Developing

Distribution by Scientific Domains
Distribution within Medical Sciences

Terms modified by Developing

  • developing area
  • developing brain
  • developing central nervous system
  • developing cerebellum
  • developing chick embryo
  • developing chick liver
  • developing child
  • developing cns
  • developing cortex
  • developing country
  • developing country around the world
  • developing country setting
  • developing economy
  • developing egg
  • developing embryo
  • developing evidence
  • developing eye
  • developing fetus
  • developing field
  • developing forebrain
  • developing fruit
  • developing gut
  • developing heart
  • developing hippocampus
  • developing human brain
  • developing inner ear
  • developing larva
  • developing leaf
  • developing limb
  • developing lung
  • developing methods
  • developing mouse
  • developing mouse brain
  • developing nation
  • developing neocortex
  • developing nervous system
  • developing offspring
  • developing oocyte
  • developing organism
  • developing process
  • developing rat
  • developing rat brain
  • developing regions
  • developing retina
  • developing seed
  • developing spinal cord
  • developing stage
  • developing states
  • developing strategy
  • developing technology
  • developing theory
  • developing thymocyte
  • developing tool
  • developing world
  • developing zebrafish
  • developing zebrafish brain

  • Selected Abstracts


    LARGE HYPERPLASTIC POLYP DEVELOPING AFTER ENDOSCOPIC MUCOSAL RESECTION OF GASTRIC ADENOMA IN A PATIENT RECEIVING IMMUNOSUPPRESSIVE THERAPY

    DIGESTIVE ENDOSCOPY, Issue 2 2006
    Geum-Youn Gwak
    A 59-year-old man underwent endoscopic mucosal resection (EMR) for gastric adenoma. He had suffered from end-stage renal disease for several years and had received renal transplantation some 5 months before EMR. Subsequently, he took immunosuppressive agents. Follow-up gastrofiberscopy 6 months after EMR showed a sessile polyp at the resection site twice as large as the original adenoma; biopsy specimens revealed a hyperplastic nature. At the time of writing, this hyperplastic polyp has neither increased in size nor developed adenomatous or carcinomatous changes by histological examinations over the past 5 years. Therefore, this is a case of hyperplastic polyp occurring at the gastric adenoma resection site, and suggests the possible effect of immunosuppressive therapy on the post-EMR healing process and hyperplastic polyp development. [source]


    CLOSE ASSOCIATION BETWEEN GERIATRIC FUNCTIONAL ABILITY AND ECONOMIC STATUS IN DEVELOPING AND DEVELOPED COUNTRIES

    JOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 8 2005
    Kiyohito Okumiya MD
    No abstract is available for this article. [source]


    EFFECT OF PROCESSING ON BACTERIAL POPULATION OF CUTTLE FISH AND CRAB AND DETERMINATION OF BACTERIAL SPOILAGE AND RANCIDITY DEVELOPING ON FROZEN STORAGE

    JOURNAL OF FOOD PROCESSING AND PRESERVATION, Issue 1 2007
    THAILAMBAL ANANTHA SUBRAMANIAN
    ABSTRACT Processing techniques like cooking and freezing exhibited significant (P < 0.001) reduction in the bacterial load of cuttlefish, Sepia pharaonis, and marine crab, Portunus pelagicus. Raw cuttle fish had 2.4 × 107 cfu/g which on cooking reduced to 9.7 × 106 cfu/g. Freezing reduced the bacterial load further as cooked frozen product had only 9.9 × 104 cfu/g. Similarly, raw crab had 2.6 × 107 cfu/g which on cooking reduced to 6.5 × 106 cfu/g. A further reduction in bacterial load was seen after freezing as cooked frozen crab exhibited only 7.3 × 104 cfu/g. Escherichia coli and Staphylococcus aureus were present in the limit of acceptability for fish and fish products. Salmonella typhimurium and Vibrio cholerae were absent even in raw stage. Biochemical analysis performed on stored frozen products of cuttle fish and crab exhibited a significant (P , 0.05) increase in bacterial spoilage and rancidity with increasing days of storage. Total volatile base nitrogen, trimethylamine, thiobarbituric acid and free fatty acid contents in frozen products of cuttle fish and crab increased significantly with 120 days of frozen storage. [source]


    A KOREAN PERSPECTIVE ON DEVELOPING A GLOBAL POLICY FOR ADVANCE DIRECTIVES

    BIOETHICS, Issue 3 2010
    SOYOON KIM
    ABSTRACT Despite the wide and daunting array of cross-cultural obstacles that the formulation of a global policy on advance directives will clearly pose, the need is equally evident. Specifically, the expansion of medical services driven by medical tourism, just to name one important example, makes this issue urgently relevant. While ensuring consistency across national borders, a global policy will have the additional and perhaps even more important effect of increasing the use of advance directives in clinical settings and enhancing their effectiveness within each country, regardless of where that country's state of the law currently stands. One cross-cultural issue that may represent a major obstacle in formulating, let alone applying, a global policy is whether patient autonomy as the underlying principle for the use of advance directives is a universal norm or a construct of western traditions that must be reconciled with alternative value systems that may place lesser significance on individual choice. A global policy, at a minimum, must emphasize respect for patient autonomy, provision of medical information, limits to the obligations for physicians, and portability. And though the development of a global policy will be no easy task, active engagement in close collaboration with the World Health Organization can make it possible. [source]


    Left Ventricular Pseudoaneurysm Developing as a Late Complication of Coronary Artery Bypass Grafting with Apicoseptal Plication

    ECHOCARDIOGRAPHY, Issue 8 2005
    Ozcan Ozeke M.D.
    Left ventricular pseudoaneurysm is a false aneurysm, which results from a left ventricle rupture contained by adherent pericardium or scar tissue. The most common etiology of left ventricular pseudoaneurysm is acute myocardial infarction but one-third of pseudoaneurysms develop following surgery. We present a case report of a patient who developed a false aneurysm of the left ventricle 2 months following surgical repair of a left ventricular aneurysm with a concomitant coronary bypass. [source]


    Banking System Failures in Developing and Transition Countries: Diagnosis and Prediction

    ECONOMIC NOTES, Issue 1 2000
    P. Honohan
    First page of article [source]


    Critical Elements in Developing an Effective Reward Strategy

    EMPLOYMENT RELATIONS TODAY, Issue 1 2001
    Barbara Estes
    First page of article [source]


    Topical dose delivery in the reptilian egg treatment model

    ENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 5 2007
    Jennifer K. Muller
    Abstract Developing assays to detect endocrine-mediated toxicity from in ovo or in utero exposure is a current challenge in regulatory toxicology. Some species of reptiles exhibiting a unique mode of sex determination, in which the incubation temperature during a critical period determines gonadal sex, have been explored as an in ovo model to screen environmental contaminants for endocrine effects. We critically review published egg-exposure studies and conclude that data regarding the pharmacokinetics of topically applied substances are insufficient to validate dose,response relationships for the effects of chemicals on in ovo endocrine function or gender determination in reptiles. The insufficiencies in these data largely result from methodological failures, including lack of measurement verification, failure to investigate and control extraneous factors affecting the measurements, and lack of independent replication of results. Considerable additional research will be necessary to alleviate these methodological inadequacies. Given the current status of the data, topical treatment of reptilian eggs cannot be considered to be a valid means of establishing causal relationships between chemical treatment and biological outcome. [source]


    Quantifying dye tracers in soil profiles by image processing

    EUROPEAN JOURNAL OF SOIL SCIENCE, Issue 2 2000
    I. Forrer
    Summary Developing and testing models for solute transport in the field requires experimental data on the spreading of solutes in the soil. Obtaining such data is costly, and a substantial part of the total costs is in the preparation and chemical analysis of the tracing compounds in the gathered samples. We developed a cheap method to quantify the concentration of the mobile dye tracer Brilliant Blue FCF from digitized photographs of stained soil profiles, and we have tested it in the field. Soil sampling and chemical analyses were necessary only to establish a calibration relation between the dye content and the colour of the soil. The digital images were corrected for geometrical distortions, varying background brightness, and colour tinges, and then they were analysed to determine the soil colour at sampling points in the profiles. The resident concentration of the dye was modelled by polynomial regression with the primary colours red, green, blue and the soil depth as explanatory variables. Concentration maps of Brilliant Blue were then computed from the digitized images with a spatial resolution of 1 mm. Validation of the technique with independent data showed that the method predicted the concentration of the dye well, provided the corrected images contained only the colours included in the calibration. [source]


    The Challenges and Successes of Developing a Literacy Community in a Minority Language in Western Canada: An Action Research Study

    FOREIGN LANGUAGE ANNALS, Issue 3 2002
    Olenka S. E. Bilash
    ABSTRACT: This article describes a community action research study in the spirit of Carr and Kemmis (1983) and Elliot (1991). Language leaders in the Ukrainian community undertook a complex literacy initiative to investigate and improve Ukrainian-English bilingualism/biliteracy in Western Canada and throughout the diaspora. In the context of the long-term absence of research funding for developing and maintaining literacy in nonmajority or nonofficial languages, this article documents project activities over several years, presents the findings of student/teacher needs assessments, shares the approach to reading preferred by participating teachers, and reveals some of the transformations teachers experienced in their own thinking about bilingualism and biliteracy as a result of their involvement in this initiative. [source]


    Developing and evaluating an interactive information skills tutorial,

    HEALTH INFORMATION & LIBRARIES JOURNAL, Issue 2 2006
    Maria J. Grant
    Objective:, To develop and evaluate a web-based interactive information skills tutorial integrated into the curriculum. To determine whether the tutorial was acceptable to students and explore the use of a skills assessment tool in identifying whether the tutorial improved skills. Methods:, The development of a tutorial on OVID medline to teach transferable information skills. A small cohort study to evaluate students' views on the tutorial and its effects on information skills. Results:, Thirteen objective assessments were usable. There was a statistically significant improvement in mean final assessment scores, compared with mean pre-training scores, F(2,14) = 11.493, P = 0.001. Eleven (85%) students had improved their overall information skills. The improvement in overall searching skills was enhanced by referral to the tutorial. Conclusions:, The tutorial was successfully developed and integrated into a Masters programme curriculum. In this setting, it appears to reinforce active learning, and was well received by students, who developed core generic searching skills and demonstrated improved information skills in the short and longer term. Students could use the tutorial for revision and study at a time and place of their choosing. Further evaluation is required to assess the impact of using the tutorial with large groups of students, and as a stand-alone teaching medium. [source]


    Remission induction, consolidation and novel agents in development for adults with acute myeloid leukaemia

    HEMATOLOGICAL ONCOLOGY, Issue 1 2010
    Mehdi Hamadani
    Abstract Chemotherapy regimens used for remission induction in AML have not changed significantly over the last several decades. However the recognition of the prognostic value of cytogenetics and genomics has been a major advance which is helping clarify the most optimal post-remission consolidation strategy among various risk groups. We are not only beginning to realize the pitfalls of a ,one-fits-all' approach with intensive, cytarabine-based chemotherapy as the mainstay, but we are finally beginning to reap the rewards of decades of basic, translational, and clinical research. Developing individualized, ,targeted' therapy for each AML patient based on unique molecular features of disease remains a daunting goal yet one that we can now begin to envision. Hypothesis-based study designs,from pre-clinical/laboratory experiments to phase-I and subsequent efficacy trials,provide the foundation for advances in the diagnosis, risk stratification, and treatment for patients with AML. Here we critically review the literature for the management of AML, try to give recommendations regarding the appropriate induction and remission strategy, clarify the role of stem cell transplantation and discuss novel agents on the horizon. Copyright © 2009 John Wiley & Sons, Ltd. [source]


    Developing and maintaining protective CD8+ memory T cells

    IMMUNOLOGICAL REVIEWS, Issue 1 2006
    Matthew A. Williams
    Summary:, A critical aim of vaccine-related research is to identify the mechanisms by which memory T cells are formed and maintained over long periods of time. In recent years, we have designed experiments aimed at addressing two key questions: (i) what are the factors that maintain functionally responsive CD8+ memory cells over long periods of time, and (ii) what are the signals during the early stages of infection that drive the differentiation of long-lived CD8+ memory T cells? We have identified a role for CD4+ T cells in the generation of CD8+ T-cell-mediated protection from secondary challenge. While CD4+ T cells appear to play a role in the programme of CD8 memory, we find that they are also required for the long-term maintenance of CD8+ memory T-cell numbers and function. This property is independent of CD40,CD40L interactions, and we propose a role for CD4+ T cells in maintaining the ability of CD8+ memory T cells to respond to interleukin-7 (IL-7) and IL-15. By manipulating both the time course of infection and the timing of antigen presentation to newly recruited CD8+ T cells, we also demonstrate that the programming of effector and memory potential are at least partially distinct processes. [source]


    The Role of Declarative Pointing in Developing a Theory of Mind

    INFANCY, Issue 3 2004
    Luigia Camaioni
    It has been suggested that the child's capacity to represent and influence another person's attentional state about an object or event in triadic interactions (declarative communication) is an early manifestation of social understanding in the second year of life. This study tested the following predictions: First, in typically developing children declarative pointing emerges later than imperative pointing. Second, the capacity to use declarative pointing is linked to the understanding of other's intentions (i.e., to the capacity to reproduce other's intended acts after seeing failed attempts to perform these acts). The study was conducted in 2 phases. In the first phase, the parents of 133 typically developing infants completed the Questionnaire on Pointing Gesture, which allowed the identification of babies able to use pointing in familiar contexts. Of these children, 40 participated in the experiment and were tested on 2 tasks: a new task designed to elicit production and comprehension of imperative and declarative pointing, and a modified version of Meltzoff's (1995) task designed to assess understanding of others' intentions. Tasks were administered to each participant in 2 sessions carried out at 3-month intervals. Children were 12 months old on average at the 1st session and 15 months old on average at the 2nd session. Results showed that children produced and understood declarative pointing later than imperative pointing. Furthermore, production of declarative pointing was clearly linked to understanding of others' intentions. No relation was found between production and comprehension of imperative pointing and intention understanding. Implications from the association between declarative pointing and inferring other's intentions are discussed. [source]


    Developing person-centred practice: nursing outcomes arising from changes to the care environment in residential settings for older people

    INTERNATIONAL JOURNAL OF OLDER PEOPLE NURSING, Issue 2 2010
    BSc (Hons) Nursing, Brendan McCormack D.Phil (Oxon), PGCEA
    mccormack b., dewing j., breslin l., coyne-nevin a., kennedy k., manning m., peelo-kilroe l., tobin c. & slater p. (2010) Developing person-centred practice: nursing outcomes arising from changes to the care environment in residential settings for older people. International Journal of Older People Nursing 5, 93,107 Aim., To present the nursing outcomes from the evaluation of developments in the care environment in residential settings for older people. Design., The evaluation data reported here is derived from a larger national programme of work that focused on the development of person-centred practice in residential services for older people using an emancipatory practice development framework. A multi-method evaluation framework was utilised. Outcome data were collected at three time points between December 2007 and September 2009. The data reported here were collected using an instrument called the ,Person-Centred Nursing Index'. Findings., Heavy workload was the main cause of stress among nurses. Personal and professional satisfaction with the job was scored highest by the total sample of nurses. Nineteen factors were examined using the Person-Centred Nursing Index. Statistically significant changes were observed in 12 of these. In addition, there were statistically significant changes in nurses' perceptions of caring, indicating a shift from a dominant focus on ,technical' aspects of care, to one where ,intimate' aspects of care were more highly valued. Relevance to clinical practice., The findings highlight the importance of the development of effective teamwork, workload management, time management and staff relationships in order to create a culture where there is a more democratic and inclusive approach to practice and space for the formation of person-centred relationships. [source]


    Developing and validating a tool to measure parenting self-efficacy

    JOURNAL OF ADVANCED NURSING, Issue 2 2005
    Sally Kendall BSc PHD RGN RHV
    Aims., This paper reports the development of a tool to measure parenting self-efficacy as an aid to evaluating parenting programmes. Background., Whilst there has been increasing interest in parenting programmes from parents, government and professionals, there is a lack of rigorous evaluation studies of their effectiveness, particularly their longer-term outcomes. Equally, there is little research evidence of the views and experiences of parents themselves. It is important to develop robust outcome measures which draw on well-developed theoretical constructs to measure parents' perceived abilities to manage their children based on their own views and experiences. Self-efficacy, a self-perception of one's ability to perform competently and effectively in a particular task or setting, may provide such a framework. Methods., Data from 12 focus groups conducted with parents and parenting programme facilitators informed the development of the tool. A thematic analysis of the focus group transcripts identified key items to be included in the self-efficacy instrument, and these were developed into 82 Likert-format statements. A multi-method approach was used to test the instrument for validity and reliability. Findings., Nine domain specific sub-scales of parenting were identified from the analysis of the focus group data. Internal reliability coefficients for the subscales ranged from 0·80 to 0·89, and the overall scale reliability was 0·94. External reliability coefficients ranged from rs = 0·58 (n = 19, P < 0·01) to rs = 0·88 (n = 19, P < 0·01). Conclusion., A valid and reliable tool to measure parenting self-efficacy has been developed, which will aid evaluation of parenting programmes. [source]


    Challenges and Opportunities for Developing and Implementing Incentives to Improve Health-Related Behaviors in Older Adults

    JOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 9 2010
    Eran Klein MD
    There is growing interest in using patient-directed incentives to change health-related behaviors. Advocates of incentive programs have proposed an ambitious research agenda for moving patient incentive programs forward. The unique cognitive and psychological features of older adults, however, present a challenge to this agenda. In particular, age-related changes in emotional regulation, executive function, and cognitive capacities, and a preference for collaborative decision-making raise questions about the suitability of these programs, particularly the structure of current financial incentives, for older adults. Differences in decision-making in older adults need to be accounted for in the design and implementation of financial incentive programs. Financial incentive programs adjusted to characteristics of older adult populations may be more likely to improve the lives of older persons and the economic success of programs that serve them. [source]


    Paresthesias Developing in an Elderly Patient after Chronic Usage of Nitrofurantoin and Vitamin B6

    JOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 12 2003
    Rhodora A. Lacerna MD
    No abstract is available for this article. [source]


    Developing and maintaining the therapeutic alliance with self-injuring patients

    JOURNAL OF CLINICAL PSYCHOLOGY, Issue 11 2007
    Nira Nafisi
    In this article, the authors outline methods of strengthening the therapist,patient bond with individuals who self-injure. Self-injuring patients present with a host of challenges that differ from other patient populations and therefore certain approaches may be more effective than others. Among the strategies described are validation, checking in, working collaboratively toward goals, providing support, and repairing a ruptured alliance. Potential pitfalls (e.g., reinforcing maladaptive behavior, negative judging, and the fundamental attribution error) to which psychotherapists often fall prey are discussed as well. Self-injury is explained as functional rather than manipulative behavior and detailed clinical guidelines and examples are provided to better illustrate approaches that will improve the therapeutic alliance. © 2007 Wiley Periodicals, Inc. J Clin Psychol: In Session 63: 1069,1079, 2007. [source]


    Developing and implementing a comprehensive approach to serving women with co-occurring disorders and histories of trauma

    JOURNAL OF COMMUNITY PSYCHOLOGY, Issue 4 2005
    Nicholas Huntington
    The Substance Abuse and Mental Health Services Administration (SAMHSA) funded the Women, Co-Occurring Disorders and Violence Study to generate empirical knowledge on how to improve services for women who are trauma survivors and have co-occurring mental health and substance use disorders. We first review the literature on the pervasiveness of trauma among women and the ways in which current service systems fail to address their needs. We then describe the four core principles of the model grantees developed to test in the project. Working through a project Steering Committee, grantees mandated that services be (a) integrated, (b) trauma-informed, (c) consumer-involved, and (d) comprehensive. For each of these principles, we describe the specifications adopted by the committee, the strategies the study sites used to implement the principle in their local settings, and the concrete lessons sites learned concerning how to implement the principle. © 2005 Wiley Periodicals, Inc. J Comm Psychol 33: 395,410, 2005. [source]


    Subcutaneous Panniculitis-Like T Cell Lymphoma Developing in a Patient with Chronic B-Cell Lympocytic Leukemia

    JOURNAL OF CUTANEOUS PATHOLOGY, Issue 1 2005
    L Shahabi
    Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is an unusual peripheral lymphoma most typically presenting with a cytotoxic (CD8-positive, TIA-1-positive) immunophenotype. SPTCLs may have an indolent or highly aggressive clinical course. Histologically, SPTCL may be notoriously difficult to diagnosis. Cases of SPTCL with a deceptively benign appearance similar to that of subcutaneous lupus erythematosus have been described. SPTCL associated with a concomitant systemic leukemia/lymphoma has not been documented in the literature. We report a case of SPTCL arising in a 65-year-old female with a well-established history of B-cell lymphocytic leukemia (BCLL). She presented with two months of recurrent fever and painless erythematous nodules on bilateral lower extremities that were clinically felt to be erythema nodosum. Initial biopsies demonstrated a polymorphous lobular infiltrate with neutrophils, karyorrhexis and lipomembranous change. An excisional biopsy demonstrated an atypical lymphoid population that expressed CD8 and TIA1. PCR analysis confirmed T-cell receptor gene arrangement. The patient was treated with systemic chemotherapy with resolution of her symptoms and complete remission. This is the first well documented case of SPTCL occurring in a patient with long standing B-CLL, and highlights the difficulty of establishing an unequivocal diagnosis of SPTCL. [source]


    Photochromism of dihydroindolizines part VII: multiaddressable photophysical properties of new photochromic dihydroindolizines bearing substituted benzo[i]phenanthridine as a fluorescing moiety,

    JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, Issue 8 2007
    Saleh Abdel-Mgeed Ahmed
    Abstract Sixteen benzo[i]phenanthridine derivatives 8a-p were prepared via photocyclization of cis-trans substituted 4-styrylquinolines in low-to-moderate yields. The chemical structure of the photocyclized benzo[i]phenanthridine derivatives was unambiguously elucidated by means of both spectral and analytical tools. The photochromic (PC) dihydroindolizines (DHIs) 8a-p based on benzo[i]phenanthridines were prepared in 19,57% yields via nucleophilic addition of benzo[i]phenanthridines 4a-p to spirocyclopropenes 5. The 1D, 2D, NOESY NMR spectra, mass spectrometry, and elemental analysis were used for characterization of the chemical structures of the newly synthesized DHIs 8a-p. Developing and tuning of the photophysical properties of the synthesized compounds by substituents in the base part have been achieved. The absorption maxima (,max) and the half-lives (t1/2) of the colored zwitterionic forms 7a-p were detected in all cases by flash-photolysis measurements due to the fast 1,5-electrocyclization back to the DHI system. Irradiation of DHI 8a-p in'CH2Cl2 solution with polychromatic light leads to the formation of green to green,blue colored betaines 7a-p after cooling with liquid nitrogen. The kinetics of the fast bleaching process of betaines 7a-p to DHIs 8a-p, studied by flash photolysis as well as low temperature FT-UV/VIS, were found to take place in the millisecond range (432,2675,ms) in dichloromethane solution and fitted well a first-order thermal back reaction. The fluorescence spectra as well as the fluorescence quantum yield were studied. Noticeable bathochromic and hypsochromic shifts in the emission spectra by changing the substituents in the base part were monitored. Interestingly, the photo-fatigue resistance of some studied betaines 7a-p showed a higher t30 -value than the standard one (dicyanopyridazine DHI). Large solvatochromic effects on the absorption maxima (,max) as well as a substantial increase in the half-lives (t1/2) with solvent polarity of betaines 7a-p were also observed. The multiaddressable PC properties of DHIs 8a-p will help these compounds to find applications. Copyright © 2007 John Wiley & Sons, Ltd. [source]


    Developing 100,ps-resolved X-ray structural analysis capabilities on beamline NW14A at the Photon Factory Advanced Ring

    JOURNAL OF SYNCHROTRON RADIATION, Issue 4 2007
    Shunsuke Nozawa
    NW14A is a newly constructed undulator beamline for 100,ps time-resolved X-ray experiments at the Photon Factory Advanced Ring. This beamline was designed to conduct a wide variety of time-resolved X-ray measurements, such as time-resolved diffraction, scattering and X-ray absorption fine structure. Its versatility is allowed by various instruments, including two undulators, three diffractometers, two pulse laser systems and an X-ray chopper. The potential for the detection of structural changes on the 100,ps time scale at NW14A is demonstrated by two examples of photo-induced structural changes in an organic crystal and photodissociation in solution. [source]


    Human mast cells express receptors for IL-3, IL-5 and GM-CSF; a partial map of receptors on human mast cells cultured in vitro

    ALLERGY, Issue 10 2004
    C. Dahl
    Background:, Mast cells have long been recognized as the principal cell type that initiates the inflammatory response characteristic of acute allergic type 1 reactions. Our goal has been to further characterize maturation of progenitors to mast cells. Methods:, Mast cells were cultured from human cord blood derived CD133+ progenitors. Mast cell function was tested using histamine release. During differentiation mast cells surface marker expression was monitored by flow cytometry. Results:, CD133+ progenitors expressed the early haematopoietic and myeloid lineage markers CD34, CD117, CD13 and CD33. Mature mast cells expressed CD117, CD13 and CD33, and expression of the high affinity immunoglobulin E recpetor Fc,RI increased during culture. Cytokine receptors interleukin (IL)-5R, IL-3R, granulocyte-macrophage-colony stimulating factor (GM-CSF)R and IL-18R were expressed at high levels during maturation. Chemokine receptors CXCR4 and CXCR2 were highly expressed on both newly purified CD133+ cells and mature cells. Conclusion:, Human mast cells can be cultured from a CD34+/CD117+/CD13+/CD33+ progenitor cell population in cord blood that is tryptase and chymase negative. Developing and mature mast cells express a wide range of chemokine and cytokine receptors. We found high levels of expression of CD123, IL-5R and GM-CSF receptors, also found on eosinophils and basophils, and high levels of expression of the receptor for the inflammatory cytokine IL-18. [source]


    Developing and maintaining accelerated degree programs within traditional institutions

    NEW DIRECTIONS FOR ADULT & CONTINUING EDUCATION, Issue 97 2003
    William J. Husson
    This chapter describes some of the essential criteria and elements for initiating and sustaining a successful accelerated degree program. [source]


    Developing and implementing culturally competent evaluation: A discussion of multicultural validity in two HIV prevention programs for Latinos

    NEW DIRECTIONS FOR EVALUATION, Issue 102 2004
    Ross F. Conner
    This chapter describes two projects and develops from them a set of five factors that facilitate multicultural validity. The chapter also includes a discussion of some limitations of these case examples and suggestions for further testing and refinement of multicultural validity in the more general context of validity within the evaluation field. [source]


    Tool to classify stool consistency: Content validity and use by persons of diverse cultures

    NURSING & HEALTH SCIENCES, Issue 2 2003
    Donna Zimmaro Bliss PhD
    Abstract Developing and testing the quality of a research instrument, including its ability to be used by culturally diverse persons, is an important methodological objective. The present study determined the content validity and feasibility of culturally diverse persons to use an instrument to classify stool consistency that has been employed in research on fecal incontinence. Five multidisciplinary clinicians experienced in assessing stool consistency determined the tool to possess content validity. Twenty-four foreign nationals of diverse cultures who spoke English as a second language (ESL) classified the consistency of nine stools using word only or word plus diagram descriptions. The agreement of the ratings of the participants were compared with the those of an experienced investigator. There was no significant difference between the ratings of participants using either type of description. There was good agreement between the classifications of the participants and those of the investigator. The findings of this study contribute to the quality of our instrument and support its use by culturally diverse persons. [source]


    Developing and setting up a patient and relatives intensive care support group

    NURSING IN CRITICAL CARE, Issue 1 2009
    Maureen Peskett
    Abstract Aim:, The purpose of this article was to highlight the need to provide support for patients and relatives following critical illness and discharge from hospital and how this can be improved through the establishment of user support groups. Background:, Critical illness predisposes patients to extended physical and psychological ill health with the potential for a reduced quality of life. The authors' personal experience, patient feedback and current literature suggested that there was a need for further support during their recovery. Methods:, Building on an existing formal follow-up service, Intensive Care Unit (ICU) Support Team for Ex-Patients established a patient-centred forum, where patients and relatives could share experiences with others who had also been through critical illness by holding drop-in sessions. Feedback from those attending these flexible and informal sessions indicates that support was needed and that patients and families have found benefit in sharing experiences with others who can empathise, having been through critical illness themselves. Conclusions:, Our experience has shown there is a need that can be met simply with minimal investment of time and funding but that addresses a gap in patient support that otherwise goes unmet. Although this was a service development in one local area, it could be adapted to ICU patients and relatives more widely. [source]


    Clear Cell Hidradenocarcinoma Developing in Pacemaker Pocket

    PACING AND CLINICAL ELECTROPHYSIOLOGY, Issue 11 2008
    CESAR V. REYES M.D.
    An octagenerian woman developed clear cell hidradenocarcinoma, a rare neoplasm of eccrine sweat gland origin, 4 years following pacemaker implantation in her right lateral chest. The tumor immunohistochemically mimicked a metastatic lobular breast carcinoma, for example, strongly positive estrogen, weakly positive progesterone, and weakly reactive mammoglobin. A complete surgical excision of the tumor was complemented with ipsilateral dissection of involved adjacent axillary lymph nodes. Recommended irradiation was refused by the patient. Retrospective 3-year mammogram review, 2-year postsurgery follow-up, and complete postmortem evaluation failed to prove a primary breast malignancy or other metastatic lesion elsewhere. [source]


    Typical Atrial Flutterlike Tachycardia Developing After Inferior Vena Cava-Tricuspid Annulus Isthmus Ablation

    PACING AND CLINICAL ELECTROPHYSIOLOGY, Issue 2 2001
    MAMORU MANITA
    First page of article [source]