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Disparate Results (disparate + result)
Selected AbstractsDisparate results in studies of methotrexate plus corticosteroids in the treatment of giant cell arteritis: Comment on the article by Hoffman et alARTHRITIS & RHEUMATISM, Issue 4 2003Juan Angel Jover MD No abstract is available for this article. [source] A comparison of offenders with intellectual disability across three levels of securityCRIMINAL BEHAVIOUR AND MENTAL HEALTH, Issue 1 2006Todd Hogue Background,A number of authors have described, with disparate results, the prevalence of people with intellectual disability and their characteristics, in a range of offender cohorts defined by service use. These have included high security, a range of criminal justice services and community services. There is a need for research comparing cohorts of offenders with intellectual disabilities across different settings. Aim and hypothesis,To conduct such a comparison and test the hypothesis that severity of characteristics measured will be highest in highest levels of residential security. Method,A clinical-record-based comparison a offenders with intellectual disability in high security (n = 73), medium/low security (n = 70), and a community service (n = 69). Results,Groups were similar in age and tested IQ levels. Early psychiatric service contact had been more likely in the lower security groups. In line with the hypothesis, more complex presentations, in particular comorbid personality disorder, was more likely in the highest security group. Both fatal and non-fatal interpersonal violence convictions were significantly related to group, with more in the high security group sustaining a conviction both at the index offence and prior to that. Over 50% of all groups had at least one conviction for a sexual offence. A regression model accounting for 78% of the variance was made up largely of disposal variables (Mental Health Act status and probation) and indications of antisocial traits (criminal damage, lifetime conviction for murder and ICD-10 personality disorder classification). Conclusions and implications for practice,The authors show that context of sampling affects most relationships between intellectual disability (ID) and offending when the methods for measuring ID are held constant. The results also present several questions on the relationship between risk, services available in an area and referral to higher security. Copyright © 2006 John Wiley & Sons, Ltd. [source] Helicobacter pylori CagA: Analysis of Sequence Diversity in Relation to Phosphorylation Motifs and Implications for the Role of CagA as a Virulence FactorHELICOBACTER, Issue 3 2001Doyle J. Evans Jr Abstract CagA is transported into host target cells and subsequently phosphorylated. Clearly this is a mechanism by which Helicobacter pylori could take control of one or more host cell signal transduction pathways. Presumably the end result of this interaction favors survival of H. pylori, irrespective of eventual damage to the host cell. CagA is noted for its amino acid (AA) sequence diversity, both within and outside the variable region of the molecule. The primary purpose of this review is to examine how variation in the type and number of CagA phosphorylation sites might determine the outcome of infection by different strains of H. pylori. The answer to this question could help to explain the widely disparate results obtained when H. pylori CagA status has been compared to type and severity of disease outcome in different populations, that is in different countries. Analysis of all available CagA sequences revealed that CagA contains both tyrosine phosphorylation motifs (TPMs) and cyclic-AMP-dependent phosphorylation motifs (CPMs). There are two potential CPMs near the N-terminus of CagA and at least two in the repeat region; these are not all equally well conserved. We also defined a 48-residue AA sequence, which includes the N-terminal TPM at tyrosine (Y)-122, which distinguishes between Eastern (Hong Kong-Taiwan-Japan-Thailand) H. pylori isolates and those from the West (Europe-Africa-the Americas-Australia). All 28 of the Eastern type CagA proteins have a functional N-terminal TPM whereas 11 of 47 (23.4%) of the Western type contain an inactive motif, with threonine (T) replacing the critical aspartic acid (D) residue. Only 13 of 24 (54%) known CagA sequences have an active TPM in the repeat region and only one has two TPMs in this region. The potential TPM near the C-terminus of CagA is not likely to be important since only 3 of 24 (12.5%) sequences were found to be intact. Protein database searches revealed that the AA sequence immediately following the TPM at Y-122 in CagA is homologous with a pair of PDZ domains which are common in signal transducing proteins, particularly tyrosine phosphatases. This provides a theoretical link between CagA and many of the observed responses of host cells to H. pylori. In summary, not all CagA proteins are equal in their potential for initiating host cell responses via signal transduction pathways. The degree of functional diversity of this protein depends upon which phosphorylation motifs are critical to the biological activity of CagA. [source] Measuring the Accuracy of Facial Approximations: A Comparative Study of Resemblance Rating and Face Array MethodsJOURNAL OF FORENSIC SCIENCES, Issue 1 2008Carl N. Stephan Ph.D. Abstract:, The success of facial approximation is thought to depend, at least in part, upon the "accuracy" of the constructed face. However, methods of accuracy assessment are varied and this range in methods may be responsible for the disparate results reported in the literature. The aim of this study was to determine if the accuracy results of one facial approximation were comparable across two different assessment methods (resemblance ratings and simultaneous face array tests using unfamiliar assessors) and if resemblance ratings co-varied with recognition responses. True-positive recognition performance from the facial approximation was poor (21%) while resemblance scores using the same facial approximation were moderately high (3 out of 5 on a five-point scale). These results are not, therefore, consistent and indicate that either different variables are being evaluated by the methods, or the same variable is being examined but with different weight/calibration. Further resemblance ratings tests of the facial approximation to three foil faces from the face array revealed that resemblance scores were similar irrespective of which face was compared, and did not closely correspond with the degree of recognition performance. This was especially the case for isolated comparisons of single faces to the facial approximation. Collectively, these results indicate that resemblance ratings are: (i) insensitive measures of a facial approximation's accuracy; and (ii) inconsistent with results of unfamiliar simultaneous face-array recognition results. These data suggest that familiar and unfamiliar recognition tests should be given increased weight in contrast to current resemblance rating tests. [source] Environmental Regulations and New Plant Location Decisions: Evidence from a Meta-AnalysisJOURNAL OF REGIONAL SCIENCE, Issue 1 2002Tim Jeppesen Stricter environmental regulations are often opposed on the grounds that they will alter equilibrium capital flows. Empirical evidence in this area remains largely unresolved, mainly due to the quite disparate results found in the literature. This paper takes a positive look at the relationship between new manufacturing plant location decisions and environmental regulations by examining data from 11 studies that provide more than 365 observations. One major result from our meta-analysis is that methodological considerations play a critical role in shaping the body of received estimates. Our empirical estimates also lend insights into future research that is necessary before any robust conclusions can be made regarding the effects of environmental regulations on capital flows. [source] Business Cycle Volatility, Uncertainty and Long-run GrowthTHE MANCHESTER SCHOOL, Issue 5 2001Richard Kneller Using data for 24 OECD economies from 1961 to 1997 we investigate whether the empirical relationship between business cycle volatility and long-run growth is positive, as Blackburn (Economic Journal, Vol. 109, No. 1 (1999), pp. 67,77) suggests, or negative, the view of the UK and other governments. The existing empirical literature is ambiguous on this issue. Here we account for the disparate results and find a significant negative relationship. This relationship is found to depend crucially on the time dimension of the data. We also find that oil price volatility and inflation uncertainty, as indicators of world and general shocks, are robustly correlated with growth. [source] | ||||||||||