como agentes causales a factores abajo-arriba. Esta dependencia intelectual en la teoría sistema-específico (i.e., teoría de marismas abajo-arriba) de muchos ecólogos y manejadores costeros tiene el potencial de tener repercusiones graves para el manejo y conservación de ecosistemas costeros frente a las crecientes amenazas humanas. Enfatizamos que las comunidades plantas vasculares marinas (marismas, pastos marinos, manglares) son potencialmente más vulnerables al pastoreo descontrolado y al colapso conducido por consumidores que lo que reconoce la teoría actualmente, particularmente en ecosistemas con baja diversidad como las marismas del Atlántico. [source] Caspase-8- and JNK-dependent AP-1 activation is required for Fas ligand-induced IL-8 productionFEBS JOURNAL, Issue 9 2007Norihiko Matsumoto Despite a dogma that apoptosis does not induce inflammation, Fas ligand (FasL), a well-known death factor, possesses pro-inflammatory activity. For example, FasL induces nuclear factor ,B (NF-,B) activity and interleukin 8 (IL-8) production by engagement of Fas in human cells. Here, we found that a dominant negative mutant of c-Jun, a component of the activator protein-1 (AP-1) transcription factor, inhibits FasL-induced AP-1 activity and IL-8 production in HEK293 cells. Selective inhibition of AP-1 did not affect NF-,B activation and vice versa, indicating that their activations were not sequential events. The FasL-induced AP-1 activation could be inhibited by deleting or introducing the lymphoproliferation (lpr) -type point mutation into the Fas death domain (DD), knocking down the Fas-associated DD protein (FADD), abrogating caspase-8 expression with small interfering RNAs, or using inhibitors for pan-caspase and caspase-8 but not caspase-1 or caspase-3. Furthermore, wildtype, but not a catalytically inactive mutant, of caspase-8 reconstituted the FasL-induced AP-1 activation in caspase-8-deficient cells. Fas ligand induced the phosphorylation of two of the three major mitogen-activated protein kinases (MAPKs): extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) but not p38 MAPK. Unexpectedly, an inhibitor for JNK but not for MAPK/ERK kinase inhibited the FasL-induced AP-1 activation and IL-8 production. These results demonstrate that FasL-induced AP-1 activation is required for optimal IL-8 production, and this process is mediated by FADD, caspase-8, and JNK. [source] Is management by objectives obsolete?GLOBAL BUSINESS AND ORGANIZATIONAL EXCELLENCE, Issue 4 2009William F. Roth Management by Objectives has been part of corporate dogma for many decades. But as its touted strengths rapidly become liabilities in the new global century, more empowering and flexible approaches sprout up as promising new models for performance management. The author examines the dampening effect Management by Objectives can have on creativity, teamwork, and the ability to respond to changes in the business. He also presents two cases of organizations that broke out of the mold: W.L. Gore and Associates' innovative approach to self-managing teams and Bridgeport Paper Company's even bolder experiment, in which employees developed and implemented a team-based organizational structure and team-directed processes for decision making, hiring and promotion, training, performance management (without MBO), rewards, and cross-team communication and integration. © 2009 Wiley Periodicals, Inc. [source] HLA antibody testing: a tool to facilitate not to prevent organ transplantationINTERNATIONAL JOURNAL OF IMMUNOGENETICS, Issue 4-5 2008Frans H. J. Claas Summary The introduction of very sensitive HLA antibody screening assays has destroyed the old dogma that pre-existence of donor specific HLA antibodies in the patient is a contra-indication for transplantation. The challenge is now to reach consensus on the parameters which predict the clinical relevance of donor specific HLA antibodies. Antibody screening assays should not only be used to prevent transplantation of patients with donor specific antibodies but also to facilitate transplantation of highly sensitized patients, both by defining acceptable HLA mismatches and non-detrimental donor specific HLA antibodies. [source] Pubic symphyseal face eburnation: an Egyptian sport story?INTERNATIONAL JOURNAL OF OSTEOARCHAEOLOGY, Issue 3 2010M. A. Judd Abstract Strenuous physical activity leaves scars on bone that attest to the demands of occupation, sport, aggression and recreation. During the assessment of 74 C-Group Nubians from Hierakonpolis (Egypt) dated to the Egyptian Middle Kingdom,Second Intermediate Period (2080,1700 BC), robust muscle insertions along the ilia and ischia were observed among some adults. In addition, a disproportionate degeneration of the pubic symphyseal faces when compared to other age-related features was also noted. In the case of one male (Burial 32), the pubic symphyseal faces were completely flattened and polished so that they resembled the eburnation that is pathognomic of osteoarthritis. Differential diagnoses are discussed and osteitis pubis, an increasingly diagnosed injury among modern athletes who participate in intense activity that involves running, kicking, twisting or leaping, is proposed as the most likely etiology. The exaggerated muscle insertions and pubic symphyseal wear, epitomised by the individual interred in Burial 32, are unique features that may be linked to the unexplained presence of this Nubian group deep in Egyptian territory during a period of political instability. Artefactual, artistic and documentary evidence records how the Egyptian pharaohs and elites conscripted Nubian athletes to the royal courts for staged contests and entertainment, part of a propaganda program engineered to reinforce among the general populace the dogma of Egyptian supremacy over the enemy. This Nubian community, serviced by Cemetery HK27C, may have functioned as a source for individuals skilled in athletics or other activities that required exceptional physical dexterity. The extraordinary modification of these pubic symphyseal faces underscores the importance of recognising paleopathological conditions that may further confound current macroscopic methods used to ascertain the chronological age of an individual. Copyright © 2009 John Wiley & Sons, Ltd. [source] Vygotsky's Non-classical Dialectical MetapsychologyJOURNAL FOR THE THEORY OF SOCIAL BEHAVIOUR, Issue 3 2003Dorothy Robbins The approach taken here is to begin to understand the focus from abstract to concrete in learning to master the principles of methodology, which are different from Western methods and procedures. This methodology is opposed to the empiricist approach of establishing rules and procedures from the concrete to the abstract. The initial discussion revolves around an explanation of the use of metaphor, metatheory, and psychology understood as a non-classical science. There is then a discussion on dialectics, dialectical synthesis, and metafacts. The core of the article is dedicated to a metatheoretical description Vygotsky uses as an abstract outline of possible guidelines in better understanding how to implement a model for non-classical psychology, using the example of a table being reflected in a mirror. A represents the actual table, while a represents the object being reflected in the mirror, and X represents the processes that take place in the mirror (i.e., the reflection of a table is the refraction of light beams). Therefore, Vygotsky concludes that both A and X are real processes and that a is their apparent, i.e., unreal result. The reflection does not exist, but both the table and the light exist. The result is that the objective existence of X and A independent of a is a dogma of materialistic psychology. There is a discussion on the interfunctional relationships of importance in such a model, and the role of consciousness, and language. The focus of this metatheoretical framework supports Vygotsky's intentions of reaching individual inner freedom and freedom of action, together with Spinoza's social determinism. [source] Ventricular Flutter Induced During Electrophysiologic Studies in Patients with Old Myocardial Infarction:JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Issue 9 2003Clinical, Electrophysiologic Predictors, Prognostic Significance Introduction: Induction of ventricular flutter during electrophysiologic (EP) studies (similar to that of ventricular fibrillation [VF]) often is viewed as a nonspecific response with limited prognostic significance. However, data supporting this dogma originate from patients without previously documented ventricular tachyarrhythmias. We examined the significance of ventricular flutter in patients with and without spontaneous ventricular arrhythmias. Methods and Results: We conducted a cohort study of all patients with myocardial infarction (MI) undergoing EP studies at our institution. Of 344 consecutive patients, 181 had previously documented spontaneous sustained ventricular arrhythmias, 61 had suspected ventricular arrhythmias, and 102 had neither. Ventricular flutter was induced in 65 (19%) of the patients. Left ventricular ejection fraction was highest among patients with inducible VF (35 ± 13), lowest for patients with inducible sustained monomorphic ventricular tachycardia (SMVT; 27 ± 9), and intermediate for patients with inducible ventricular flutter (30 ± 10). Similarly, the coupling intervals needed to induce the arrhythmia were shortest for VF (200 ± 28 msec), intermediate for ventricular flutter (209 ± 27 msec), and longest for SMVT (230 ± 35 msec). During 5 ± 8 years of follow-up, the risk for ventricular tachycardia/VF was high for patients with SMVT and ventricular flutter and low for patients with inducible VF and noninducible patients (46%, 34%, 17%, and 14%, P < 0.005). Conclusion: Patients with inducible ventricular flutter appear to be "intermediate" between patients with inducible VF and patients with SMVT in terms of clinical and electrophysiologic correlates. However, the prognostic value of inducible ventricular flutter is comparable to that of SMVT. (J Cardiovasc Electrophysiol, Vol. 14, pp. 913-919, September 2003) [source] Effect of Two Types of Control Questions and Two Question Formats on the Outcomes of Polygraph Examinations,JOURNAL OF FORENSIC SCIENCES, Issue 4 2008Frank Horvath Ph.D. Abstract:, Two major variations of polygraph "Control Question" testing, the Zone Comparison (ZoC) and the Modified General Question Test (MGQT) were evaluated. Within each, the type of control question, Exclusive or "time bar" (e.g., "Before you were 21, did you ever...") and Nonexclusive or "no time bar"(e.g., "Did you ever,.?") was manipulated in a mock theft scenario, with 80 male and 40 female subjects randomly assigned to be either innocent or guilty. Polygraphic data collected by experienced field examiners were numerically scored by an evaluator blind to all aspects of the study. Decision accuracy was not related to the type of procedure (ZoC/MGQT) used or the subject's sex. Accuracy was significantly related to the type of control question [,2(2) = 11.46, p = 0.003; ,c = 0.29]. Nonexclusive control questions produced greater accuracy than Exclusive control questions on both innocent and guilty subjects. These results and subjects' self-reports support the general "theory" on which control question (CQ) testing is based. The need for better empirical support of accepted dogma and current field practices is strongly indicated by these findings. [source] Abundant Tissue Butyrylcholinesterase and Its Possible Function in the Acetylcholinesterase Knockout MouseJOURNAL OF NEUROCHEMISTRY, Issue 3 2000Bin Li Abstract: We have described recently an acetylcholinesterase (AChE) knockout mouse. While comparing the tissue distribution of AChE and butyrylcholinesterase (BChE), we found that extraction buffers containing Triton X-100 strongly inhibited mouse BChE activity. In contrast, buffers with Tween 20 caused no inhibition of BChE. Conventional techniques grossly underestimated BChE activity by up to 15-fold. In Tween 20 buffer, the intestine, serum, lung, liver, and heart had higher BChE than AChE activity. Only brain had higher AChE than BChE activity in AChE +/+ mice. These findings contradict the dogma, based mainly on observations in Triton X-100 extracts, that BChE is a minor cholinesterase in animal tissues. AChE +/- mice had 50% of normal AChE activity and AChE -/- mice had none, but all mice had similar levels of BChE activity. BChE was inhibited by Triton X-100 in all species tested, except rat and chicken. Inhibition was reversible and competitive with substrate binding. The active site of rat BChE was unique, having an arginine in place of leucine at position 286 (human BChE numbering) in the acyl-binding pocket of the active site, thus explaining the lack of inhibition of rat BChE by Triton X-100. The generally high levels of BChE activity in tissues, including the motor endplate, and the observation that mice live without AChE, suggest that BChE has an essential function in nullizygous mice and probably in wild-type mice as well. [source] Methylprednisolone exacerbates axonal loss following optic nerve trauma in ratsJOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, Issue 2 2002KD Steinsapir PURPOSE: This study investigates the clinical dogma that very high doses of methylprednisolone helpful in spinal cord injury are also helpful in optic nerve trauma. Methods: The right optic nerve of 29 male rats received a 5 second traumatic crush followed 30 minutes later by one of five intravenous treatments (methylprednisolone 30 mg/kg, 60 mg/kg, 90 mg/kg, 120 mg/kg, or saline). Treatment was continued for three additional administrations at 6 hour intervals. Untreated sham controls (n = 7) were also prepared. Six weeks after injury, animals were sacrificed, perfused and optic nerves systematically counted. RESULTS: Axon counts (means +/, s.e.m.) were as follows: Saline = 16,670 +/, 8,900 (n = 5); Methylprednisolone: 30 mg/kg = 8,098 +/, 4,741 (n = 5); 60 mg/kg = 6,925 +/, 6,517 (n = 4); 90 mg/kg = 2,663 +/, 2,653 (n = 4); 120 mg/kg = 6,149 +/, 3,487 (n = 6). Consequently, the data revealed that saline treated animals retained more axons than those that were administered methylprednisolone (p < 0.02). CONCLUSIONS: We conclude that methylprednisolone exacerbates axonal loss following crush injury in the rat optic nerve. Based on the results of this study, clinical studies of traumatic optic neuropathy in the future should also examine the possibility that corticosteroid treatment may have an adverse effect on visual outcome following optic nerve trauma. [source] Birds select conventional over organic wheat when given free choiceJOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, Issue 11 2010Ailsa J McKenzie Abstract BACKGROUND: Global demand for organic produce is increasing by ,4 billion annually. One key reason why consumers buy organic food is because they consider it to be better for human and animal health. Reviews comparing organic and conventional food have stated that organic food is preferred by birds and mammals in choice tests. RESULTS: This study shows the opposite result,that captive birds in the laboratory and wild garden birds both consumed more conventional than organic wheat when given free choice. There was a lag in preference formation during which time birds learnt to distinguish between the two food types, which is likely to explain why the present results differ from those of previous studies. A further experiment confirmed that, of 16 potential causal factors, detection by birds of consistently higher levels of protein in conventional seeds (a common difference between many organic and conventional foodstuffs) is the likely mechanism behind this pattern. CONCLUSION: The results of this study suggest that the current dogma that organic food is preferred to conventional food may not always be true, which is of considerable importance for consumer perceptions of organically grown food. Copyright © 2010 Society of Chemical Industry [source] Factor XI deficiency in animal modelsJOURNAL OF THROMBOSIS AND HAEMOSTASIS, Issue 2009T. RENNÉ Summary., The blood coagulation system forms fibrin to limit blood loss from sites of injury, but also contributes to occlusive diseases such as deep vein thrombosis, myocardial infarction, and stroke. In the current model of a coagulation balance, normal hemostasis and thrombosis represent two sides of the same coin; however, data from coagulation factor XI-deficient animal models have challenged this dogma. Gene targeting of factor XI, a serine protease of the intrinsic pathway of coagulation, severely impairs arterial thrombus formation but is not associated with excessive bleeding. Mechanistically, factor XI may be activated by factor XII following contact activation or by thrombin in a feedback activation loop. This review focuses on the role of factor XI, and its deficiency states as novel target for prevention of thrombosis with low bleeding risk in animal models. [source] Medical Evidence and Expert Testimony in Child Sexual AbuseJUVENILE AND FAMILY COURT JOURNAL, Issue 1 2006LORI D. FRASIER ABSTRACT Expert medical testimony in child sexual abuse cases can be critical to the outcome of a legal case. This article will review the development of the medical knowledge and clinical expertise in child sexual abuse. Since the passage of mandatory child abuse reporting laws, the forensic medical examination of a child for evidence of sexual abuse has become standard. Until recently, many myths regarding female genital anatomy existed but were based primarily on dogma and lack of empirical research. Over the past 25 years, many research studies and accumulating clinical evidence have expanded medical knowledge and debunked old myths. Physical evidence, even in cases of alleged genital or anal penetration is rare. Sexually transmitted infections are also uncommon and often require medical interpretation as to their significance in a prepubertal child. Specialized medical knowledge, training, and clinical expertise have developed in order to evaluate children presenting with allegations of sexual abuse. Such medical expertise provides invaluable service to courts. We review criteria for evaluating such expertise in light of current medical practice. [source] Effector and regulatory mechanisms in allergic contact dermatitisALLERGY, Issue 12 2009M. Vocanson Allergic contact dermatitis (ACD), one of the commonest occupational diseases, is a T-cell-mediated skin inflammation caused by repeated skin exposure to contact allergens, i.e. nonprotein chemicals called haptens. Allergic contact dermatitis, also referred to as contact hypersensitivity, is mediated by CD8+ T cells, which are primed in lymphoid organs during the sensitization phase and are recruited in the skin upon re-exposure to the hapten. Subsets of CD4+ T cells endowed with suppressive activity are responsible for both the down-regulation of eczema in allergic patients and the prevention of priming to haptens in nonallergic individuals. Therefore, ACD should be considered as a breakdown of the skin immune tolerance to haptens. Recent advances in the pathophysiology of ACD have demonstrated the important role of skin innate immunity in the sensitization process and have revisited the dogma that Langerhans cells are mandatory for CD8+ T-cell priming. They have also introduced mast cells as a pivotal actor in the magnitude of the inflammatory reaction. Finally, the most recent studies address the nature, the mode and the site of action of the regulatory T cells that control the skin inflammation with the aim of developing new strategies of tolerance induction in allergic patients. [source] THE SON MORE VISIBLE: IMMATERIALISM AND THE INCARNATIONMODERN THEOLOGY, Issue 1 2010MARC A. HIGHT In this article we argue that an immaterialist ontology,a metaphysic that denies the existence of material substance,is more consonant with Christian dogma than any ontology that includes the existence of material substance. We use the philosophy of the famous eighteenth-century Irish immaterialist George Berkeley as a guide while engaging one particularly difficult Christian mystery: the doctrine of the Incarnation of Christ. The goal is to make plausible the claim that, from the analysis of this one example, there are strong reasons for thinking that if one wants to be a Christian one ought to be an immaterialist. [source] God Takes our Place: A Religious-Philosophical Approach to the Concept of StellvertretungMODERN THEOLOGY, Issue 3 2001Christof Gestrich What does it mean to say, theologically, that God takes our (human beings') place (Stelle)? In himself becoming human (the incarnation), does God enter into joys and needs, into the possibilities and the limitations of the human, in such a way as to take them all to himself? Or does he, specifically, take the blame of all people? Or only that of those who believe? Or is it something else again that is meant? What does it mean to say that ,God stands up for us' is the event of salvation, a claim which the church has in mind with its central dogma of the incarnation of God in Jesus Christ? How is human Stellvertreten, occurring in different forms, connected with the divine Stellvertreten? What does the word ,Stelle' (of humans) mean at all? [source] Knowing God by reason alone: what Vatican I never saidNEW BLACKFRIARS, Issue 1033 2010Fergus Kerr OP Abstract While the First Vatican Council (1869,70) decreed that for Catholics it is a dogma of faith that we can have certain knowledge of God by the natural light of reason it was only in the Anti-Modernist Oath (1910) that this knowledge was defined as rationally demonstrable by cosmological arguments. [source] Performing the Same Score: Repentance, Truth and Doctrine in Ecumenical TheologyNEW BLACKFRIARS, Issue 1020 2008Jeffrey McCurry Abstract This article develops the fruitful metaphor of musical performance to think about church-dividing conflicts over doctrine. In particular, I show that just as there is more than one way for a score of music to be faithfully performed, so there can be more than one way for shared fundamental dogma to be faithfully articulated in different confessional or doctrinal traditions. When the disagreements between the Chalcedonian and non-Chalcedonian churches over christological doctrine are reframed as contrasting but not contradictory "performances" of one shared scriptural and Nicene dogma, possibilities for ecumenical reconciliation are strenghthened. Indeed, while not articulating its practice by means of the metaphor of a musical performance, the Roman Catholic magisterium is already approaching doctrinal reconciliation in just this way. [source] The Roman invasion of Britain (AD 43) in imperial perspective: a response to Frere and FulfordOXFORD JOURNAL OF ARCHAEOLOGY, Issue 4 2002Eberhard Sauer Few subjects have been more passionately discussed recently than the question of whether the invasion force in AD 43 landed in Kent or on the south coast or simultaneously in both areas. Recently Professor Frere and Professor Fulford joined forces to produce a series of arguments, each independently, supporting a landing in Kent. It is argued here that while archaeological or strategic considerations do not exclude either theory, some of the new ,evidence', especially Frere's and Fulford's logistical and linguistic arguments , is demonstrably incorrect. Furthermore, the Kent hypothesis relies on the assumption of an unmentioned far,distance embassy and other non,straightforward interpretations of our main textual source, Cassius Dio. It is, however, not the aim of this paper to replace one one,sided hypothesis by another, but to point out the dangers of dogma. [source] Epistemic Communities: A Reply to TokePOLITICS, Issue 3 2000Claire Dunlop This article contests the understanding of Peter M. Haas's ,epistemic communities' approach, forwarded by David Toke in his article in Politics of May 1999. It is argued that while Toke diagnoses the approach's failing correctly, the cause he identifies is off the mark. This particularly concerns his assertion of a positivist dogma underscoring the thesis, which is rejected as a misinterpretation of Haas. Rather, it is contended that the framework's inability to engage with the real world of politics, and the other groups therein, is a product of its lack of theoretical refinement and rigorous empirical examination. [source] Trajectories in the Development of Islamic Theological Thought: the Synthesis of Kal,mRELIGION COMPASS (ELECTRONIC), Issue 4 2007Mustafa Shah The field of Islamic theology (kal,m) is not merely a receptacle for the presentation of the creedal statements and doctrinal catechisms of Islam; it derives its raison d'être not only from the articulation and elucidation of the doctrines of faith, but also by means of its rational and painstaking explication of dogma. While many of the dogmatic statements expressed in Islamic theology naturally emanate from a traditional substratum, countless more are the result of dialectical discussions as theologians expounded upon abstract constructs of religious dogma. Recent academic research is exploring the history, trends and conceptual achievements behind the Islamic experiment with theology, providing insights into the tradition's ability to integrate, refine and expand theological constructs. Scholars are also concerned with issues such as origins, authenticity and ascription, although such matters are not deflecting attention from the rich stock of resources and materials kal,m has to offer. [source] Changing Perceptions of Change: The Role of Scientists in Tamarix and River ManagementRESTORATION ECOLOGY, Issue 2 2009Juliet C. Stromberg Abstract Initially introduced to western United States to provide ecosystem services such as erosion control, Tamarix by the mid-1900s had became vilified as a profligate waster of water. This large shrub continues, today, to be indicted for various presumed environmental and economic costs, and millions of dollars are expended on its eradication. In this review, we examine the role of scientists in driving changes in perceptions of Tamarix from valuable import to vilified invader and (in some instances) back to a productive member of riparian plant communities. Scientists over the years have sustained a negative perception of Tamarix by, among other things, (1) citing outmoded sources; (2) inferring causation from correlative studies; (3) applying conclusions beyond the scope (domain) of the studies; and (4) emphasizing findings that present the species as an extreme or unnatural agent of change. Recent research is challenging the prevailing dogma regarding Tamarix's role in ecosystem function and habitat degradation and many scientists now recommend management shifts from "pest plant" eradication to systemic, process-based restoration. However, prejudice against this and other non-native species persists. To further close the gap between science and management, it is important for scientists to strive to (1) cite sources appropriately; (2) avoid reflexive antiexotic bias; (3) avoid war-based and pestilence-based terminology; (4) heed the levels of certainty and the environmental domain of studies; (5) maintain up-to-date information on educational Web sites; and (6) prior to undertaking restoration or management actions, conduct a thorough and critical review of the literature. [source] | ||||||||||||||||||||||||||||