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Different Amplitudes (different + amplitude)
Selected AbstractsExamination of fatigue crack driving force parameterFATIGUE & FRACTURE OF ENGINEERING MATERIALS AND STRUCTURES, Issue 9 2008Y. XIONG ABSTRACT Most of the previous parameters that utilized as a crack driving force were established in modifying the parameter Kop in Elber's effective SIF range ,Keff(=Kmax,Kop). However, the parameters that replaced the traditional parameter Kop were based on different measurements or theoretical calculations, so it is difficult to distinguish their differences. This paper focuses on the physical meaning of compliance changes caused by plastic deformation at the crack tip; the tests were carried out under different amplitude loading for structural steel. Based on these test results, differences of several parameter ,Keff in literature are analysed and an improved two-parameter driving force ,Kdrive(=(Kmax)n(,K,)1-n) has been proposed. Experimental data for several different types of materials taken from literature were used in the analyses. Presented results indicate that the ,Kdrive parameter was equally effective or better than ,K(=Kmax,Kmin), ,Keff(=Kmax,Kop) and ,K*(= (Kmax),(,K+)1,,) in correlating and predicting the R -ratio effects on fatigue crack growth rate. [source] Upper limb movement interruptions are correlated to freezing of gait in Parkinson's diseaseEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 7 2009Alice Nieuwboer Abstract Freezing of gait (FOG) in patients with Parkinson's disease (PD) is a common problem of unknown origin, which possibly reflects a general motor control deficit. We investigated the relationship between the frequency of freezing episodes during gait and during a bimanual task in control and subjects with PD with and without FOG. Group differences in spatiotemporal characteristics were also examined as well as the effects of visual cueing. Twenty patients with PD in the off-phase of the medication cycle and five age-matched controls performed a repetitive drawing task in an anti-phase pattern on a digitizer tablet. The task was offered at two different speeds (comfortable and maximal) and two different amplitudes (small and large) with and without visual cueing. The results showed that freezing episodes in the upper limbs occurred in only 10.4% of patient trials and that their occurrence was correlated with FOG scores (Spearman's rho = 0.64). Overall, few spatiotemporal differences were found between freezers, non-freezers and controls, except for an overshooting of the target amplitude in controls. Effects of visual cueing were largely similar in all groups, except for the variability of relative phase, which decreased in non-freezers and controls, and was unaffected in freezers. Despite the fact that general motor differences between subgroups were small, freezing episodes were manifest during a bimanual repetitive upper limb task and were correlated to FOG. Further study into upper limb movement breakdown is warranted to understand the parallel deficits that lead up to FOG. [source] Bidirectional synaptic plasticity as a consequence of interdependent Ca2+ -controlled phosphorylation and dephosphorylation pathwaysEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 12 2003Pablo D'Alcantara Abstract Postsynaptic Ca2+ signals of different amplitudes and durations are able to induce either long-lasting potentiation (LPT) or depression (LTD). The bidirectional character of synaptic plasticity may result at least in part from an increased or decreased responsiveness of the glutamatergic ,-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor (AMPA-R) due to the modification of conductance and/or channel number, and controlled by the balance between the activities of phosphorylation and dephosphorylation pathways. AMPA-R depression can be induced by a long-lived Ca2+ signal of moderate amplitude favouring the activation of the dephosphorylation pathway, whereas a shorter but higher Ca2+ signal would induce AMPA-R potentiation resulting from the preferential activation of the phosphorylation pathway. Within the framework of a model involving calcium/calmodulin-dependent protein kinase II (CaMKII), calcineurin (PP2B) and type 1 protein phosphatase (PP1), we aimed at delineating the conditions allowing a biphasic U-shaped relationship between AMPA-R and Ca2+ signal amplitude, and thus bidirectional plasticity. Our theoretical analysis shows that such a property may be observed if the phosphorylation pathway: (i) displays higher cooperativity in its Ca2+ -dependence than the dephosphorylation pathway; (ii) displays a basal Ca2+ -independent activity; or (iii) is directly inhibited by the dephosphorylation pathway. Because the experimentally observed inactivation of CaMKII by PP1 accounts for this latter characteristic, we aimed at verifying whether a realistic model using reported parameters values can simulate the induction of either LTP or LTD, depending on the time and amplitude characteristics of the Ca2+ signal. Our simulations demonstrate that the experimentally observed bidirectional nature of Ca2+ -dependent synaptic plasticity could be the consequence of the PP1-mediated inactivation of CaMKII. [source] Finding the strike direction of fractures using GPRGEOPHYSICAL PROSPECTING, Issue 3 2001Soon Jee Seol GPR reflection energy varies with antenna orientation relative to the strike and dip of the reflector. This directional dependence of GPR responses was investigated through numerical experiments and was used to estimate the azimuth of fractures and joints. Three antenna configurations were considered in this study: perpendicular-broadside (YY mode), parallel-broadside (XX mode) and cross-polarization (YX mode). The reflection energy in the cross-polarization mode shows a shape characteristic similar to the strike, regardless of the dip angle. Those in the other two modes show quite different amplitudes from the strike, depending on the dip angle. We have developed a strike-direction-finding scheme using data obtained from the three different modes for the same survey line. The azimuth angle of each reflector was displayed in colour on the GPR profile. This scheme was applied to a field survey at a granite quarry in southern Korea. The GPR profiles showed different images of the reflectors depending on the antenna configuration. The estimated azimuths of reflectors obtained using our scheme matched fairly well with those of known fractures and joints. [source] Linear stability analysis of oscillating Ekman boundary layersPROCEEDINGS IN APPLIED MATHEMATICS & MECHANICS, Issue 1 2009Martin Withalm The analysed Ekman layer is generated in a fluid layer rotating around an axis normal to its two bounding rigid plates. One of the plates is stationary, the other moving at certain Reynolds numbers. An additional oscillation is added to the moving plate at different amplitudes and frequencies. The linear stability of this system is determined via a Floquet analysis and a Galerkin-approximation of the corresponding Navier-Stokes-Equations. If the frequencies of the oscillations are small the critical Reynolds numbers of the Type I and Type II instabilities do not differ much from steady Ekman layers. Also for a purely oscillating system the critical values of the instabilities are almost consistent with those for a steady system. Interestingly, for higher frequencies the Type II instability does not appear any more. Instead the boundary layer becomes unstable only in terms of a Type I instability. In comparison with findings of other authors these results seem to be quite reasonable. (© 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] After-effects of near-threshold stimulation in single human motor axonsTHE JOURNAL OF PHYSIOLOGY, Issue 3 2005Hugh Bostock Subthreshold electrical stimuli can generate a long-lasting increase in axonal excitability, superficially resembling the phase of superexcitability that follows a conditioning nerve impulse. This phenomenon of ,subthreshold superexcitability' has been investigated in single motor axons in six healthy human subjects, by tracking the excitability changes produced by conditioning stimuli of different amplitudes and waveforms. Near-threshold 1 ms stimuli caused a mean decrease in threshold at 5 ms of 22.1 ± 6.0% (mean ±s.d.) if excitation occurred, or 6.9 ± 2.6% if excitation did not occur. The subthreshold superexcitability was maximal at an interval of about 5 ms, and fell to zero at 30 ms. It appeared to be made up of two components: a passive component linearly related to conditioning stimulus amplitude, and a non-linear active component. The active component appeared when conditioning stimuli exceeded 60% of threshold, and accounted for a maximal threshold decrease of 2.6 ± 1.3%. The passive component was directly proportional to stimulus charge, when conditioning stimulus duration was varied between 0.2 and 2 ms, and could be eliminated by using triphasic stimuli with zero net charge. This change in stimulus waveform had little effect on the active component of subthreshold superexcitability or on the ,suprathreshold superexcitability' that followed excitation. It is concluded that subthreshold superexcitability in human motor axons is mainly due to the passive electrotonic effects of the stimulating current, but this is supplemented by an active component (about 12% of suprathreshold superexcitability), due to a local response of voltage-dependent sodium channels. [source] Tayler instability with Hall effect in young neutron starsASTRONOMISCHE NACHRICHTEN, Issue 1 2009G. Rüdiger Abstract Collapse calculations indicate that the hot young neutron stars rotate differentially so that strong toroidal magnetic field components should exist in the outer shell where also the Hall effect appears to be important when the Hall parameter = ,B, exceeds unity. The amplitudes of the induced toroidal magnetic fields are limited by the current-induced Tayler instability. An important characteristics of the Hall effect is its distinct dependence on the sign of the magnetic field. We find for fast rotation that positive (negative) Hall parameters essentially reduce (increase) the stability domain. It is thus concluded that the toroidal field belts in young neutron stars induced by their differential rotation should have different amplitudes in both hemispheres which later are frozen in. Due to the effect of magnetic suppression of the heat conductivity also the brightness of the two hemispheres should be different. As a possible example for our scenario the isolated neutron star RBS 1223 is considered which has been found to exhibit different X-ray brightness at both hemispheres (© 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Sinusoidal ELF magnetic fields affect acetylcholinesterase activity in cerebellum synaptosomal membranesBIOELECTROMAGNETICS, Issue 4 2010Silvia Ravera Abstract The effects of extremely low frequency magnetic fields (ELF-MF) on acetylcholinesterase (AChE) activity of synaptosomal membranes were investigated. Sinusoidal fields with 50,Hz frequency and different amplitudes caused AChE activity to decrease about 27% with a threshold of about 0.74,mT. The decrease in enzymatic activity was independent of the time of permanence in the field and was completely reversible. Identical results were obtained with exposure to static MF of the same amplitudes. Moreover, the inhibitory effects on enzymatic activity are spread over frequency windows with different maximal values at 60, 200, 350, and 475,Hz. When synaptosomal membranes were solubilized with Triton, ELF-MF did not affect AChE activity, suggesting the crucial role of the membrane, as well as the lipid linkage of the enzyme, in determining the conditions for inactivation. The results are discussed in order to give an interpretation at molecular level of the macroscopic effects produced by ELF-MF on biological systems, in particular the alterations of embryo development in many organisms due to acetylcholine accumulation. Bioelectromagnetics 31:270,276, 2010. © 2009 Wiley-Liss, Inc. [source] Electromagnetic Field Treatment of Nerve Crush Injury in a Rat Model: Effect of Signal Configuration on Functional RecoveryBIOELECTROMAGNETICS, Issue 4 2007Janet L. Walker Abstract Electromagnetic fields (EMFs) have been demonstrated to enhance mammalian peripheral nerve regeneration in vitro and in vivo. Using an EMF signal shown to enhance neurite outgrowth in vitro, we tested this field in vivo using three different amplitudes. The rat sciatic nerve was crushed. Whole body exposure was performed for 4 h/day for 5 days in a 96-turn solenoid coil controlled by a signal generator and power amplifier. The induced electric field at the target tissue consisted of a bipolar rectangular pulse, having 1 and 0.3 ms durations in each polarity, respectively. Pulse repetition rate was 2 per second. By varying the current, the coils produced fields consisting of sham (no current) and peak magnetic fields of 0.03 mT, 0.3 mT, and 3 mT, corresponding to peak induced electric fields of 1, 10, and 100 µV/cm, respectively, at the tissue target. Walking function was assessed over 43 days using video recording and measurement of the 1,5 toe-spread, using an imaging program. Comparing injured to uninjured hind limbs, mean responses were evaluated using a linear mixed statistical model. There was no difference found in recovery of the toe-spread function between any EMF treatments compared to sham. Bioelectromagnetics 28:256,263, 2007. © 2007 Wiley-Liss, Inc. [source] | ||||||||||