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Different Operations (different + operations)
Selected AbstractsContinuous infusion of factor concentrates in children with haemophilia A in comparison with bolus injectionsHAEMOPHILIA, Issue 3 2006C. BIDLINGMAIER Summary., Although the concept of continuous infusion (CI) of factor concentrates is well known, prospective paediatric data are rare. We present a prospective open-labelled non-randomized study focusing on safety, efficacy and factor VIII (FVIII) usage compared with bolus injections (BI) in children. In 43 consecutive patients (0.5,17 years; median: 9.6) undergoing different operations, CI was started with an initial FVIII-bolus of 70 IU kg,1 bodyweight, followed by a median infusion rate of 4.4 IU kg,1 h,1 (range: 2.8,9.5) dose adjusted for daily FVIII levels (target: 60,80%). No direct serious adverse events occurred; however, two out of 43 patients, both from the group of four patients with less than 20 exposure days (ED) before starting CI, developed a high-responding inhibitor. Two CI patients showed mild thrombophlebitis or rash. Infusion rates needed to achieve adequate FVIII levels were highly predictable and could be reduced because of decreasing FVIII clearance. Bleeding, requiring additional boli, was observed in eight out of 43 patients. Therapy duration and factor usage of CI were influenced by the procedure, but not by the product used or thrombophilia. Twelve of these CI patients were compared with 12 contemporary consecutive age- and procedure-matched BI patients. Compared with BI patients, CI patients saved 30% FVIII (812.9 vs. 563.2 IU kg,1, P < 0.006). We conclude that CI forms a safe and effective method for perioperative care in children and reduces factor usage. Because of the unknown risk of inhibitor development, we will use CI only in patients beyond 20 ED. [source] A methodology for systemic-structural analysis and design of manual-based manufacturing operationsHUMAN FACTORS AND ERGONOMICS IN MANUFACTURING & SERVICE INDUSTRIES, Issue 3 2001Gregory Bedny The main objective of this study was to develop a method for systemic-structural analysis and design of manufacturing assembly operations based on the activity theory. The "activity" was defined as behavior distinctively specific to workers, associated with mobilizations and realization of conscious manufacturing goals. The fundamental units of analysis of activity are actions that are both motor and mental. Activity is considered as a complicated structure of actions that are logically ordered in space and time. Each action is comprised of different operations. The building blocks of motor actions are motions. The building blocks of cognitive actions are mental operations. Activity integrates not merely cognitive and behavioral components, but the energy components as well. The proposed methodology is illustrated using an example of two manufacturing assembly operations. © 2001 John Wiley and Sons, Inc. [source] General Flowshop Models: Job Dependent Capacities, Job Overlapping and DeteriorationINTERNATIONAL TRANSACTIONS IN OPERATIONAL RESEARCH, Issue 4 2002Gerd Finke Several extensions of the two-machine flowshop model that arise in industrial applications are considered. These modifications of the classical case concern buffer capacities that vary with the size of the part, and processing times that are variable and increase in situations of overlapping and long waiting periods between the different operations. [source] Recurrent venous thromboembolism after surgery-provoked versus unprovoked thromboembolismJOURNAL OF THROMBOSIS AND HAEMOSTASIS, Issue 5 2010R. H. WHITE Summary.,Background: The incidence of recurrent venous thromboembolism (VTE) varies depending on the nature of the initial provoking risk factor(s). Objectives: To compare the incidence and time course of recurrent VTE after unprovoked VTE vs. VTE provoked by nine different types of surgery. Methods: Retrospective analysis of linked California hospital and emergency department discharge records. Between 1997 and 2007, all surgery-provoked VTE cases had a first-time VTE event diagnosed within 60 days after undergoing a major operation. The incidence of recurrent VTE was compared during specified follow-up periods by matching each surgery-provoked case with three unprovoked cases based on age, race, gender, VTE event, calendar year and co-morbidity. Results: The 4-year Kaplan,Meier cumulative incidence of recurrent VTE was 14.7% (95%CI: 14.2,15.1) in the matched unprovoked VTE group vs. 7.6% (CI: 7.0,8.2) in 11 797 patients with surgery-provoked VTE (P < 0.001). The overall risk reduction was 48%, which ranged from 64% lower risk (P < 0.001) after coronary bypass surgery to 25% lower risk (P = 0.06) after disc surgery. The risk of recurrent VTE 1,5 years after the index event was significantly lower in the surgery group (HR = 0.47, CI: 0.41,0.53). Within the surgery-provoked group, the risk of recurrent VTE was similar in men and women (HR = 1.0, CI: 0.8,1.3). Conclusions: The risk of recurrent VTE after surgery-provoked VTE was approximately 50% lower than after unprovoked VTE, confirming the view that provoked VTE is associated with a lower risk of recurrent VTE. However, there was appreciable heterogeneity in the relative risk of recurrent VTE associated with different operations. [source] | ||||||||||