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Different Lines (different + line)
Selected AbstractsThe self in conflict: The evolution of mediationCONFLICT RESOLUTION QUARTERLY, Issue 2 2007Richard McGuigan Developmentalists such as Baldwin (1975); Basseches (1984); Cook-Greuter (1990, 1999, 2000); Kegan (1982, 1994, 2001); Loevinger (1976, 1979, 1983, 1993, 1997, 1998, 2002); Piaget (1970); and Wade (1996) have devoted their research to the growth of different lines of development in individuals. A developmental understanding of conflict has implications for conflict theorists and interveners. In applying Kegan's staged model of adult psychological development to the experi-ence of conflict, we can better understand the meaning-making that underlies the behaviors that disputants exhibit in conflict, thereby allowing interveners to help the disputants expand their understanding of the conflict situation and find new pathways to its resolution. [source] The genetics of autismACTA PSYCHIATRICA SCANDINAVICA, Issue 6 2001M. Lauritsen Objective: To review systematically the empirical evidence for the involvement of genetic risk factors in infantile autism. Method: We aimed at including all relevant papers written in English. We conducted a Medline search in September 2000. In addition we searched the reference lists of related papers. Results: A relatively small number of reports including family and twin studies, comorbidity, cytogenetic and molecular genetic studies were reviewed. Conclusion: As well family, twin, cytogenetic and molecular genetic studies supported the importance of genetic risk factors in infantile autism. In most individual cases probably at least a few gene variants simultaneously determine the genetic risk. Presently the most interesting chromosome regions concerning the aetiology of autism are chromosomes 7q31,35, 15q11,13 and 16p13.3 which have been suggested by different lines of genetic research. [source] EVOLUTION UNDER RELAXED SEXUAL CONFLICT IN THE BULB MITE RHIZOGLYPHUS ROBINIEVOLUTION, Issue 9 2006Magdalena Tilszer Abstract The experimental evolution under different levels of sexual conflict have been used to demonstrate antagonistic coevolution in muscids, but among other taxa a similar approach has not been employed. Here, we describe the results of 37 generations of evolution under either experimentally enforced monogamy or polygamy in the bulb mite Rhizoglyphus robini. Three replicates were maintained for each treatment. Monogamy makes male and female interests congruent; thus selection is expected to decrease harmfulness of males to their partners. Our results were consistent with this prediction in that females from monogamous lines achieved lower fecundity when housed with males from polygamous lines. Fecundity of polygamous females was not affected by mating system under which their partners evolved, which suggests that they were more resistant to male-induced harm. As predicted by the antagonistic coevolution hypothesis, the decrease in harmfulness of monogamous males was accompanied by a decline in reproductive competitiveness. In contrast, female fecundity and embryonic viability, which were not expected to be correlated with male harmfulness, did not differ between monogamous and polygamous lines. None of the fitness components assayed differed between individuals obtained from crosses between parents from the same line and those obtained from crosses between parents from different lines within the same mating system. This indicates that inbreeding depression did not confound our results. However, interpretation of our results is complicated by the fact that both males and females from monogamous lines evolved smaller body size compared to individuals from polygamous lines. Although a decrease in reproductive performance of males from monogamous lines was still significant when body size was taken into account, we were not able to separate the effects of male body size and mating system in their influence on fecundity of their female partners. [source] REPRESSION OF COMPETITION AND THE EVOLUTION OF COOPERATIONEVOLUTION, Issue 4 2003Steven A. Frank Abstract Repression of competition within groups joins kin selection as the second major force in the history of life shaping the evolution of cooperation. When opportunities for competition against neighbors are limited within groups, individuals can increase their own success only by enhancing the efficiency and productivity of their group. Thus, characters that repress competition within groups promote cooperation and enhance group success. Leigh first expressed this idea in the context of fair meiosis, in which each chromosome has an equal chance of transmission via gametes. Randomized success means that each part of the genome can increase its own success only by enhancing the total number of progeny and thus increasing the success of the group. Alexander used this insight about repression of competition in fair meiosis to develop his theories for the evolution of human sociality. Alexander argued that human social structures spread when they repress competition within groups and promote successful group-against-group competition. Buss introduced a new example with his suggestion that metazoan success depended on repression of competition between cellular lineages. Maynard Smith synthesized different lines of thought on repression of competition. In this paper, I develop simple mathematical models to illustrate the main processes by which repression of competition evolves. With the concepts made clear, I then explain the history of the idea. I finish by summarizing many new developments in this subject and the most promising lines for future study. [source] Analyses of the CYP11B gene family in the guinea pig suggest the existence of a primordial CYP11B gene with aldosterone synthase activityFEBS JOURNAL, Issue 15 2002Hannes E. Bülow In this study we describe the isolation of three genes of the CYP11B family of the guinea pig. CYP11B1 codes for the previously described 11,-hydroxylase [Bülow, H.E.,Möbius, K., Bähr, V. & Bernhardt, R. (1996) Biochem. Biophys. Res. Commun. 221, 304,312] while CYP11B2 represents the aldosterone synthase gene. As no expression for CYP11B3 was detected this gene might represent a pseudogene. Transient transfection assays show higher substrate specificity for its proper substrate for CYP11B1 as compared to CYP11B2, which could account for the zone-specific synthesis of mineralocorticoids and glucocorticoids, respectively. Thus, CYP11B2 displayed a fourfold higher ability to perform 11,-hydroxylation of androstenedione than CYP11B1, while this difference is diminished with the size of the C17 substituent of the substrate. Furthermore, analyses with the electron transfer protein adrenodoxin indicate differential sensitivity of CYP11B1 and CYP11B2 as well as the three hydroxylation steps catalysed by CYP11B2 to the availability of reducing equivalents. Together, both mechanisms point to novel protein intrinsic modalities to achieve tissue-specific production of mineralocorticoids and glucocorticoids in the guinea pig. In addition, we conducted phylogenetic analyses. These experiments suggest that a common CYP11B ancestor gene that possessed both 11,-hydroxylase and aldosterone synthase activity underwent a gene duplication event before or shortly after the mammalian radiation with subsequent independent evolution of the system in different lines. Thus, a differential mineralocorticoid and glucocorticoid synthesis might be an exclusive achievement of mammals. [source] The ancient inhabitants of Jebel Moya redux: measures of population affinity based on dental morphologyINTERNATIONAL JOURNAL OF OSTEOARCHAEOLOGY, Issue 2 2007J. D. Irish Abstract This paper reexamines some of the methods and craniometric findings in the classic volume The Ancient Inhabitants of Jebel Moya (Sudan) (1955) by Mukherjee, Rao & Trevor, in light of recent archaeological data and relative to a new dental morphological study. Archaeological evidence characterises these inhabitants as having been heavily influenced by outside sources; yet they managed to establish and maintain their own distinctive culture as seen in the site features and surviving artefact collections. The dental study, modelled after the original craniometric-based investigation and using the same or similar comparative samples, detected complementary indications of outside biological influence. In the study, up to 36 dental traits were recorded in a total of 19 African samples. The most influential traits in driving inter-sample variation were then identified, and phenetic affinities were calculated using the Mahalanobis D2 statistic for non-metric traits. If phenetic similarity provides an estimate of genetic relatedness, these affinities, like the original craniometric findings, suggest that the Jebel Moyans exhibited a mosaic of features that are reminiscent of, yet distinct from, both sub-Saharan and North African peoples. Together, these different lines of evidence correspond to portray the Jebel Moya populace as a uniform, although distinct, biocultural amalgam. Copyright © 2006 John Wiley & Sons, Ltd. [source] Merkel cell carcinoma with squamous and sarcomatous differentiationJOURNAL OF CUTANEOUS PATHOLOGY, Issue 10 2008June H. K. Hwang Merkel cell carcinoma is an aggressive neuroendocrine tumor historically thought to arise from neural crest-derived cutaneous neuroendocrine cells. Recent evidence supports an epidermal origin. We present a case of Merkel cell carcinoma arising on the upper arm of a 94-year-old woman that had multiple morphologic patterns: small cells typical of Merkel cell carcinoma, malignant cells with squamous differentiation and malignant poorly differentiated spindle cells. Subsequent metastatic disease in regional lymph nodes showed only the small cells and the malignant spindle cells. To our knowledge, this is the first case of Merkel cell carcinoma showing these three patterns of differentiation at first presentation. This morphology raises the possibility that Merkel cell carcinomas may arise from epidermal stem cells that can differentiate along different lines. [source] Nitrous Oxide Determination in Postmortem Biological Samples: A Case of Serial Fatal Poisoning in a Public Hospital,JOURNAL OF FORENSIC SCIENCES, Issue 1 2010Diana Poli Ph.D. Abstract:, In a public hospital, eight cases of fatal poisoning by nitrous oxide (N2O) occurred under oxygen administration, due to an erroneous swapping of the lines in the gas system. The aim of the study was to clarify the factors involved in asphyxia by characterizing gases from different lines and measuring N2O concentrations in postmortem biological samples from bodies exhumed. Analyses carried out on the gas system confirmed the erroneous substitution of O2 line with N2O and air line with O2. Consequently, high N2O amounts were revealed in several tissues and gaseous biological samples. All specimens were analyzed by headspace gas chromatography technique. A rigorous quantitative analysis was possible only in blood (11.29,2152.04 mg/L) and urine (95.11 mg/L) and in air samples from stomach and trachea (from 5.28 to 83.63 g/m3). This study demonstrates that N2O can be detected in biological samples even 1 month after death. [source] The Interaction of Plasmodiophora brassicae and Arabidopsis thaliana: Parameters for Disease Quantification and Screening of Mutant LinesJOURNAL OF PHYTOPATHOLOGY, Issue 11-12 2002J. Siemens Abstract The soil-borne obligate pathogen Plasmodiophora brassicae causes clubroot disease in species of Brassicaceae, including Arabidopsis thaliana. The host,pathogen interaction was studied with respect to the age of the plant at the time point of inoculation and to different infection pressures in order to establish a standardization of infection parameters and evaluation of disease extent for A. thaliana lines. Spore number per root weight, root and shoot weight of inoculated and non-inoculated plants as well as infection rate and disease index (DI) were analysed and correlated. The disease extent of different lines was comparable as measured by the relation of root weight of inoculated and non-inoculated plants (Ri/Rni index) and the DI. Most of the 71 screened A. thaliana lines turned out to be susceptible. However, the mutant lines tu8, tu3, det1-1, and rhd3-1 showed a certain degree of tolerance under specific culture conditions. The reactions of rhd3-1 indicate that hypertrophy is a prerequisite for maturation of the pathogen. The reactions of the tu3 and tu8 mutants indicate a role of indole glucosinolates and indole-3-acetonitrile/IAA in development of clubroot disease. [source] Spectroscopic study of the long-period dust-producing WC7pd+O9 binary HD 192641MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, Issue 1 2005L. Lefèvre ABSTRACT We present the results of an optical spectroscopic study of the massive Wolf,Rayet (WR) binary HD 192641 = WR 137. These 1986,2000 data cover the dust-formation maximum in 1997. Combining all available measurements of radial velocities, we derive, for the first time, a spectroscopic orbit with period 4766 ± 66 d (13.05 ± 0.18 yr). The resulting masses, adopting i= 67 °, are MO= 20 ± 2 M, for the O component and MWR= 4.4 ± 1.5 M, for the WR component. These appear, respectively, approximately normal and on the low side for the given spectral types. Analysis of the intense multisite spectroscopic monitoring in 1999 shows that the C iii,5696 and C iv,,5802/12 lines have the highest intrinsic variability levels. The periodogram analysis yields a small-amplitude modulation in the absorption troughs of the C iv,,5802/12 and He i,5876 lines with a period of 0.83 d, which could be related either to pulsations or large-scale rotating structures as seen in the WN4 star EZ Canis Majoris (WR 6). Wavelet analysis of the strong emission lines of C iii,5696 and C iv,,5802/12 enabled us to isolate and follow for several hours small structures (emission subpeaks) associated with density enhancements within the wind of the Wolf,Rayet star. Cross-correlating the variability patterns seen in different lines, we find a weak but significant correlation between the variability in emission lines with different ionization potentials, i.e. in lines formed at different distances from the WR stellar core. Adopting a , wind-velocity law, from the motion of individual subpeaks we find ,, 5, which is significantly larger than the canonical value ,, 1 found in O star winds. [source] The association between mutations in the lysosomal protein glucocerebrosidase and parkinsonism,MOVEMENT DISORDERS, Issue 11 2009John DePaolo BA Abstract A body of work has emerged over the past decade demonstrating a relationship between mutations in glucocerebrosidase gene (GBA), the gene implicated in Gaucher disease (GD), and the development of parkinsonism. Several different lines of research support this relationship. First, patients with GD who are homozygous for mutations in GBA have a higher than expected propensity to develop Parkinson's disease (PD). Furthermore, carriers of GBA mutations, particularly family members of patients with GD, have displayed an increased rate of parkinsonism. Subsequently, investigators from centers around the world screened cohorts of patients with parkinsonism for GBA mutations and found that overall, subjects with PD, as well as other Lewy body disorders, have at least a fivefold increase in the number of carriers of GBA mutations as compared to age-matched controls. In addition, neuropathologic studies of subjects with parkinsonism carrying GBA mutations demonstrate Lewy bodies, depletion of neurons of the substantia nigra, and involvement of hippocampal layers CA2,4. Although the basis for this association has yet to be elucidated, evidence continues to support the role of GBA as a PD risk factor across different centers, synucleinopathies, and ethnicities. Further studies of the association between GD and parkinsonism will stimulate new insights into the pathophysiology of the two disorders and will prove crucial for both genetic counseling of patients and family members and the design of relevant therapeutic strategies for specific patients with parkinsonism. © 2009 Movement Disorder Society [source] Quantifying the three main components of salinity tolerance in cerealsPLANT CELL & ENVIRONMENT, Issue 3 2009KARTHIKA RAJENDRAN ABSTRACT Salinity stress is a major factor inhibiting cereal yield throughout the world. Tolerance to salinity stress can be considered to contain three main components: Na+ exclusion, tolerance to Na+ in the tissues and osmotic tolerance. To date, most experimental work on salinity tolerance in cereals has focused on Na+ exclusion due in part to its ease of measurement. It has become apparent, however, that Na+ exclusion is not the sole mechanism for salinity tolerance in cereals, and research needs to expand to study osmotic tolerance and tissue tolerance. Here, we develop assays for high throughput quantification of Na+ exclusion, Na+ tissue tolerance and osmotic tolerance in 12 Triticum monococcum accessions, mainly using commercially available image capture and analysis equipment. We show that different lines use different combinations of the three tolerance mechanisms to increase their total salinity tolerance, with a positive correlation observed between a plant's total salinity tolerance and the sum of its proficiency in Na+ exclusion, osmotic tolerance and tissue tolerance. The assays developed in this study can be easily adapted for other cereals and used in high throughput, forward genetic experiments to elucidate the molecular basis of these components of salinity tolerance. [source] mtDNA variability in two Bantu-speaking populations (Shona and Hutu) from Eastern Africa: Implications for peopling and migration patterns in sub-Saharan AfricaAMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, Issue 2 2009Loredana Castrì Abstract In this study, we report novel data on mitochondrial DNA in two of the largest eastern Bantu-speaking populations, the Shona from Zimbabwe and the Hutu from Rwanda. The goal is to evaluate the genetic relationships of these two ethnic groups with other Bantu-speaking populations. Moreover, by comparing our data with those from other Niger-Congo speaking populations, we aim to clarify some aspects of evolutionary and demographic processes accompanying the spread of Bantu languages in sub-Saharan Africa and to test if patterns of genetic variation fit with models of population expansion based on linguistic and archeological data. The results indicate that the Shona and Hutu are closely related to the other Bantu-speaking populations. However, there are some differences in haplogroup composition between the two populations, mainly due to different genetic contributions from neighboring populations. This result is confirmed by estimates of migration rates which show high levels of gene flow not only between pairs of Bantu-speaking populations, but also between Bantu and non-Bantu speakers. The observed pattern of genetic variability (high genetic homogeneity and high levels of gene flow) supports a linguistic model suggesting a gradual spread of Bantu-speakers, with strong interactions between the different lines of Bantu-speaker descent, and is also in agreement with recent archeological findings. In conclusion, our data emphasize the role that population admixture has played at different times and to varying degrees in the dispersal of Bantu languages. Am J Phys Anthropol, 2009. © 2009 Wiley-Liss, Inc. [source] The Late Pleistocene Colonization of South America: An Interdisciplinary PerspectiveANNALS OF HUMAN GENETICS, Issue 5 2009Francisco Rothhammer Summary In this article, we briefly review scenarios for the first peopling of the New World, including the Clovis First/Single Origin, Tripartite, and Dual Migration models. We then discuss bioanthropological, molecular genetic, archaeological and biogeographic evidence for the peopling of the continent. To conclude, we draw on different lines of evidence to make inferences concerning the timing, direction, and type of early human dispersion in South America. [source] Distinctions in descriptive and instrumental stakeholder theory: a challenge for empirical researchBUSINESS ETHICS: A EUROPEAN REVIEW, Issue 1 2010Niklas Egels-Zandén Stakeholder theory is one of the most influential theories in business ethics. It is perhaps not surprising that a theory as popular as stakeholder theory should be used in different ways, but when the disparity between different uses becomes too great, it is questionable whether all the ,stakeholder research' refers to the same underlying theory. This paper starts to clarify this definitional confusion by distinguishing between three different ways in which different lines of stakeholder research are connected with descriptive and instrumental stakeholder theory. First, a distinction is made between research connected with descriptive and with instrumental stakeholder theory as defined by Donaldson & Preston in the narrow or broad sense. Second, a distinction is made between research that interprets descriptive and instrumental stakeholder theories as either hypotheses or research areas. Third, a distinction is made between research that interprets Donaldson & Preston's central concept of ,stakeholder management' as either behaviour or rationale. Finally, the paper discusses the implications of these differences for empirical research into stakeholder theory. [source] Tapetoretinal degenerations: Experiences, experiments and expectationsACTA OPHTHALMOLOGICA, Issue 3 2000Berndt Ehinger ABSTRACT. Tapetoretinal degenerations are a common cause for vision problems, but have until recently not been amenable to rational treatment. With rapidly increasing insights into basic neurobiology and pathobiology this has now begun to change. From having been a relatively small group of largely unknown yet fairly prevalent disorders, they are rapidly forming a large set of well defined diseases, and it is easy to predict that our knowledge about them will continue to increase for many years to come. Vitamin A (15 ,000 IU daily) is currently the only rational treatment available. However, in experimental animals, therapy strategies are now actively being developed along several different lines. Apoptotic photoreceptor cell death can be delayed with different drugs, and at least one of them, diltiazem, is approved for human use in cardiovascular diseases. It remains to be seen if it has any clinically significant effect in human tapetoretinal degenerations. Other strategies aim at counteracting the production of harmful protein variants, acting either on DNA or mRNA levels. Transgenes can also be used to induce the production of important but missing metabolic components. Finally, cells or retina sheets can be transplanted, either to replace failing cells or as a source for missing trophic factors. Neither of these strategies has yet been transferred to humans, but trials are under way. With the high increase in the flow of new information on tapetoretinal disorders, much more precise diagnoses and much improved treatments are soon to be expected, augmenting considerably the possibilities for ophthalmologists to help patients with such diseases. It is not likely that there will be a single treatment for all the many varieties. Instead, we are most likely going to see pharmacological treatments for some of them, DNA transfers for some, and transplantations for others. [source] | |||||||||||||||||||