Home About us Contact
|
Home About us Contact | ||
|
|
||
Differing Levels (differing + level)
Selected AbstractsSmall-scaled geographical variation in life-history traits of the blowfly Calliphora vicina between rural and urban populationsENTOMOLOGIA EXPERIMENTALIS ET APPLICATA, Issue 3 2009C. C. Hwang Abstract The impact of the urban heat-island effect, the warming-up of an urban area caused by human activity, on the blowfly Calliphora vicina Robineau-Desvoidy (Diptera: Calliphoridae) was examined at two British sites, 30 km apart. Waterloo in Central London is a highly urbanised built-up area, whereas Box Hill in the county of Surrey is a rural pasture and woodland location. The phenotypic plasticity of 12 C. vicina cultures, originated from single females from each of the two sites, was measured using three developmental characters: adult body size (represented as the length of the cross vein dm-cu of the right wing), development time as accumulated degree-days (ADD), and growth rate (length of dm-cu/ADD), along a constant temperature series of 16, 20, 24, and 28 °C in the laboratory. The blowflies from Box Hill had the same ADD as those from Waterloo, but showed a significantly larger adult size and growth rate at lower temperatures, suggesting the existence of local adaptations that may be caused by the differing levels of urbanisation between the two studied sites. Not surprisingly, a trade-off between adult size and development time was found. Females showed longer development times than males at all four temperatures, indicating they may need to ingest more food as larvae to furnish ovarioles and increase fecundity. However, females had larger adult size than males at 16 and 20 °C but a reverse at 28 °C, suggesting that females may be more cold-adapted than males. [source] Substrate specificity of a maize ribosome-inactivating protein differs across diverse taxaFEBS JOURNAL, Issue 7 2000Julie E. Krawetz The superfamily of ribosome-inactivating proteins (RIPs) consists of toxins that catalytically inactivate ribosomes at a universally conserved region of the large ribosomal RNA. RIPs carry out a single N-glycosidation event that alters the binding site of the translational elongational factor eEF1A and causes a cessation of protein synthesis that leads to subsequent cell death. Maize RIP1 is a kernel-specific RIP with the unusual property of being produced as a zymogen, proRIP1. ProRIP1 accumulates during seed development and becomes active during germination when cellular proteases remove acidic residues from a central domain and both termini. These deletions also result in RIP activation in vitro. However, the effectiveness of RIP1 activity against target ribosomes remains species-dependent. To determine the potential efficiency of maize RIP1 as a plant defense protein, we used quantitative RNA gel blots to detect products of RIP activity against intact ribosomal substrates from various species. We determined the enzyme specificity of recombinant maize proRIP1 (rproRIP1), papain-activated rproRIP1 and MOD1 (an active deletion mutant of rproRIP1) against ribosomal substrates with differing levels of RIP sensitivity. The rproRIP1 had no detectable enzymatic activity against ribosomes from any of the species assayed. The papain-activated rproRIP1 was more active than MOD1 against ribosomes from either rabbit or the corn pathogen, Aspergillus flavus, but the difference was much more marked when rabbit ribosomes were used as a substrate. The papain-activated rproRIP1 was much more active against rabbit ribosomes than homologous Zea mays ribosomes and had no detectable effect on Escherichia coli ribosomes. [source] A mouse embryonic stem cell model of Schwann cell differentiation for studies of the role of neurofibromatosis type 1 in Schwann cell development and tumor formationGLIA, Issue 11 2007Therese M. Roth Abstract The neurofibromatosis Type 1 (NF1) gene functions as a tumor suppressor gene. One known function of neurofibromin, the NF1 protein product, is to accelerate the slow intrinsic GTPase activity of Ras to increase the production of inactive rasGDP, with wide-ranging effects on p21ras pathways. Loss of neurofibromin in the autosomal dominant disorder NF1 is associated with tumors of the peripheral nervous system, particularly neurofibromas, benign lesions in which the major affected cell type is the Schwann cell (SC). NF1 is the most common cancer predisposition syndrome affecting the nervous system. We have developed an in vitro system for differentiating mouse embryonic stem cells (mESC) that are NF1 wild type (+/+), heterozygous (+/,), or null (,/,) into SC-like cells to study the role of NF1 in SC development and tumor formation. These mES-generated SC-like cells, regardless of their NF1 status, express SC markers correlated with their stage of maturation, including myelin proteins. They also support and preferentially direct neurite outgrowth from primary neurons. NF1 null and heterozygous SC-like cells proliferate at an accelerated rate compared to NF1 wild type; this growth advantage can be reverted to wild type levels using an inhibitor of MAP kinase kinase (Mek). The mESC of all NF1 types can also be differentiated into neuron-like cells. This novel model system provides an ideal paradigm for studies of the role of NF1 in cell growth and differentiation of the different cell types affected by NF1 in cells with differing levels of neurofibromin that are neither transformed nor malignant. © 2007 Wiley-Liss, Inc. [source] Parent, child, and contextual predictors of childhood physical punishmentINFANT AND CHILD DEVELOPMENT, Issue 3 2002Lianne J. Woodward Abstract Data gathered over the course of an 18-year longitudinal study of 1025 New Zealand children were used to: (a) develop a profile of the maternal, child, and contextual factors associated with differing levels of exposure to maternal physical punishment, and (b) identify the key predictors of maternal physical punishment as reported by young people at age 18. Results revealed the presence of clear linear associations between the extent of young people's reported exposure to physical punishment and a wide range of maternal, child, and contextual factors. The key predictors of physical punishment suggested that the psychosocial profile of those mothers at greatest risk of physically punishing or mistreating their child was that of a young woman with a personal history of strict parenting who entered motherhood at an early age, and who was attempting to parent a behaviourally difficult child within a dysfunctional family environment characterized by elevated rates of inter-parental violence and childhood sexual abuse. These findings were consistent with a cumulative risk factor model in which increasing risk factor exposure is associated with increasing levels of child physical punishment/maltreatment. Copyright © 2002 John Wiley & Sons, Ltd. [source] Variation in the development of postcranial robusticity: an example from Çatalhöyük, TurkeyINTERNATIONAL JOURNAL OF OSTEOARCHAEOLOGY, Issue 3 2007L. W. Cowgill Abstract While the study of variation in adult postcranial robusticity has a long history, few analyses have examined the acquisition of postcranial robusticity within an ontogenetic context. This research evaluates differences in the ontogenetic trajectories of immature femora from three samples, in order to assess the point at which differences in levels of adult postcranial robusticity arise during development. Femoral midshaft cross-sectional properties were compared between three diverse samples: Neolithic agriculturalists from Çatalhöyük, Turkey (n,=,42); Byzantine agriculturalists from Çatalhöyük, Turkey (n,=,24); and urban Americans from the Denver Growth Study (n,=,151). While the two adult samples from Çatalhöyük do not differ statistically, both Neolithic and Byzantine adults have relatively larger cortical and total areas than the American urban adults, and these differences are clearly established by the age of six. In addition, by the age of three, individuals from the Denver Growth Study have already attained a greater percentage of their adult length, total area, and cortical area relative to those in both the Neolithic and Byzantine samples. These results indicate that the differing levels of postcranial robusticity characterising adult populations appear relatively early during development, and that populations vary in the rate and pattern through which adult levels of postcranial robusticity are achieved. Copyright © 2007 John Wiley & Sons, Ltd. [source] How Does the Timing of Hospice Referral Influence Hospice Care in the Last Days of Life?JOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 6 2003Susan C. Miller PhD OBJECTIVES: To determine factors associated with the type of hospice care received in the last days of life and, in particular, how the timing of referral influences the use of continuous hospice home care and inpatient hospice care. DESIGN: Retrospective cohort study. SETTING: Twenty-one hospice programs across seven states under the ownership of one hospice parent provider. PARTICIPANTS: Hospice patients who were cared for and died between October 1, 1998, and September 30, 1999 (N = 28,747). MEASUREMENTS: Patient sociodemographic and clinical data were merged with use data from the provider's centralized information system to examine the factors associated with the differing levels of hospice care in the last week of life. In the last days of life, patients were classified as having received routine hospice home care only, having received continuous hospice home care, or having died in an inpatient hospice bed. RESULTS: Twenty-three percent of the patients received continuous hospice home care during the last week of life, and 34% died in an inpatient hospice bed. Patients with hospice stays of less than 7 days had a lower likelihood of receiving continuous hospice home care than those who had stays of more than 30 days (adjusted odds ratio (AOR) = 0.81, 95% confidence interval (CI) = 0.75,0.87). Patients with hospice stays of 14 days or less had a greater likelihood of dying in an inpatient hospice bed. Furthermore, patients with stays of less than 7 days who were referred from hospitals were six times likelier to die in an inpatient hospice bed than those who were referred from another source (AOR = 6.40, 95% CI = 5.74,7.14). Patients in nursing homes had a 93% lower likelihood of dying in an inpatient hospice bed than patients in the community without a live-in caregiver (AOR = 0.07, 95% CI = 0.03,0.19). Strong independent associations were observed between several other covariates and the study outcomes, particularly the covariates of which state hospice care was provided in and level of pain intensity. CONCLUSION: Findings suggest that continuous hospice home care in the last week of life is less likely to occur when patients have short hospice stays. Also, the probability of dying in an inpatient hospice bed is substantially greater for patients referred from hospitals and referred closer to time of death. Further work to determine the appropriateness of use of the different levels of hospice care is needed. [source] Evidence of pesticide resistance in medium-sized mammalian pests: a case study with 1080 poison and Australian rabbitsJOURNAL OF APPLIED ECOLOGY, Issue 4 2002Laurie E. Twigg Summary 1Toxicant-resistance is a potential, or very real, problem with many pest-control programmes world-wide. However, apart from rodents, pesticide-resistance has not been well documented in vertebrates. We assessed the potential impact of developing resistance to 1080 in rabbit populations with differing levels of historical exposure to 1080-baiting programmes in south-western Australia. 2The sensitivity to 1080 of three out of the four populations of rabbits Oryctolagus cuniculus examined had decreased significantly since Australian rabbits were last tested over 25 years ago. The lethal dose50 (LD50) values for these populations, as determined from formal toxicity trials, ranged from 0·744 to 1·019 mg pure 1080 kg,1, and were significantly greater (P < 0·05) than the previously reported values for Australian rabbits (LD50 range 0·34,0·46 mg pure 1080 kg,1). The LD50 value for the fourth population (0·584 mg pure 1080 kg,1), which has had the least exposure to 1080, did not differ from that reported previously (P > 0·05). 3The lethal dose99 (LD99) values for the four rabbit populations tested ranged from 1·181 to 1·666 mg pure 1080 kg,1, and suggested that, theoretically, all rabbits should be killed during routine baiting campaigns provided that there is no loss of active ingredient from the bait. In reality, the efficacy of 1080 poison bait laid in trails for controlling free-ranging rabbits was reduced in those populations where rabbits had decreased sensitivity to 1080. Mean reductions in rabbit numbers 7,9 days after trail baiting of resistant and sensitive populations ranged from 51·2% to 65·2%, and from 76·4% to 76·5%, respectively. 4These findings suggest that genetic resistance to 1080 is developing in at least some populations of Australian rabbits. This has world-wide implications for agricultural protection and wildlife conservation programmes that rely on a 1080-baiting strategy for reducing the impact of vertebrate pests. [source] An Application of Item Response Time: The Effort-Moderated IRT ModelJOURNAL OF EDUCATIONAL MEASUREMENT, Issue 1 2006Steven L. Wise The validity of inferences based on achievement test scores is dependent on the amount of effort that examinees put forth while taking the test. With low-stakes tests, for which this problem is particularly prevalent, there is a consequent need for psychometric models that can take into account differing levels of examinee effort. This article introduces the effort-moderated IRT model, which incorporates item response time into proficiency estimation and item parameter estimation. In two studies of the effort-moderated model when rapid guessing (i.e., reflecting low examinee effort) was present, one based on real data and the other on simulated data, the effort-moderated model performed better than the standard 3PL model. Specifically, it was found that the effort-moderated model (a) showed better model fit, (b) yielded more accurate item parameter estimates, (c) more accurately estimated test information, and (d) yielded proficiency estimates with higher convergent validity. [source] Regional and cellular distribution of mitochondrial ferritin in the mouse brainJOURNAL OF NEUROSCIENCE RESEARCH, Issue 14 2010Amanda M. Snyder Abstract Iron and mitochondrial dysfunction are important in many neurodegenerative diseases. Several iron transport proteins have been identified that are associated with mitochondria, most recently mitochondrial ferritin. Here we describe the cellular distribution of mitochondrial ferritin in multiple regions of the brain in C57/BL6 mice. Mitochondrial ferritin was found in all regions of the brain, although staining intensity varied between regions. Mitochondrial ferritin was detected throughout the layers of cerebral cortex and in the cerebellum, hippocampus, striatum, choroid plexus, and ependymal cells. The cell type in the brain that stains most prominently for mitochondrial ferritin is neuronal, but oligodendrocytes also stain strongly in both gray matter and in white matter tracts. Mice deficient in H-ferritin do not differ in the mitochondrial ferritin staining pattern or intensity compared with C57/BL6 mice, suggesting that there is no compensatory expression of these proteins. In addition, by using inbred mouse strains with differing levels of iron content, we have shown that regional brain iron content does not affect expression of mitochondria ferritin. The expression of mitochondria ferritin appears to be more influenced by mitochondrial density. Indeed, at an intracellular level, mitochondrial ferritin immunoreaction product is strongest where mitochondrial density is high, as seen in the ependymal cells. Given the importance and relationship between iron and mitochondrial activity, understanding the role of mitochondrial ferritin can be expected to contribute to our knowledge of mitochondrial dysfunction and neurodegenerative disease. © 2010 Wiley-Liss, Inc. [source] Aminoglycoside-mediated partial suppression of MECP2 nonsense mutations responsible for Rett syndrome in vitroJOURNAL OF NEUROSCIENCE RESEARCH, Issue 11 2010Andreea C. Popescu Abstract Rett syndrome is a pediatric neurological condition that affects primarily girls. Approximately 30% of Rett syndrome cases arise from point mutations that introduce a premature stop codon into the MECP2 gene. Several studies have now shown that certain aminoglycosides can facilitate read-through of some types of nonsense mutations in a context-dependent manner and allow the generation of a full-length protein. It remains mostly unclear whether different nonsense mutations of MECP2 will be responsive to aminoglycoside treatment. In this study, we tested whether the common premature terminating mutations of MECP2 seen in Rett syndrome cases can be partially suppressed by aminoglycoside administration. Our results show that aminoglycosides allow different mutant forms of MECP2 to be overcome in transiently transfected HEK293 cells, but with differing levels of efficiency. In addition, we also show that aminoglycosides increased the prevalence of full-length MeCP2 protein in a dose-dependent manner in a lymphocyte cell line derived from a Rett syndrome girl with the R255X mutation. This study helps to establish the "proof of principle" that some nonsense mutations causing Rett syndrome can be at least partially suppressed by drug treatment. © 2010 Wiley-Liss, Inc. [source] Influence of Educational Background on Stated Retreatment Choices for Suboptimal Fixed Prosthodontic ConditionsJOURNAL OF PROSTHODONTICS, Issue 2 2008Riyadh Akeel BDS Abstract Purpose: The aim of this study was to compare the stated retreatment choices for defined, suboptimal fixed prosthodontic scenarios among groups of dental professionals with differing levels of education. Materials and Methods: The study population (n = 75) comprised interns (n = 27), various categories of graduate students (n = 32), and specialist staff (n = 16) from the same institution. Participants were required to record their choices of retreatment or no retreatment for 22 suboptimal fixed prosthodontic scenarios. Results: Participants' choices varied within and between groups, with regard to specific scenarios. Intergroup differences that were statistically significant were for faulty occlusion (p= 0.013), open margin (p= 0.019), defective root filling (p= 0.001), periapical radiolucency (p= 0.011), and improper pontic design (p= 0.005), when no signs and symptoms, no caries, or no inflammation were present. The results confirm the widely-acknowledged variability in decision making that exists among dental professionals in general. Conclusion: The tendency for a significantly more interventive approach by those on a training pathway focused on imparting primarily clinical/technical skills than those enrolled in more conventional, academically-based programs, suggests that an educational dimension cannot be overlooked in the characterization of dentists' stated retreatment decision choices. [source] Incongruent patterns of genetic connectivity among four ophiuroid species with differing coral host specificity on North Atlantic seamountsMARINE ECOLOGY, Issue 2010Walter Cho Abstract Seamounts are considered to play a defining role in the evolution and diversity of marine fauna, acting as ,stepping-stones' for dispersal, regional centers of genetic isolation and speciation, and refugia for deep-sea populations. This study focused on the patterns of dispersal and genetic connectivity of four seamount ophiuroid species (Asteroschema clavigera, Ophiocreas oedipus, Ophioplinthaca abyssalis, and Ophioplinthaca chelys) displaying differing levels of associative (epifaunal) specificity to cold-water coral hosts inhabiting the New England and Corner Rise Seamount chains, and Muir Seamount in the Northwestern Atlantic. Analyses of mt16S and mtCOI revealed evidence for recent population expansion and high gene flow for all four species. However, species-specific genetic differentiation was significant based on seamount region and depth. Significant differences were found among regional seamount groups for A. clavigera, within seamount regions and seamounts for O. chelys, among 250-m depth intervals for A. clavigera, among 100-m depth intervals for O. oedipus, and there were indications of isolation by distance for A. clavigera and O. oedipus. In addition, A. clavigera and O. oedipus, broadcast spawners with high fidelity to specific coral hosts, displayed predominantly westward historical migration, whereas the ophioplinthacids, with lower host-specificity, displayed predominantly eastward migration. No congruent patterns of historical migration were evident among species and seamounts, yet these patterns can be correlated with species-specific host specificity, specific depth strata, and dispersal strategies. Conservation efforts to protect seamount ecosystems should promote multi-species approaches to genetic connectivity, and consider the impact of the ,dependence' of biodiversity on host fauna in these vulnerable marine ecosystems. [source] A mixed-methods study of interprofessional learning of resuscitation skillsMEDICAL EDUCATION, Issue 9 2009Paul Bradley Objectives, This study aimed to identify the effects of interprofessional resuscitation skills teaching on medical and nursing students' attitudes, leadership, team-working and performance skills. Methods, Year 2 medical and nursing students learned resuscitation skills in uniprofessional or interprofessional settings, prior to undergoing observational ratings of video-recorded leadership, teamwork and skills performance and subsequent focus group interviews. The Readiness for Interprofessional Learning Scale (RIPLS) was administered pre- and post-intervention and again 3,4 months later. Results, There was no significant difference between interprofessional and uniprofessional teams for leadership, team dynamics or resuscitation tasks performance. Gender, previous interprofessional learning experience, professional background and previous leadership experience had no significant effect. Interview analysis showed broad support for interprofessional education (IPE) matched to clinical reality with perceived benefits for teamwork, communication and improved understanding of roles and perspectives. Concerns included inappropriate role adoption, hierarchy issues, professional identity and the timing of IPE episodes. The RIPLS subscales for professional identity and team-working increased significantly post-intervention for interprofessional groups but returned to pre-test levels by 3,4 months. However, interviews showed interprofessional groups retained a ,residual positivity' towards IPE, more so than uniprofessional groups. Conclusions, An intervention based on common, relevant, shared learning outcomes set in a realistic educational context can work with students who have differing levels of previous IPE and skills training experience. Qualitatively, positive attitudes outlast quantitative changes measured using the RIPLS. Further quantitative and qualitative work is required to examine other domains of learning, the timing of interventions and impact on attitudes towards IPE. [source] MODELING IMPACTS OF BIOENERGY MARKETS ON NONINDUSTRIAL PRIVATE FOREST MANAGEMENT IN THE SOUTHEASTERN UNITED STATESNATURAL RESOURCE MODELING, Issue 3 2009ANDRES SUSAETA Abstract The potential impacts of bioenergy markets on slash pine plantation management on nonindustrial private forestlands in the southeastern United States were analyzed. We developed an integrated Black,Scholes and modified Hartman model to achieve this task. The risk of damage from catastrophic natural disturbances such as wildfires and pest outbreaks associated with the exclusion/incorporation of thinnings and variation in timber salvage rates was also included. Three scenario sets were considered:,status quo,or,no thinning scenario, thinning scenario for pulpwood,,and,thinning scenario for bioenergy,at differing levels of risk and salvage. The results indicated that the incorporation of thinnings either for pulpwood or bioenergy increases the forestland value regardless of the risk when the salvage value of the stand is 0.8. When the two thinning scenarios were compared, the land expectation value for the,thinning scenario for bioenergy,was greater at any level of risk compared with the,thinning scenario for pulpwood, averaging a difference of 11.5% and 11.7% for salvageable portions of 0.8 and 0, respectively. [source] Mobility of boron,polyol complexes in the hemiparasitic association between Rhinanthus minor and Hordeum vulgare: the effects of nitrogen nutritionPHYSIOLOGIA PLANTARUM, Issue 1 2008Fan Jiang Boron (B) is an essential nutrient required for plant growth and physiological processes. Long-distance B transport is facilitated by the formation of B,polyol complexes. We investigated B uptake and distribution in response to differing levels of exogenous nitrogen supply in the hemiparasitic association between Rhinanthus minor and Hordeum vulgare (barley) and in unparasitised barley and single Rhinanthus plants. In this system, the polyol mannitol is the major assimilate in Rhinanthus, whereas polyols are not detectable in barley. Furthermore, previous studies have shown that the accumulation of polyols within Rhinanthus is negatively affected by the application of exogenous nitrogen. Within the association, the strongest accumulation of B was detected in lateral buds and inflorescences of Rhinanthus, consistent with the greatest B demand in strong sink organs supplied through the phloem that contain high concentrations of mannitol. In the host, the strongest B accumulation was found in xylem-supported leaf lamellae. Roots and sheaths did not accumulate substantial amounts of B, while re-circulation of B through the phloem vessels accounted for only 10% (unparasitised) and 8% (parasitised) of the xylem sap-imported B in the mannitol-free barley hosts. In contrast, 53% (attached) and 39% (in the absence of a host) of the xylem sap-imported B was re-circulated in the phloem in the mannitol-rich Rhinanthus. We therefore present the first quantitative uptake and flow models of long-distance B transport in polyol-rich and polyol-free plants. Our findings are consistent with a close relationship between B re-translocation and mannitol concentrations in phloem vessels. [source] An analysis of predictors of team satisfaction in product development teams with differing levels of virtualnessR & D MANAGEMENT, Issue 5 2009Eric M. Stark The purpose of this study is to empirically examine and assess the moderating effects of extent of virtualness on a variety of well-established predictors of new product development team satisfaction. We focus our study on 178 different new product development teams from a variety of industries and use extent of virtualness as a structural characteristic of the teams, measuring it on a continuum. The predictors of team satisfaction we studied are relationship conflict, familiarity, goal clarity and preference for group work. Primary findings include: (1) relationship conflict has a more deleterious effect on team member satisfaction as teams become more virtual, mainly because it is very difficult for team members of virtual teams to resolve their interpersonal disputes; (2) the relationship between preference for group work and team satisfaction is moderated by extent of virtualness, such that preference for group work increases team satisfaction more as virtualness increases; (3) goal clarity and familiarity are not moderated by extent of virtualness, but have a significant direct effect on team satisfaction. Managerial and research implications of these findings relative to new product development teams are also discussed. [source] Hominoid seminal protein evolution and ancestral mating behaviorAMERICAN JOURNAL OF PRIMATOLOGY, Issue 10 2008Sarah J. Carnahan Abstract Hominoid mating systems show extensive variation among species. The degree of sexual dimorphism in body size and canine size varies among primates in accordance with their mating system, as does the testes size and the consistency of ejaculated semen, in response to differing levels of sperm competition. To investigate patterns of evolution at hominoid seminal proteins and to make inferences regarding the mating systems of extinct taxa, we sequenced the entire coding region of the prostate-specific transglutaminase (TGM4) gene in human, chimpanzee, bonobo, western lowland gorilla, eastern lowland gorilla, orangutan, and siamang, including multiple humans, chimps, and gorillas. Partial DNA sequence of the coding regions was also obtained for one eastern lowland gorilla at the semenogelin genes (SEMG1 and SEMG2), which code for the predominant proteins in semen. Patterns of nucleotide variation and inferred protein sequence change were evaluated within and between species. Combining the present data with previous studies demonstrates a high rate of amino acid substitutions, and low intraspecific variation, at seminal proteins in Pan, presumably driven by strong sperm competition. Both gorilla species apparently possess nonfunctional TGM4, SEMG1, and SEMG2 genes, suggesting that gorillas have had low sperm competition, and therefore their current polygynous mating system, for a long time before their divergence. Similarly, orangutans show longstanding stasis at TGM4, which may be interpreted as evidence for an unchanging mating system for most of their evolution after their divergence from African apes. In contrast to the great apes, the data from humans could be interpreted as evidence of fluctuations between different mating systems or alternatively as a relaxed functional constraint in these proteins. It is our hope that this study is a first step toward developing a model to predict ancestral mating systems from extant molecular data to complement interpretations from the fossil record. Am. J. Primatol. 70:939,948, 2008. © 2008 Wiley-Liss, Inc. [source] The tooth, the whole tooth and nothing but the tooth: how belief in the Tooth Fairy can engender false memories,APPLIED COGNITIVE PSYCHOLOGY, Issue 5 2008Gabrielle F. Principe To examine how children's fantasy beliefs can affect memory for their experiences, 5- and 6-year-olds with differing levels of belief in the reality of the Tooth Fairy were prompted to recall their most recent primary tooth loss in either a truthful or fun manner. Many of the children who fully believed in the existence of the Tooth Fairy reported supernatural experiences consistent with the myth under both sets of recall instructions, whereas those who realized the fictionality of the myth recalled mainly realistic experiences. However, those children with equivocal beliefs evidenced a different pattern under each set of instructions, recalling mainly realistic experiences when asked to be truthful and reporting many fantastical experiences when prompted to relate the tooth loss in a fun manner. These findings suggest that children's beliefs in the reality of fantastic phenomena can give rise to genuine constructive memory errors in line with their fantasies. Copyright © 2007 John Wiley & Sons, Ltd. [source] Ethical consumers in search of marketsBUSINESS STRATEGY AND THE ENVIRONMENT, Issue 4 2007Peter Wheale Abstract Research in ethical consumerism has concentrated on attempts to either categorize ethical consumers or to uncover their decision-making processes, but to-date there have been few investigations into the key ethical drivers behind the decision-making process. This study attempts to identify these ethical drivers within their particular product groups by means of a survey of self-proclaimed ethical consumers distributed via a questionnaire placed in the Ethical Consumer Magazine. The findings indicate that environmental issues are ranked above human rights and animal rights/welfare issues and that the ethical consumer considers the product groups to have differential importance ranging from the food products goods group, being the most strongly associated with ethical issues, to the ,brown goods' group (electric goods such as stereos and TVs), which proved to be least associated with these issues. An examination of the ethical drivers within each group suggests that ethical consumers consider each product group on the basis of its bundle of ethical attributes, with differing levels of importance placed on each ethical issue within the purchase decision. Copyright © 2005 John Wiley & Sons, Ltd and ERP Environment. [source] Can true monocular keratoconus occur?CLINICAL AND EXPERIMENTAL OPTOMETRY, Issue 6 2003Anthony J Phillips MPhil FCOptom FAAO FVCO FCLSA FBOA(HD) DipCLP Evidence increasingly supports keratoconus as an inherited, genetic disorder. If this is the case, it would be expected to express itself as a binocular condition even though variable expression of the gene may show differing levels in the two eyes. It is a common occurrence in specialist contact lens practices to see pseudo-monocular keratoconus, that is, an overt clinical level of the condition in one eye and forme fruste keratoconus in the other. The advent of videokeratoscopy has shown almost every case of apparent monocular keratoconus to be different expressions of the condition in the two eyes. Nevertheless, rare cases of the condition are seen that appear to be truly monocular. Such a case is presented in which the condition has been present for more than 23 years. The age of the subject makes the future onset of keratoconus highly unlikely and videokeratoscopy does not show the presence of forme fruste in the ,good' eye. There is no history of monocular eye rubbing. Pachymetry shows the normal eye to be well within the range of normal corneal thickness, while the keratoconus in the other eye is sufficiently advanced to warrant corneal grafting. Thus, it is a case of true monocular keratoconus and represents an extreme example of variable gene expression. [source] The impact of surgeon and pathologist on lymph node retrieval in colorectal cancer and its impact on survival for patients with Dukes' stage B diseaseCOLORECTAL DISEASE, Issue 2 2008M. D. Evans Abstract Objective, An adequate lymph node harvest is necessary for accurate Dukes' stage discrimination in colorectal cancer. The aim of this study is to identify the effect of variables, including the individual surgeon and pathologist, on lymph node harvest in a single institution. Method, Three hundred and eighty one consecutive patients had resection for colorectal cancer, in a single unit. Factors influencing lymph node retrieval, including individual surgeon and reporting pathologist, were subjected to uni- and multivariate analysis. Actuarial survival of all patients with Dukes' stage B and C disease was then calculated and survival compared between Dukes' stage B and C at differing levels of lymph node harvest. Results, The unit median lymph node harvest was 13 nodes/patient (95% CI 13.1,14.5). There was no difference in lymph node harvest between specialist colorectal surgeons and the pooled results of four nonspecialist consultant surgeons. However, there was a significant difference between reporting pathologists (P < 0.001). On univariate analysis, operation type, operative urgency, Dukes' stage, T-stage, reporting pathologist and use of neoadjuvant therapy in rectal cancer, were found to significantly affect lymph node retrieval. On multivariate analysis, operation type, T-stage, reporting pathologist and neoadjuvant therapy in rectal cancer remained significant variables. Patients with one or more lymph node metastasis had greater nodal harvests than those without (median 15 vs 12 P = 0.02). Survival of patients with Dukes' stage B disease was found to improve as lymph node harvest increased. Conclusion, Overall lymph node harvest, in this unit, varied according to the reporting pathologist but not operating surgeon. As lymph node harvest increased to 15 per patient, the probability of identifying a metastatic node increased. [source] | |||||||||||||||||||