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Different Picture (different + picture)
Selected AbstractsMicrobial Toll-like receptor ligands differentially regulate CXCL10/IP-10 expression in fibroblasts and mononuclear leukocytes in synergy with IFN-, and provide a mechanism for enhanced synovial chemokine levels in septic arthritisEUROPEAN JOURNAL OF IMMUNOLOGY, Issue 11 2003Paul Proost Abstract The CXC chemokine IFN-,-inducible protein-10 (IP-10/CXCL10) activates CXC chemokine receptor 3 (CXCR3) and attracts activated T cells and natural killer cells. Peripheral blood mononuclearcells (PBMC) produce low but significant amounts of IP-10/CXCL10 protein upon stimulation with double-stranded (ds) RNA, the Toll-like receptor 3 (TLR3) ligand. IFN-, is a superior IP-10/CXCL10inducer. The bacterial TLR4 and TLR2 ligands, LPS and peptidoglycan (PGN), inhibit IFN-,- or dsRNA-dependent IP-10/CXCL10 production in PBMC, whereas IL-8/CXCL8 production was enhanced. In fibroblasts a different picture emerges with IFN-, inducing moderate and dsRNA provoking strong IP-10/CXCL10 production. Furthermore, treatment of fibroblasts with IFN-, in combination with bacterial LPS or PGN results in a synergistic production of IP-10/CXCL10 and IL-8/CXCL8. The synergistic induction of IP-10/CXCL10 in fibroblasts is reflected by significantly enhanced IP-10/CXCL10 concentrations in synovial fluids of septic compared to osteoarthritis patients to reach on average higher levels than those of IL-8/CXCL8. These high amounts of IP-10/CXCL10 produced by connective tissue fibroblasts not only attract CXCR3 expressing activated Th1 cells and natural killer cells to sites of infection but may also antagonize the CCR3 dependent attraction of Th2 lymphocytes and exert CXCR3-independent, defensin-like antibacterial activity. [source] Differential actions of p60c-Src and Lck kinases on the Ras regulators p120-GAP and GDP/GTP exchange factor CDC25MmFEBS JOURNAL, Issue 11 2001Carmela Giglione It is known that the human Ras GTPase activating protein (GAP) p120-GAP can be phosphorylated by different members of the Src kinase family and recently phosphorylation of the GDP/GTP exchange factor (GEF) CDC25Mm/GRF1 by proteins of the Src kinase family has been revealed in vivo[Kiyono, M., Kaziro, Y. & Satoh, T. (2000) J. Biol. Chem.275, 5441,5446]. As it still remains unclear how these phosphorylations can influence the Ras pathway we have analyzed the ability of p60c-Src and Lck to phosphorylate these two Ras regulators and have compared the activity of the phosphorylated and unphosphorylated forms. Both kinases were found to phosphorylate full-length or truncated forms of GAP and GEF. The use of the catalytic domain of p60c-Src showed that its SH3/SH2 domains are not required for the interaction and the phosphorylation of both regulators. Remarkably, the phosphorylations by the two kinases were accompanied by different functional effects. The phosphorylation of p120-GAP by p60c-Src inhibited its ability to stimulate the Ha-Ras-GTPase activity, whereas phosphorylation by Lck did not display any effect. A different picture became evident with CDC25Mm; phosphorylation by Lck increased its capacity to stimulate the GDP/GTP exchange on Ha-Ras, whereas its phosphorylation by p60c-Src was ineffective. Our results suggest that phosphorylation by p60c-Src and Lck is a selective process that can modulate the activity of p120-GAP and CDC25Mm towards Ras proteins. [source] MULTILEVEL FRAMING: AN ALTERNATIVE UNDERSTANDING OF BUDGET CONTROL IN PUBLIC ENTERPRISESFINANCIAL ACCOUNTABILITY & MANAGEMENT, Issue 2 2010Lars Fallan This paper addresses the question as to why there tends to be recurring budget deviations in public sector service organizations. In the public sector, budgets and actuals are loosely coupled, and budgets may serve other institutional functions than control purposes. However, little research has addressed how the framing of budget information may explain the different functions of the budgets as control devices. The paper argues that the valence of budget deviations varies between organizations, and that organizations that have a positively oriented valence towards budget surpluses have a propensity to underspend the budgets. Consequently, organizations that have a positively oriented valence towards budget deficits tend to overspend the budgets. The empirical part analyses the budget situations in the Central Bank of Norway and in a large university hospital in Norway. In the case of the Bank, it was found that underspending of budgets was framed as performance measures indicating high organizational efficiency. The Hospital, on the other hand, showed a different picture as budget deficits were the situation during all years studied. One main finding was the key actors' roles as translators of the society's expectations as to the fulfilling of the organizations' missions. These translators function as mediators between the institutional context and pressures, the organizations' goals and the internal budget processes. The conventional wisdom that the budget also acts as a means of communication and as symbols and ritual acts that reflect the institutional contingencies of the organizations, is further developed by describing how organizations' goals valence the role of budgets. [source] ,You've got to grow up when you've got a kid': Marginalized young women's accounts of motherhoodJOURNAL OF COMMUNITY & APPLIED SOCIAL PSYCHOLOGY, Issue 4 2008Alison Rolfe Abstract Teenage motherhood has been a source of considerable debate in policy and media circles in recent years. This paper explores the meanings of teenage motherhood for young women who were mothers before the age of 21, who were living in economically deprived areas of England and most of whom had been in residential or foster care. Qualitative interviews were carried out at several sites across England, with a total of 33 young women taking part in group interviews and one-to-one interviews. The accounts of the young women suggest that they talk about motherhood in three main ways: as ,hardship and reward', ,growing up and responsibility' and ,doing things differently'. It is argued that these ways of talking about motherhood present a different picture of teenage motherhood from that of dominant discourses. Furthermore, the young women are active in negotiating and constructing their own identities as mothers, carers and women. Copyright © 2008 John Wiley & Sons, Ltd. [source] High school students' literacy practices and identities, and the figured world of schoolJOURNAL OF RESEARCH IN READING, Issue 3 2001Wendy Luttrell Conventional wisdom holds that American teenagers do not read or write , that they are a media-driven group who prefer movies, television and playing video games. Ethnographic data gathered in the High School Literacy Project, a study of four North Carolina high schools, showed a far different picture of teenage literacy. This paper reports on partial findings of the larger study and argues that students use their literacy practices to form their identities within, and sometimes in opposition to, the figured worlds of school, work and family. Many students look to school to provide formal literacy experiences, but find their reading and writing passions at odds with the demands of the school curriculum. [source] Genetic structure of avian populations , allozymes revisitedMOLECULAR ECOLOGY, Issue 10 2000P.-A. Crochet Abstract Selection on allozymes has sometimes been advanced as one explanation for the low levels of population differentiation detected in avian populations by the use of enzymatic markers. Comparisons of the amount of population subdivision (estimated by FST values or analogous indices) measured by enzymatic and mitochondrial DNA (mtDNA) markers in birds were seen as evidence for this because mtDNA typically produces a more structured picture of population subdivisions. In fact, when taking into account the smaller effective population size of mtDNA, nuclear and mitochondrial markers give concordant results. Some discrepancies still exist, but I suggest that some might originate from different amounts of nuclear vs. mitochondrial gene flow due to partial reproductive isolation. Variable number of tandem repeat (VNTR) loci do not provide a dramatically different picture of population structures in birds compared to allozymes. Although more tests are needed, such as comparing the amount of genetic structure detected in the same populations with allozymes and microsatellites, the low levels of population subdivision measured with allozymes in birds seem to reflect historical and demographic processes and would not appear to result from any peculiarities of bird enzymatic loci. [source] Interpersonal Interaction and Economic Theory: The Case of Public GoodsANNALS OF PUBLIC AND COOPERATIVE ECONOMICS, Issue 2 2000Nicholas Bardsley Interpersonal interaction in public goods contexts is very different in character to its depiction in economic theory, despite the fact that the standard model is based on a small number of apparently plausible assumptions. Approaches to the problem are reviewed both from within and outside economics. It is argued that quick fixes such as a taste for giving do not provide a way forward. An improved understanding of why people contribute to such goods seems to require a different picture of the relationships between individuals than obtains in standard microeconomic theory, where they are usually depicted as asocial. No single economic model at present is consistent with all the relevant field and laboratory data. It is argued that there are defensible ideas from outside the discipline which ought to be explored, relying on different conceptions of rationality and/or more radically social agents. Three such suggestions are considered, one concerning the expressive/communicative aspect of behaviour, a second the possibility of a part-whole relationship between interacting agents and the third a version of conformism. [source] Surveillance of work-related disorders in Australia using general practitioner dataAUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH, Issue 4 2002Tim R. Driscoll Objectives: The focus of this paper is to compare the main findings regarding work-related problems managed in general practice with those of other data sources in the occupational and public health arenas that provide some information on work-related disorders in Australia, in order to examine the implications for surveillance and prevention. Methods: Data on work-related disorders managed in general practice were obtained from a larger study of general practice activity that involved a cluster random sample of all significantly active general practitioners in Australia from 1998 to 2000. These data were compared with other Australian datasets containing information on work-related disorders. Results: Despite a predominance of musculoskeletal conditions in all the data sources, general practitioner data provided a different picture of work-related disorders in the community to workers' compensation information from the National Data Set of Compensation-based Statistics (NDS) and the limited information on work-related disorders available from other studies of general practice and emergency departments. The mix of conditions was different in many aspects, and diseases were much less common in the NDS. Conclusions: General practitioner data supplement data provided by other sources, particularly the NDS, and make an important contribution to filling some of the gaps in information about work-related diseases and more minor work-related injuries. Implications: General practitioners could prove a useful supplementary source of data on work-related disorders, but the optimal content of, and method for obtaining, these data is not clear. [source] Stability of emotion-modulated startle during short and long picture presentationPSYCHOPHYSIOLOGY, Issue 5 2005Christine L. Larson Abstract Following reports on improved test,retest reliability of emotion-modulated startle during a 6-s picture presentation when different pictures are presented at each assessment (Larson et al., 2000) and data suggesting that brief picture presentations also elicit affective blink modulation (Codispoti, Bradley, & Lang, 2001), we assessed test,retest reliability of blink modulation during brief picture presentations. At two acoustic startle sessions (4 weeks apart) subjects viewed different IAPS pictures for either 6 s (long group) or 300 ms (short), with emotion modulation assessed at three different points in time during and following picture viewing. Group ANOVAs revealed emotion modulation for both short and long groups. In addition, comparable and, in some cases, greater stability of emotion modulation was found for short compared to long picture presentations. Stability was generally low for individual probe times for both groups. [source] | ||||||||||||||||