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Diverse Populations (diverse + population)

Distribution by Scientific Domains

Medical Sciences	58%
Life Sciences	17%
Psychology	7%
Humanities and Social Sciences	7%
Education	5%

Selected Abstracts

Pregnancy Intention and Preterm Birth: Differential Associations Among a Diverse Population of Women

PERSPECTIVES ON SEXUAL AND REPRODUCTIVE HEALTH, Issue 2 2008
Aimee Afable-Munsuz
CONTEXT:,Studies published to date provide mixed evidence on the relationship between unintended pregnancy and preterm birth, and none take into consideration that the meaning of unintended pregnancy may vary across racial and ethnic groups. METHODS:,Data from the 1999,2003 rounds of the Maternal and Infant Health Assessment, a population-based, representative survey of postpartum women in California, were used to assess the relationship between pregnancy intention and preterm birth. For racial and ethnic groups in which an association was found, sequential logistic regression was conducted to further examine the relationship while controlling for socioeconomic characteristics. RESULTS:,In unadjusted results, pregnancy intention was associated with preterm birth among both whites and immigrant Latinas, but not among blacks or U.S.-born Latinas. Among whites, compared with women who reported that their pregnancy was intended, those who were unsure about their pregnancy had elevated odds of preterm birth (odds ratio, 1.4), as did those who reported their pregnancy was unwanted (1.7) or mistimed (1.4). Among immigrant Latinas, those who reported being unsure about their pregnancy were at higher risk of preterm birth than were those who reported an intended pregnancy (1.6). After adjustment for socioeconomic factors, the association remained significant for immigrant Latinas who were unsure about their pregnancy (1.5), but none of the associations remained significant for whites. CONCLUSIONS:,Women's interpretations of questions about pregnancy intention and their social experiences regarding pregnancy intention may vary by race or ethnicity. Studies on the association between pregnancy intention and preterm birth may need to be group-specific. [source]

Benign Breast Disease: Emerging Findings in a Diverse Population

THE BREAST JOURNAL, Issue 2 2007
Lynn C. Hartmann MD
No abstract is available for this article. [source]

Enhancing Mental Health Service Delivery to Ethnically Diverse Populations: Introduction to the Special Series

CLINICAL PSYCHOLOGY: SCIENCE AND PRACTICE, Issue 4 2003
A. Toy Caldwell-ColbertArticle first published online: 11 MAY 200
The American Psychological Association's adoption of guidelines for providing psychological services to diverse populations and the enactment by the National Institutes of Health (NIH) of regulations that required the representation of women and ethnic minorities in NIH-funded research projects called attention to the need to improve mental health services for ethnically diverse populations. This special series illustrates the relevance of cultural and ethnic factors in addressing contemporary mental health needs and the role of these factors in the work of clinicians who serve ethnically diverse clinical populations. The articles comprising the series examine the mental health dimensions of five contemporary clinical practice issues: HIV/AIDS, eating disorders, hate crimes, folk healing, and youth at high risk for drug abuse. [source]

LANGUAGE-RELATED DIFFERENCES IN ENVIRONMENTAL BENEFITS ESTIMATION: EVIDENCE FROM A MAIL SURVEY

CONTEMPORARY ECONOMIC POLICY, Issue 1 2008
XIAOLIN REN
In contingent valuation studies, failing to accommodate populations with limited language skills might yield biased estimates. In the United States, there are many residents primarily fluent in Spanish. This study uses conditional logit models applied to data from a bilingual (English and Spanish) conjoint choice mail survey to evaluate the effects of language proficiency on estimates of the economic benefits of contaminated site cleanup. Results indicate that language does have significant effects on welfare estimates. The results suggest that mail surveys addressing environmental issues that may affect a linguistically diverse population should be designed at the outset with multiple languages in mind. (JEL Q51, J19) [source]

MAINTENANCE OF ANDRODIOECY IN THE FRESHWATER SHRIMP, EULIMNADIA TEXANA: ESTIMATES OF INBREEDING DEPRESSION IN TWO POPULATIONS

EVOLUTION, Issue 3 2000
Stephen C. Weeks
Abstract., Androdioecy is an uncommon form of reproduction in which males coexist with hermaphrodites. Androdioecy is thought to be difficult to evolve in species that regularly inbreed. The freshwater shrimp Eulimnadia texana has recently been described as both androdioecious and highly selfing and is thus anomalous. Inbreeding depression is one factor that may maintain males in these populations. Here we examine the extent of "late" inbreeding depression (after sexual maturity) in these clam shrimp using two tests: (1) comparing the fitness of shrimp varying in their levels of individual heterozygosity from two natural populations that differ in overall genetic diversity; and (2) specifically outcrossing and selfing shrimp from these same populations and comparing fitness of the resulting offspring. The effects of inbreeding differed within each population. In the more genetically diverse population, fecundity, size, and mortality were significantly reduced in inbred shrimp. In the less genetically diverse population, none of the fitness measures was significantly lowered in selfed shrimp. Combining estimates of early inbreeding depression from a previous study with current estimates of late inbreeding depression suggests that inbreeding depression is substantial (,= 0.68) in the more diverse population and somewhat lower (,= 0.50) in the less diverse population. However, given that males have higher mortality rates than hermaphrodites, neither estimate of inbreeding depression is large enough to account for the maintenance of males in either population by inbreeding depression alone. Thus, the stability of androdioecy in this system is likely only if hermaphrodites are unable to self-fertilize many of their own eggs when not mated to a male or if male mating success is generally high (or at least high when males are rare). Patterns of fitness responses in the two populations were consistent with the hypothesis that inbreeding depression is caused by partially recessive deleterious alleles, although a formal test of this hypothesis still needs to be conducted. [source]

Evaluating Medical Effectiveness for the California Health Benefits Review Program

HEALTH SERVICES RESEARCH, Issue 3p2 2006
Harold S. Luft
An important aspect of the mandate assessments requested by the California legislature is a review of the scientific and medical literature on the medical effectiveness of the proposed health insurance benefit mandate. Although such a review bears many similarities to effectiveness reviews that might be undertaken for publication as research studies, several important differences arise from the requirements of the California legislation. Our reviews are intended to assist the legislators in deciding whether to support a specific mandate to modify health insurance benefits in a particular way. Thus, our assessments focus on how the scientific literature bears on the proposed mandate, which may involve a complicated chain of potential effects leading from altered coverage to ultimate impact on health. Evidence may be available for only some of the links in the chain. Furthermore, not all the evidence may be directly applicable to the diverse population of California or the subpopulation affected by the mandate. The mandate reviews, including the medical effectiveness analyses, may be used in a potentially contentious decision making setting. The legislative calendar requires that they need to be timely, yet they must be as valid, credible, and based on the best information available as possible. The focus on applicability also implies the need for informed, technical decisions concerning the relevance of the articles for the report, and these decisions need to be made as transparent as possible. These goals and constraints yield an approach that differs somewhat from an investigator-initiated review of the literature. [source]

Utility of citrate dialysate in management of acute kidney injury in children

HEMODIALYSIS INTERNATIONAL, Issue 2010
Coral HANEVOLD
Abstract Dialysis concentrate acidified with citrate as opposed to acetate has been reported to prevent clotting in hemodialysis circuits, and improve dialysis efficiency in adults. There is no information on its use in children. The purpose of the study was to evaluate the utility of citrate dialysate for renal replacement therapy in a pediatric population with acute kidney injury. We performed a retrospective review of our experience using Citrasate® concentrate from December 2007 to August 2009. All treatments were provided using the Fresenius 2008 dialysis machine. Citrasate® was utilized in 7 children aged 60.3±51.0 months (mean±SD), range 13 months to 12 years. The number of treatments varied from 4 to 31 (mean 12±8 treatments) for a total of 89 treatments. Rare sporadic mild hypocalcemia was noted but could not be definitively linked with the use of Citrasate®. Four children also required low-dose heparin (3.6,15 U/kg/h) due to clotting. Activated clotting times (when checked) were not affected by this low-dose heparin therapy. Some degree of clotting occurred in 21 of 89 (23.5%) treatments. Early termination of treatment due to thrombosis was required in 7 of 89 (7.8%) treatments. In summary, use of Citrasate® dialysis concentrate was well tolerated in critically ill children with acute kidney injury. Citrasate® reduced but did not completely eliminate the need for heparin in our population. Further study in a more diverse population would be helpful. [source]

Halitosis among racially diverse populations: an update

INTERNATIONAL JOURNAL OF DENTAL HYGIENE, Issue 1 2008
S Rayman
Abstract:, The aim of this paper is to highlight the cultural perceptions of halitosis to dental professionals. Halitosis (oral malodour or bad breath) is caused mainly by tongue coating and periodontal disease. Bacterial metabolism of amino acids leads to metabolites including many compounds, such as indole, skatole and volatile sulphur compounds (VSC), hydrogen sulphide, methyl mercaptan and dimethyl sulphide. They are claimed to be the main aetiological agents for halitosis. Gastrointestinal diseases are also generally believed to cause halitosis. In general, physicians and dentists are poorly informed about the causes and treatments for halitosis. The paper reviews the prevalence and distribution of halitosis, oral malodour, its aetiology, concepts of general and oral health and diseases and their perception among racially diverse population. Eating, smoking and drinking habits and understanding of halitosis as a social norm among different people has been highlighted. The treatment options have also been presented very briefly. A brief discussion about general importance within existing healthcare services has been highlighted. Oral malodour may rank only behind dental caries and periodontal disease as the cause of patient's visits to the dentist. It is a public social health problem. The perception of halitosis is different in culturally diverse populations. So the dental professionals should be aware of the cultural perceptions of halitosis among racially and culturally diverse populations. There is a need to integrate the cultural awareness and knowledge about halitosis among the dental professional for better understanding of halitosis to treat patients with the social dilemma of halitosis to improve the quality of life and well-being of individuals with the problem. It is concluded that dental professionals (especially dental hygienists) should be prepared to practice in a culturally diverse environment in a sensitive and appropriate manner, to deliver optimal oral health and hygiene care. [source]

Prevalence and utility of DSM-IV eating disorder diagnostic criteria among youth,

INTERNATIONAL JOURNAL OF EATING DISORDERS, Issue 5 2007
Diann M. Ackard PhD
Abstract Objective: To examine the prevalence and utility of DSM-IV eating disorder (ED) criteria and anorexia (AN), bulimia (BN), and binge eating disorder (BED) among adolescents. Method: An ethnically diverse population-based sample of 4,746 public middle and high school students completed anthropometric measures and Project EAT survey items. Results: Many youth endorsed body shape perception disturbance (41.5% female; 24.9% male), undue influence of body shape/weight on self-esteem (36.4% female; 23.9% male), and compensatory behavior (9.4% female; 13.5% male). Prevalence among females and males, respectively, was: AN = 0.04%, 0%; BN = 0.3%, 0.2%; BED = 1.9%, 0.3%. Analyses of individual criteria showed high sensitivity and negative predictive values for each disorder and corresponding criteria, low specificity for several AN (27.8%) and BN (32.0%) criteria, and low positive predictive values (0.06,40.2%). Conclusion: Body disparagement and compensatory behaviors indicate eating disturbance, despite low prevalence of EDs. Diagnostic classification may be clinically useful, but is complicated for use in epidemiological populations. © 2007 by Wiley Periodicals, Inc. Int J Eat Disord 2007. [source]

An Examination of the Danish Immigrant-Trade Link

INTERNATIONAL MIGRATION, Issue 5 2007
Roger White
ABSTRACT This paper investigates the influence of immigrants on Danish imports and exports. As public and political debates concerning immigration policy are expected to continue, the findings presented here provide valuable information. Prior to 2002, Denmark's immigration policy was among the most liberal in Europe. However, concerns regarding terrorism, social services depletion, and detrimental labour market effects, all purported to stem from immigration, led the Danish government to severely tighten its policy. In examining Denmark, we explore the immigrant-trade relationship in a small host country that is globally well-integrated, open to trade, and proximate to both major trading partners and primary immigrant source nations. Further, as the share of the Danish population constituted by immigrants increased from 2.6 to 5.6 per cent between 1980 and 2000, Denmark presents an opportunity to consider immigrant-trade links for an increasingly diverse population that was initially relatively homogenous. We consider a number of variations regarding home countries and trade values to estimate immigrant-trade links using a Tobit specification. The findings presented here, when considered in relation to prior research, suggest that the presence and magnitude of immigrant-trade links vary according to host country population homogeneity. Cet article étudie l'influence des immigrants sur les importations et les exportations danoises. Comme il est prévu que les débats publics et politiques sur la politique d'immigration se poursuivent, les conclusions présentées ici fournissent des informations très utiles. Avant 2002, la politique danoise d'immigration était l'une des plus libérales d'Europe. Cependant, les craintes liées au terrorisme, à l'épuisement de l'action sociale et aux effets néfastes sur le marché du travail - que l'on tend à attribuer à l'immigration, ont poussé le Gouvernement danois à durcir sérieusement sa politique. Cet examen du cas du Danemark nous permet d'étudier les liens entre immigration et commerce dans un petit pays d'accueil globalement bien intégré, ouvert au commerce et proche à la fois des grands partenaires commerciaux et des principales nations d'origine des immigrants. Par ailleurs, étant donné que la proportion d'immigrants au sein de la population danoise est passée de 2,6 à 5,6 % entre 1980 et 2000, le Danemark offre la possibilité d'étudier les liens entre immigration et commerce dans une population sans cesse plus hétérogène, par contraste avec son homogénéité d'autrefois. L'auteur considère plusieurs variations en fonction des pays d'origine et des valeurs commerciales afin d'évaluer les liens entre immigration et commerce grâce au modèle Tobit. Les résultats présentés, ajoutés aux travaux de recherche précédents, suggèrent que l'existence et l'importance des liens entre immigration et commerce varient en fonction de l'homogénéité de la population du pays d'accueil. En este documento se investiga la influencia de los inmigrantes sobre las importaciones y exportaciones danesas. Dado que se espera una continuación de los debates públicos y políticos sobre la política de inmigración, las conclusiones que aquí se presentan son de gran utilidad. Con anterioridad a 2002, la política de inmigración de Dinamarca era una de las más liberales de Europa. Sin embargo, inquietudes relacionadas con el terrorismo, el agotamiento de los servicios sociales y los efectos perjudiciales para el mercado laboral, todo lo cual supuestamente se debe a la inmigración, condujeron al Gobierno danés a adoptar una política mucho más estricta. Al examinar la situación en Dinamarca, exploramos la relación entre la inmigración y el comercio en un pequeño país de acogida que, en términos globales, puede decirse que goza de un buen nivel de integración y apertura al comercio y proximidad a los asociados comerciales más importantes y a los principales países de origen de la primera inmigración. Por otro lado, teniendo en cuenta que el porcentaje de la población danesa constituido por inmigrantes aumentó del 2,6 al 5,6 por ciento entre 1980 y 2000, la situación en Dinamarca es una oportunidad para examinar los vínculos entre la inmigración y el comercio con respecto a una población cada vez más diversa, que inicialmente era relativamente homogénea. Se han considerado una serie de variaciones en relación con los países de origen y los valores del comercio para estimar los vínculos entre la inmigración y el comercio, utilizando una especificación Tobit. Las conclusiones que se presentan, al examinarse en relación con anteriores trabajos de investigación, sugieren que la presencia y la magnitud de los vínculos entre la inmigración y el comercio varían según la homogeneidad demográfica del país de acogida. [source]

Individualized care: its conceptualization and practice within a multiethnic society

JOURNAL OF ADVANCED NURSING, Issue 1 2000
Kate Gerrish BNurs MSc PhD RGN RM DN Cert
Individualized care: its conceptualization and practice within a multiethnic society This paper reports on the selected findings from a larger ethnographic study of the provision of individualized care by district nurses to patients from different ethnic backgrounds. Undertaken in an English community National Health Service (NHS) Trust serving an ethnically diverse population, the study comprised two stages. First, an organizational profile of the Trust was undertaken in order to analyse the local policy context. Data were collected by means of in-depth interviews with managers and a review of policy documentation and caseload profiles. Second, a participant observational study was undertaken focusing on six district nursing teams. Purposive sampling was used to identify four teams with high minority ethnic caseloads and two teams with predominately white ethnic majority caseloads. Interview transcripts and field notes were analysed by drawing upon the principles of dimensional analysis. This paper focuses upon aspects of the second stage, namely how the nurses' conceptualized and practised individualized care. Six principles underpinning the philosophy of individualized care expounded by the nurses were identified: respecting individuality; holistic care; focusing on nursing needs; promoting independence; partnership and negotiation of care; and equity and fairness. Each is examined in turn and consideration given to how they were modified in their transformation into practice. Some implications for patients from minority ethnic backgrounds of the nurses' conceptualization and practice of individualized care are discussed. The lack of internal consistency within the nurses' discourse, the impact of policy directives on care delivery and the influence of factors outside the nurses' control, served to illuminate the complexity whereby the ideals of individualized care were adjusted and reworked in the realities of everyday nursing practice. This in turn raised questions about the appropriateness of the current interpretation and practice of individualized care in a multi-ethnic society. [source]

Pastoralist's livestock and settlements influence game bird diversity and abundance in a savanna ecosystem of southern Kenya

AFRICAN JOURNAL OF ECOLOGY, Issue 1 2009
Dana L. Morris
Abstract We investigated the vegetation structure and density of game birds along a successional gradient created by varying intensity of human settlement in a pastoral community in Shompole group ranch in southern Kenya. We examined four habitat types including heavily-grazed grass in currently occupied settlements, short grass in seasonal settlements, patches of bushed woodland in settlement sites that had been abandoned up to 30 years ago, and tall grass in a wildlife sanctuary. Vegetation biomass was the highest in the sanctuary where livestock are excluded and the lowest in the vicinity of currently occupied settlements. Abundance of doves (Oena spp. and Streptopelia spp.) was best associated with moderate grazing and per cent green grass, which provide good foraging opportunities. Francolin and spurfowl (Francolinus spp.) were positively associated with vegetation biomass. Quail (Coturnix spp.) were positively associated with tree cover. These data reflect the importance of maintaining a balance of wildlife and livestock grazing with patches of ungrazed grasslands and bushed woodlands in providing a mosaic of habitats that support a diverse population of game birds. The results have wide application for an integrated management approach to livestock, wildlife and game bird management in the savannas. Résumé Nous avons étudié la structure de la végétation et la densité du gibier à plume le long d'un gradient créé par la variation de l'intensité des installations humaines, dans une communauté pastorale dans un ranch de Shompole, dans le sud du Kenya. Nous avons examiné quatre types d'habitats: l'herbe fortement broutée dans les installations qui sont actuellement occupées, l'herbe courte des installations saisonnières, les îlots de broussailles dans les anciennes installations abandonnées parfois depuis 30 ans et les hautes herbes d'un sanctuaire de la faune. La biomasse de la végétation était la plus grande dans le sanctuaire d'où le bétail était exclu et la plus basse dans le voisinage des installations encore occupées. L'abondance des tourterelles (Oena spp. et Streptopelia spp.) était plutôt liée à un broutage modéré et à un pourcentage d'herbe verte qui donnent de bonnes possibilités de se nourrir. Les francolins (Francolinus spp.) étaient positivement liés à la biomasse de la végétation. Les cailles (Coturnix spp.) étaient positivement liées à la couverture arborée. Ces données reflètent l'importance de conserver un équilibre entre les pâturages de la faune sauvage et du bétail et des îlots non pâturés et des broussailles, pour créer une mosaïque d'habitats qui accueillent une population variée de gibier à plume. Les résultats peuvent largement trouver une application dans les approches intégrées de gestion du bétail, de la faune sauvage et du gibier à plume en savane. [source]

Assessment of periodontal conditions and systemic disease in older subjects

JOURNAL OF CLINICAL PERIODONTOLOGY, Issue 9 2002
I. Focus on osteoporosis
Abstract Background: Osteoporosis (OPOR) is a common chronic disease, especially in older women. Patients are often unaware of the condition until they experience bone fractures. Studies have suggested that OPOR and periodontitis are associated diseases and exaggerated by cytokine activity. Panoramic radiography (PMX) allows studies of mandibular cortical index (MCI), which is potentially diagnostic for OPOR. Aims: i) To study the prevalence of self-reported history of OPOR in an older, ethnically diverse population, ii) to assess the agreement between PMX/MCI findings and self-reported OPOR, and iii) to assess the likelihood of having both a self-reported history of OPOR and a diagnosis of periodontitis. Materials and methods: PMX and medical history were obtained from 1084 subjects aged 60,75 (mean age 67.6, SD ± 4.7). Of the films, 90.3% were useful for analysis. PMXs were studied using MCI. The PMXs were used to grade subjects as not having periodontitis or with one of three grades of periodontitis severity. Results: A positive MCI was found in 38.9% of the subjects, in contrast to 8.2% self-reported OPOR. The intraclass correlation between MCI and self-reported OPOR was 0.20 (P < 0.01). The likelihood of an association between OPOR and MCI was 2.6 (95%CI: 1.6, 4.1, P < 0.001). Subjects with self-reported OPOR and a positive MCI had worse periodontal conditions (P < 0.01). The Mantel-Haentzel odds ratio for OPOR and periodontitis was 1.8 (95%CI: 1.2, 2.5, P < 0.001). Conclusions: The prevalence of positive MCI was high and consistent with epidemiological studies, but only partly consistent with a self-reported history of osteoporosis with a higher prevalence of positive MCI in Chinese women. Horizontal alveolar bone loss is associated with both positive self-reported OPOR and MCI. [source]

A Conceptual Framework for Hispanic Oral Health Care

JOURNAL OF PUBLIC HEALTH DENTISTRY, Issue 1 2008
Gloria C. Mejia DDS
Abstract The need to study the health and health care determinants of US Hispanics is mandated by their rapid population growth. Nonetheless, it is challenging to study such a diverse population that incorporates many similarities and differences in values and experiences. This paper aims to highlight the factors that should be considered in Hispanic oral health research in the United States, and presents, in a theoretical framework, the relationships between these factors. The proposed ecological framework is supported by an extensive literature review, with an emphasis on the factors that are reported to differ among ethnic groups. It has a foundation in social science and is based on existing models from different fields of knowledge. To be comprehensive, the framework simultaneously addresses individual and environmental constructs. Within these, antecedent factors shape the intention to seek oral health care, while empowerment factors play a mediating role between intention and actual receipt of care. Individual antecedent factors incorporate risk markers, need, and predisposing factors. Environmental antecedent factors are represented by social constructs that allude to the population's health culture. Empowerment factors explain the level of control that a person perceives or the environment provides in receiving care. A thorough consideration of the factors that drive Hispanics' oral health care usage will aid US researchers and practitioners in improving this population's health and access to care. [source]

Relatedness of Macrophomina phaseolina isolates from tallgrass prairie, maize, soybean and sorghum

MOLECULAR ECOLOGY, Issue 1 2010
A. A. SALEH
Abstract Agricultural and wild ecosystems may interact through shared pathogens such as Macrophomina phaseolina, a generalist clonal fungus with more than 284 plant hosts that is likely to become more important under climate change scenarios of increased heat and drought stress. To evaluate the degree of subdivision in populations of M. phaseolina in Kansas agriculture and wildlands, we compared 143 isolates from maize fields adjacent to tallgrass prairie, nearby sorghum fields, widely dispersed soybean fields and isolates from eight plant species in tallgrass prairie. Isolate growth phenotypes were evaluated on a medium containing chlorate. Genetic characteristics were analysed based on amplified fragment length polymorphisms and the sequence of the rDNA-internal transcribed spacer (ITS) region. The average genetic similarity was 58% among isolates in the tallgrass prairie, 71% in the maize fields, 75% in the sorghum fields and 80% in the dispersed soybean fields. The isolates were divided into four clusters: one containing most of the isolates from maize and soybean, two others containing isolates from wild plants and sorghum, and a fourth containing a single isolate recovered from Solidago canadensis in the tallgrass prairie. Most of the sorghum isolates had the dense phenotype on media containing chlorate, while those from other hosts had either feathery or restricted phenotypes. These results suggest that the tallgrass prairie supports a more diverse population of M. phaseolina per area than do any of the crop species. Subpopulations show incomplete specialization by host. These results also suggest that inoculum produced in agriculture may influence tallgrass prairie communities, and conversely that different pathogen subpopulations in tallgrass prairie can interact there to generate ,hybrids' with novel genetic profiles and pathogenic capabilities. [source]

Historically underserved students: What we know, what we still need to know

NEW DIRECTIONS FOR COMMUNITY COLLEGES, Issue 135 2006
Denise Green Assistant Professor of Educational Psychology
Community colleges educate many traditionally underserved students, including students of color, first-generation students, and low-income students. This chapter discusses what we know about these students, how they have fared in college transitions, how educational pipeline and deficit models have helped or hindered their progress, and what community college educators should seek to understand about this diverse population of students. [source]

Elevated IRT levels in African-American infants: Implications for newborn screening in an ethnically diverse population

PEDIATRIC PULMONOLOGY, Issue 7 2008
Robert Giusti MD
Abstract During the first 4 years of newborn screening (NBS) for Cystic Fibrosis (CF) in New York there was a statistically significant, twofold greater relative risk of an Immunoreactive Trypsinogen (IRT) level greater than 95% in African-American infants. The reason for this previously reported increase in IRT level in African-American infants is unclear. The positive predictive value of a screen positive result in this population was only 0.3%. The bulk of screen-positive African-American infants were in the top 0.2% (IRT) group, with no CF mutations isolated. Repeat IRT testing at 2,3 weeks of age may represent a suitable approach to decrease the false-positive rate in this population. Pediatr Pulmonol. 2008; 43:638,641. © 2008 Wiley-Liss, Inc. [source]

Ergonomic and socioeconomic risk factors for hospital workers' compensation injury claims

AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, Issue 7 2009
Jon Boyer ScD
Abstract Background Hospital workers are a diverse population with high rates of musculoskeletal disorders (MSDs). The risk of MSD leading to workers' compensation (WC) claims is likely to show a gradient by socioeconomic status (SES) that may be partly explained by working conditions. Methods A single community hospital provided workforce demographics and WC claim records for 2003,2005. An ergonomic job exposure matrix (JEM) was developed for these healthcare jobs from direct observation of physical workload and extraction of physical and psychosocial job requirements from the O*NET online database. Occupational exposures and SES categories were assigned to workers through their O*NET job titles. Univariate and multivariate Poisson regression analyses were performed to estimate the propensity to file an injury claim in relation to individual factors, occupational exposures, and SES. Results The jobs with the highest injury rates were nurses, semi-professionals, and semi-skilled. Increased physical work and psychological demands along with low job tenure were associated with an increase in risk, while risk decreased with psychosocial rewards and supervisor support. Both occupational and individual factors mediated the relationship between SES and rate of injury claims. Conclusions Physical and organizational features of these hospital jobs along with low job tenure predicted WC injury claim risk and explained a substantial proportion of the effects of SES. Further studies that include lifestyle risk factors and control for prior injuries and co-morbidities are warranted to strengthen the current study findings. Am. J. Ind. Med. 52:551,562, 2009. © 2009 Wiley-Liss, Inc. [source]

The Effect of Ethnicity on the Relationship Between Premature Coronary Artery Disease and Traditional Cardiac Risk Factors Among Uninsured Young Adults

PREVENTIVE CARDIOLOGY, Issue 3 2009
Amit P. Amin MD
Prior studies of premature coronary artery disease (CAD) in young adults did not address the association of race/ethnicity and risk factors. Therefore, the authors conducted a study of 400 patients 40 years and older undergoing coronary angiography at a large, urban public hospital that serves predominately minority, uninsured populations. The prevalence of risk factors and their association with premature CAD varied markedly by ethnic group. Among blacks, dyslipidemia, diabetes, and smoking were independently associated with premature CAD. Among Hispanics, dyslipidemia, male sex, and family history of CAD were independently associated with premature CAD. Smoking was the only risk factor in whites, and no independent risk factor was identified in Asian Indians. Whites and Asian Indians had a higher prevalence of disease than blacks or Hispanics,before and after adjusting for risk factor imbalances across ethnic groups. In this ethnically diverse population, the authors' findings underscore the importance of identifying distinctive risk factors in various ethnic groups. [source]

ALIX-ing phospholipids with endosome biogenesis

BIOESSAYS, Issue 6 2004
Ivan Dikic
Endosomes, which comprise a diverse population of membrane vesicles and tubules, sort proteins and lipids to various cellular destinations. The organization and functions of these pleiomorphic cellular organelles have been extensively studied. Matsuo et al.1 now provide new exciting evidence on the role of lysobiphosphatidic acid (LBPA), a resident phospholipid of internal vesicles of the late endosome, in the control of membrane invagination and endosome biogenesis. In vivo, LBPA functions are controlled by the adaptor protein Alix and depend on pH gradients along the endosomal compartments. BioEssays 26:604,607, 2004. © 2004 Wiley Periodicals, Inc. [source]

Trials update in wales

CYTOPATHOLOGY, Issue 2007
A. Fiander
Three ongoing studies will be presented and discussed. Prevalence of Human Papillomavirus Infection in a South Wales Screening population Methods: A total of 10 000 consecutive, anonymous liquid based cytology screening samples were collected over a five month period in 2004. Age, cytology result and social deprivation score was provided for each specimen. The methodology was chosen to ensure inclusion of all women attending routine cervical screening, avoiding potential constraints associated with obtaining individual informed consent. The liquid based cytology samples were processed and reported by the receiving cytology laboratory and the residual specimens sent to the HPV Research Laboratory, Wales College of Medicine, where they were processed and stored at -80°C until analysis. High risk and low risk HPV Typing was undertaken using PCR , EIA (Jacobs et al 1997). Full high risk typing was performed on HPV positive specimens. Results: The study population had a mean age of 38 years with 92% negative, 5% borderline and 3% dyskaryotic cytology. The average social deprivation score was 17.4 (based upon the Welsh Index of multiple deprivation). The following results will be presented: HPV prevalence by age. HPV prevalence by cytology result. Type specific HPV prevalence in single and multiple infection. Conclusion: This study represents the largest type specific HPV Prevalence Study in the UK to date. As such it will form a useful base line against which to access performance of marketed HPV tests and evaluating the impact following implementation of HPV vaccination. [Funded by Welsh Office for Research and Development] CRISP , 1 Study (Cervical Randomized Intervention Study Protocol -1) Background: Indole-3-carbinol (I3C) and Diindolylmethane (DIM) are found in cruciferous vegetables and have been identified as compounds that could potentially prevent or halt carcinogenesis. I3C spontaneously forms DIM in vivo during acid digestion. I3C has been shown to prevent the development of cervical cancer in HPV 16 transgenic mice and both I3C and DIM have been shown to promote cell death in cervical cancer cell models. DIM is the major active bi-product of I3C and preliminary data indicate that DIM is active in cervical dysplasia and may be better tolerated than I3C. Aim: To investigate chemoprevention of high grade cervical neoplasia using Diindolylmethane (DIM) supplementation in women with low grade cytological abnormalities on cervical cytology. Objectives: To observe any reduction in the prevalence of histological proven high-grade cervical intraepithelial neoplasia (CIN) after 6 months of supplementation. ,,To observe any reduction in the prevalence of cytological abnormalities. ,,To observe any changes in the clinical appearance of the cervix. To assess acceptability and monitor any side effects of DIM supplementation. ,,To assess whether any benefit is seen in relation to Human Papillomavirus (HPV) status including HPV Type, Viral load and integration. Methods: This is a double blind randomized placebo-controlled trial involving 600,700 women with low grade cytological abnormalities on a cervical smear. Randomization is in the ratio of 2 : 1 in favour of active medication. Women with first mildly dyskaryotic smear or second borderline smear are eligible. They are asked to take two capsules daily for 6 months. At the end of 6 months they undergo repeat cervical cytology, HPV testing and colposcopy. Results: A progress report will be given for this ongoing study. [Funded: - Cancer Research UK] Type Specific HPV Infection in Welsh Cervical Cancers Background: Whilst there have been numerous studies of HPV infection associated with cervical cancer and on prevalence of Human Papillomavirus in diverse populations there have been no studies of these variables in the same population. Against a background of prophylactic HPV vaccination it is important to assess potential protection against cervical cancer within a given population. The most comprehensive analysis of HPV type specific cervical cancer is a meta-analysis published by the IARC in 2003. This however included only three UK based studies, totalling 118 cases, 75 of which were only investigated by HPV type PCR for four high risk types. None of this data was presented with associated population based prevalence data. Therefore, the research objectives for this study in combination with the first study above, are as follows: To determine the frequency of specific HPV types in cervical cancers in Wales. To compare the distribution of specific HPV types amongst cervical cancers with their prevalence in the general population. This will allow accurate delineation of the relationship between prevalence of specific HPV types in the general population and their association with clinically relevant disease. This information is a pre-requisite to assess the potential impact of prophylactic vaccination against HPV infection in Wales. Methods: Welsh Cervical Cancer specimens from 2000,2005 will be identified from pathology departments within Wales. The pathology of each tumour will be reviewed by a single Gynaecological Pathologist. The age of the patient and pathological features of the tumour will be noted. DNA will be extracted from the paraffin sections and HPV typed by PCR-EIA. Results: A progress report will be given for this ongoing study. [Funded by Welsh Office for Research and Development] [source]

Thermophilic anaerobes in Arctic marine sediments induced to mineralize complex organic matter at high temperature

ENVIRONMENTAL MICROBIOLOGY, Issue 4 2010
Casey Hubert
Summary Marine sediments harbour diverse populations of dormant thermophilic bacterial spores that become active in sediment incubation experiments at much higher than in situ temperature. This response was investigated in the presence of natural complex organic matter in sediments of two Arctic fjords, as well as with the addition of freeze-dried Spirulina or individual high-molecular-weight polysaccharides. During 50°C incubation experiments, Arctic thermophiles catalysed extensive mineralization of the organic matter via extracellular enzymatic hydrolysis, fermentation and sulfate reduction. This high temperature-induced food chain mirrors sediment microbial processes occurring at cold in situ temperatures (near 0°C), yet it is catalysed by a completely different set of microorganisms. Using sulfate reduction rates (SRR) as a proxy for organic matter mineralization showed that differences in organic matter reactivity determined the extent of the thermophilic response. Fjord sediments with higher in situ SRR also supported higher SRR at 50°C. Amendment with Spirulina significantly increased volatile fatty acids production and SRR relative to unamended sediment in 50°C incubations. Spirulina amendment also revealed temporally distinct sulfate reduction phases, consistent with 16S rRNA clone library detection of multiple thermophilic Desulfotomaculum spp. enriched at 50°C. Incubations with four different fluorescently labelled polysaccharides at 4°C and 50°C showed that the thermophilic population in Arctic sediments produce a different suite of polymer-hydrolysing enzymes than those used in situ by the cold-adapted microbial community. Over time, dormant marine microorganisms like these are buried in marine sediments and might eventually encounter warmer conditions that favour their activation. Distinct enzymatic capacities for organic polymer degradation could allow specific heterotrophic populations like these to play a role in sustaining microbial metabolism in the deep, warm, marine biosphere. [source]

Halitosis among racially diverse populations: an update

Emergency Department Lactate Is Associated with Mortality in Older Adults Admitted With and Without Infections

ACADEMIC EMERGENCY MEDICINE, Issue 3 2010
Daniel A. Del Portal MD
Abstract Objectives:, Serum lactate values in the emergency department (ED) have been associated with mortality in diverse populations of critically ill patients. This study investigates whether serum lactate values measured in the ED are associated with mortality in older patients admitted to the hospital, both with and without infections. Methods:, This is a retrospective cohort study performed at two urban teaching hospitals. The study population includes 1,655 older ED patients (age , 65 years) over a 3-year period (2004,2006) who had serum lactate measured prior to admission. The presence or absence of infection was determined by review of International Classification of Diseases Ninth Revision (ICD-9) admission diagnosis codes. Mortality during hospitalization was determined by review of inpatient records. Mortality at 30 and at 60 days was determined using a state death registry. Results:, In patients with infections, increasing serum lactate values of ,2.0 mmol/L were linearly associated with relative risk (RR) of mortality during hospitalization (RR = 1.9 to 3.6 with increasing lactate), at 30 days (RR = 1.7 to 2.6), and at 60 days (RR = 1.4 to 2.3) when compared to patients with serum lactate levels of <2.0 mmol/L. In patients without infections, a similar association was observed (RR = 1.1 to 3.9 during hospitalization, RR = 1.2 to 2.6 at 30 days, RR = 1.1 to 2.4 at 60 days). In both groups of patients, serum lactate had a greater magnitude of association with mortality than either of two other commonly ordered laboratory tests, leukocyte count and serum creatinine. Conclusions:, Higher ED lactate values are associated with greater mortality in a broad cohort of admitted patients over age 65 years, regardless of the presence or absence of infection. ACADEMIC EMERGENCY MEDICINE 2010; 17:260,268 © 2010 by the Society for Academic Emergency Medicine [source]

Outcomes Associated with Opioid Use in the Treatment of Chronic Noncancer Pain in Older Adults: A Systematic Review and Meta-Analysis

JOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 7 2010
Maria Papaleontiou MD
This systematic review summarizes existing evidence regarding the efficacy, safety, and abuse and misuse potential of opioids as treatment for chronic noncancer pain in older adults. Multiple databases were searched to identify relevant studies published in English (1/1/80,7/1/09) with a mean study population age of 60 and older. Forty-three articles were identified and retained for review (40 reported safety and efficacy data, the remaining 3 reported misuse or abuse outcome data). The weighted mean subject age was 64.1 (mean age range 60,73). Studies enrolled patients with osteoarthritis (70%), neuropathic pain (13%), and other pain-producing disorders (17%). The mean duration of treatment studies was 4 weeks (range 1.5,156 weeks), and only five (12%) lasted longer than 12 weeks. In meta-analyses, effect sizes were ,0.557 (P<.001) for pain reduction, ,0.432 (P<.001) for physical disability reduction, and 0.859 (P=.31) for improved sleep. The effect size for the Medical Outcomes Study 36-item Health Survey was 0.191 (P=.17) for the physical component score and ,0.220 (P=.04) for the mental component score. Adults aged 65 and older were as likely as those younger than 65 to benefit from treatment. Common adverse events included constipation (median frequency of occurrence 30%), nausea (28%), and dizziness (22%) and prompted opioid discontinuation in 25% of cases. Abuse and misuse behaviors were negatively associated with older age. In older adults with chronic pain and no significant comorbidity, short-term use of opioids is associated with reduction in pain intensity and better physical functioning but poorer mental health functioning. The long-term safety, efficacy, and abuse potential of this treatment practice in diverse populations of older persons remain to be determined. [source]

Hydrolysis and microbial community analyses in two-stage anaerobic digestion of energy crops

JOURNAL OF APPLIED MICROBIOLOGY, Issue 3 2007
D.G. Cirne
Abstract Aims:, The roles of the diverse populations of micro-organisms responsible for biodegradation of organic matter to form methane and carbon dioxide are rudimentarily understood. To expand the knowledge on links between microbial communities and the rate limiting, hydrolytic stage of two-stage biogas production from energy crops, this study was performed. Methods and Results:, The process performance and microbial communities (as determined by fluorescence in situ hybridization) in two separate two-stage batch digestions of sugar beets and grass/clover were studied. The microbial populations developed in the hydrolytic stage of anaerobic digestion of beets and grass/clover showed very few similarities, despite that the hydrolysis dynamics were similar. In both substrates, the solubilization of organic material was rapid for the first 10 days and accompanied by a build-up of volatile fatty acids (VFAs) and lactate. Between days 10 and 15, VFA and lactate concentrations decreased, as did the solubilization rates. For both substrates, Archaea started to appear in the hydrolytic stage between days 10 and 15, and the fraction of Bacteria decreased. The major bacterial group detected in the leachate fraction for beets was Alphaproteobacteria, whereas for grass/clover it was Firmicutes. The number of cells that bound to probes specifically targeting bacteria with cellulolytic activity was higher in the digestion of grass than in the digestion of beet. Conclusions:, This study allowed the identification of the general bacterial groups involved, and the identification of a clear shift in the microbial population when hydrolysis rate became limiting for each of the substrates investigated. Significance and Impact of the Study:, The findings from this study could be considered as a first step towards the development of strategies to stimulate hydrolysis further and ultimately increasing the methane production rates and yields from reactor-based digestion of these substrates. [source]

Literature review: considerations in undertaking focus group research with culturally and linguistically diverse groups

JOURNAL OF CLINICAL NURSING, Issue 6 2007
Elizabeth J Halcomb BN, IC Cert
Aims., This integrated literature review seeks to identify the key considerations in conducting focus groups and discusses the specific considerations for focus group research with culturally and linguistically diverse groups. Background., The focus group method is a technique of group interview that generates data through the opinions expressed by participants. Focus groups have become an increasingly popular method of data collection in health care research. Although focus groups have been used extensively with Western populations, they are a particularly useful tool for engaging culturally and linguistically diverse populations. The success of focus groups in this context is dependent upon the cultural competence of the research team and the research questions. Methods., The electronic databases Medline, CINAHL, Embase, Psychlit and the Internet using the Google Scholar search engine were explored using the search terms ,focus group', ,cultural sensitivity', ,transcultural nursing', ,transcultural care', ,cultural diversity' and ,ethnic groups'. Hand searching of reference lists and relevant journals was also undertaken. English language articles were selected for the review if they discussed the following issues: (i) methodological implications of the focus group method; (ii) strengths and limitations of the focus group method; (iii) recommendations for researchers and (iv) use of the focus group in culturally and linguistically diverse groups. Conclusions were drawn from each of the articles and consensus regarding a summary of recommendations was derived from a minimum of two authors. Results., Findings from this review revealed several key issues involving focus group implementation including recruitment, sample size, data collection, data analysis and use within multicultural populations. Strengths and limitations of the focus group method were also identified. Conclusions., Focus groups are a useful tool to expand existing knowledge about service provision and identify consumer needs that will assist in the development of future intervention programmes, particularly within multicultural populations. Careful planning related to methodological and pragmatic issues are critical in deriving effective data and protecting participants. Relevance to clinical practice., Focus groups can facilitate increased understanding of perspectives of culturally and linguistically diverse groups and thereby shape clinical practice to better meet the needs of these groups. [source]

Thiopurine S -methyltransferase (TPMT) genetic polymorphisms in Mexican newborns

JOURNAL OF CLINICAL PHARMACY & THERAPEUTICS, Issue 6 2009
A. González-del Angel MD
Abstract Background:, Thiopurine S -methyltransferase (TPMT) is involved in the toxicity and therapeutic efficacy of thiopurine drugs, and its gene exhibits genetic polymorphisms that differ across diverse populations. Four TPMT polymorphisms (TPMT*2, *3A, *3B and *3C) account for 80,95% of alleles that cause reduced enzyme activity. To date, only a single study in the Mexican population involving 108 individuals has been performed, but the regional and ethnic origin of this population was not described. Accordingly, information about the TPMT polymorphism in the Mexican population is limited. Objective:, To determine the TPMT allele and genotype frequencies in a sample of newborns from Mexico City. Methods:, Three hundred and sixty DNA samples from unrelated, anonymous individuals were obtained from dried blood spots collected on filter paper as part of the Newborn Screening National Program. Allele-specific polymerase chain reaction for the TPMT*2 allele and PCR restriction fragment length polymorphism for TPMT*3A, TPMT*3B, TPMT*3C alleles were used to determine the respective allelic and genotypic frequencies. Results and Discussion:, Of 720 TPMT alleles analysed, 49 (6·81%) were deficiency alleles. The most common deficiency allele was TPMT*3A (5·69%), followed by TPMT*3C (0·56%), TPMT*3B (0·28%) and TPMT*2 (0·28%). Fourty-five newborns were heterozygous for one mutant allele (12·5%) and two showed a genotype with two deficiency alleles (0·56%). Despite its unique ethnic composition, our Mexican population exhibited variant allele frequencies that were similar to some Caucasian populations. Conclusion:, Our data suggest that approximately 1 in 180 persons born in Mexico City might have low or undetectable TPMT enzyme activity, a frequency that, overall, is somewhat higher than that reported for Caucasian populations generally (1 in 300). [source]

Antibodies to neutrophil cytoplasma in patients with ulcerative colitis and their first-degree relatives in Thailand

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Issue 8 2001
Charkaphan Osangthamnont
Abstract Background: The prevalence of perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) does not significantly vary in ethnically diverse populations. The prevalence of p-ANCA is high in ulcerative colitis and primary sclerosing cholangitis. While the prevalence of ulcerative colitis in Asian populations is low, it is interesting to know the prevalence of p-ANCA in such a population. Methods: Sera from 33 cases of ulcerative colitis diagnosed during the last 10 years at the diarrhea clinic, Division of Gastroenterology, Siriraj Hospital, were prospectively compared with case controls consisting of 15 cases of diarrhea from non-inflammatory bowel diseases and 25 non-diarrheic patients. Indirect immunofluorescence assay was used to detect p-ANCA in all the sera. Results: Positive p-ANCA tests were found in 13 of the 33 patients with ulcerative colitis and in one of the 40 controls. Sensitivity of the test was 39.4% and the specificity was 97.5%. The one patient with positive p-ANCA in the control group was the patient with irritable bowel syndrome. Of the 13 p-ANCA-positive ulcerative colitis patients, two cases were found to have proctosigmoiditis, seven cases had left-sided colitis, and four cases had pancolitis. Perinuclear antineutrophil cytoplasmic antibodies was one of the 22 cases of first-degree relatives of ulcerative colitis patients (22 relatives from 12 index ulcerative colitis cases). There was no correlation between the positivity of p-ANCA and disease activity, and extent of the disease. Conclusion: The prevalence of p-ANCA in Thai patients with ulcerative colitis (39.4%) is lower than that in the Western population. Although the prevalence of p-ANCA is low in the Thai population, it should serve as a useful tool in diagnosing ulcerative colitis in this part of the world where the disease is uncommon and difficult to diagnose. The negativity of p-ANCA in almost all first-degree relatives of Thai ulcerative colitis patients should be further elucidated. [source]

Physical Activity Research in Nursing

JOURNAL OF NURSING SCHOLARSHIP, Issue 4 2001
Lorraine B. Robbins
Purpose: To present exemplars of physical activity research in nursing, illustrate the importance of physical activity research across the lifespan, and recommend directions for theory development and research. Methods: Studies of physical activity and exercise currently being conducted by nurse investigators were reported and critiqued by attendees of the Midwest Nursing Research Society 2000 Preconference session entitled "Promoting Physical Activity Among Diverse Groups Across the Health Continuum." Physical activity and exercise literature during the past decade was reviewed. Databases searched included Medline, CINAHL, Wilson, and ERIC. Findings: Investigators have emphasized the need to evaluate the effects of theory-based physical activity interventions designed to alter key correlates of physical activity identified through descriptive research. Conclusions: Regular physical activity is necessary for health promotion and disease prevention for all populations. Continued research in this important area of health behavior is critical to identify the most effective interventions to increase physical activity among diverse populations. [source]