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Different Levels (different + level)
Kinds of Different Levels Selected AbstractsEffect of Different Levels of Wheat Straw Soil Surface Coverage on Weed Flora in Vicia faba CropsJOURNAL OF AGRONOMY AND CROP SCIENCE, Issue 4 2003D. Bilalis Abstract The crop system implemented on organic farms requires that crop residues are incorporated into the soil following the end of wheat cultivation. This system leads to a reduction in soil moisture and the creation of favourable conditions for the emergence of weeds. In contrast, covering the soil with 60 % crop residues was found to maintain soil moisture and lead to a reduction in dry weed mass, population density and population frequency as well as a reduction in population diversity, regardless of the initial weed flora before the implementation of different soil tillage systems. Finally, an increase in the prevalence of broad-leafed weeds was observed as the level of soil cover increased. [source] A Placebo-Controlled Randomized Clinical Trial of Naltrexone in the Context of Different Levels of Psychosocial InterventionALCOHOLISM, Issue 7 2008David W. Oslin Background:, Naltrexone is approved for the treatment of alcohol dependence when used in conjunction with a psychosocial intervention. This study was undertaken to examine the impact of 3 types of psychosocial treatment combined with either naltrexone or placebo treatment on alcohol dependency over 24 weeks of treatment: (1) Cognitive-Behavioral Therapy (CBT) + medication clinic, (2) BRENDA (an intervention promoting pharmacotherapy) + medication clinic, and (3) a medication clinic model with limited therapeutic content. Methods:, Two hundred and forty alcohol-dependent subjects were enrolled in a 24-week double-blind placebo-controlled study of naltrexone (100 mg/d). Subjects were also randomly assigned to 1 of 3 psychosocial interventions. All patients were assessed for alcohol use, medication adherence, and adverse events at regularly scheduled research visits. Results:, There was a modest main treatment effect for the psychosocial condition favoring those subjects randomized to CBT. Intent-to-treat analyses suggested that there was no overall efficacy of naltrexone and no medication by psychosocial intervention interaction. There was a relatively low level of medication adherence (50% adhered) across conditions, and this was associated with poor outcome. Conclusions:, Results from this 24-week treatment study demonstrate the importance of the psychosocial component in the treatment of alcohol dependence. Moreover, results demonstrate a substantial association between medication adherence and treatment outcomes. The findings suggest that further research is needed to determine the appropriate use of pharmacotherapy in maximizing treatment response. [source] Instructional Efficiency of Performance Analysis Training for Learners at Different Levels of Competency in Using a Web-Based EPSSPERFORMANCE IMPROVEMENT QUARTERLY, Issue 4 2004A. Aubteen Darabi ABSTRACT The measure of performance improvement potential (Gilbert, 1978) in human performance technology uses an exemplary performance as a criterion against which to measure the potential improvement in the performance of a workforce. The measure is calculated based on the performance efficiency which compares expended resources to productivity. The same notion is used to measure the efficiency of instructional conditions, based on learners' mental effort invested in a learning task compared to their performance. This article compares the efficiency of an instructional condition for three groups of students differentiated by their use of an electronic performance support system (EPSS) to conduct a performance analysis project. The results indicated that the instruction was most efficient for those learners who showed greater competency in using the EPSS. Implications for using this technique as a means of formative evaluation of a course are discussed. [source] Comparative Analysis of Phytophthora infestans Induced Gene Expression in Potato Cultivars with Different Levels of ResistancePLANT BIOLOGY, Issue 6 2005B. Ros Abstract: Differential gene expression was analyzed after infection with Phytophthora infestans in six potato cultivars with different levels of resistance to late blight. To verify the infection of the potato leaflets, the amount of phytopathogen mRNA within the plant material was quantified by real-time quantitative PCR. The expression of 182 genes selected from two subtracted cDNA libraries was studied with cDNA array hybridization using RNA from non-infected and infected potato leaflets. Gene up- and down-regulation were clearly detectable in all cultivars 72 h post inoculation. Gene expression patterns in susceptible cultivars differed from those in potato varieties with a higher level of resistance. In general, a stronger gene induction was observed in the susceptible cultivars compared to the moderately to highly resistant potato varieties. Five genes with the highest homology to stress and/or defence-related genes were induced specifically in the susceptible cultivars. Four genes responded to pathogen attack independently of the level of resistance of the cultivar used, and three genes were repressed in infected tissue of most cultivars. Even in the absence of P. infestans infection, six genes showed higher expression levels in the somewhat resistant cultivars Bettina and Matilda. Possible reasons for the different levels of gene expression are discussed. [source] Warrior nurse: duality and complementarity of role in the operational environmentJOURNAL OF ADVANCED NURSING, Issue 1 2008Lauren Griffiths Abstract Title.,Warrior nurse: duality and complementarity of role in the operational environment Aim., This paper is a report of a study to explore the nature of military nursing in an environment of war, in particular the union of personal, professional and organizational tenets and to identify the actual or potential effect this had on the nursing role in this unique environment. Background., The history of nursing is intrinsically linked with war. There is an irony to this relationship. Active involvement with military activities has provided a vehicle in which nursing has developed, albeit through fostering war, which itself destroys health and contravenes the ethos of nursing. Military nurses, one would assume, are able to reconcile the dichotomy existing between their caring role and being a member of an organization associated with conflict. Methods., A grounded theory design was adopted and the data were collected from 1999 to 2002 using a series of in-depth interviews and focus group with of 24 military nurses. Findings., Three categories were identified: ,It's Just Different Levels', ,That Double Hat' and ,It's Who We Are!' The first illustrates the reality of conflict. ,That Double Hat' outlines the military nurses dual role: those of caring and the military. ,It's Who We Are!' demonstrates the transition from nurse-to-warrior. These integrate to create the core category: ,Caring for War: Transition to Warrior'. Conclusion., The symbiotic relationship of carer and warrior arises as a consequence of strategies used by military nurses to embrace their dual role. Further research is needed to explore the essence of the caring role within a conflict zone from military and civilian perspectives. [source] Condition Assessment by Visual Inspection for a Bridge Management SystemCOMPUTER-AIDED CIVIL AND INFRASTRUCTURE ENGINEERING, Issue 2 2005Vincenzo Gattulli This article deals with a procedure for bridge condition assessment by visual inspection developed during the planning and preliminary design of the BMS for the public railway networks in Italy. The main modules adopted in the procedure are: bridge inventory, computer-aided visual inspection, automated defect catalog, and priority-ranking procedure. The probabilistic models used to calibrate the condition evaluation algorithm are discussed. Different levels of deficiency have been individuated for each class of bridge structure belonging to the managed stock. The procedure allows comparison and relative ranking of deficiency conditions across different types of bridge structures. The results of a visual inspection campaign conducted for a set of bridges with different structural characteristics are reported and evaluated within the framework of the developed BMS. [source] Control of flexor motoneuron activity during single leg walking of the stick insect on an electronically controlled treadwheelDEVELOPMENTAL NEUROBIOLOGY, Issue 3 2003Jens Peter Gabriel Abstract In the present study, motoneurons innervating the flexor tibiae muscle of the stick insect (Cuniculina impigra) middle leg were recorded intracellularly while the single leg performed walking-like movements on a treadwheel. Different levels of belt friction (equivalent to a change in load) were used to study the control of activity of flexor motoneurons. During slow leg movements no fast motoneurons were active, but a recruitment of these neurons could be observed during faster leg movements. The firing rate of slow and fast motoneurons increased with incremented belt friction. Also, the force applied to the treadwheel at different frictional levels was adapted closely to the friction of the treadwheel to be overcome. The motoneurons innervating the flexor tibiae were recruited progressively during the stance phase, with the slow motoneurons being active earlier than the fast (half-maximal spike frequency after 10,15% and 50,60% of the stance phase, respectively). The resting membrane potential was more hyperpolarized in fast motoneurons (64.6 ± 6.5 mV) than in slow motoneurons (,52.9 ± 5.4 mV). However, the threshold for the initiation of action potentials was not statistically significantly different in both types of flexor motoneurons. Therefore, action potentials were generated in fast motoneurons after a longer period of depolarization and thus later during the stance phase than in slow motoneurons. We show that motoneurons of the flexor tibiae receive substantial common excitatory inputs during the stance phase and that the difference in resting membrane potential between slow and fast motoneurons is likely to play a crucial role in their consecutive recruitment. © 2003 Wiley Periodicals, Inc. J Neurobiol 56: 237,251, 2003 [source] ISOLATION BY DISTANCE IN EQUILIBRIUM AND NONEQUILIBRIUM POPULATIONS OF FOUR TALITRID SPECIES IN THE MEDITERRANEAN SEAEVOLUTION, Issue 5 2000Elvira De Matthaeis Abstract Allozymic variation at 21,23 loci was studied in 28 populations of Talitrus saltator, 23 populations of Orchestia montagui, 13 populations of O. stephenseni, and five populations of Platorchestia platensis from the Mediterranean Basin. Different levels of gene flow (Nm,) were detected within each species at the scale of the whole Mediterranean: O. montagui and P. platensis had low population structure, with levels of Nm, 1, whereas the T. saltator and O. stephenseni populations have values of Nm, < 1. The relationship between Nm, and geographic distance was analyzed to test for the presence of an isolation by distance pattern in the spatial genetic variation within each species. A model of isolation by distance is useful to describe the pattern of genetic structuring of study species at the scale of the whole Mediterranean: geographic distance explained from 28% to 70% of the variation in gene flow. In the Aegean area all species showed an island model of genetic structuring regardless of the levels of gene flow. [source] Effects of Nutrients, Fish, Charophytes and Algal Sediment Recruitment on the Phytoplankton Ecology of a Shallow LakeINTERNATIONAL REVIEW OF HYDROBIOLOGY, Issue 6 2007María-José Villena Abstract The influence of nutrient levels, fish density and charophytes on the phytoplankton ecology of a shallow Mediterranean lake was studied by means of an in situ mesocosm experiment. Different levels of nutrients and fish were added over the course of an eight-week experiment, during which charophytes were removed towards the end. After submerged plants were removed, phytoplankton biomass increased significantly in all the mesocosms, with a reduction of algal diversity and species richness and dominance of cyanobacteria. Cyanobacteria recruited from the sediment played an important role in sustaining planktonic populations of the dominant species. Oscillatorial species (Pseudanabaena galeata, Planktolyngbya limnetica) dominated at higher nutrient levels (0.5,1 mg L,1 P and 5,10 mg L,1 N) and chroococcal cyanobacteria (Merismopedia tenuissima) at lower nutrient levels. Density of planktivorous fish had little effect on the algal recruitment from the sediment and phytoplankton biomass and diversity. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Setting Up a Multidisciplinary Program for Management of Patent Foramen Ovale-Mediated SyndromesJOURNAL OF INTERVENTIONAL CARDIOLOGY, Issue 3 2006GIANLUCA RIGATELLI M.D. Background: These days no codified multidisciplinary protocol has been reported to manage all the different patent foramen ovale (PFO)-mediated syndromes. We sought to propose a multidisciplinary program of diagnosis, treatment, and follow-up of all PFO-mediated syndromes based on an in-hospital multidisciplinary task force and to review the activities during the first year. Methods: From September 2004, we organized in our hospital, a 600-bed tertiary hospital, a management program for PFO-mediated syndromes based on a task force composed of cardiologists, neurologists, and internists. Different levels of protocols were created in order to cover diagnosis, treatment, and follow-up of PFO-mediated syndromes. We reviewed the activity of our program in the first year up to September 2005. Results: Thirty-five patients (23 female, mean age 65 ± 24 years) were evaluated for suspected PFO-mediated syndromes: 20 for cryptogenic stroke, 2 for peripheral and coronary embolisms, 3 for platypnea-orthodeoxia, 9 for emicrania with aura, and 1 with hypoxiemia during neurosurgical intervention in the posterior cranial fossa. Diagnosis of PFO was confirmed in 25 patients. According to the multidisciplinary protocols, 15 patients failed to meet the requirements for transcatheter closure and were left in medical therapy whereas 11 patients (7 patients with PFO, 2 with multiperforated ASD, and 2 with a secundum ASD) underwent transcatheter closure. After a mean follow-up of 10.8 ± 4.9 months, no recurrent PFO syndromes were noted in patients treated with devices. Conclusion: The first year of our multidisciplinary program allowed a reasonable and potentially successful approach for correctly identifying patients with PFO-mediated syndromes until randomized studies are completed. [source] Regulatory proteins of eukaryotic initiation factor 2-alpha subunit (eIF2,) phosphatase, under ischemic reperfusion and toleranceJOURNAL OF NEUROCHEMISTRY, Issue 4 2007Lidia García-Bonilla Abstract Phosphorylation of the , subunit of eukaryotic translation initiation factor 2 (eIF2,), which is one of the substrates of protein phosphatase 1 (PP1), occurs rapidly during the first minutes of post-ischemic reperfusion after an episode of cerebral ischemia. In the present work, two experimental models of transient global ischemia and ischemic tolerance (IT) were used to study PP1 interacting/regulatory proteins following ischemic reperfusion. For that purpose we utilized PP1 purified by microcystin chromatography, as well as 2D DIGE of PP1, and PP1, immunoprecipitates. The highest levels of phosphorylated eIF2, found after 30 min reperfusion in rats without IT, correlated with increased levels in PP1 immunoprecipitates of the inhibitor DARPP32 as well as GRP78 and HSC70 proteins. After 4 h reperfusion, the levels of these proteins in PP1c complexes had returned to control values, in parallel to a significant decrease in eIF2, phosphorylated levels. IT that promoted a decrease in eIF2, phosphorylated levels after 30 min reperfusion induced the association of GADD34 with PP1c, while prevented that of DARPP32, GRP78, and HSC70. Different levels of HSC70 and DARPP32 associated with PP1, and PP1, isoforms, whereas GRP78 was only detected in PP1, immunoprecipitates. Here we suggest that PP1, through different signaling complexes with their interacting proteins, may modulate the eIF2, phosphorylation/dephosphorylation during reperfusion after a transient global ischemia in the rat brain. Of particular interest is the potential role of GADD34/PP1c complexes after tolerance acquisition. [source] Effects of PEEP levels following repeated recruitment maneuvers on ventilator-induced lung injuryACTA ANAESTHESIOLOGICA SCANDINAVICA, Issue 4 2008S.-C. KO Background: Different levels of positive end-expiratory pressure (PEEP) with and without a recruitment maneuver (RM) may have a significant impact on ventilator-induced lung injury but this issue has not been well addressed. Methods: Anesthetized rats received hydrochloric acid (HCl, pH 1.5) aspiration, followed by mechanical ventilation with a tidal volume of 6 ml/kg. The animals were randomized into four groups of 10 each: (1) high PEEP at 6 cm H2O with an RM by applying peak airway pressure at 30 cm H2O for 10 s every 15 min; (2) low PEEP at 2 cm H2O with RM; (3) high PEEP alone; and (4) low PEEP alone. Results: The mean arterial pressure and the amounts of fluid infused were similar in the four groups. Application of the higher PEEP improved oxygenation compared with the lower PEEP groups (P<0.05). The lung compliance was better reserved, and the systemic cytokine responses and lung wet to dry ratio were lower in the high PEEP than in the low PEEP group for a given RM (P<0.05). Conclusions: The use of a combination of periodic RM and the higher PEEP had an additive effect in improving oxygenation and pulmonary mechanics and attenuation of inflammation. [source] Identification of sources and inheritance of resistance of Chinese Brassica vegetables to white blisterPLANT BREEDING, Issue 6 2009M. R. Santos Abstract There is no information in the literature about the variability of resistance of Chinese Brassica vegetables, pak choi and Chinese cabbage, to the white blister disease caused by Albugo candida (Pers.) Kuntze. A collection of 43 accessions of pak choi and 19 accessions of Chinese cabbage was screened for resistance to the Portuguese A. candida isolate Ac 506 at the cotyledon stage. Different levels of resistance were found among the germplasm tested, ranging from complete resistance to full susceptibility. Most of the accessions were highly susceptible with less than 10% of resistant seedlings, and only four accessions of pak choi, presenting more than 50% resistant seedlings, were considered as new sources or resistance to white blister. Inheritance of resistance at the cotyledon stage was studied in two crosses between the most resistant pak choi accession, BRA 117, and the highly susceptible rapid cycling Brassica rapa line CrGC 1.19. It was proposed that resistance to white blister in pak choi BRA 117 is controlled by two nuclear genes with dominant recessive epistatic gene action. [source] Ethnic and Sex Differences in Ownership of Preventive Health Equipment Among Rural Older Adults With DiabetesTHE JOURNAL OF RURAL HEALTH, Issue 4 2007Ronny A. Bell PhD ABSTRACT:,Context:Diabetes self-management is important for achieving successful health outcomes. Different levels of self-management have been reported among various populations, though little is known about ownership of equipment that can enhance accomplishment of these tasks.Purpose:This study examined diabetes self-management equipment ownership among rural older adults.Methods:Participants included African American, American Indian, and white men and women 65 years of age and older. Data included equipment ownership overall and by ethnicity and sex across diabetes self-management domains (glucose monitoring, foot care, medication adherence, exercise, and diet). Associations between equipment ownership and demographic and health characteristics were assessed using logistic regression.Findings:Equipment ownership ranged from 85.0% for blood glucose meters to less than 11% for special socks, modified dishes, and various forms of home exercise equipment. Equipment ownership was associated with ethnicity, living arrangements, mobility, poverty status, and formal education.Conclusions:Rural older adults with diabetes are at risk because they lack equipment to perform some self-management tasks. Providers should be sensitive to and assist patients in overcoming this barrier. [source] The use of squid protein hydrolysate as a protein source in microdiets for gilthead seabream Sparus aurata larvaeAQUACULTURE NUTRITION, Issue 1 2000Kolkovski In the present study, the use of predigested proteins as an ingredient of microdiets offered to gilthead seabream larvae was tested. The protein source (freeze-dried squid powder) was hydrolysed with protease (trypsin and pancreatin). Different levels of raw squid protein and hydrolysate (100% protein, 50% protein/50% hydrolysate, 100% hydrolysate) were added to the microdiets to produce a dietary protein level of 65%. For comparison, cofeeding of Artemia nauplii and microdiet as well as microdiet supplemented with pancreatin were also offered to the larvae. The final average dry weights of 32-day-old larvae were 1.65 ± 0.04 mg, 1.38 ± 0.06 mg and 1.13 ± 0.1 mg, respectively, for larvae cofed 0%, 50% and 100% hydrolysate microdiets and Artemia nauplii. Survival of larvae was not affected by protein source. The survival of larvae cofed Artemia nauplii and microdiet was significantly higher than that of larvae fed exclusively on microdiet (68% and 80%, respectively). These results suggest that the use of hydrolysate (at 50% greater) as a protein source in diets for seabream larvae is not to be recommended. [source] A genetic algorithm for the identification of conformationally invariant regions in protein moleculesACTA CRYSTALLOGRAPHICA SECTION D, Issue 2 2002Thomas R. Schneider Understanding macromolecular function often relies on the comparison of different structural models of a molecule. In such a comparative analysis, the identification of the part of the molecule that is conformationally invariant with respect to a set of conformers is a critical step, as the corresponding subset of atoms constitutes the reference for subsequent analysis for example by least-squares superposition. A method is presented that categorizes atoms in a molecule as either conformationally invariant or flexible by automatic analysis of an ensemble of conformers (e.g. crystal structures from different crystal forms or molecules related by non-crystallographic symmetry). Different levels of coordinate precision, both for different models and for individual atoms, are taken explicitly into account via a modified form of Cruickshank's DPI [Cruickshank (1999), Acta Cryst. D55, 583,601] and are propagated into error-scaled difference distance matrices [Schneider (2000), Acta Cryst. D56, 715,721]. All pairwise error-scaled difference distance matrices are then analysed simultaneously using a genetic algorithm. The algorithm has been tested on several well known examples and has been found to converge rapidly to reasonable results using a standard set of parameters. In addition to the description of the algorithm, a criterion is suggested for testing the identity of two three-dimensional models within experimental error without any explicit superposition. [source] The need and total cost of Finnish eyecare services: a simulation model for 2005,2040ACTA OPHTHALMOLOGICA, Issue 8 2009Anja Tuulonen Abstract. Purpose:, The aims of this study were: (i) to create a structural simulation model capable of predicting the future need and cost of eyecare services in Finland; and (ii) to test and rank different policy alternatives for access to care and the required physician workforce. Methods:, Using the system dynamics approach, the number and cost of patients with cataract, glaucoma, diabetic retinopathy and age-related macular degeneration (AMD) were described with causal-loop diagrams and were then translated into a set of mathematical equations to build a computer simulation model. Mathematically, the problem was formulated as a set of differential equations that were solved numerically with specialized software. The validity of the model was tested against prevalence and administrative historical data. The costs covered by the public sector in Finland were obtained from 2003 from the Finnish Hospital Discharge Register (including outpatient care), the Finnish Social Insurance Institution and a survey of hospital price lists. Different levels of access to public care were then simulated in four eye diseases, for which the model estimated the need for services and resources and their costs in the years 2005,2040. Results:, The model forecasted that the adoption of the 2005 national ,access to care' criteria for cataract surgery would shorten waiting lists. If the workload of Finnish ophthalmologists were kept at the 2003 level, the graduation rate of new ophthalmologists would have to increase by 75% from the current level. If all glaucoma patients were followed in the public sector in future, even this increase in training would not meet the demand for physician workforce. The current model indicated that the screening frequency of diabetes can be increased without large sacrifices in terms of costs. AMD therapy has a significant role in the allocation of future resources in eyecare. The modelling study predicted that ageing alone will increase the costs of eyecare during the next four decades in Finland by about 1% per year in real terms (undiscounted and without inflation of unit costs). The increases in total yearly costs were on average 8.6% between 2001 and 2003. Conclusions:, The results of this modelling study indicate that policy initiatives, such as defining criteria for access to care, can have substantial implications on the demand for care and waiting times whereas the effect of ageing alone was relatively small. Measures to control several other factors , such as the adoption and price level of new technologies, treatments and practice patterns , will be at least equally important in order to restrain healthcare costs effectively. [source] Multiparameter immunophenotyping by flow cytometry in multiple myeloma: The diagnostic utility of defining ranges of normal antigenic expression in comparison to histology,CYTOMETRY, Issue 4 2010Elisa Cannizzo Abstract Background: Numerous studies have reported on the immunophenotype of plasma cells (PCs) in monoclonal gammopathy of undetermined significance (MGUS) and in plasma cell myeloma (PCM), but very few have examined the immunophenotype of normal PCs. In this study, an objective definition of normal range of expression for each antigen was found on normal control PCs. Using these new ranges of normal expression (new method) is different from using a static 20% of PCs cut-off for all antigens as described in the literature (traditional method). These newly calculated normal ranges for each antigen were applied to our data, and compared to histologic and immunohistochemical findings. Methods: Bone marrow samples from 46 patients with PC neoplasms and 15 normal controls were studied. A minimum of 100 PC were analyzed for each patient and control sample. An 8-color staining method was applied to study the immunophenotype of PCs, using a BD FACSCanto II. Results: By the new ranges of normality calculated in this study it was determined that different antigens have different level of expression on polyclonal PCs. CD19 correlated with histology by both the traditional and new methods, but had superior correlation by the new method. Conclusions: This report is the first 8-color immunophenotypic study of PCM in which a "range of normal expression" for each antigen is defined. This is a critical step to help distinguish between a normal and neoplastic PC immunophenotype and discern which antigens are of diagnostic importance. © 2010 Clinical Cytometry Society [source] Social Desirability of Earnings TestsGERMAN ECONOMIC REVIEW, Issue 2 2008Helmuth Cremer Earnings tests; social security; age-related taxation; retirement age Abstract. In many countries, pension systems involve some form of earnings test; i.e. an individual's benefits are reduced if he has labor income. This paper examines whether or not such earnings tests emerge when pension system and income tax are optimally designed. We use a simple model with individuals differing both in productivity and in their health status. The working life of an individual has two ,endings': an official retirement age at which he starts drawing pension benefits (while possibly supplementing them with some labor income) and an effective age of retirement at which professional activity is completely given up. Weekly work time is endogenous, but constant in the period before official retirement and again constant (but possibly at a different level), after official retirement. Earnings tests mean that earnings are subject to a higher tax after official retirement than before. We show under which conditions earnings tests emerge both under a linear and under a non-linear tax scheme. In particular, we show that earnings tests will occur if heterogeneities in health or productivity are more significant after official retirement than before. [source] A haplotype of the catalase gene confers an increased risk of essential hypertension in Chinese Han,HUMAN MUTATION, Issue 3 2010Zhimin Wang Abstract Our previous study in an isolated population showed an association between a genetic variant in the catalase gene (CAT) and essential hypertension (EH). This study indicates that three variants in the promoter and 5,-UTR region of CAT are predominant in Chinese Han, and they form two major haplotypes. A case,control study showed that the CATH2 haplotype confers susceptibility to EH (Pgenotype=0.0017, and Pallilc=0.00078). Subjects bearing CATH1/CATH2 and CATH2/CATH2 genotypes demonstrated a higher susceptibility to EH than CATH1/CATH1 homozygotes, with odds ratios of 1.474 and 1.625, respectively. Also, CATH1/CATH1 individuals had a later-onset age (P=0.015). Expression analysis using luciferase reporter vectors indicated that the CATH1 haplotype showed a lower transcriptional activity than the haplotype CATH2 (P<0.05 in all four cell lines), and we observed similar results in the endogenous allelic expression ratios of CATH1/CATH2 in cell lines. In contrast, most CATH1 haplotypes showed a higher transcription level than CATH2 haplotypes (10 out of 11 or 90.9%) in blood from normal individuals (P<0.01). We therefore hypothesize that CATH1 and CATH2 may play alternating roles at different level of oxidative stress. Hum Mutat 31:272,278, 2010. © 2009 Wiley-Liss, Inc. [source] A model for intervention research in late-life depressionINTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, Issue 12 2009George S. Alexopoulos Abstract Objective To serve as a conceptual map of the role of new interventions designed to reduce the burden of late-life depression. Methods We identified three needs to be addressed by intervention research: (1) the need for novel interventions given that the existing treatments leave many older adults depressed and disabled; (2) the need for procedures enabling community-based agencies to offer interventions of known efficacy with fidelity; and (3) the need to increase access of depressed older adults to care. Results Our model orders novel interventions according to their role in serving depressed older adults and according to their position in the efficacy, effectiveness, implementation, and dissemination testing continuum. We describe three interventions designed by our institute to exemplify intervention research at different level of the model. A common element is that each intervention personalizes care both at the level of the individuals served and the level of community agencies providing care. To this end, each intervention is designed to accommodate the strengths and limitations of both patients and agencies and introduces changes in the patients' environment and community agencies needed in order to assimilate the new intervention. Conclusions We suggest that this model provides conceptual guidance on how to shorten the testing cycle and bring urgently needed novel treatments and implementation approaches to the community. While replication studies are important, propose that most of the support should be directed to those projects that take rational risks, and after adequate preliminary evidence, make the next step along the testing continuum. Copyright © 2009 John Wiley & Sons, Ltd. [source] On the role of context in hierarchical fuzzy controllersINTERNATIONAL JOURNAL OF INTELLIGENT SYSTEMS, Issue 5 2002Luis Magdalena This article analyzes the role of context in hierarchical fuzzy controllers based on the decomposition of the input space. The usual consideration in most hierarchical fuzzy systems is the reduction of dimensionality problems. This article will analyze how to profit from the qualities of context as a key question in the definition of a fuzzy controller, to reduce the design efforts by making it easier to introduce the expert knowledge in that process. The idea is to use the output of a level of the hierarchy as the method to define (or adjust) the normalization functions (considered as contextual information) applied to the variables of the following level of that hierarchy. Two different situations will be analyzed, including an application example for each case. In the first case the decomposition will affect variables placed at the same level of description (abstraction) regarding the problem to be solved. In the second case, the decomposition process works on variables placed at different levels of description of the problem (descriptions with a different level of abstraction). © 2002 Wiley Periodicals, Inc. [source] Theoretical study of the oxidative polymerization of aniline with peroxydisulfate: Tetramer formationINTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY, Issue 2 2008-Marjanovi, Gordana Abstract Semi-empirical quantum chemical study of the oxidative polymerization of aniline with ammonium peroxydisulfate, in aqueous solutions without added acid, has been based on the MNDO-PM3 computations of thermodynamic, redox, and acid,base properties of reactive species and the intermediates, combined with the MM2 molecular mechanics force-field method and conductor-like screening model of solvation. The main reaction routes of aniline tetramerization are proposed. The regioselectivity of the formation of aniline tetramers by redox and electrophilic aromatic substitution reactions is analyzed. It was proved that the linear NC4 coupled tetra-aniline is formed as a dominant product by three different pathways: comproportionation redox reaction between N -phenyl-1,4-benzoquinonediimine and 4-aminodiphenylamine, the one-electron oxidation of aniline with its half-oxidized NC4 coupled trimer, and the electrophilic aromatic substitution reaction of aniline with fully oxidized NC4 coupled trianiline nitrenium cation. The electrophilic aromatic substitution reaction of the NC4 coupled aniline trimer with aniline nitrenium cation, as well as the oxidation of aniline with half-oxidized branched trimer, lead to the branched aniline tetramers. The competing character of different tetramerization routes is highlighted. The oxidative intramolecular cyclization of branched oligoanilines and polyaniline, leading to the generation of substituted phenazine units, has been predicted to accompany the classical routes of the polymerization of aniline. Various molecular (branched vs. linear) oligomeric structures produced at different level of acidity during the course of polymerization and their impact on the formation of supramolecular structures of conducting polyaniline (nanorods and nanotubes vs. granular morphology), are discussed. © 2007 Wiley Periodicals, Inc. Int J Quantum Chem, 2008 [source] Using Cpk index with fuzzy numbers to evaluate service qualityINTERNATIONAL TRANSACTIONS IN OPERATIONAL RESEARCH, Issue 6 2002Hong Tau Lee Service quality is measured by customers' satisfaction. Traditionally, the degree of satisfaction is calculated from the data obtained from questionnaires that have been filled by customers directly. The percentile of each different level of a customer's satisfaction is employed to summarize and compare the quality of service provided by different enterprises. This approach does not consider the consistency of the customers' perceptions, thus making comparison difficult. This paper introduces the concept of a process capability index that considers both the average and the consistency of the data simultaneously. Evaluations of service quality are usually vague and linguistic. We use the fuzzy numbers of linguistic variables developed in fuzzy set theory to modify the process capability index, and then apply it to evaluate the quality of a service. The average and consistency of the data obtained from a service quality evaluation are thus considered simultaneously, making the comparison of the performance of service quality easier. Moreover, the value of the index can be applied to help to point out the direction for improving the performance of service quality whenever it is lower than some default value. [source] Is there a Difference?JOURNAL OF BUSINESS FINANCE & ACCOUNTING, Issue 1-2 2007The Performance Characteristics of SRI Equity Indices Abstract:, This study analyses whether stock indices that represent socially responsible investments (SRI) exhibit a different performance compared to conventional benchmark indices. In contrast to other studies, the analysis concentrates on SRI indices and not on investment funds. This has several advantages, since transaction costs of funds, the timing activities and the skill of the fund management do not have to be considered. A direct measure of the performance effects of SRI screens is therefore examined. The 29 SRI stock indices are analysed by single-equation models as well as by multi-equation systems that exploit the information in the cross-section. SRI stock indices do not exhibit a different level of risk-adjusted return than conventional benchmarks. But many SRI indices have a higher risk relative to the benchmarks. The findings are robust to the use of different benchmark indices and apply to all common types of SRI screening. [source] RING CHARACTERIZATION OF QUALITY INDICES IN BUTTERHEAD LETTUCE CULTIVATED UNDER MULCH AND BARE SOILJOURNAL OF FOOD QUALITY, Issue 4 2010MARÍA G. GOÑI ABSTRACT Butterhead lettuce was characterized by physical, microbiological and nutritional quality indices as a function of plant zoning and soil management (bare soil and mulch). Quality indices were measured in all the rings from the external toward the internal ratio. Assayed indices were: relative water content, water content, free and bound water, and the ratio between free water and total water, leaf area and color, total microbial counts (TMC) and ascorbic acid content (AA). The lettuce characterization by rings showed a remarkable plant zoning as a function of leaf age and development; also, some initial indices were affected by the soil management employed. Plastic mulches affect the microclimate around the plant, resulting in better plant water status. However, the use of black plastic covers could absorb sunlight therefore increasing soil temperature and causing lower AA and higher TMC in lettuce tissue. PRACTICAL APPLICATIONS During lettuce development, each leaf had a different level of exposure to environmental conditions, such as light, humidity, nutrients absorption and temperature affecting the quality indices of the raw material and introducing a source of variability in the physico-chemical, biochemical, nutritional and microbiological indices within the plant. In this way, the location of the leaf within the whole plant is an important factor to be considered. Moreover, during lettuce heads trading, it is a common practice to remove the external leaves as storage advances. These leaves are more perishable than middle and internal ones because of their direct exposure to environmental conditions. Understanding the way in which physical, microbiological and nutritional indices were distributed in the whole lettuce plant could be of interest, to know the value of the losses of regular green grocers' practices, from a nutritional and a safety point of view. [source] Dental Health Differences by Social Class in Home-Dwelling Seniors of Barcelona, SpainJOURNAL OF PUBLIC HEALTH DENTISTRY, Issue 4 2006Vladimir Pizarro DDS Abstract Background:The aim of this study was to assess dental health differences by social class in home-dwelling seniors in Spain. Methods:A cross-sectional household survey of a cohort of senior residents in Barcelona (Spain) was undertaken. Of 891 survivors (72 years or older), 561 (62.9%) oral examinations were completed according to the DMF Index (Decayed, Missing and Filled teeth). Results:42% of participants were edentate. The individuals of social class IV-V were more likely to be edentate, and to have fewer than 15 teeth compared to those in social class I-II. The DMF Index in dentate individuals (Adjusted mean=16.4) also showed significantly worse dental health for lower social classes (p = 0.001). Conclusions:The results of this study indicate a different level of utilization of dental health services and dental health by social class in home-dwelling seniors. Further research is needed to understand the barriers of access and social inequality. [source] Sound Level of Environmental Music and Drinking Behavior: A Field Experiment With Beer DrinkersALCOHOLISM, Issue 10 2008Nicolas Guéguen Objective:, It had been found that environmental music was associated with an increase in alcohol consumption. The presence versus absence of music, high versus slow tempo and the different styles of environmental music is associated with different level of alcohol consumption. However, the effect of the level of the environmental music played in a bar still remained in question. Methods:, Forty male beer drinkers were observed in a bar. According to a random distribution, patrons were exposed to the usual level of environmental music played in 2 bars where the experiment was carried out or were exposed to a high level. Results:, The results show that high level volume led to increase alcohol consumption and reduced the average amount of time spent by the patrons to drink their glass. Conclusions:, The impact of environmental music on consumption was discussed and the "arousal" hypothesis and the negative effect of loud music on social interaction were used to explain our results. [source] Impact of improved phosphite hydrolytic stability on the processing stabilization of polypropyleneJOURNAL OF VINYL & ADDITIVE TECHNOLOGY, Issue 4 2005Brian Johnson It is well known that some high-performance phosphite antioxidants are particularly sensitive to hydrolysis. This process has two principal consequences: 1) the creation of potential handling issues, as the product can become sticky, and 2) a possible loss in the performance of this type of antioxidant. In this article both of these are addressed. First, changes in the hydrolytic stability of a high-performance phosphite are examined by formulating with co-additives of different chemical natures. Second, changes in the hydrolytic stability of the phosphite when using different additive physical forms are investigated. Third, the influence of hydrolysis on the processing stabilization performance of the high-performance phosphite is evaluated. It is seen that the rate of hydrolysis of the high-performance phosphite is drastically reduced both by altering the physical form of the additive package and by the correct selection of the co-additive package. This selection not only extends the storage life of the high-performance phosphite but also minimizes the risk of any handling issues. Furthermore, it is concluded that hydrolysis does not necessarily mean a loss in performance but, contrary to general perception, can actually lead to an enhancement of the processing stability. The final conclusion of this study is that the hydrolysis mechanism of the phosphite is strongly influenced by the physical form of the additive package and by the chemical nature of the co-additives. This difference in mechanism is responsible for a different level of processing performance but is not discussed in detail in this publication. J. VINYL. ADDIT. TECHNOL. 11:136,142, 2005. © 2005 Society of Plastics Engineers. [source] Functional rarefaction: estimating functional diversity from field dataOIKOS, Issue 2 2008Steven C. Walker Studies in biodiversity-ecosystem function and conservation biology have led to the development of diversity indices that take species' functional differences into account. We identify two broad classes of indices: those that monotonically increase with species richness (MSR indices) and those that weight the contribution of each species by abundance or occurrence (weighted indices). We argue that weighted indices are easier to estimate without bias but tend to ignore information provided by rare species. Conversely, MSR indices fully incorporate information provided by rare species but are nearly always underestimated when communities are not exhaustively surveyed. This is because of the well-studied fact that additional sampling of a community may reveal previously undiscovered species. We use the rarefaction technique from species richness studies to address sample-size-induced bias when estimating functional diversity indices. Rarefaction transforms any given MSR index into a family of unbiased weighted indices, each with a different level of sensitivity to rare species. Thus rarefaction simultaneously solves the problem of bias and the problem of sensitivity to rare species. We present formulae and algorithms for conducting a functional rarefaction analysis of the two most widely cited MSR indices: functional attribute diversity (FAD) and Petchey and Gaston's functional diversity (FD). These formulae also demonstrate a relationship between three seemingly unrelated functional diversity indices: FAD, FD and Rao's quadratic entropy. Statistical theory is also provided in order to prove that all desirable statistical properties of species richness rarefaction are preserved for functional rarefaction. [source] | |||||||||||||||||||||||||||||||||||||||||||||||||