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Developmental Failure (developmental + failure)

Distribution by Scientific Domains

Medical Sciences	75%

Selected Abstracts

Developmental disorders of glucose metabolism in infants

CHILD: CARE, HEALTH AND DEVELOPMENT, Issue 2002
R. Hume
Abstract Background Developmental failures to adequately control postnatal blood glucose levels are common in the transition from fetal to infant life and can persist for many months. The standard method of functionally measuring hepatic glucose production and/or disordered glucose production is the response to a glucagon tolerance test. Method We adapted the standard glucagon tolerance test used for children and adults for use in preterm infants. 79 consecutive preterm infants gestational age range 25,36 weeks (mean 32.2 weeks), mean birth weight 1.66 kg admitted to the Neonatal Intensive Care Unit, Ninewells Hospital, Dundee and who survived to discharge home were recruited into the study. At the time of discharge home the characteristics of the group were as follows: adjusted mean gestational age 36.7 weeks, mean discharge weight 2.23 kg. Results In this study of preterm infants the maximal increase in plasma glucose following administration of a glucagon tolerance test is 1.39 ± 07 mmol/L, n = 78 (range 0,3.98 mmol/L). Conclusions An increase in plasma glucose of less than 4 mmol/L is considered abnormal in adults following administration of a fasting glucagon tolerance test. The responses of preterm infants and adults to glucagon are clearly different. The attenuated response to glucagon in the preterm infants is consistent with the low levels of hepatic glucose-6-phosphatase activity in premature infants as glucose-6-phosphatase is the terminal step of the two main pathways of liver glucose production. [source]

The management of tics,,

MOVEMENT DISORDERS, Issue 1 2009
David Shprecher DO
Abstract A tic is a stereotyped repetitive involuntary movement or sound, frequently preceded by premonitory sensations or urges. Most tic disorders are genetic or idiopathic in nature, possibly due to a developmental failure of inhibitory function within frontal-subcortical circuits modulating volitional movements. Currently available oral medications can reduce the severity of tics, but rarely eliminate them. Botulinum toxin injections can be effective if there are a few particularly disabling motor tics. Deep brain stimulation has been reported to be an effective treatment for the most severe cases, but remains unproven. A comprehensive evaluation accounting for secondary causes, psychosocial factors, and comorbid neuropsychiatric conditions is essential to successful treatment of tic disorders. © 2008 Movement Disorder Society [source]

Pregnancy and successful labor in the course of chronic lymphocytic leukemia

AMERICAN JOURNAL OF HEMATOLOGY, Issue 3 2002
Günhan Gürman
Abstract Pregnancy and leukemia are difficult to manage. Protecting the mother from hemorrhage and infection and the fetus from developmental failure are the main aims. Chronic lymphocytic leukemia (CLL) has been seen very rarely with pregnancy. In this article, the successful labor of a 43-year-old woman with CLL is reported. She was not a candidate for chemotherapy at that time. She was without symptoms when she got pregnant. In the 30th gestational week she was found to have urinary tract infection and preterm labor and she was stabilized. Gestational diabetes and preeclampsia were also determined after that period and managed. The patient was delivered by cesarean section in the 39th gestational week. Cord blood was collected and preserved. No postpartum complication was seen in either the patient or the infant. This is one of the rare cases presenting CLL with pregnancy in the literature. Am. J. Hematol. 71:208,210, 2002. © 2002 Wiley-Liss, Inc. [source]

Former Foster Youth Attending College: Resilience and the Transition to Young Adulthood

AMERICAN JOURNAL OF ORTHOPSYCHIATRY, Issue 3 2005
Alice M. Hines PhD
The primary purpose of this study was to further research and theory development in the area of risk and resilience by exploring factors associated with academic success among former foster youth,a group at high risk for developmental failure. Using data obtained from in-depth qualitative interviews with 14 former foster youth currently attending a 4-year university, the study described in this article explored factors related to their academic success. Results indicated that factors at the individual, family, and community levels and encompassing more than 1 system at a time were integral in understanding developmental pathways of these youth. Results further suggested that resilience in 1 developmental or functional domain was not necessarily reflected in others. Findings are discussed in terms of conceptual and theoretical directions for further research in the area of resilience and the transition to young adulthood, with a particular emphasis on former foster youth. [source]